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All Journal Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JTP - Jurnal Teknologi Pendidikan Jurnal Integrasi Kesehatan dan Sains Jurnal Kebidanan Khatulistiwa JOURNAL LA MEDIHEALTICO Jurnal Kesehatan Metro Sai Wawai Media Penelitian dan Pengembangan Kesehatan
Setyorini Irianti
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Althea Medical Journal

 1 
Soursop Leaves (Annona muricata Folium) on Mice (Mus musculus) Fetus Suryani, Yunita; Sitorus, Truly Deti Rose; Irianti, Setyorini
Althea Medical Journa Vol 1, No 1 (2014)
Publisher : Althea Medical Journa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.889 KB)

Abstract

Background: Soursop leaf ethanol extract (Annona muricata (L) Folium) contains acetogenins which are cytotoxic and have the ability to halt cell growth. This study aimed to understand whether acetogenins have teratogenic effects on mice fetus (Mus musculus).Methods: This study was performed at the Pharmacology and Therapy Laboratory of the Faculty of Medicine, Universitas Padjadjaran, Bandung, between October and November 2012. The study  was an experimental laboratory study  utilizing 27 pregnant mice which were divided into 3 groups. The first group was the negative control, the second was given soursop leaf ethanol extract at pre-implantation phase (day 1 to 5) and the third had the extract provided in the organogenesis phase (day 6 to 15). Laparotomy was performed on the 19th day of pregnancy. The parameters used were the number of implantation, the number of live and dead or resorbed fetus, the weight and length of the fetus, as well as the macroscopic external morphology abnormalities. The data gained from test subjects were compared to those of the control group. The statistical test used was the normality tes with the Kolmogorov-Smirnov method which was then followed by T-test or Mann-Whitney statistical tests.Results: The experiment exhibited significant differences in the weight and length of the fetus (p-value 0.000), proving that soursop leaf ethanol extract could inhibit intrauterine growth. Aside from that, external morphological abnormalities such as hemorrhage on the head, face, neck, back, forelimbs, hindlimbs, and microcephaly were also found.Conclusion: The soursop leaf ethanol extract (Annona muricata (L) Folium) has a teratogenic effect on mouse (Mus musculus) fetus. [AMJ.2014;1(1):48–53]Key words: Acetogenins, Soursop leaf ethanol extract, TeratogenicEfek Teratogenik Ekstrak Etanol Daun Sirsak (Annona muricata Folium) terhadap Fetus Mencit (Mus musculus) Latar belakang: Ekstrak etanol daun sirsak (Annona muricata Folium) mengandung senyawa aktif Acetogenins yang bersifat sitotoksik atau dapat menghambat pertumbuhan sel. Penelitian ini dilakukan untuk mengetahui efek teratogenik Acetogenins terhadap fetus mencit (Mus musculus).Metode: Penelitian ini dilakukan di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjadaran periode Oktober–November 2012. Penelitian bersifat eksperimental laboratorik dengan metode sampel acak menggunakan 27 ekor mencit hamil yang dibagi dalam 3 kelompok. Kelompok 1 sebagai kontrol negatif, kelompok 2 diberikan ekstrak etanol daun sirsak pada masa praimplantasi (hari ke-1 sampai ke-5), dan kelompok 3 menerima ekstrak pada masa organogenesis (hari ke-6 sampai ke-15). Laparotomi dilakukan pada hari ke-19 kehamilan. Parameter yang digunakan berupa jumlah hasil implantasi, jumlah fetus hidup, jumlah fetus mati atau resorbsi, berat dan panjang badan fetus, serta abnormalitas morfologi eksternal fetus yang dinilai secara makroskopis. Data yang didapat pada kelompok perlakuan dibandingkan dengan kelompok kontrol. Uji statistik yang digunakan adalah uji normalitas data dengan uji Kolmogorov-Smirnov dan dilanjutkan dengan uji T- atau Mann-Whitney.Hasil: Hasil penelitian menunjukkan perbedaan signifikan pada berat dan panjang fetus mencit (nilai p 0,000), sehingga ekstrak etanol daun sirsak terbukti menghambat pertumbuhan intrauteri. Selain itu ditemukan juga kelainan morfologi eksternal seperti perdarahan pada kepala, wajah, leher, punggung, tangan, kaki, dan mikrosefali.Simpulan: Ekstrak etanol daun sirsak (Annona muricata Folium) memiliki efek teratogenik terhadap fetus mencit (Mus musculus).Kata kunci: Acetogenins, ekstrak etanol daun sirsak, teratogenik
Soursop Leaves (Annona muricata Folium) on Mice (Mus musculus) Fetus Yunita Suryani; Truly Deti Rose Sitorus; Setyorini Irianti
Althea Medical Journal Vol 1, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.889 KB)

