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All Journal Media Penelitian dan Pengembangan Kesehatan Jurnal Biotek Medisiana Indonesia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kefarmasian Indonesia
Ani Isnawati
Puslitbang Farmasi dan Obat Tradisional, Balitbangkes
Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Public Health

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Penyakit Peptik dan Misoprostol Raini, Mariana; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 3, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i3.2851

Abstract

Peptic mucus synthesize especially prostaglandine E2 and 12. Prostaglandine E2 and l2 can impede acid secrete and stimulate mucus and bicarbonate secretion. Misoprostol, a synthetic methyl ester analogue of prostaglandin is both a powerful inhibitor of gastric secretion and is able to protect the gastroduodenal mucosa from damage. Misoprostol and other prostaglandine derivatives can be alternative drug of peptic ulcer relapse because the metyl ester of prostaglandin exert an antisecretion and protective effects on peptic mucus. The clinical eflectiveness of misoprostol is comparable to cimethidin in short term treatment of peptic and duodenum ulcer as well as reducing duodenal ulcer relapse. Misoprostol may prevent gastrointestinal and peptic ulcer in long term treatment of Non Steroid Anti Inflamation Drug. The side eflect of misoprostol is cervix maturation and uterotonic. This article describe misoprostol eflecliveness on peptic and duodenum ulcer treatment.
Kualitas Ekstrak Etanol 70% Daun Kelor (Moringa oleifera Lamk) dalam Ramuan Penambah ASI Alegantina, Sukmayati; Isnawati, Ani; Widowati, Lucie
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 1, FEBRUARI 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

From the collection of data (SDKI) in 2002-2003, it is found that the number of exclusive breastfeeding in infants below the age of two months covers only 64% of total infants. The most alarming facts are that 13% of infants under two months have been fed infant milk formula and one of three infants aged 2-3 months has been given additional food. Therefore, using Kelor as herba to facilitating breast milk is needed as extract requirement. In addition, this research considers characterization of Kelor extract as a first step to standardize Kelor extract. Sample is extract of Kelor leaf from East Java. To ensure quality requirements of 70% ethanol extract from Kelor leaf for herbal medicine, it has to meet the quality requirement guidelines established by BPOM. Examination includes non-specific parameter such as water content, total ash, total acid insoluble ash, and extract microscopic examination. In the other side, specific parameter includes content of dilute alkohol, content of dilute water, assay of total alkaloid and chemistry compound test. Characteristic of 70 % ethanol extract from Kelor leaf for non-specific parameter are water content 15,68%, total ash 3,04%, total acid insoluble ash 1,13% and loss on drying 29,70% , whereas characteristic of spesific parameter for content of dilute etanol 33,11%, content of dilute water 47,53%, and assay Trigonellin 15,68 %. The conclusion is non spesific characteristic from kelor leaf etanol extract, that is water content does not meet the quality requirement guidelines
Formulation of Dihydroartemisinin-Piperaquine (DHP) Generic Tablet as Antimalarials Drug Yunarto, Nanang; Isnawati, Ani; Aini, Nurul; Kurniatri, Arifayu Addiena; Adelina, Rosa; Setyorini, Herni Asih
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 1, FEBRUARI 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i1.2911

Abstract

The incidence of malaria in Indonesia is about two million cases annually. Dihydroartemisinin-piperaquine (DHP) is the first line therapy recommended for uncomplicated malaria treatment, whereas DHP is still fully imported. The generic DHP tablet formulation has the potential to become the first of DHP drug which is locally produced. This study is aimed to formulate generic DHP film coated tablets for antimalaria drug. Tablets were compressed with the combination of wet granulation for piperaquine phosphate (PQP) and direct compression method for DHA and coated with a moisture barier coating material. The parameters to evaluate the quality of DHP tablets are physical properties, assay, and dissolution test. DHA and PQP assay were performed by HPLC method. The dissolution testing was conducted by in house method using HCl 0.1 N medium. The result shows physical properties of filmcoated tablets meet the requirement, i.e. uniform weight, 7.0-8.5 kp hardness, 0.02% friability and 3 minute 22 seconds disintegration. The assay to determine DHA in tablet was 95.17% and PQP was 97.05%. The result of dissolution testing shows the content of DHA and PQP in the tablet were 113.51% and 96.55%, respesctively. The formulation which is developed meets the general requirement of API in tablet 90–110% and dissolution requirement >75%.
Karakterisasi Simplisia dan Ekstrak Kulit Buah Duku (Lansium domesticum Corr) dari Provinsi Sumatera Selatan dan Jambi Salim, Milana; Sulistyaningrum, Novi; Isnawati, Ani; Sitorus, Hotnida; Yahya, Yahya; Ni'mah, Tanwirotun
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2947

