Article Per Year (5 Year)
p-Index From 2021 - 2026
1.745
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi e-Journal Pustaka Kesehatan Al-Kimia Chemistry Indonesian Journal of Chemical Research JFIOnline Jurnal Jamu Indonesia Dedication : Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Jurnal Natural Dedication : Jurnal Pengabdian Masyarakat Journal of Agropharmacy Indonesian Journal of Jamu
Nia Kristiningrum
Fakultas Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 26 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 10 Documents
Search
Journal : e-Journal Pustaka Kesehatan

 1 
Deteksi Kemurnian Air Zamzam Menggunakan Metode Spektrofotometri Fourier Transform Infrared (FTIR) dan Kemometrik (Detection of Zamzam Water Purity Using Fourier Transform Infrared (FTIR) Spectroscopy Technique and Chemometrics) Kun Rasyida; Bambang Kuswandi; Nia Kristiningrum
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Zamzam water is the holy water located in the city centre of Mecca. This water is believed to have lots of benefits so that it consumed by moslems around the world. In 2010, saudi authorities implement strict rules regarding export of zamzam water. The rules led to the increase sale of fake zamzam water globally. The determination of zamzam water purity was develoved using FTIR spectroscopy combined with multivariate statistical methods (chemometrics). Zamzam water sample simulation consist of pure zamzam water, mineral water, and a mixture of zamzam water with mineral water in the concentration range of 10%-100%. Analysis of data using PLS, LDA, SIMCA, and SVM were based on two sets of data, in the whole absorption (4000-700 cm-1) and the absorption 1800-700 cm-1. The classification model LDA of data on the whole spectrum without preliminary treatment is the best chemometric classification model with recognition capabilitiy and ability of prediction of 100%, respectively. FTIR spectroscopy and chemometric methods have been sucessfully applied to detect the purity of zamzam water samples of circulating in Jember. Keywords: zamzam water, FTIR spectroscopy, chemometrics, training set, test set.
Penentuan Kadar Fenol Total pada Ekstrak Daun Tanaman Menggunakan Metode Spektroskopi NIR dan Kemometrik (Determination of Total Phenolic in Leave Extracts Using Spectroscopy NIR and Chemometric) Fracilia Arinda Ratnasari; Lestyo Wulandari; Nia Kristiningrum
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Phenols are group which having one or more hydroxyl groups which attached in aromatic ring and are found in plants. The aim of this research was to study whether NIR and chemometric methods could be used to determine the total phenol content of leave extracts. These methods were compared to UV-Vis spectrophotometry. Phenol was extracted from plant leaves by ultrasonic and maceration. NIR spectral data of selected leave extracts were correlated with total phenol content using chemometric. In this study, the chemometric method that used for quantitative and qualitative analysis were Partial Least Square (PLS) and Linear Discriminant Analysis (LDA), respectively. The PLS R2 calibration was 0.9920369 and RMSEC was 2.0049472. In addition, the R2 of LOOCV and 2-Fold-Cross-Validation were 0.9939401 and 0.9834646, respectively. Furthermore, LDA gave accuracy of 100%. The significance of phenol total that have been measured by NIR and UV-Vis spectrophotometry was evaluated with paired samples T-test and gave no significant difference. In conclusion, total phenol content can be measured using NIR and chemometric methods.   Keywords: phenol, chemometric, LDA, NIR, PLS
Validasi dan Penetapan Kadar Rhodamin B pada Lipstik yang Beredar di Sekitar Universitas Jember dengan Metode KLT-Densitometri (Validation TLC-densitometry method for determination of Rhodamine B in Lipstick at Jember University Area) Risa Wahyu Ananda; Nia Kristiningrum; Yuni Retnaningtyas
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Rhodamine B is one of the synthetic dyes that forbidden in cosmetics. The study was conducted to validate TLC-densitometry method for determination Rhodamin B in lipstick at Jember University area. Samples was taken by purposive sampling method. The analyte were dissolved with ethanol 70% and cromatographed on silica Gel GF 254 TLC plate using etil asetat : metanol : amoniak in the ratio (15:3:3) (v/v/v). Then, validation and determination sample can be done using TLC-densitometry with maximum wavelength 554 nm. Method was found linear over the concentration range of 6 – 32 ng with correlation coefficient of 0,9965. Spesificity showed calculation of purity and identity more than 0.99. The limits of detection and quantitation limits obtained 0.558 and 1.86 ng/spot. The precision test which includes precision repeatability and intermediate precision, amounting to RSD 6.57% and test accuracy , resulting % recovery and RSD value of 97.74 % ± 2.54% . Based on these results lipstick sample purposively sampled none containing rhodamine B and safe consumer use. Keywords: TLC - densitometry , lipstick , rhodamine B , the validation method of analysis
Penetapan Kadar Fenol Total dan Pengujian Aktivitas Antioksidan Minyak Jahe Gajah (Zingiber officinale var. officinale) (Determination of Total Phenolic Content and Antioxidant Activity of Jahe Gajah (Zingiber officinale var. officinale) Oil) Tsabit Barki; Nia Kristiningrum; Endah Puspitasari; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5897

