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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Jurnal MIPA CHEMISTRY PROGRESS agriTECH Molekul: Jurnal Ilmiah Kimia The Studies of Social Sciences Makara Journal of Science Molekul: Jurnal Ilmiah Kimia

Dewa Gede Katja

Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Sam Ratulangi, Kampus Unsrat, Bahu Manado 95115

Author-ID : 296960

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Materials Science & Nanotechnology Mathematics Physics Social Sciences

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FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT BATANG Chisocheton sp. (C.DC) Harms (Meliaceae) Katja, Dewa Gede
CHEMISTRY PROGRESS Vol 13, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.13.2.2020.31672

Tujuan penelitian ini untuk mengetahui golongan senyawa metabolit sekunder dan aktivitas antioksidan dari setiap ekstrak kulit batang Chisocheton sp. C.DC Harms (Meliaceae). Hasil ekstraksi 200 g serbuk kulit batang Chisocheton sp. C.DC Harms (Meliaceae) dengan n-heksana, etil asetat dan metanol masing-masing dengan 2000 mL berturut-turut menghasilkan 7,193 g ekstrak pekat n-heksana, 8,798 g ekstrak pekat etil asetat dan 18,683 g ekstrak pekat metanol. Hasil uji fitokimia menunjukkan adanya golongan senyawa flavonoid, triterpenoid dan tanin. Hasil uji aktivitas antioksidan dengan metode DPPH menunjukkan bahwa ekstrak n-heksana memberikan nilai IC50 sebesar 337,28 Âµg/mL, ekstrak metanol sebesar 216,73 Âµg/mL, dan ekstrak etil asetat sebesar 199,89 Âµg/mL yang berarti etil asetat memiliki kemampuan yang paling besar dalam menangkap radikal bebas.ABSTRACTThe objective of this study was determine the class of secondary metabolite compounds and antioxidant activity of each stem bark extract of Chisocheton sp. C.DC Harms (Meliaceae). The results of the extraction of 200 g Chisocheton sp. C.DC Harms (Meliaceae) with n-hexane, ethyl acetate and methanol with 2000 mL each yielded 7,193 g of concentrated extract n-hexane, 8,798 g of concentrated extract of ethyl acetate and 18,683 g of concentrated methanol extract. Phytochemical test results showed the presence of flavonoid, triterpenoid and tannin compounds. The results of the antioxidant activity test using the DPPH method showed that the n-hexane extract gave an IC50 value of 337,28 Âµg/mL, methanol extract was 216,73 Âµg/mL, and ethyl acetate extract was 199,89 Âµg/mL which means that ethyl acetate has the ability to greatest in capturing free radicals.

SENYAWA STIGMASTEROL (STEROID) DARI KULIT BATANG Chisocheton celebicus koord (MELIACEAE) Katja, Dewa Gede
CHEMISTRY PROGRESS Vol 14, No 1 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.14.1.2021.34154

ABSRTAKStigmasterol (suatu steroid) dengan rumus molekul C29H48O Â telah doiisolasi dari kulit batang chisocheton celebicus (Meliacea) menggunakan pelarut n-heksan, kemudian dipisahkan dengan teknik kromatografi dan dihasilkan isolat murni berupa kristal jarum tak berwarna(10,2 mg) dengan titik leleh 169-1710C. Struktur kimia stigmasterol diidentifikasi berdasarkan data-data spektroskopi meliputi IR, NMR-1D, NMR-2D dan masa,serta perbandingan dengan data spektroskopi yang diperoleh dari literatur. Penemuan senyawa stigmasterol dari kulit batang Chisocheton celebicus dilaporkan untuk pertama kalinya dalam penelitian ini..Â ABSTRACTStigmasterol C29H48O has been isolated from the bark of Chisocheton celebicus (Meliacee) in n-hexan and separated using several chromatography and it has been pure isolated the crystal calorness compound (10,2 mg). The chemical structure of isolated compound was identified on the basis of spectroscopic data including IR, 1D-NMR, 2D-NMR and mass along with comparison with those spectral data previously reported. The discovery of stigmasterol compound from the bark C. celebicus reported for the first time in this study.