Abstract

Duku (Lansium domesticum Corr var duku) is a seasonal native plant from South Sumatra and Jambi. Peel of Duku is useful as botanical insecticide. in South Sumatra and Jambi. The research proves that the skin duku can be useful as an insecticide plant. Quality of compounds in plants can be affected by the origin area of plant, body parts of plants, and extract characters. This study aims to characterize the simplicia and duku peel extract from South Sumatra and Jambi Province. The sample were collected from Simpang Agung Village, OKU Selatan District and Rengas Bandung Village, Muaro Jambi District. The peel was extracted using acetone, while the charactherization based on standardization method from Badan POM Indonesia. Non-Specific parameters which measured were water content, water soluble ash and acid insoluble ash. Specific parameters which measured were water soluble extract, ethanol soluble extract, chromatogram, and chemical compound. Simplicia from Simpang Agung Village contain lower water content, water soluble ash, and acid insoluble ash than simplicia from Rengas Bandung Village. Chromatogram pattern of the peel extract from both village were similar and contain terpenoid and fenolic compound. However hexane yield extract from Simpang Agung Village higher than extract from Rengas Bandung Village therefore contain more insecticides material (terpenoid).
Profil Disolusi Tablet Amlodipin dan Perbandingan Kadar Dua Produk Generik dengan Produk Inovator Alegantina, Sukmayati; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.3029

Abstract

Amlodipine is an antihypertensive and antianginal drug belonging to the class of dihydropyridine calcium antagonist (calcium ion antagonist). Amlodipine patent term expired in 2007, thus nowadays some national pharmaceutical manufacturers produce amlodipine as generics and branded generics medicine. In order to determine the quality of generic amlodipine, dissolution profile and contents of two generic amlodipine were studied by comparing them with their innovator product. The dissolution test was carried out using a type 2 (paddle) and the dissolved content was determined by using UV spectrophotometer, whereas amlodipine content tablet was determined by using HPLC (High Performance Liquid Chromatography). The results showed that all of the three tablets met the FDA requirements of dissolution, i.e.within 30 minutes they should be dissolved not less than 85%. All of the three tablets had the same dissolution profile p=0,521 (CI=95%), whereas both the generic and branded generic tablet compared to the innovator product had similar or comparables profile , (f2>50). The content of all three tablets are not significantly different with p=0,08 (CI = 95%). The highest content of amlodipine was found in amlodipine a tablet with an average content of 102,69%.
Studi Docking Molekuler Catechin Gallate, Epicatechin Gallate, Gallocatechin Gallate, dan Epigallocatechin Gallate Isnawati, Ani; Adelina, Rosa
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Indonesia has the second biggest natural in the world. This natural resources could be used as raw material for drug if well managed. As we know, 96% of raw material in Indonesia are imported which caused the price of drugs are expensive. In order to overcome the problem, it is essential to conduct research about Indonesian plants which are potential as dyslipidemia drug. The molecular docking study is one of insilico studies that is used to screen compounds based on their working mechanism to protein. In this study, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were docked using Moleculer Operating Environtment (MOE). Software in order to determine their affinity and interaction with HMG-CoA reductase enzyme which has a role in cholesterol/fat metabolism. This research used simvastatin and atorvastatin as the standard drug for dyslipidemia. The result of molecular docking showed that Gibbs values of simvastatin, atorvastatin, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were -6,4974; -8,543; -9,5736; -10,6395; -10,4765; and -10,598. The results stated that four cathechin derivates have an inhibiting energy better than simvastatin and atorvastatin. These are potential as dyslipidemia drugs candidate.
Deskripsi Hasil Uji Angka Lempeng Total (ALT) Pada Beberapa Susu Formula Bayi Puspandari, Nelly; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3693

Abstract

Infant formula is the nutrient source for some babies who were not breastfed. Risk factors for infection in infants less than 6 months old who consume formula are greater than those who were breastfed. This is due to the baby's immune system is not well formed. Therefore, it is important to supervise formula safety more strict than adult’s food. Total plate count (TPC) is one of the factors considered in the infant formula. The aim of this study is to define safety of infant formula based on total plate count within infant formula distributed in Indonesia in 2011. The study was a cross sectional study. The samples were representative of infant formula distributed in 23 province. Total plate count method and interpretation were conducted based on ISO/TS 22964. The TPC of each samples were examined three times. The TPC of all infant formulas were below of SNI breakpoint, which is less than 104cfu/gram. TPC ranged from
Kandungan Gizi Mikro (Besi, Seng), Nitrit dan Formalin pada Daging Sapi dari Pasar Tradisional dan Swalayan Alegantina, Sukmayati; Isnawati, Ani; Winarsih, Winarsih; Ernawati, Fitrah; Imanningsih, Nelis; Setyorini, Herni Asih
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3725