Abstract

Jahe gajah (Zingiber officinale var. officinale) is one of export commodity plant in Indonesia. Part of jahe gajah often to be used is the rhizome, that content lots of essentials oil. One of the essential oil content is a phenolic compound. Phenolic compound is a natural product function as antioxidant reducing oxidative damage in the body that cause inflammation. The aim of this study was to determine the total phenolic content and antioxidant activity of jahe gajah oil. The total phenol content was determined using Folin-Ciocalteu method and the antioxidant activity assay was done using DPPH method. The total phenol content for jahe gajah oil was 0.626 ± 0.022 mg GAE/g . The IC50 of jahe gajah oil was 5,766 ± 0,087 µl/ml. Antioxidant activity from jahe gajah oil was suggested to be contributed by the phenolic compound and result from synergistic action of all constituents. Keywords: essential oil, aktivitas antioxidant, phenolic content
Pengembangan Time-Temperature Indicator Berbasis Ekstrak Kulit Manggis (Garcinia mangostana L.) sebagai Sensor Penurunan Kualitas Susu Sapi Akibat Kesalahan Suhu Penyimpanan (Development of Time-Temperature Indicator Based on Mangosteen Rind (Garcinia Yayan Ika Rachmawati; Bambang Kuswandi; Nia Kristiningrum
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Anthocyanin is reddish purple pigment found abundantly in fruits, vegetables, and flowers. Time-temperature indicator (TTI) based on anthocyanin extracted from mangosteen rind was developed for monitoring quality of cow's milk, especially fresh milk stored at room temperature. TTI consists of two membranes, namely indicator membranes and acetic acid membranes. Extract of mangosteen rind and sodium hidroxide solution was also co-immobilized onto Whatman filter paper to make indicator membrane, while acetic acid solution was also separately immobilized onto filter paper obtain acetic acid membrane. Color changes as TTI's responses were monitored directly using both visual inspection and quantitative measurement via color image analysis using ImageJ software. The color changes were further correlated with cow's milk freshness parameters such as pH, smell, and number of microbial. Fresh cow's milk quality spoiled after 4 hours stored at room temperature and color changes of TTI to bright yellow occured after 4 hours of exposure at room temperature. The result shown that the TTI can be applied for monitoring quality of cow's milk stored in room temperature. Keywords: mangosteen rind, TTI, cow's milk quality
Pengembangan Sensor Kesegaran Edible untuk Fillet Ikan Tuna (Thunnus albacares) Berbasis Antosianin Kulit Buah Juwet (Syzygium cumini) dengan Membran Selulosa Bakterial Lilis Amongsari; Bambang Kuswandi; Nia Kristiningrum
Pustaka Kesehatan Vol 8 No 2 (2020): Volume 8 No. 2, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i2.11460

Abstract

Produk perikanan merupakan bahan pangan yang banyak digemari oleh masyarakat. Salah satu hasil pengolahan produk perikanan yang disukai masyarakat adalah fillet ikan tuna. Hal tersebut diikuti dengan tuntutan kualitas mutu produk fillet ikan tuna, sehingga dibutuhkan suatu alat analisa yang dapat menganalisis kesegaran fillet ikan tuna secara mudah dan praktis. Penelitian ini bertujuan untuk mengembangkan sensor kesegaran edible berbasis indikator antosianin dari ekstrak kulit buah juwet (Syzygium cumini) dengan membran selulosa bakterial dari nata de coco. Sensor kesegaran edible tersebut dapat diaplikasikan sebagai sensor kesegaran dan mengetahui tingkat kesegaran fillet ikan tuna dengan berbagai parameter. Dilakukan uji parameter kesegaran fillet ikan tuna meliputi uji total mikroba, uji total volatile bases nitrogen (TVB-N), nilai pH, nilai tekstur, dan uji organoleptis. Perubahan warna sensor kesegaran edible diamati secara visual dan diuji menggunakan program ImageJ untuk menentukan nilai mean green. Hasil menunjukkan perubahan warna sensor kesegaran yaitu ungu tua saat fillet ikan tuna dalam keadaan segar, ungu muda saat fillet ikan tuna masih segar dan abu-abu ketika fillet ikan tuna sudah tidak lagi segar. Nilai mean green sensor kesegaran edible meningkat seiring dengan penurunan tingkat kesegaran fillet ikan tuna.
Pengembangan Sensor Kimia Berbasis Strip Tes untuk Deteksi Logam Berat Merkuri pada Sampel Produk Jamu Rizqi Amaliyah; Nia Kristiningrum; Indah Purnama Sary
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.16552

