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All Journal HAYATI Journal of Biosciences Medicina journal of internal medicine E-Jurnal Medika Udayana Berkala Kedokteran Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico KESANS : International Journal of Health and Science GANESHA MEDICINA Hang Tuah Medical Journal Eduvest - Journal of Universal Studies Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
I Made Pande Dwipayana
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Denpasar, Bali, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Relationship between Interleukin 6 and Estradiol Levels in Obese and Adult Men Dwipayana, I Made Pande; Semadi, I Made Siswadi; Nugraha, Ida Bagus Aditya; Gotera, Wira; Saraswati, Made Ratna; Suastika, Ketut; Saraswati, Putu Ayu Indah
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24498

Abstract

Obesity is a chronic disease characterized by a pathophysiological process that causes an increase in adipose tissue mass, leading to an increased risk of morbidity and mortality. Currently, there are many conditions that allow the interaction between environmental factors and genes that lead to various metabolic disease complications, such as diabetes mellitus and heart attack. Health workers are at the forefront of managing obesity and its associated complications. The study was conducted at Ngoerah Hospital from March to October 2024. The target population in this study were adult male medical personnel with and without obesity, working at Ngurah Hospital. The inclusion criteria in this study: male health workers in the environment at Ngoerah Hospital aged 18-45 years and willing to participate in the study by signing informed consent. Exclusion criteria in this study were all male health workers with infectious or inflammatory diseases, and or suffering from malignancies or a history of chemotherapy, and or with the use of hormonal therapy. The sample size of the study was 64 subjects. Data analysis included descriptive statistics, a normality test using the Kolmogorov-Smirnov test, a comparison test using the Mann-Whitney U test, and a correlation test using the Spearman rank correlation. This study was approved by the Research Ethics Commission, approval number 1697/UN14.2.2.VII.14/LT/2024. The results of this study found that IL-6 and estradiol levels in the obese group were higher than the non-obese group, however, the differences were not statistically significant. This may be attributed to the relatively young age of the subjects and the absence of significant inflammation in the early stages of obesity. There was no significant correlation between IL-6 and estradiol in all subjects, obese and non-obese groups.
Co-Authors A Santoso A. A. Putu Eka Darmaputra Juliantara AA Gede Budhiarta, AA Gede AA Istri Sri Kumala Dewi, AA Istri Sri Kumala AAG Budhiarta Aditya Rachman Anak Agung Gde Budhiarta Anak Agung Gde Budhiarta Anak Agung Gede Budhiarta Ari Puji Astiti Bayu Mayura, I Putu Budhiarta, Anak Agung Gde H Taniguchi I Ketut Suastika I Komang Realiska I Made Ady Wirawan I Made Siswadi Semadi I Made Siswadi Semadi I Made Siswadi Semadi I. K. Suastika I.A.A. Widhiartini Ida Bagus Aditya Nugraha Ida Bagus Yorky Brahmantya IGN Gunadi IMR Saraswati Indraguna Pinatih, Gde Ngurah Isabella Soerjanto Putri K Badjra Nadha K Rina Kadek Dina Puspitasari Kartadinata, Sarah Levina Kevin Ezekia Komang Agus Wira Nugraha Made Agus Hendrayana MADE RATNA SARASWATI . Made Wihandani, Desak Made Windha Prajaskari Armi Marisye Christantia Mona Mentari Pagi Surbakti N Kajiwara Nathasia Ni Made Alit Arini Ni Putu Tesi Maratni Nila Wahyuni Parastan, Rovie Hikari Putra Sugiharta, Adhika Tri Putu Ayu Suastidewi PUTU SARASWATI LAKSMI DEWI R. Prawira Bayu Putra Dewa Rena, Ni Made Renny Anggreni S., Hantono Saraswati, Putu Ayu Indah Siorcani, Putu Tasha Stefani, Lidwina Sutanegara - W Wita Wan Muhamad Syafiq Wardana, Rr. Cattleya Allayka Wira Gotera