Abstract

Beef is a nutritious food to consume due to its nutrient content that needed by human body. The demand for beef increases in certain times, such as in religion event or in the holiday. Special treatment is needed for the slaughter time to ready to consume beef, such as freezing or refrigerating. This research aimed to identify the quality of fresh beef as well as frozen beef in the traditional market and frozen beef in supermarket regarding its content of micronutrient (iron and zinc), preservatives (nitrate), and another dangerous additional food (formaldehyde) in cub roll, upper thighs, and lower thighs of beef. This was a cross-sectional and laboratory observational designed research. The result showed that iron, zinc, and nitrite concentration on fresh beef and frozen beef in traditional market and supermarket on any side of the beef sample was not significantly different (p>0.05). Nitrite concentration was within the permitted level. All beef samples also had not contain formaldehyde.
Determination of HPLC Chromatogram Profile of Katuk (Breynia androgyna (L.) Chakrab. & N.P.Balakr) Plants from Ristoja's Results using Chemometric Analysis Yunarto, Nanang; Alegantina, Sukmayati; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.6040

Abstract

The katuk plant was known as Sauropus androgynous (L.) Merr, but the name is changed to Breynia androgyna (L.) Chakrab. & N.P. Balakr since the publication of Chakrab's & N.P. Balakr in the 2012 Journal of Plant Taxonomists. The content of chemical compounds and secondary metabolites of katuk leaf are strongly influenced by different habitat or location. Therefore, the Center for Research and Development of Medicinal Plants and Traditional Medicines, National Institute of Health Research and Development (NIHRD) has conducted Research on medicinal plants and herbs (RISTOJA) results on 58 samples of katuk plants originating from 7 provinces and used by 13 ethnic groups in Indonesia. This study aims to obtain plant quality based on the description of the High-Performance Liquid Chromatography (HPLC) chromatogram profile, in order to obtain the suitability of the efficacy of medicinal plants with their benefits for the community in an area. Test using HPLC with a gradient mobile phase, mixture of acetonitrile and methanol for 60 minutes. The results of the chromatogram were analyzed chemometrically by using Principal Component Analysis (PCA) data interpretation. PCA results showed that from HPLC chromatograms at 254 nm and 366 nm, each gave 3 different clusters, namely Clusters A, B and C where each cluster has the same chromatogram profile of katuk plants. Cluster A which was identified at a wavelength of 254 nm was the most used cluster by 7 ethnic groups with a total of 28 Katuk samples. Similarly, the chromatogram at a wavelength of 366 nm with the largest cluster is cluster A which is used by 11 ethnic groups with a total of 45 samples of katuk plants. where each cluster had the same chromatogram profile of katuk Plants.
Antioxidant and Inhibition Lipase Enzyme Activity of Centella asiatica Leaf Extract Yunarto, Nanang; Mawadatun, Ummi; Reswandaru, Uud Nourma; Sopian, Ahmad; Isnawati, Ani; Alegantina, Sukmayati
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6609

Abstract

Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a herbal medicine with reported antioxidant effect in vitro. Centella asiatica contains secondary metabolites asiaticoside which are included in the terpenoid group. The study evaluated the respective antioxidant potential and lipase enzyme inhibition of Centella asiatica leaves extract (CAE). Centella asiatica were extracted in ethanol, and the extract was assayed for the measurement of asiaticoside. Ethanolic extracts of asiaticoside content were prepared for HPLC analysis The antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1-picrylhydrazyl as well as reducing. The anti-hyperlipidemic effect was evaluated in vitro lipase inhibitory activity test carried out enzymatically using the ELISA method with simvastatin as a comparison. The results showed asiaticoside contain in CAE 1.26%; the IC50 value of the antioxidant test of CAE was 11.38 g/mL; the IC50 value of the lipase enzyme in the CAE was 26.14 g/mL. The antioxidant activity of CAE is categorized as very strong and has the potential to inhibit lipase enzymes. The study suggests that CAE has the potential to inhibit lipase activity, suppressing lipid digestion and thereby diminishing entry of lipids into the body.  
Co-Authors . Murhandini . Pudjiastuti Ahmad Sopian, Ahmad Aini Nurul Arifayu Addiena Kurniatri Bafadal, Mentarry Budiarti, Mery Delima -, Delima Emiliana Tjitra Fitrah Ernawati Herni Asih Setyorini Hotnida Sitorus Indri Rooslamiati Jokopriambodo, Wahyu Lucie Widowati Maratu Soleha Mariana Raini Mariana Raini2, Mariana Mawadatun, Ummi Milana Salim Mus, Nurul Muhlisa Nanang Yunarto Nelis Imanningsih Nelly Puspandari Ni'mah, Tanwirotun Nisaa, Nur Rezky Khairun Novi Sulistyaningrum Nyoman Fitri Prasetya, Fajar Reswandaru, Uud Nourma Retno Gitawati Rosa Adelina Soblia, Hamim Tsalis Sri Endreswari Sukmayati Alegantina Winarsih Winarsih Yahya Yahya