Abstract

The use of plants as a traditional medicine in the modern era is still in high demand. One of the herbs commonly used by Indonesian is analgesic herbal medicine. The safety aspect of herbal medicine should be considered, such as heavy metal contamination. Mercury is the typical heavy metal found in polluting herbal plants. The maximum mercury level allowed in a medicinal preparation has been regulated by BPOM RI, as much as ≤ 0.5 ppm. A high level of mercury contamination causing toxic effects on the body due to protein precipitation, which inhibits enzyme activity and acts as a corrosive material. A technology that allows the detection of mercury is a chemical sensor. The strip test is optimal if the reagent 1-(2-thiazolyl azo)-2-naphthol (TAN) concentration at 1000 ppm and the sample has been confirmed at pH 7. The results of the strip test characterization showed that the response time was in the range of minutes 17 to 24, the use time of the test strips for 28 days if stored in room temperature and 29 days if stored at in refrigerator temperature, linearity with r = 0.998, Vx0 = 3.96%, p-value = 0.00000172, LOD = 0.102 ppm and LOQ = 0.306 ppm, interference value <5%, precision with RSD 6.54%, and accuracy with the value of % recovery 98.007%. T-test analysis showed p= 0.872, meaning no significant difference between the application of TAN-based test strips with the ICP-AES method.
Penetapan Kadar Inulin dalam Ekstrak Umbi Dahlia variabilis dan Dahlia pinnata dengan Metode KLT Densitometri (Determination of Inulin Content in Dahlia variabilis and Dahlia pinnata Tuber Extract by TLC Densitometry Method) Khoirun Nisa'; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inulin is a polymer which have many benefits for health and used widely for food. The absence of research on determination of inulin content in dahlia tuber extract from different species, made this study very important to do. The purpose of this study was to determine the inulin content in dahlia tuber extract from different species. So it can be known the most effective type of dahlia to be the major source of inulin production. The method used in this study was TLC densitometry. The result showed that the inulin content in Dahlia variabilis tuber extract was 73.93 ± 1.209%, and the inulin content in Dahlia pinnata tuber extract was 66.76 ± 0.572%. The inulin content in Dahlia variabilis and Dahlia pinnata tuber extract were significantly different. Keywords: inulin, dahlia tuber, Dahlia variabilis, Dahlia pinnata, TLC densitometry
Deteksi Daging Babi pada Sampel Bakso Menggunakan Metode Near Infra Red (NIR) dan Kemometrik sebagai Verifikasi Kehalalan (Detection of Pork in Beef Meatball Sample using Near Infra Red and Chemometrics as Halal Verification) Khrisna Agung Cendekiawan; Bambang Kuswandi; Nia Kristiningrum
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Meatball (bakso) is one of the favorite foods in Indonesia. The adulteration of pork in beef meatball occurs frequently. This study was aimed to develop a fast and non destructive technique for the detection and classification of pork in beef meatball using Near infrared (NIR) spectroscopy, combined with chemometrics, e.g. partial least square (PLS) and linear discriminant analysis (LDA). The spectral bands associated with pork protein (PP), beef protein (BP), and their mixtures in meatball formulation were scanned, interpreted, and identified by relating them to those spectroscopically representative to pure PF and BF. Study was done in four phases successively; (1) preparation of trained sample; (2) analysis of meatball powder by NIR Spectrophotometer. NIR spectrum were used to form three data sets, i.e. (a) spectrum in full region, (b) spectrum with first derivative, and (c) spectrum with second derivative; then (3) classification model of chemometrics to PLS and LDA was formed using the Unscrambler X 10.2 Software. (4) the NIR method and the best model of chemometric were applied in meatball samples for the prediction in compared with Xematest Pork result. Then prediction from Xematest Pork compared with The result from NIR-Chemometric. Xematest Pork is simillar with the result of NIR-Chemometric. Keywords: beef meatball, pork, adulteration, NIR, LDA.
Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker . Ifada; Ayik Rosita Puspaningtyas1; Ika Oktavianawati; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid. Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.
Co-Authors . Ifada Adelia A Devi Devi Aida, Siti Nor Aulia, Rizki Putri Ayik Rosita Puspaningtyas1 Bambang Kuswandi Bambang Kuswandi CRISTIANTY, FRANSISKA MARIA Dian Agung Pangaribowo Diana Holidah Dwi Koko Pratoko Dyanshah, Danny Agus Endah Puspitasari Fifteen Aprila Fajrin Fracilia Arinda Ratnasari Hamzah, Muhammad Hafidi Hamzah, Muhammad Hafidi Ika Oktavianawati Indah Purnama Sary Indah Purnama Sary, Indah Purnama Jazila, Yusrin Jazila, Yusrin Nur Khoirun Nisa' Khrisna Agung Cendekiawan Kun Rasyida Lestyo Wulandari Lilis Amongsari Nurud Diniyah Putri Aditama, Tiara Sagita Regol S Raudiah Raudiah Renggani, Hidayah Dwi Reny Diastri Noviriana Retnaningtyas, Yuni - Risa Wahyu Ananda Rizqi Amaliyah Sallama, Solihatus Sri Hernawati Syaifullah, Abim Tanfidz Alishlah, Tanfidz Tsabit Barki WARDANI, PRAMUDIA Wardhani, Firdha Aprillia Yayan Ika Rachmawati Yuni Retnaningtyas