Aktivitas Antioksidan Ekstrak Fenolik dari Kulit Buah Manggis (Garcinia mangostana L.) Dungir, Stevi G.; Katja, Dewa G.; Kamu, Vanda S.
Jurnal MIPA Vol 1, No 1 (2012)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.1.1.2012.424

Penelitian ini bertujuan untuk menentukan kandungan total senyawa fenolik dan aktivitas antioksidan dari ekstrak kulit buah manggis. Sampel yang digunakan adalah kulit buah manggis segar dan kering, diekstraksi dengan pelarut air panas dan metanol selama 24 jam. Metode penelitian ini dilakukan dengan menentukan kandungan total senyawa fenolik dan aktivitas antioksidan menggunakan metode penangkal radikal bebas DPPH. Kandungan total senyawa fenolik tertinggi pada ekstrak metanol sampel kering (MK), diikuti ekstrak metanol sampel basah (MB), ekstrak air sampel kering (AK), dan ekstrak air sampel basah (AB). Aktivitas antioksidan sebagai penangkal radikal bebas DPPH yang besar diketahui dengan nilai IC50 yang kecil, yaitu aktivitas antioksidan tertinggi pada MK sebesar 44,49 mg/L, diikuti MB, AK, AB berturut-turut 54,95; 346,73; 346,74 mg/L.

Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD Dewa Gede Katja; Desi Harneti; Tri Mayanti; Nurlelasari Nurlelasari; Rani Maharani; Yoshihito Shiono; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 2, November 2019
Publisher : Syarif Hidayatullah State Islamic University

In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.

Mekanisme dan Kinetika Quenching Oksigen Singlet dari Senyawa Fenolik Daun Cengkeh Terhadap Fotoksidasi yang Disensitasi oleh Eritrosin Edi Suryanto; Johnly A Rorong; Dewa Gede Katja
agriTECH Vol 32, No 2 (2012)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

The objectives of this research were to isolate phenolic compound of clove leaves and to study the mechanism and kinetic of singlet oxygen quenching. Clove leaves was extracted by steam distillation using water for 6 hours. Crude clove leaves oil was purifi ed by distillation under reduced pressure. Isolated fractions were determined its structure by infrared (IR), nuclear magnetic resonance (1H-NMR), and mass spectrometry (MS) techniques. The effects of 0, 500, 1000 and 1500 ppm isolated compound on the photooxidation of linoleic acid (0,03M) containing 15 ppm erythrosine in ethanol were studied by measuring peroxide value of the oil. The quenching mechanism and kinetics of eugenol were studied by the steady-state kinetic method. Samples of 0; 0,06 x 10-4; 0,12 x 10-4; 0,24 x 10-4 dan 0,48x 10-4 mM eugenol prepared in water contained 0; 17,05 x10-4; 34,10 x 10-4; 68,19 x 10-4 and 136,39 x 10-4 mM of erythrosine stored under fl uorescent light (4000 lux) at room temperature for 15 hours. The result indicated that eugenol content of clove oil, F1, F2, F3 and F4 were 49.68; 54.32; 87.16 and 73.65%, respectively. The structure of F3 was identifi ed by IR spectrometry which shows strong absorption at 3448 cm-1 indicating hydroxyl group from the phenolic compound and the 1H NMR spectra showed that the number of proton ring was 3 hydrogen while the mass spectrometry showed the molecular ion peak at m/e = 164 as base peak and the absence of peak at (M-41)+ as the indicator of eugenol. The result showed that eugenol had antiphotooxidation activity on erythrosine sensitized photooxidation of oil. The mechanism of singlet oxygen quenching on erythrosine photodegradation showed that eugenol only quenched singlet oxygen. The total quenching rate constant of eugenol was 4,42 x 108/M/s.ABSTRAKPenelitian ini bertujuan untuk mengisolasi senyawa fenolik dalam daun cengkeh dan mempelajari mekanisme dan kinetika quenching oksigen singlet. Daun cengkeh diekstraksi dengan cara destilasi uap menggunakan air selama 6 jam. Minyak daun cengkeh kasar selanjutnya dimurnikan dengan destilasi pengurangan tekanan. Fraksi-fraksi yang terisolasi ditentukan strukturnya dengan metoda infra merah (IR), resonansi magnetik inti (1H NMR), dan spectrometer massa (MS). Efek 0, 500, 1000 dan 1500 ppm eugenol terhadap fotooksidasi asam linoleat (0,03M) yang mengandung 15 ppm eritrosin dalam etanol dipelajari dengan mengukur angka peroksida minyak. Mekanisme dan kinetika quenching oleh eugenol dipelajari dengan metode steady-state. Sampel 0; 0,06 x 10-4; 0,12 x 10-4; 0,24 x 10-4 dan 0,48x 10-4 mM eugenol dipersiapkan dalam pelarut air yang juga mengandung 0; 17,05 x10-4; 34,10 x 10-4; 68,19 x 10-4 dan 136,39 x 10-4 mM eritrosin yang disinari oleh cahaya fl uoresen (4000 lux) pada suhu kamar selama 15 jam. Hasil analisis kandungan eugenol dari minyak cengkeh, F1, F2, F3 dan F4 berturut-turut adalah 49,68; 54,32; 87,16 dan 73,65%. Kebenaran struktur F3 diidentifi kasi dengan spektrometer IR pada serapan kuat 3448 cm-1 yang menunjukkan adanya gugus hidroksil dari senyawa fenolik sedangkan pada 1H NMR menunjukkan jumlah proton pada cincin aromatic menjadi 3 atom H dan spektrometer massa menunjukkan m/e = 164 sebagai puncak tertinggi dan tidak muncul puncak (M-14)+ sebagai petunjuk adanya eugenol. Hasil ini menunjukkan bahwa eugenol memiliki aktivitas antifotooksidatif terhadap fotooksidasi asam linoleat yang disensitasi oleh eritrosin. Mekanisme quenching oksigen singlet terhadap fotodegrasi eritrosin oleh eugenol menunjukkan bahwa eugenol hanya menstabilkan oksigen singlet. Konstanta laju quenching oksigen singlet total oleh eugenol adalah 4,42 x 108/M/s.

