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All Journal Jurnal Ilmiah Farmasi e-Journal Pustaka Kesehatan Al-Kimia Chemistry Indonesian Journal of Chemical Research JFIOnline Jurnal Jamu Indonesia Dedication : Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Jurnal Natural Dedication : Jurnal Pengabdian Masyarakat Journal of Agropharmacy Indonesian Journal of Jamu
Nia Kristiningrum
Fakultas Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pemberdayaan Santri Pondok Pesantren Mahasiswa Syafi'ur Rohman Jember Melalui Program Budidaya TOGA Pangaribowo, Dian Agung; Kristiningrum, Nia; Diniyah, Nurud; Sallama, Solihatus; Dyanshah, Danny Agus
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2025)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v6i2.11360

Abstract

Pembangunan kesehatan merupakan salah satu syarat untuk menuju kemakmuran suatu daerah. Salah satu program pemberdayaan masyarakat untuk berperilaku hidup bersih dan sehat adalah lewat Pondok Pesantren. Pondok Pesantren Mahasiswa Syafi’ur Rohman merupakan salah satu pondok pesantren (ponpes) di Jember, Jawa Timur yang berjarak 1,5 km dari Universitas Jember. Berdasarkan catatan poskestren, penyakit yang sering dialami oleh santri pondok terkait dengan melemahnya sistem imun, yaitu flu, tenggorokan sakit, demam ringan, sakit kepala, dan bersin-bersin. Dalam upaya peningkatan derajat kesehatan santri pondok, dapat dilakukan lewat pengelolaan tanaman obat keluarga (TOGA) menjadi produk jamu. Metode pelaksanaan kegiatan pada pengabdian masyarakat ini berupa pembangunan taman TOGA, edukasi terkait TOGA dan pelatihan pengolahan TOGA menjadi produk jamu. Lewat kegiatan ini diharapkan ponpes dapat memanfaatkan TOGA menjadi produk jamu dan santri secara rutin minum jamu. Hasil dari kegiatan pengabdian ini yaitu: 1) berdirinya taman TOGA dan media sosial taman TOGA 2) pengurus dan santri pondok memahami terkait manfaat TOGA 3) pengurus dan santri pondok dapat mengolah TOGA menjadi produk jamu berupa sirup jahe dan minuman bunga telang. Dengan adanya kegiatan pengabdian masyarakat, pengurus dan santri pondok telah mendapatkan wawasan tambahan terkait pengelolaan TOGA.
Penentuan Kadar Flavonoid Total dan Klasifikasi Serbuk Daun Murbei (Morus alba L.) Berbeda Ketinggian Tempat Tanam Syaifullah, Abim; Kristiningrum, Nia; Pangaribowo, Dian Agung; Wulandari, Lestyo
Journal of Agropharmacy Vol. 1 No. 1 (2024)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Mulberry (Morus alba L.) is a plant from the Moraceae family which has a high flavonoid content. This research aims to determine the ability of NIR spectroscopy and chemometrics to classify mulberry leaf powder based on different planting heights and determine the total flavonoid content using the Uv-Vis spectrophotometric method. The classification of mulberry leaf powder originating from the lowlands, midlands, and highlands provides valid results using NIR spectra and chemometric data from the LDA and SIMCA models with an accuracy value of 100%. The average results of determining total flavonoid content using Uv-Vis spectrophotometry showed that the highest levels were in the highlands, followed by the medium and lowlands with total flavonoid levels respectively, namely 6.453 ± 1.194 mg QE/g powder; 5.889 ± 0.944 mg QE/g powder; and 5.177 ± 0.998 mg QE/g powder. The results of the One Way ANOVA test showed that the total flavonoid content of mulberry leaf powder from different altitude areas did not have a significant difference.
Validasi Metode Penentuan Kadar Asam Klorogenat dan Kafein secara Simultan pada Serbuk Daun Kopi Robusta (Coffea Canephora) dengan Metode KLT Densitometri Putri Aditama, Tiara Sagita; Kristiningrum, Nia; Wulandari, Lestyo; Holidah, Diana; Alishlah, Tanfidz; Puspitasari, Endah
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Coffee contains bioactive compounds such as chlorogenic acid and caffeine. Chlorogenic acid is recognized as a natural antioxidant, while caffeine is widely used to reduce fatigue and drowsiness. This study aims to simultaneously determine the content of chlorogenic acid and caffeine in robusta coffee leaf powder (Coffea canephora) using Thin Layer Chromatography (TLC) densitometry. The study identified an optimal eluent composition of ethyl acetate:formic acid:distilled water (18:1:1), with maximum wavelengths of 330 nm for chlorogenic acid and 274 nm for caffeine. High linearity was demonstrated with correlation coefficients of 0.993 for chlorogenic acid and 0.994 for caffeine. Sensitivity was validated with LOD values of 100.664 ng for chlorogenic acid and 297.232 ng for caffeine, and LOQ values of 301.994 ng for chlorogenic acid and 891.697 ng for caffeine. Selectivity was confirmed as the method effectively separated chlorogenic acid, caffeine, and other compounds with a resolution (Rs) ≥ 1.5, while specificity was evidenced through purity and identity values exceeding 0.99. Precision was proven through repeatability (%RSD for chlorogenic acid: 2.94%; caffeine: 2.27%) and intermediate precision (%RSD for chlorogenic acid: 2.26%; caffeine: 2.18%). Accuracy was achieved with mean recovery rates of 102.22% for chlorogenic acid and 99.73% for caffeine. The determination of chlorogenic acid and caffeine concentrations in robusta coffee leaf powder revealed variations between samples: PTPN XII Renteng yielded 2.278% ± 0.209% for chlorogenic acid and 1.171% ± 0.821% for caffeine, while Puslitkoka Indonesia samples showed 1.238% ± 0.206% for chlorogenic acid and 0.917% ± 0.823% for caffeine. Based on validation parameter assessments, the method is deemed valid as it meets all acceptance criteria for each parameter. This research provides an efficient and accurate analytical approach for simultaneous determination of bioactive compounds in robusta coffee leaves.
Oral glucose tolerance assay of extract from Mangifera foetida l. and Pandanus amaryllifolius roxb. leaves RETNANINGTYAS, YUNI; CRISTIANTY, FRANSISKA MARIA; KRISTININGRUM, NIA; WARDANI, PRAMUDIA
Jurnal Natural Volume 24 Number 1, February 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i1.30982

