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Journal : Journal of Applied Holistic Nursing Science

Determinants of Mortality in Epithelial Ovarian Cancer: Systematic Review and Meta-analysis (Last 5 Years) Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Mulansari, Nadia Ayu; Soloan, Garry; Sini, Kieran Pasha Ivan; Wulandari, Anisa Saphira; Arifa, Vira Nur; Masrie, Marshaly Safira; Faqih, Fahrayhansyah Muhammad; Wirawan, Bintang
Journal of Applied Holistic Nursing Science Vol. 2 No. 2 (2026): February 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jahns.v2i2.375

Abstract

ABSTRACT Background: Ovarian cancer, ranking third among gynecologic cancers, poses a significant global health challenge. Despite affecting over 239,000 annually and causing 150,000 deaths, the overall survival rate is 45.6%. Variability in survival rates across different stages necessitates a detailed understanding of contributing factors. This systematic review and meta-analysis explores recent research to illuminate crucial aspects influencing epithelial ovarian cancer (EOC) patient outcomes. Methods: A protocol registered in PROSPERO (ID: CRD42024502616) guided this systematic review, focusing on cohort studies examining prognostic factors for EOC mortality. Eligibility criteria included relevance to mortality risk, clear extraction methods, and English language. A PRISMA-guided search with the keywords “((Ovarian Cancer) AND (Mortality) AND (Risk)” across Scopus, PubMed, and Cochrane. Evaluation of 66,191 samples from 16 cohort studies identified several key prognostic factors for mortality in epithelial ovarian cancer (EOC). Results: Advanced FIGO stage (III-IV) and high-grade serous histology were significant predictors of higher mortality, with stage III-IV showing a risk ratio of 3.62 (95% CI 3.35–3.91). Older age, greater inflammation (higher BMI, smoking), and bilateral tumors also increased mortality risk. Additionally, lifestyle factors like reduced physical activity and rural living, as well as treatment-related factors such as perioperative red blood cell transfusion, were associated with poorer survival outcomes. This systematic review provides comprehensive insights into the complex landscape of EOC survival. Key prognostic factors for mortality in EOC patients include advanced cancer stage, high-grade serous histology, older age, inflammation, and bilateral tumors. Treatment factors such as perioperative transfusion and neoadjuvant chemotherapy intensity also play a critical role. Conclusion: These findings highlight the need for personalized treatment strategies based on these factors to improve survival outcomes for EOC patients.
Co-Authors Abdullah, Muhammad Raoul Taufiq Adiyarianni, Ghina Ahmad Fauzi Alexander AW Peters Alifaturrasyid Syafaatullah Ridwan Alifaturrasyid Syafaatullah Ridwan Amalia, Ginva Andi Darma Putra Andrijono Andrijono Anggaraeni, Tricia Dewi Ani Retno Prijanti Aria Kekalih Arifa, Vira Nur Arini Setiawati As’syifa, Salsa Billa Bambang Sutrisna Binathara , Geraldus Sigap Gung Binathara, Geraldus Sigap Gung Bintang Wirawan Darmiati, Sawitri Elfahmi, Khalida Ikhlasiya Tajdar Gefariena Fadhly, RM Ali Faisha Rahma, Melly Faqih, Fahrayhansyah Muhammad Fauzi Ahmad Muda Ferry Sandra Fiastuti Witjaksono Gatot Purwoto Hadinata, Valencia Hariyono Winarto Hariyono Winarto Iwan Darmansjah Jan Susilo Joedo Prihartono Junita Indarti Kadarusman, Adib Kamil Putra Kartiwa Hadi Nuryanto Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Laila Nuranna Laila Nuranna Laila Nuranna Liedapraja, Mediana s. Lisnawati Liva Wijaya Malano, Yoarva Masrie, Marshaly Safira Mayhana, Shuffa Chilla Metasyah, Namira Michael Adrian Muhammad Haekal Muhammad Haekal Muhammad Ilyas Mutiara Riani Nadia Ayu Mulansari, Nadia Ayu Nasution, Hiro Hidaya Danial Oktalia, Arisda Oni Khonsa Purnomo Hyaswicaksono Putra, Abdul Hafiidh Surya Ridwan, Alifaturrasyid Syafaatullah Rizky Humairah , Inas Sahat B. Matondang Sekarutami, Sri Mutya SEPTELIA INAWATI WANANDI Sini, Kieran Pasha Ivan Siregar, Trifonia Pingkan Sitorus, Christina Soloan, Garry Sri Mutya Sekarutami Surahman Hakim Surya Putra, Abdul Hafiidh Suryoadji, Kemal Akbar Tofan Widya Utami Tofan Widya Utami Tricia Dewi Anggraeni Utami, Tofan Widya Widya Utami, Tofan Wulandari, Anisa Saphira Wulyo Rajabto Zahra, Reihana