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Pengembangan Sensor Kesegaran Edible untuk Fillet Ikan Tuna (Thunnus albacares) Berbasis Antosianin Kulit Buah Juwet (Syzygium cumini) dengan Membran Selulosa Bakterial Lilis Amongsari; Bambang Kuswandi; Nia Kristiningrum
Pustaka Kesehatan Vol 8 No 2 (2020): Volume 8 No. 2, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i2.11460

Produk perikanan merupakan bahan pangan yang banyak digemari oleh masyarakat. Salah satu hasil pengolahan produk perikanan yang disukai masyarakat adalah fillet ikan tuna. Hal tersebut diikuti dengan tuntutan kualitas mutu produk fillet ikan tuna, sehingga dibutuhkan suatu alat analisa yang dapat menganalisis kesegaran fillet ikan tuna secara mudah dan praktis. Penelitian ini bertujuan untuk mengembangkan sensor kesegaran edible berbasis indikator antosianin dari ekstrak kulit buah juwet (Syzygium cumini) dengan membran selulosa bakterial dari nata de coco. Sensor kesegaran edible tersebut dapat diaplikasikan sebagai sensor kesegaran dan mengetahui tingkat kesegaran fillet ikan tuna dengan berbagai parameter. Dilakukan uji parameter kesegaran fillet ikan tuna meliputi uji total mikroba, uji total volatile bases nitrogen (TVB-N), nilai pH, nilai tekstur, dan uji organoleptis. Perubahan warna sensor kesegaran edible diamati secara visual dan diuji menggunakan program ImageJ untuk menentukan nilai mean green. Hasil menunjukkan perubahan warna sensor kesegaran yaitu ungu tua saat fillet ikan tuna dalam keadaan segar, ungu muda saat fillet ikan tuna masih segar dan abu-abu ketika fillet ikan tuna sudah tidak lagi segar. Nilai mean green sensor kesegaran edible meningkat seiring dengan penurunan tingkat kesegaran fillet ikan tuna.

Pengembangan Sensor Kimia Berbasis Strip Tes untuk Deteksi Logam Berat Merkuri pada Sampel Produk Jamu Rizqi Amaliyah; Nia Kristiningrum; Indah Purnama Sary
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.16552

The use of plants as a traditional medicine in the modern era is still in high demand. One of the herbs commonly used by Indonesian is analgesic herbal medicine. The safety aspect of herbal medicine should be considered, such as heavy metal contamination. Mercury is the typical heavy metal found in polluting herbal plants. The maximum mercury level allowed in a medicinal preparation has been regulated by BPOM RI, as much as ≤ 0.5 ppm. A high level of mercury contamination causing toxic effects on the body due to protein precipitation, which inhibits enzyme activity and acts as a corrosive material. A technology that allows the detection of mercury is a chemical sensor. The strip test is optimal if the reagent 1-(2-thiazolyl azo)-2-naphthol (TAN) concentration at 1000 ppm and the sample has been confirmed at pH 7. The results of the strip test characterization showed that the response time was in the range of minutes 17 to 24, the use time of the test strips for 28 days if stored in room temperature and 29 days if stored at in refrigerator temperature, linearity with r = 0.998, Vx0 = 3.96%, p-value = 0.00000172, LOD = 0.102 ppm and LOQ = 0.306 ppm, interference value <5%, precision with RSD 6.54%, and accuracy with the value of % recovery 98.007%. T-test analysis showed p= 0.872, meaning no significant difference between the application of TAN-based test strips with the ICP-AES method.

Penetapan Kadar Inulin dalam Ekstrak Umbi Dahlia variabilis dan Dahlia pinnata dengan Metode KLT Densitometri (Determination of Inulin Content in Dahlia variabilis and Dahlia pinnata Tuber Extract by TLC Densitometry Method) Khoirun Nisa'; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Inulin is a polymer which have many benefits for health and used widely for food. The absence of research on determination of inulin content in dahlia tuber extract from different species, made this study very important to do. The purpose of this study was to determine the inulin content in dahlia tuber extract from different species. So it can be known the most effective type of dahlia to be the major source of inulin production. The method used in this study was TLC densitometry. The result showed that the inulin content in Dahlia variabilis tuber extract was 73.93 ± 1.209%, and the inulin content in Dahlia pinnata tuber extract was 66.76 ± 0.572%. The inulin content in Dahlia variabilis and Dahlia pinnata tuber extract were significantly different. Keywords: inulin, dahlia tuber, Dahlia variabilis, Dahlia pinnata, TLC densitometry