Abstract

Background: Soursop leaf ethanol extract (Annona muricata (L) Folium) contains acetogenins which are cytotoxic and have the ability to halt cell growth. This study aimed to understand whether acetogenins have teratogenic effects on mice fetus (Mus musculus).Methods: This study was performed at the Pharmacology and Therapy Laboratory of the Faculty of Medicine, Universitas Padjadjaran, Bandung, between October and November 2012. The study  was an experimental laboratory study  utilizing 27 pregnant mice which were divided into 3 groups. The first group was the negative control, the second was given soursop leaf ethanol extract at pre-implantation phase (day 1 to 5) and the third had the extract provided in the organogenesis phase (day 6 to 15). Laparotomy was performed on the 19th day of pregnancy. The parameters used were the number of implantation, the number of live and dead or resorbed fetus, the weight and length of the fetus, as well as the macroscopic external morphology abnormalities. The data gained from test subjects were compared to those of the control group. The statistical test used was the normality tes with the Kolmogorov-Smirnov method which was then followed by T-test or Mann-Whitney statistical tests.Results: The experiment exhibited significant differences in the weight and length of the fetus (p-value 0.000), proving that soursop leaf ethanol extract could inhibit intrauterine growth. Aside from that, external morphological abnormalities such as hemorrhage on the head, face, neck, back, forelimbs, hindlimbs, and microcephaly were also found.Conclusion: The soursop leaf ethanol extract (Annona muricata (L) Folium) has a teratogenic effect on mouse (Mus musculus) fetus. [AMJ.2014;1(1):48–53]Key words: Acetogenins, Soursop leaf ethanol extract, TeratogenicEfek Teratogenik Ekstrak Etanol Daun Sirsak (Annona muricata Folium) terhadap Fetus Mencit (Mus musculus) Latar belakang: Ekstrak etanol daun sirsak (Annona muricata Folium) mengandung senyawa aktif Acetogenins yang bersifat sitotoksik atau dapat menghambat pertumbuhan sel. Penelitian ini dilakukan untuk mengetahui efek teratogenik Acetogenins terhadap fetus mencit (Mus musculus).Metode: Penelitian ini dilakukan di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjadaran periode Oktober–November 2012. Penelitian bersifat eksperimental laboratorik dengan metode sampel acak menggunakan 27 ekor mencit hamil yang dibagi dalam 3 kelompok. Kelompok 1 sebagai kontrol negatif, kelompok 2 diberikan ekstrak etanol daun sirsak pada masa praimplantasi (hari ke-1 sampai ke-5), dan kelompok 3 menerima ekstrak pada masa organogenesis (hari ke-6 sampai ke-15). Laparotomi dilakukan pada hari ke-19 kehamilan. Parameter yang digunakan berupa jumlah hasil implantasi, jumlah fetus hidup, jumlah fetus mati atau resorbsi, berat dan panjang badan fetus, serta abnormalitas morfologi eksternal fetus yang dinilai secara makroskopis. Data yang didapat pada kelompok perlakuan dibandingkan dengan kelompok kontrol. Uji statistik yang digunakan adalah uji normalitas data dengan uji Kolmogorov-Smirnov dan dilanjutkan dengan uji T- atau Mann-Whitney.Hasil: Hasil penelitian menunjukkan perbedaan signifikan pada berat dan panjang fetus mencit (nilai p 0,000), sehingga ekstrak etanol daun sirsak terbukti menghambat pertumbuhan intrauteri. Selain itu ditemukan juga kelainan morfologi eksternal seperti perdarahan pada kepala, wajah, leher, punggung, tangan, kaki, dan mikrosefali.Simpulan: Ekstrak etanol daun sirsak (Annona muricata Folium) memiliki efek teratogenik terhadap fetus mencit (Mus musculus).Kata kunci: Acetogenins, ekstrak etanol daun sirsak, teratogenik DOI: 10.15850/amj.v1n1.297
Maternal Risk Factors among Pregnant Women with Miscarriage Sofia, Norlaila; Fadlyana, Eddy; Irianti, Setyorini; Krisnadi, Sofie; Susiarno, Hadi
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3037

