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All Journal HAYATI Journal of Biosciences Medicina journal of internal medicine E-Jurnal Medika Udayana Berkala Kedokteran Jurnal Penyakit Dalam Udayana JPSCR : Journal of Pharmaceutical Science and Clinical Research ISM (Intisari Sains Medis) : Jurnal Kedokteran PREPOTIF : Jurnal Kesehatan Masyarakat Neurologico Spinale Medico Chirurgico MAHESA : Malahayati Health Student Journal KESANS : International Journal of Health and Science GANESHA MEDICINA MEDICINUS Hang Tuah Medical Journal Eduvest - Journal of Universal Studies Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
I Made Pande Dwipayana
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Denpasar, Bali, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Hubungan Status Gizi Terhadap Kejadian Dislipidemia pada Mahasiswa Program Pendidikan Dokter Spesialis Ilmu Penyakit Dalam RSUP Prof. dr. I.G.N.G. Ngoerah I Dewa Gede Agung Suta Ariwangsa; I Made Pande Dwipayana
MEDICINUS Vol. 39 No. 2: MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/sqn0k793

Abstract

Background: Nutritional status plays an important role in determining individual’s health. Obesity is closely associatedwith dyslipidemia, mainly through insulin resistance mechanisms and proinflammatory adipokines, which contribute tothe development of metabolic syndrome. However, recent evidence suggests that obesity‑related dyslipidemia does notfollow a single, uniform pathophysiological pattern; instead, its characteristics may vary across individuals. This studyaimed to examine the relationship between nutritional status and dyslipidemia among residents of the Internal Medicine Specialist Program at RSUP Prof. dr. I.G.N.G. Ngoerah, Denpasar. Methods: This cross‑sectional study was conducted in August 2023 at RSUP Prof. dr. I.G.N.G. Ngoerah, Denpasar. The study subjects were residents of the Internal Medicine Specialist Program. Data were collected through measurements of body mass index (BMI) as an indicator of nutritional status and lipid profile examination as an indicator of dyslipidemia. The association between variables was analyzed using the Chi‑Square test, with statistical significance set at p<0.05. Results: A total of 115 subjects were enrolled in the study, with 60% men and 40% women and a mean age of 31.25 ± 3.82 years. Of these, 74 subjects (64,3%) were classified as obese, and 57 subjects had dyslipidemia. Forty‑six (46) subjects had presented with obesity and dyslipidemia, while 11subjects had dyslipidemia in the absence of obesity. Meanwhile, 30 subjects had neither obesity nor dyslipidemia, and 28 participants were obese without dyslipidemia. The Chi‑Square test showed a significant association between nutritional status and dyslipidemia (p<0,001). Conclusion: This study demonstrates a significant relationship between nutritional status and dyslipidemia. Further research is needed to explore specific factors that contribute to obesity and dyslipidemia among residents in specialist medical training programs.Keywords: nutritional status, obesity, dyslipidemia, resident physicians, PPDS
HIPOKALSEMIA PASCA TIROIDEKTOMI : LAPORAN KASUS Trisnawati, Ni Nyoman Ayu; Dwipayana, I Made Pande
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.54820

Abstract

Hipokalsemia merupakan suatu gangguan biokimia yang dapat bersifat asimtomatik pada kasus ringan atau muncul sebagai kondisi akut yang mengancam jiwa. Kadar kalsium dalam tubuh diatur oleh hormon paratiroid (parathyroid hormone/PTH), vitamin D, dan kalsitonin melalui efek spesifik pada saluran cerna, ginjal, dan tulang. Kami melaporkan sebuah kasus hipokalsemia pasca-tiroidektomi pada seorang perempuan berusia 62 tahun. Pasien datang dengan keluhan rasa kaku pada mulut, tangan, dan kaki. Pemeriksaan fisik menunjukkan tanda Chvostek positif, interval QT memanjang pada elektrokardiografi, serta hipokalsemia pada pemeriksaan laboratorium. Gejala klinis membaik setelah empat hari pemberian terapi kalsium dan kalsitriol. Namun, hipokalsemia akibat hipoparatiroidisme primer memiliki kecenderungan untuk kambuh. Oleh karena itu, diperlukan pemberian rutin kalsium oral dan kalsitriol oral sebagai terapi jangka panjang. Pemantauan laboratorium juga perlu dilakukan secara berkala, setidaknya setiap 3–6 bulan. Ke depan, terapi pengganti menggunakan PTH rekombinan dapat menjadi alternatif pengobatan pada kasus hipokalsemia pasca-tiroidektomi.
Differences Between Serum Total Testosterone Levels in Obese and Non-Obese Male Health Workers Saraswati, Putu Ayu Indah; Suastika, Ketut; Dwipayana, I Made Pande
MAHESA : Malahayati Health Student Journal Vol 6, No 3 (2026): Volume 6 Nomor 3 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i3.20851