Deteksi Daging Babi pada Sampel Bakso Menggunakan Metode Near Infra Red (NIR) dan Kemometrik sebagai Verifikasi Kehalalan (Detection of Pork in Beef Meatball Sample using Near Infra Red and Chemometrics as Halal Verification) Khrisna Agung Cendekiawan; Bambang Kuswandi; Nia Kristiningrum
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Meatball (bakso) is one of the favorite foods in Indonesia. The adulteration of pork in beef meatball occurs frequently. This study was aimed to develop a fast and non destructive technique for the detection and classiﬁcation of pork in beef meatball using Near infrared (NIR) spectroscopy, combined with chemometrics, e.g. partial least square (PLS) and linear discriminant analysis (LDA). The spectral bands associated with pork protein (PP), beef protein (BP), and their mixtures in meatball formulation were scanned, interpreted, and identiﬁed by relating them to those spectroscopically representative to pure PF and BF. Study was done in four phases successively; (1) preparation of trained sample; (2) analysis of meatball powder by NIR Spectrophotometer. NIR spectrum were used to form three data sets, i.e. (a) spectrum in full region, (b) spectrum with first derivative, and (c) spectrum with second derivative; then (3) classification model of chemometrics to PLS and LDA was formed using the Unscrambler X 10.2 Software. (4) the NIR method and the best model of chemometric were applied in meatball samples for the prediction in compared with Xematest Pork result. Then prediction from Xematest Pork compared with The result from NIR-Chemometric. Xematest Pork is simillar with the result of NIR-Chemometric. Keywords: beef meatball, pork, adulteration, NIR, LDA.

Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker . Ifada; Ayik Rosita Puspaningtyas1; Ika Oktavianawati; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid. Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.

Uji aktivitas antibakteri ekstrak etanol dan fraksi daun gempol (Nauclea orientalis L.) terhadap bakteri Escherichia coli dan Staphylococcus aureus Nia Kristiningrum; Reny Diastri Noviriana; Lestyo Wulandari
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art1

Background: The leaves of gempol (N. orientalis L.), a family of Rubiaceae, have antibacterial activity. Objective: The aim of this research was to determine the antibacterial activity of gempol leaf ethanolic extract and its fractions. Methods: The antibacterial activity test was carried out using the disk diffusion method. The positive and negative controls used were a disk of 10 μg gentamicin and 10% DMSO solution, respectively. The test solution concentrations for each sample, including for the ethanolic extract, hexane fraction, ethyl acetate, and residue of gempol leaves, were 0.25%, 0.5%, 1%, 2%, and 5%. Results: The antibacterial activity of the ethanolic extract, hexane fraction, ethyl acetate fraction, and residue of gempol leaves against E. coli and S. aureus was significantly different from each other. The residue had the highest antibacterial activity followed by that of the ethyl acetate fraction, hexane fraction, and ethanolic extract. Conclusion: The antibacterial activity of gempol leaves against S. aureus was greater than against E. coli.Keywords: Gempol, Nauclea orientalis, extract, fractions, antibacterial, diffusion IntisariLatar Belakang: Daun gempol (N. orientalis L.) merupakan salah satu famili Rubiaceae yang telah diketahui memiliki aktivitas anthelmintik dan antibakteri.Tujuan: penelitian ini adalah untuk mengetahui aktivitas antibakteri berdasarkan zona hambat ekstrak etanol dan fraksi daun gempol.Metode: yang digunakan ialah metode difusi cakram yang menghasilkan diameter zona hambat sebagai hasil dari uji aktivitas antibakteri. Kontrol positif yang digunakan yaitu cakram gentamisin 10 μg sedangkan kontrol negatif yang digunakan yaitu DMSO 10%. Larutan uji meliputi ekstrak etanol, fraksi heksana, etil asetat, dan residu daun gempol dengan masing-masing konsentrasi yaitu 0,25%; 0,5%; 1%; 2%; dan 5%.Hasil: Aktivitas antibakteri dari ekstrak etanol, fraksi heksan, etil asetat dan residu daun gempol terhadap E. coli dan S. aureus menunjukkan perbedaan yang signifikan. Residu memiliki aktivitas antibakteri tertinggi diikuti oleh fraksi etil asetat, fraksi heksana dan ekstrak etanol.Kesimpulan: Aktivitas antibakteri pada S. aureus lebih besar dari pada E. coli.Kata kunci: Gempol, Nauclea orientalis, ekstrak, fraksi, antibakteri, difusi

Pelatihan Pembuatan Souvenir Sabun Kepada Kelompok Ibu-Ibu Rumah Tangga Kecamatan Kaliwates Kabupaten Jember Dalam Rangka Meningkatkan Perekonomian Masyarakat Dwi Koko Pratoko; Nia Kristiningrum; Adelia A Devi Devi; Regol S Raudiah Raudiah
Dedication : Jurnal Pengabdian Masyarakat Vol 3 No 2 (2019)
Publisher : LPPM Universitas PGRI Argopuro Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31537/dedication.v3i2.232

Sasaran dari kegiatan pengabdian masyarakat ini adalah kelompok ibu-ibu rumah tangga di Kecamatan Kaliwates Jember. Metode pelaksanaan dari kegiatan ini dibagi menjadi beberapa tahap yaitu persiapan, pelaksanaan pelatihan pembuatan souvenir sabun dan pelatihan pembuatan toko daring. Peserta dibagi menjadi kelompok-kelompok kecil sehingga sangat efektif dalam meningkakan pemahaman dan keterampilan kerja peserta. Adanya kegiatan ini diharapkan dapat memberikan ide, pengetahuan dan keterampilan bagi kelompok ibu rumah tangga tersebut sehingga mempunyai rumah produksi souvenir sabun dan harapannya bisa meningkatkan perekonomian keluarganya.