7-HIDROKSI-6-METOKSI KUMARIN (SKOPOLETIN) DARI KULIT BATANG Chisocheton celebicus (MELIACEAE) Dewa G. Katja; Andre A. Sonda; Desi Harneti P. Huspa; Tri Mayanti; Unang Supratman
Jurnal Kimia (Journal of Chemistry) Vol. 9, No. 2 Juli 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

7-hydroxy-6-methoxy coumarin (scopoletin) has been isolated from the bark of Chisocheton celebicus (Meliacee) using several chromatographic techniques. The chemical structure of 7-hydroxy-6-methoxy coumarin was identified on the basis of spectroscopic data including UV, IR, 1D-NMR, 2D-NMR and mass along with by comparison with those spectral data previously reported. The discovery of scopoletin from the bark C. celebicus reported for the first time in this study.

Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines Tri Mayanti; Nur Insani Amir; Dewa Gede Katja; Sofa Fajriah; Ahmad Darmawan; Unang Supratman; Khlaijah Awang; Yoshihito Shiono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.15976

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.

Cytotoxic Steroids from The Stem Bark of Chisocheton cumingianus (Meliaceae) Dewa Gede Katja; Kindi Farabi; Nurlelasari Nurlelasari; Desi Harneti; Euis Julaeha; Ace Tatang Hidayat; Tri Mayanti; Rani Maharani; Unang Supratman; Khalijah Awang
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

Three cytotoxic steroids, stigmasterol (1), stigmast-5-en-3b-ol (2) and b-sitosterol-3-O-acetate (3) were isolated from the stem bark of Chisocheton cumingianus. The chemical structures of those compounds were identified based on spectroscopic data and by comparison with those data previously reported. All of the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells in vitro. Compounds 1-3 showed cytotoxicity activity against P-388 murine leukemia cells with IC50values of 12.4, 60.8, and ÃÂ 100 mg/mL, respectively.

Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae) Katja, Dewa Gede; Farabi, Kindi; Harneti, Desi; Mayanti, Tri; Supratman, Unang
Makara Journal of Science Vol. 21, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Plants belonging to the Chisocheton genus are a rich source of tetracylic triterpenoids with diverse biological activities. Two triterpenoid compounds,dammar-20,24-dien-3-one (1) and 3β-hydroxy-tirucall-7-en (2) were isolated from the stembark of Chisocheton celebicus. The chemical structures of compounds 1 and 2 were identified by spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and they were compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic effects against P-388 murineleukemia cells. The compounds showed cytotoxicity against P-388 murine leukemia cells, with IC50 values of 30.2 and 4.3 μg/mL, respectively.

Pembuatan Serbuk Tanaman Obat dalam Upaya Peningkatan Kesehatan bagi Ibu-Ibu PKK Desa Tumaratas, Kecamatan Langowan Barat, Kabupaten Minahasa Kamu, Vanda Selvana; Runtuwene, Max Revolta John; Katja, Dewa Gede
The Studies of Social Sciences Vol. 6 No. 1 (2024): The Studies of Social Sciences
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/tsss.v6i1.51707

Telah dilakukan kegiatan pengabdian Program Kemitraan Masyarakat (PKM) pembuatan serbuk tanaman obat bagi Ibu-ibu PKK Desa Tumaratas, Kecamatan Langowan Barat, Kabupaten Minahasa, Sulawesi Utara. Kegiatan pelatihan diawali dengan pengumpulan data Desa Tumaratas serta wawancara dengan perangkat desa dan dilanjutkan dengan perumusan jenis kegiatan yang akan dilakukan. Oleh karena beberapa tanaman obat merupakan juga tanaman yang dapat ditanam di pekarangan rumah dan sering digunakan sebagai bumbu dapur, maka untuk pemanfaatan lanjutan tanaman obat ini, dapaat dibuat dalam bentuk serbuk supaya mempermudah saat mengkonsumsi tanaman obat tersebut. Kegiatan pelatihan ini diberikan kepada 35 Ibu PKK Desa Tumaratas. Kegiatan diawali dengan pendahuluan mengenai pentingnya tanaman obat serta jenis-jenis tanaman obat yang mudah ditanam, diolah, dan dimanfaatkan sebagai obat herbal. Selanjutnya dilakukan asesmen awal terhadap peserta kegiatan mengenai pemahaman tentang tanaman obat, kemudian dilanjutkan dengan pelatihan kepada Ibu-ibu PKK untuk membuat tanaman obat dalam bentuk serbuk, dan diakhiri dengan asesmen akhir. Tanaman obat yang digunakan adalah jahe, kunyit, dan lengkuas. Dari kegiatan ini diperoleh bahwa sekitar 69% peserta memiliki pemahaman awal yang sudah cukup baik mengenai tanaman obat. Dan di akhir kegiatan sebanyak 94% peserta sudah memiliki pengetahuan yang sangat baik mengenai tanaman obat dan telah berhasil membuat serbuk tanaman obat.

Co-Authors Abigael, Reliana Ace Tatang Hidayat Ahmad Darmawan Andre A. Sonda Ba'u, Defrikson Desi Harneti Putri Huspa Edi Suryanto Edi Suryanto Erwin Sitorus Euis Julaeha Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Frenly Wehantouw Harry S. J. Koleangan Henry Aritonang Hilmayanti, Erina Johnly A Rorong Johnly A. Rorong Junito, Junito Khalijah Awang Khlaijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Koleangan, Harry Steven Julius Lidya I. Momuat Lidya Irma Momuat Mantiri, Sisilia A Max R.J Runtuwene Max Revolta John Runtuwene Meiske S. Sangi Naini, Al Arofatus Novita Thaib, Novita Nur Insani Amir Nurlelasari Nurlelasari Paulina yamlean Pettanaga, Putri Firania Pollo, Hard Napoleon Rani Maharani Rani Maharani Salim, Muhammad Fajrin Saranaung, Andika Sari, Aprilia Permata Sinaga, Jonathan Cavin Ezra Sinaga, Siska Elisahbet Sofa Fajriah Sofa Fajriah Stevi G. Dungir Sujana, Kinaya Vizria Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Unang Supratman Vanda S Kamu Vanda S. Kamu Vanda Selvana Kamu Yenny Tambunan Yoshihito Shiono Yoshihito Shiono

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