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All Journal Journal of Nutrition College e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences Majalah Obat Tradisional UNEJ e-Proceeding Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JURNAL PENDIDIKAN TAMBUSAI Medical and Health Science Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Anesthesiology and Reanimation (IJAR) Buletin Poltanesa Journal of Community Development Journal of Arabic Literature (Jali) Narra J AKSONA CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Jember Medical Journal (JMJ) Jurnal Penelitian International Journal of Health and Information System (IJHIS)
Jauhar Firdaus
Departemen Fisiologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Exploring the role of polysaccharides in mitigating organ damage caused by pesticide-induced toxicity: A systematic review and meta-analysis of in vivo studies Sakinah, Elly N.; Diniyah, Nurud; Subagio, Achmad; Marchianti, Ancah CN.; Firdaus, Jauhar; Fambudi, Stela S.; Amini, Stefia A.; Putri, Dhiani E.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1553

Abstract

Although polysaccharides have demonstrated potential in alleviating dysbiosis, the overall impact of polysaccharides on minimizing oxidative stress and organ damage in vivo has not been thoroughly investigated. The aim of this study was to investigate the comprehensive effects of polysaccharides in mitigating pesticide toxicity in animal studies, focusing on biomarkers related to oxidative stress, antioxidant activity, kidney injury, lipid profiles, liver function, and the preservation of liver and kidney weights. A systematic search was conducted across nine indexed databases, including PubMed, Cochrane CENTRAL, Taylor & Francis, Scopus, Sage, EBSCO, ProQuest, ScienceDirect, and Google Scholar. Rayyan.ai was used to screen in vivo studies that met the predefined inclusion and exclusion criteria. The quality of the selected in vivo studies was evaluated using SYRCLE’s Risk of Bias tool, specifically designed for animal studies. Thirteen randomized animal studies, comprising 330 mice and rats, were included in the analysis. The findings revealed that polysaccharides significantly increased antioxidant levels, including catalase (CAT) (p<0.00001), superoxide dismutase (SOD) (p<0.00001), glutathione peroxidase (GPx) (p<0.00001), and reduced glutathione (GSH) (p<0.00001). Polysaccharides also significantly reduced oxidative stress markers, such as malondialdehyde (MDA) (p<0.00001) and nitric oxide (NO) (p<0.0001), as well as kidney injury biomarkers, including serum creatinine (p<0.00001) and urea (p<0.00001). Additionally, improvements in lipid profiles were observed, with significant reductions in triglycerides (TG) (p=0.04) and total cholesterol (TC) (p<0.00001). However, there were no significant differences in high-density lipoprotein (HDL) (p=0.28) and low-density lipoprotein (LDL) (p=0.32) levels. Polysaccharides significantly alleviate liver biomarkers, including aspartate transaminase (AST) (p<0.0001), alanine transaminase (ALT) (p<0.005), and alkaline phosphatase (ALP) (p<0.0001). Polysaccharides also contributed to the maintenance of liver weight (p=0.009), although no significant differences were observed in kidney weights (p=0.81). The study highlights that polysaccharides exert significant effects in enhancing antioxidant levels, reducing oxidative stress and organ damage biomarkers, and preserving liver weights.
Co-Authors Abu Khoiri Achmad Subagio Adelia Handoko Aisya, Meutia Citra Al Munawir Alif Kufari Alyssandra Afqorina Agung Amini, Stefia A. Andi Muhammad, Andi Angela, Patricia Angga Mardro Raharjo Aris Prasetyo Aris Prasetyo Azham Purwandhono Bagus Hermansyah Bagus Satrio Pambudi Bagus Satrio Pambudi, Bagus Satrio Baidowi, Ivan Iqbal Caesarina, Ancah Cahyana, Nugraha Wahyu Cicih Komariah Dini Agustina Dita Diana Parti El Milla, Kardiana Izza Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Erma Sulistyaningsih Fambudi, Stela S. Habibbur Rochman Salim Hairrudin Hairrudin Handoko, Adelia Haniefah, Yumna Rifda Heni Fatmawati Ida Srisurani Wiji Astuti Inke Kusumastuti Inreswari, Laksmi Irawan Fajar Kusuma Karim, Muhdie Karisma Adya Pertiwi Komang Dewi Fridayanti Kristianingrum Dian Sofiana Kristianingrum Dian Sofiana kristianningrum dian Kristianningrum Dian Sofiana Labibah, Zhafirah Rana Laksmi Indreswari Lubis, Arinie Awindya Marchianti, Ancah CN. Maria Ulfa moh sholeh, moh Moh. Nur Indra Caesar Muhammad Fakhri Ali Muhammad Rijal Fahrudin Hidayat Nabiel, Rifaldy Ngurah Agung Reza Satria Nugraha Putra Nofica, Cheila Nurud Diniyah Pattipeilohy, Florence Pattipeilohy, Florence Marianty Pipiet Wulandari Pralampita, Pulong Wijang Prasetyo, Aris Putri, Dhiani E. Raharjo, Angga Rumastika, Nindya Shinta Sakinah, Elly N. Salshabilla, Dinda Syahva septa surya wahyudi, septa surya Setia, Bagus Sheilla Rachmania, Sheilla Sofiana, Kristianingrum Dian Sudarmanto, Yohanes Sudjarwo, Raisa sulihah, nurfaizah titisari Supangat Supangat Supangat Supangat Suryono Suryono T Ariani Widiastini Tartila, Jasmine Tristianti, Farmitalia Nisa Winanda, Leony Agnes Savira Wulan, Herlina Nur Yonas Hadisubroto Yudha Nurdian Yuli Hermansyah Zahrah Febianti Zahreni Hamzah