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All Journal Jurnal Pendidikan dan Pembelajaran Kimia (JPPK) Jurnal Pendidikan Fisika PROSIDING SEMINAR KIMIA Jurnal Pendidikan Kimia (JPKim) Jurnal Inovasi Pembelajaran Kimia (Journal Of Innovation in Chemistry Education) Eduproxima : Jurnal Ilmiah Pendidikan IPA Indonesian Journal of Chemical Science and Technology Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Educenter: Jurnal Ilmiah Pendidikan Indonesian Journal of Advanced Research (IJAR) Madani: Multidisciplinary Scientific Journal Jurnal Medika Veterinaria EDUCENTER JURNAL PENDIDIKAN
Roza, Destria
Universitas Negeri Medan
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HKSA ANALYSIS AND DOCKING OF ANTIOXIDANT ACTIVITY OF CURCUMIN ANALOGUES AGAINST TYROSINASE ENZYME Chosya, Cahya; Roza, Destria; Nugraha, Asep Wahyu
Jurnal Pendidikan dan Pembelajaran Kimia Vol 13, No 2 (2024): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

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Abstract

Abstract : The aim of the HKSA and Docking analysis was to determine the potential of curcumin analogues as antioxidants for the activity of the tyrosinase enzyme. Predictor calculations were carried out using the hyperchem application with the CNDO semi-empirical geometric optimization method Multilinear regression analysis using SPSS to find the relationship between predictors and the activity of curcumin analogue derivative compounds as tyrosinase inhibitors. The best HKSA equation model is : LogIC50  : -3.195 – (1.135 x HOMO) + (1.064 x LUMO) - (0.239 x LogP) + (0.155 x HE) With a value of R = 0,984; R­2 = 0,969; Adj R2 = 0,948; SE = 0,183; F count  = 10,209; Sign = 0,000. This equation is used to predict new compounds derived from curcumin analogs that can be used as new tyrosinase inhibitors. The parameters for selecting this compound were because it had better activity and LogIC50 values compared to the parent compound. To see the affinity between the new curcumin analogue derivative compound and the tyrosinase enzyme, docking was carried out using Autodock Tools, which was visualized using Biovia discovery studio. The docking results show that the compound 2,5-bis (4-hydroxy 3-allyl benzylidene) cyclopentanone has potential inhibitory activity on the tyrosinase receptor as an antioxidant activity because it has the same amino acid residue as the original ligand (Tyrosine) with the binding energy of the compound 2,5- bis (4-hydroxy 3-allylbenzylidene) cyclopentanone is -5.92 kcal/mol and the Ki value is 46.03 uM, which is better than the binding energy of the compound (Tyrosine) which is -4.96 kcal/mol and the Ki value is 231.77 uM.Keywords: Curcumin, Tyrosinase, Antioxidant, QSAR, Docking DOI: 10.23960/jppk.v13i2.30560
Flavonoid Isolation And Toxicity Test Using The BSLT (Brine Shrimp Lethality TestI) Method From Parasite Flower Coffe Extract (Loranthus ferrugineus Roxb.) Roza, Destria; Girsang, Sedianta
Indonesian Journal of Chemical Science and Technology (IJCST) Vol. 7 No. 2 (2024): JULY 2024
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v7i2.62301

Abstract

This research aims to isolate compounds from extracts of coffee parasite flowers (Loranthus ferrugineus Roxb.) and determine their toxicity activity using the BSLT (Brine Shrimp Lethality Test) method. The results of the identification of secondary metabolite compounds show that the coffee parasite flower extract contains alkaloids, saponins, tannins and flavonoids. The results of the toxicity activity of the coffee parasite flower extract using the BSLT method show that the extract has high bioactivity and has an LC50 value of 93.4266 µg/mL. Meanwhile, isolation of flavonoid compounds from coffee parasite flower extract (Loranthus ferrugineus Roxb.) based on infrared spectroscopy (IR) analysis showed the presence of vibrations of the O-H, С-Н, С-О, C-C, and C-O groups which indicated the presence of flavonoid group compounds.
Co-Authors Albinus Silalahi Anna Juniar Asep Wahyu Nugraha Astrika Sari Sinaga Astrika Sari Sinaga Bajoka Nainggolan Chosya, Cahya Christesya Ambarita Dewi Wulandari Frisca Zahrona Utami Harahap Girsang, Sedianta Gulo, Kristin Wulan Liberti Vivanis H, Herlinawati Ida Duma Riris Ida Dumariris Irham Ramadhani Junifa Layla Sihombing, Junifa Layla M Aswin Rangkuti Marini Damanik Mawaddah Rahmi Murniaty Simorangkir Nora Susanti Nova Betria Sinaga Rini Selly Rini Selly, Rini Salsabila, Fuaddinda Putri Samosir, Tico Guinessha Sembiring, Erika Fortuna Sagita Siska Juita Gea Siti Khodijah Dalimunthe Sri Adelila Sari Sri Adelila Sari* Syarifuddin Syarifuddin Tico Guinessha Samosir Tita Juwitaningsih Tita Juwitaningsih Tita Juwitaningsih Wawan Bunawan Yul Ifda Tanjung