Abstract

ABSTRACT Obesity is a metabolic condition that poses a global health challenge and is associated with various complications, including reduced testosterone levels. Low testosterone is a critical component in metabolic syndrome and hormonal dysfunction in men. This study aims to analyze the differences in total serum testosterone levels between obese and non-obese male healthcare workers and identify factors influencing low testosterone levels at Prof. dr. I.G.N.G. Ngoerah General Hospital, Denpasar. This cross-sectional study involved 89 male healthcare workers grouped based on body mass index (BMI): obese (BMI ≥ 25 kg/m²) and non-obese (BMI 25 kg/m²). Total serum testosterone levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical analysis included bivariate tests using Chi-Square and Fisher-Exact tests, followed by multivariate logistic regression to determine the relationship between obesity and low testosterone levels, adjusting for confounding factors such as age, type 2 diabetes mellitus, hypertension, and heart disease. The mean total serum testosterone level was 528.74 ± 265.13 ng/dL. The prevalence of low testosterone was significantly higher in the obese group (82.6%) compared to the non-obese group (17.4%), with an odds ratio (OR) of 13.691 (p 0.001). Multivariate analysis identified obesity as an independent predictor of low testosterone, with an adjusted odds ratio (AOR) of 6.101 (95% CI: 1.531–24.307; p = 0.010). Age was also a significant factor, with participants aged ≥30 years having a higher risk of low testosterone compared to younger participants (AOR: 4.961; 95% CI: 1.118–22.004; p = 0.035). Type 2 diabetes mellitus was strongly associated with low testosterone levels (OR: 22.909; p 0.001) but was not significant in the multivariate analysis (p = 0.060). Obesity is a significant risk factor for low testosterone levels in male healthcare workers, with age being another key determinant. These findings highlight the importance of early detection and management of obesity to prevent hormonal dysfunction. Keywords: Obesity, Total Serum Testosterone, Male Healthcare Workers.
Diagnostic and Management of Idiophatic Panhypopituitarism A Case Report Ida Bagus Aditya Nugraha; Komang Agus Wira Nugraha; Anak Agung Gede Budhiarta; Ketut Suastika; Wira Gotera; Made Ratna Saraswati; I Made Pande Dwipayana; I Made Siswadi Semadi
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66266/inajemd.v1i1.5

Abstract

Hypopituitarism is marked by decreased secretion of one, several, or all anterior or posterior pituitary hormones. A rare disorder, panhypopituitarism indicates the loss of all the pituitary hormones but often is used in clinical practice to describe a patient's deficiency in growth hormone, gonadotropins, corticotropin, and thyrotropin in whom the posterior pituitary function remains intact. Hypopituitarism may occur because of diverse etiologies and lead to substantial morbidity and mortality. Despite advances in the diagnosis and management of pituitary disorders, hypopituitarism is still associated with increased long-term cardiovascular mortality. We report a rare case of a 22-year-old boy with idiopathic panhypopituitarism. The patient has deficiency of growth hormone, gonadotropin, corticotropin, and thyrotropin, yet the underlying etiology remains unknown in this patient because of lack of imaging data. This is very challenging to do prompt diagnosis and management of panhypopituitarism. The management is needing multiple hormonereplacement therapy, based on the result of pituitary hormone laboratory examination. Prompt treatment is needed to prevent further morbidity and mortality in this patient. hypothyroidism, growth hormon
The Effect of Flaxseed (Linum usitatissimum) Ethanol Extract on LDL Cholesterol Levels and Foam Cell Number in the Aorta of Male Wistar Rats (Rattus norvegicus) Fed A High-Fat and High-Fructose Diet Marcella, Marzha; Wihandani, Desak Made; Artini, I Gusti Ayu; Sumadi, I Wayan Juli; Dwipayana, I Made Pande; Sriwidyani, Ni Putu
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.100142

