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All Journal Jurnal Pendidikan dan Pembelajaran Kimia (JPPK) Jurnal Pendidikan Fisika PROSIDING SEMINAR KIMIA Jurnal Pendidikan Kimia (JPKim) Jurnal Inovasi Pembelajaran Kimia (Journal Of Innovation in Chemistry Education) Eduproxima : Jurnal Ilmiah Pendidikan IPA Indonesian Journal of Chemical Science and Technology Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Journal of Science and Science Education (JoSSEd) Educenter: Jurnal Ilmiah Pendidikan Indonesian Journal of Advanced Research (IJAR) Madani: Multidisciplinary Scientific Journal Jurnal Medika Veterinaria EDUCENTER JURNAL PENDIDIKAN
Roza, Destria
Universitas Negeri Medan
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HKSA ANALYSIS AND DOCKING OF ANTIOXIDANT ACTIVITY OF CURCUMIN ANALOGUES AGAINST TYROSINASE ENZYME Chosya, Cahya; Roza, Destria; Nugraha, Asep Wahyu
Jurnal Pendidikan dan Pembelajaran Kimia Vol 13, No 2 (2024): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

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Abstract

Abstract : The aim of the HKSA and Docking analysis was to determine the potential of curcumin analogues as antioxidants for the activity of the tyrosinase enzyme. Predictor calculations were carried out using the hyperchem application with the CNDO semi-empirical geometric optimization method Multilinear regression analysis using SPSS to find the relationship between predictors and the activity of curcumin analogue derivative compounds as tyrosinase inhibitors. The best HKSA equation model is : LogIC50  : -3.195 – (1.135 x HOMO) + (1.064 x LUMO) - (0.239 x LogP) + (0.155 x HE) With a value of R = 0,984; R­2 = 0,969; Adj R2 = 0,948; SE = 0,183; F count  = 10,209; Sign = 0,000. This equation is used to predict new compounds derived from curcumin analogs that can be used as new tyrosinase inhibitors. The parameters for selecting this compound were because it had better activity and LogIC50 values compared to the parent compound. To see the affinity between the new curcumin analogue derivative compound and the tyrosinase enzyme, docking was carried out using Autodock Tools, which was visualized using Biovia discovery studio. The docking results show that the compound 2,5-bis (4-hydroxy 3-allyl benzylidene) cyclopentanone has potential inhibitory activity on the tyrosinase receptor as an antioxidant activity because it has the same amino acid residue as the original ligand (Tyrosine) with the binding energy of the compound 2,5- bis (4-hydroxy 3-allylbenzylidene) cyclopentanone is -5.92 kcal/mol and the Ki value is 46.03 uM, which is better than the binding energy of the compound (Tyrosine) which is -4.96 kcal/mol and the Ki value is 231.77 uM.Keywords: Curcumin, Tyrosinase, Antioxidant, QSAR, Docking DOI: 10.23960/jppk.v13i2.30560
Flavonoid Isolation And Toxicity Test Using The BSLT (Brine Shrimp Lethality TestI) Method From Parasite Flower Coffe Extract (Loranthus ferrugineus Roxb.) Roza, Destria; Girsang, Sedianta
Indonesian Journal of Chemical Science and Technology (IJCST) Vol. 7 No. 2 (2024): JULY 2024
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v7i2.62301

Abstract

This research aims to isolate compounds from extracts of coffee parasite flowers (Loranthus ferrugineus Roxb.) and determine their toxicity activity using the BSLT (Brine Shrimp Lethality Test) method. The results of the identification of secondary metabolite compounds show that the coffee parasite flower extract contains alkaloids, saponins, tannins and flavonoids. The results of the toxicity activity of the coffee parasite flower extract using the BSLT method show that the extract has high bioactivity and has an LC50 value of 93.4266 µg/mL. Meanwhile, isolation of flavonoid compounds from coffee parasite flower extract (Loranthus ferrugineus Roxb.) based on infrared spectroscopy (IR) analysis showed the presence of vibrations of the O-H, С-Н, С-О, C-C, and C-O groups which indicated the presence of flavonoid group compounds.
Implementation of Problem Based Learning Model Assisted by Electronic Student Worksheets to Improve Learning Outcomes and Learning Motivation on Reaction Rate Material Manurung, Elisa; Pulungan, Ahmad Nasir; Sudrajat, Ajat; Amdayani, Susilawati; Roza, Destria
Journal of Science and Science Education Vol. 6 No. 2 (2025): October
Publisher : Pascasarjana, Mataram University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jossed.v6i2.12064

Abstract

Learning media serves to assist teachers in conveying information to students and can increase student learning motivation. This study aims to determine the application of the Problem Based Learning learning model assisted by E-LKPD to improve learning outcomes, learning motivation and the relationship between learning motivation and learning outcomes on the reaction rate material at Kartika 1-2 Medan Private High School. The type of research used is Quasy Experiment using pretest posttest. Sampling was done by purposive sampling. The sample consisted of one class, namely class XI IPA 4 as the experimental class (n = 30). Learning outcome data were processed using the Normalized Gain (N-Gain) test. The hypothesis was tested by linear regression and correlation test. The effectiveness of the Problem Based Learning learning model to improve learning outcomes and learning motivation on the reaction rate material is seen from the average posttest and pretest scores of 33.5 and 89.83, then the average N-gain value of 0.84 is included in the high category. The average value of students' initial and final learning motivation measured using a learning motivation questionnaire is 93.62, which is in the high category. These results indicate an increase in student learning outcomes after learning using the Problem Based Learning model assisted by E-LKPD. Hypothesis testing produces a value of rhit= 0.71 and rtabel = 0.36 at the significance level (  = 0.05) which shows that rhit > rtabel so it can be concluded that there is a significant relationship between learning outcomes and student learning motivation.
Co-Authors Ahmad Nasir Pulungan Ajat Sudrajat Albinus Silalahi Amdayani, Susilawati Anna Juniar Asep Wahyu Nugraha Astrika Sari Sinaga Astrika Sari Sinaga Bajoka Nainggolan Chosya, Cahya Christesya Ambarita Dewi Wulandari Frisca Zahrona Utami Harahap Girsang, Sedianta Gulo, Kristin Wulan Liberti Vivanis H, Herlinawati Ida Duma Riris Ida Dumariris Irham Ramadhani Junifa Layla Sihombing, Junifa Layla M Aswin Rangkuti Manurung, Elisa Marini Damanik Mawaddah Rahmi Murniaty Simorangkir Nora Susanti Nova Betria Sinaga Rini Selly Rini Selly, Rini Salsabila, Fuaddinda Putri Samosir, Tico Guinessha Sembiring, Erika Fortuna Sagita Siska Juita Gea Siti Khodijah Dalimunthe Sri Adelila Sari Sri Adelila Sari* Syarifuddin Syarifuddin Tico Guinessha Samosir Tita Juwitaningsih Tita Juwitaningsih Tita Juwitaningsih Wawan Bunawan Yul Ifda Tanjung