Abstract

Background: Approximately, 4.1% of maternal deaths in Indonesia occur due to miscarriage. Miscarriage might be caused by various factors such as fetal, maternal, and external factors. Monitoring and early detection of maternal factors might prevent miscarriage.  This study aimed to analyze the influence of maternal factors on the incidence of miscarriage. Methods: This was an analytic observational study with a case-control design conducted in Banjar District, South Kalimantan in August–September 2022. Data was collected from the medical records of pregnant women who experienced miscarriage (n=60) and pregnant women who did not (n=120). Data was analyzed using the chi square test and logistic regression. The level of maternal risk factors for the incidence of miscarriage was determined from the odds ratio (OR) value at a 95% confidence interval.Results: The results revealed that parity (p=0.000; OR=2.2), nutritional status (p=0.000; OR=77.1), level of education (p=0.001; OR=3.5), and employment status (p=0.000; OR=8.1) had a significant effect on the incidence of miscarriage.Conclusion: Maternal factors such as parity, nutritional status, education level, and employment status influence on the incidence of miscarriage, therefore, it is essential to educate pregnant women on various factors related to miscarriage.
Co-Authors Adhi Pribadi Ahmad Parwis Ahmad Parwis Akhmad Yogi Pramatirta, Akhmad Yogi Alfonsus Zeus Amillia Siddiq Ana Mariana, Ana Andi Kurniadi, Andi Andri Reza Rahmadi Anita D Anwar Anita Deborah Anwar Anwar, Anita D Aprianti, Nurul Azmi Arshandi Faisal Shiddiq Avivi, Safiya Fathina Aziz, Muhammad Alamsyah Benny Hasan Purwara Billy Nusa Anggara Budi Handono Budi Setiabudiawan Dany Hilmanto Dida Akhmad Gurnida Dodi Suardi Dyah Ayu Puspita Eddy Fadlyana Eduward Yacub Prasangka Fadhilah Zulfa Fahdiansyah Fahdiansyah Fahdiansyah Fahdiansyah Fauzi, Ali Amali Fidkya Allish Gusasih, Bahar Sangkur Herman Susanto Johanes C. Mose Johannes Cornelius Mose Jusuf Sulaeman Effendi Krisnadi, Sofie Kurnia Wahyudi, Kurnia Kusteja, Nadya Fauzia Laniyati Hamijoyo, Laniyati Lillah, Alfarisi Syukron Lulu Eva Rakhmilla, Lulu Eva Lumentut, Anastasia Mariane M. Rizkar Arev Sukarsa Maelissa, Merlin Margreth Nugrahani, Annisa Dewi Nurul Islamy Octaviana, Hana Rifa Passamula, Muhammad Hasan Puspitasari, Maya Khaerunnisa Raden Tina Dewi Judistiani Ramdhan, Muhammad Raihan Ruswana Anwar Sapiie, Tuti Wahmurti A. Sefty Mariany Samosir Sofia, Norlaila Sofie R. Krisnadi Sulaiman, Aina Zakia Supriyatin, Dedeh Susiarno, Hadi Syahidah, Putri Nadya Sylvia Rachmayati Tan, Zaki Miftah Nalalindra Teuku Kyan Nuryasin Truly Deti Rose Sitorus Truly Deti Rose Sitorus Vebri Anita Sinaga Will Hans Windi Nurdiawan Wirawan, Wahyudi Wiryawan Permadi Wulan Ardhana Iswari Yuni Susanti Pratiwi, Yuni Susanti Yuniartis, Putri Yunita Suryani Yunita Suryani Zulvayanti Zulvayanti