Abstract

This study examines the potential antidiabetic activity of a combination of Mangifera foetida L. and Pandanus amaryllifolius Roxb. leaves. Mangifera leaves contain a compound called mangiferin, which acts as an antidiabetic and antioxidant. On the other hand, Pandanus leaves, are rich in terpenoids and steroids that also possess anti-diabetic effects. An Oral Glucose Tolerance Test (OGTT) was conducted on male mice of the Babl/c strain to assess the antidiabetic effects. The test involved administering a combination of ethanolic leaf extracts from Mangifera foetida L. and Pandanus amaryllifolius Roxb. in a 1:1 ratio. The study followed a pre-test design with a control group, comprising six treatment groups, each consisting of four male mice. The groups were described as follows: Group 1 was served as the normal group without any treatment. Groups II-IV received single extracts or combinations of extracts at doses of 62.5 mg/200g BW, 125 mg/200g BW, and 250 mg/200g BW. Group V acted as the positive control and was given oral glucose and glibenclamide at a dose of 0.09 mg/200g BW. Group VI was served as the negative control, receiving oral glucose and distilled water. The group that exhibited the highest percentage of decreased blood sugar levels was the one given oral glucose at a dose of 0.078g/20g BW of mice, along with the combination of Mangifera foetida L. and Pandanus amaryllifolius Roxb. leaves extract (1:1) at a dose of 35 mg/20g BW. This group demonstrated a decrease of 71.985 4.858 in blood glucose levels. The ANOVA analysis confirmed that the percentage decrease in blood sugar levels was significantly different from the positive control, indicating a higher effectiveness of the combination treatment in reducing blood glucose levels than the positive control.
Studi Aktivitas Antioksidan Kombinasi Ektrak Etanol Daun Mangga Bachang (Mangifera foetida Lour.) dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Kristiningrum, Nia; Hernawati, Sri; Aulia, Rizki Putri; Wardani, Pramudia
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2018: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.447 KB)