Abstract

A diet high in saturated fat and fructose leads to dyslipidemia, increasing atherosclerosis risk. Although lipid-lowering medications are available, they have certain limitations. Flaxseed, rich in ALA, lignans, and phytosterols, may improve lipid profiles and act as an antioxidant. This study evaluated the effectiveness of flaxseed in preventing LDL cholesterol elevation and aortic foam cell formation in male Wistar rats fed a high-fat, high-fructose (HFHF) diet.This actual experimental study used a post-test-only control group design for 35 days. Twenty-five male Wistar rats were randomly assigned to five groups: N (normal control, standard diet), K (negative control, HFHF diet), and three treatment groups (P1, P2, P3, HFHF diet) receiving flaxseed ethanol extract at doses of 200, 400, and 800 mg/kgBW/day. LDL cholesterol levels (mg/dL) and aortic foam cell counts (cells/HPF) were measured. Data were analyzed using Shapiro-Wilk and Levene tests for normality and homogeneity, followed by one-way ANOVA, Kruskal-Wallis, and Tukey-HSD post hoc tests. LDL cholesterol levels in groups N, P1, P2, and P3 were significantly lower than in group K (p = 0.007), with P2 showing the most significant inhibition (p = 0.035). Foam cell counts were lower in treatment groups than in group K (p = 0.257), but no significant differences were found among them. Flaxseed (Linum usitatissimum) ethanol extract at 400 mg/kgBW/day was the most effective in preventing an increase in LDL cholesterol. However, the extract at all three doses was ineffective in preventing an increase in aortic foam cells in male Wistar rats (Rattus norvegicus) fed an HFHF diet.
Co-Authors A Santoso A. A. Putu Eka Darmaputra Juliantara AA Gede Budhiarta, AA Gede AA Istri Sri Kumala Dewi, AA Istri Sri Kumala AAG Budhiarta Aditya Rachman Anak Agung Gde Budhiarta Anak Agung Gde Budhiarta Anak Agung Gede Budhiarta Ari Puji Astiti Bayu Mayura, I Putu Budhiarta, Anak Agung Gde Desak Made Wihandani H Taniguchi I Dewa Gede Agung Suta Ariwangsa I Gusti Ayu Artini I Ketut Suastika I Komang Realiska I Made Ady Wirawan I Made Siswadi Semadi I Made Siswadi Semadi I Made Siswadi Semadi I Wayan Juli Sumadi I. K. Suastika I.A.A. Widhiartini Ida Bagus Aditya Nugraha Ida Bagus Yorky Brahmantya IGN Gunadi IMR Saraswati Indraguna Pinatih, Gde Ngurah Isabella Soerjanto Putri K Badjra Nadha K Rina Kadek Dina Puspitasari Kartadinata, Sarah Levina Kevin Ezekia Komang Agus Wira Nugraha Made Agus Hendrayana MADE RATNA SARASWATI . Made Wihandani, Desak Made Windha Prajaskari Armi Marcella, Marzha Marisye Christantia Mona Mentari Pagi Surbakti N Kajiwara Nathasia Ni Made Alit Arini Ni Putu Sriwidyani Ni Putu Tesi Maratni Nila Wahyuni Parastan, Rovie Hikari Putra Sugiharta, Adhika Tri Putu Ayu Suastidewi PUTU SARASWATI LAKSMI DEWI R. Prawira Bayu Putra Dewa Rena, Ni Made Renny Anggreni S., Hantono Saraswati, Putu Ayu Indah Siorcani, Putu Tasha Stefani, Lidwina Sutanegara - Trisnawati, Ni Nyoman Ayu W Wita Wan Muhamad Syafiq Wardana, Rr. Cattleya Allayka Wira Gotera