Stability Indicating RP-HPLC for Quantification Mangiferin in Extract of Three Species Mango Leaves Retnaningtyas, Yuni; Kristiningrum, Nia; Renggani, Hidayah Dwi; Sary, Indah Purnama
Indonesian Journal of Chemical Research Vol 8 No 1 (2020): Edisi Bulan Mei (Edition for May)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.8-yun

The stability indication of Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was validated for quantitative determination of mangiferin on three species mango leaves (Mangifera odorata Griff, Mangifera foetida Lour, and Mangifera indica L.). The samples were extracted by maseration method using methanol and concentrated using rotary evaporator. The method carried out on stationary phase a purospher RP-18 endcapped (25 cm Ã— 4.6 mm i.d., 5 Âµm) column with a mobile phase consisting of methanol: phosphoric acid 0.1% (v/v) (31:69); flow rate:0.8 mL/min; solvent methanol, detection was carried out at 258 nm. The analytical performace this measurement is good with the value of linearity (r2=0.998), precision (%RSD=0.649%), and accuration (10.67%). The forced degradation studies were carried out according to the International Conference on Harmonization (ICH) guidelines. The results indicating that the complete separation between degradation products and mangiferin peak occured. The degradation limit of mangiferin 5â€“20% (according to the guideline of ICH) except in basic condition (100%). The method was succesful applied to determine of the mangiferin in pakel (Mangifera foetida), kweni (Mangifera indica) and kopyor (Mangifera odorata) extract. The mangiferin content was obtained are pakel (9.95%), kopyor (7.40%) and kweni (Mangifera odorata) (2.49%) respectively.

Determination of Total Citronelal Levels and Development of FTIR-Chemometric Classification Model of Cymbopogon winterianus Jowitt Oil from Different Altitudes of Planting Areas Jazila, Yusrin; Kristiningrum, Nia; Wulandari, Lestyo
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.279

Cymbopogon winterianus Jowitt oil (CWJ oil) is a vegetable oil with very wide uses in food sector, cosmetics, medicines and chemical industry. Citronelal compound is one of the quality requirements that determine the quality of CWJ oil. This study aims to develop a chemometric-FTIR classification model and to determine the total citronellal content of Cymbopogon winterianus Jowitt oil grown in low and medium lands. The sample used was citronella oil from Jember and Banyuwangi regions. The cleaned CWJ herbal samples were withered, chopped and distilled to produce CWJ oil. CWJ oil was scanned using FTIR spectroscopy and then the FTIR spectras were analyzed using LDA, SVM and SIMCA to form a CWJ oil classification model. The selected classification model was then validated using leave one out cross validation and external validation. The LDA classification model showed the best results with 100% accuracy of model recognition and validation. The results of the determination of total citronellal levels of CWJ oil using the hydroxylamine method showed that samples of CWJ oil from Banyuwangi had higher levels of total citronellal than samples from Jember. The average levels of total citronellal CWJ oil from Banyuwangi and Jember regions were 32.84%, and 26.06%, respectively.

Determination of Total Citronelal Levels and Development of FTIR-Chemometric Classification Model of Cymbopogon winterianus Jowitt Oil from Different Altitudes of Planting Areas Jazila, Yusrin Nur; Kristiningrum, Nia; Wulandari, Lestyo
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.279

Cymbopogon winterianus Jowitt oil (CWJ oil) is a vegetable oil with very wide uses in food sector, cosmetics, medicines and chemical industry. Citronelal compound is one of the quality requirements that determine the quality of CWJ oil. This study aims to develop a chemometric-FTIR classification model and to determine the total citronellal content of Cymbopogon winterianus Jowitt oil grown in low and medium lands. The sample used was citronella oil from Jember and Banyuwangi regions. The cleaned CWJ herbal samples were withered, chopped and distilled to produce CWJ oil. CWJ oil was scanned using FTIR spectroscopy and then the FTIR spectras were analyzed using LDA, SVM and SIMCA to form a CWJ oil classification model. The selected classification model was then validated using leave one out cross validation and external validation. The LDA classification model showed the best results with 100% accuracy of model recognition and validation. The results of the determination of total citronellal levels of CWJ oil using the hydroxylamine method showed that samples of CWJ oil from Banyuwangi had higher levels of total citronellal than samples from Jember. The average levels of total citronellal CWJ oil from Banyuwangi and Jember regions were 32.84%, and 26.06%, respectively.

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