Abstract

Radikal bebas berperan sebagai pemicu pada berbagai penyakit degeneraif diantaranya adalah diabetes melitus dan hipertensi. Secara umum ada mekanisme perlindungan dalam sel dan jaringan tubuh terhadap radikal bebas namun pertahanan dari dalam tubuh seringkali masih kurang sehingga dapat menyebabkan stres oksidatif pada sel. Resiko dari penyakit ini dapat dikurangi dengan mensuplai senyawa antioksidan alami yang berasal dari tanaman. Diantara tanaman yang memiliki potensi sebagai antioksidan yaitu rosella (Hibiscus sabdariffa L.). Kelopak bunga rosella mengandung banyak asam organik seperti asam sitrat, asam askorbat, dan pektin serta mengandung polifenol seperti antosianin, asam fenolik, dan flavonoid.Tanaman lain yang didugamemiliki potensi sebagai antioksidan adalah mangga pakel (Mangifera foetida Lour.). Hal ini disebabkan karena kandungan mangiferin pada daun mangga yang merupakan senyawa golongan polifenol. Pada penelitian ini dilakukan uji aktivitas antioksidan kombinasi antara ekstrak etanol daun mangga pakel dan kelopak bunga rosella dalam berbagai perbandingan dengan tujuan mendapatkan kombinasi yang memiliki aktivitas antioksidan yang paling tinggi. Metode yang digunakan pada pengujian aktivitas antioksidan adalah metode DPPH (1,1-diphenyl-2-picryl hydrazyl). DPPH merupakan senyawa radikal bebas yang stabil. Dalam bentuk radikal DPPH dapat diabsorbansi pada panjang gelombang 515-520 nm tetapi dengan adanya reaksi dengan senyawa antioksidan akan mengalami penurunan absorbansi. Hasil penelitian menunjukkan bahwa Nilai IC50 untuk ekstrak etanol daun mangga pakel sebesar 7,634±0,142 µg/ml, ekstrak etanol kelopak bunga rosella 83,154±0,286 µg/ml, dan nilai IC50 kombinasi ekstrak etanol daun mangga pakel dengan ekstrak etanol kelopak bunga rosella pada perbandingan 2:1 adalah 27,005±0,218 µg/ml, perbandingan 1:1 adalah 43,277±0,504 µg/ml dan perbandingan 1:2 adalah 58,171±0,875 µg/ml. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa ekstrak yang memiliki aktivitas antioksidan terbesar adalah ekstrak etanol daun mangga pakel, sedangkan kombinasi ekstrak yang memiliki aktivitas antioksidan terbesar adalah kombinasi ekstrak etanol daun mangga pakel dan ekstrak etanol kelopak bunga rosella dengan perbandingan 1:1.
Biosynthesis of silver nanoparticles with antioxidant activity using Mesona palustris Bl. leaf water extract RETNANINGTYAS, YUNI; AIDA, SITI NOR; KRISTININGRUM, NIA
Jurnal Natural Volume 25 Number 3, October 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v25i3.41204

Abstract

Mesona palustris Bl. has considerable potential. Still, it has yet to be matched by its utilization in nanotechnology, especially nanoparticles (1-100 nm), which have superior physicochemical properties and activities. This laboratory study aims to determine the potential of of Mesona palustris Bl. leaf water extract as a bioreductant and capping agent in the biosynthesis of silver nanoparticles (AgNPs), as well as to evaluate the antioxidant activity of the synthesized AgNPs using the DPPH assay. The biosynthesis method produced optimum AgNPs with a ratio of 1% Mesona palustris Bl. leaf water extract, AgNO3, and dispersing medium 0.75:7:5 (v/v) synthesized for 60 minutes at 55C. The maximum wavelength of AgNPs produced was 433 nm with an absorbance of 0.677. FT-IR spectrophotometric characterization showed that phenolic compounds in the Mesona palustris Bl. leaf water extract is thought to act as a bioreductors and capping agent in the synthesis of AgNPs. SEM results showed that the AgNPs were spherical. Meanwhile, the PSA test results showed the average size of AgNPs was 81 nm, and the polydispersity index was 0.323 (moderately polydispersed). The IC50 value of AgNPs synthesized with Mesona palustris Bl. leaf water extract against DPPH free radicals was 71.501 1.347 g/mL, which is included in the potent antioxidant and better than Mesona palustris Bl. leaf water extract.
Co-Authors . Ifada Adelia A Devi Devi Aida, Siti Nor Aulia, Rizki Putri Ayik Rosita Puspaningtyas1 Bambang Kuswandi Bambang Kuswandi CRISTIANTY, FRANSISKA MARIA Dian Agung Pangaribowo Diana Holidah Dwi Koko Pratoko Dyanshah, Danny Agus Endah Puspitasari Fifteen Aprila Fajrin Fracilia Arinda Ratnasari Hamzah, Muhammad Hafidi Hamzah, Muhammad Hafidi Ika Oktavianawati Indah Purnama Sary Indah Purnama Sary, Indah Purnama Jazila, Yusrin Jazila, Yusrin Nur Khoirun Nisa' Khrisna Agung Cendekiawan Kun Rasyida Lestyo Wulandari Lilis Amongsari Nurud Diniyah Putri Aditama, Tiara Sagita Regol S Raudiah Raudiah Renggani, Hidayah Dwi Reny Diastri Noviriana Risa Wahyu Ananda Rizqi Amaliyah Sallama, Solihatus Sri Hernawati Syaifullah, Abim Tanfidz Alishlah, Tanfidz Tsabit Barki WARDANI, PRAMUDIA Wardhani, Firdha Aprillia Yayan Ika Rachmawati Yuni Retnaningtyas