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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmiah Kesehatan Jurnal Kesmas dan Gizi (JKG) Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Cermin Dunia Kedokteran Khazanah: Jurnal Mahasiswa Indonesian Journal of Cancer eJournal Kedokteran Indonesia Griya Widya: Journal of Sexual and Reproductive Health Jurnal Kesehatan Cendikia Jenius Journal of Applied Holistic Nursing Science JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Cermin Dunia Kedokteran
Fitriyadi Kusuma
Department Of Obstetrics And Gynecology, Faculty Of Medicine, University Of Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : The Indonesian Biomedical Journal

 1 
Survivin and Telomerase as Radiotherapeutic Response Predictors of Subjects with Stage IIIB Cervical Squamous Cell Carcinoma Fitriyadi Kusuma; Andrijono Andrijono; Ani Retno Prijanti; Laila Nuranna; Sri Mutya Sekarutami; Bambang Sutrisna; Ferry Sandra
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.813

Abstract

BACKGROUND: Cervical cancer is one of the most prevalent cancers in women. Even with similar clinicopathologic features, radiotherapy outcomes are still vary among patients. This research was conducted to measure radiotherapy responses on cervical cancer patients by using Survivin, Telomerase and Cytochrome C.METHODS: Subjects who matched the criteria were selected and requested to fill questionnaires. Subjects were then evaluated with magnetic resonance imaging (MRI) pre- and post-3D conformal radiotherapy. Histopathological study was conducted using resected tumors to determine the differentiation type. Enzyme-linked Immunosorbent Assays for detection of Survivin, Telomerase and Cytochrome C was performed using the resected tumors as well.RESULTS: There were 76 patients in this study. Mean ofage was 50 and diameter of tumor size was 5.35 cm. Mean levels of Survivin, Telomerase and Cytochrome C were 632.82 pg/mL, 5.59 pg/mL and 204.75 ng/mL, respectively. There were significant correlations between radiotherapy response and Survivin (p=0.041) or Telomerase (p=0.022). Subjects with lower Survivin level (<932 pg/mL) had higher 1-year survival rate (63%) than subjects with higher Survivin level (50%). Similar results were obtained for subjects with lower Telomerase level (<5.75 pg/mL), who had higher 1-year survival rate (60%) than subjects with higher Telomerase level (43%).CONCLUSION: Since radiotherapy response is significantly correlated with Survivin and Telomerase levels and subjects with lower Survivin or Telomerase level have higher 1-year survival rate, it can be suggested that Survivin and Telomerase could be potential predictors of radiotherapeutic response for subjects with stage IIIB cervical squamous cell carcinoma.KEYWORDS: cervical cancer, radiotherapy Survivin, Telomerase, Cytochrome C
Co-Authors Abdullah, Muhammad Raoul Taufiq Adiyarianni, Ghina Ahmad Fauzi Alexander AW Peters Alifaturrasyid Syafaatullah Ridwan Alifaturrasyid Syafaatullah Ridwan Amalia, Ginva Andi Darma Putra Andrijono Andrijono Anggaraeni, Tricia Dewi Ani Retno Prijanti Aria Kekalih Arifa, Vira Nur Arini Setiawati As’syifa, Salsa Billa Bambang Sutrisna Binathara , Geraldus Sigap Gung Binathara, Geraldus Sigap Gung Bintang Wirawan Darmiati, Sawitri Elfahmi, Khalida Ikhlasiya Tajdar Gefariena Fadhly, RM Ali Faisha Rahma, Melly Faqih, Fahrayhansyah Muhammad Fauzi Ahmad Muda Ferry Sandra Fiastuti Witjaksono Gatot Purwoto Hadinata, Valencia Hariyono Winarto Hariyono Winarto Iwan Darmansjah Jan Susilo Joedo Prihartono Junita Indarti Kadarusman, Adib Kamil Putra Kartiwa Hadi Nuryanto Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Laila Nuranna Laila Nuranna Laila Nuranna Liedapraja, Mediana s. Lisnawati Liva Wijaya Malano, Yoarva Masrie, Marshaly Safira Mayhana, Shuffa Chilla Metasyah, Namira Michael Adrian Muhammad Haekal Muhammad Haekal Muhammad Ilyas Mutiara Riani Nadia Ayu Mulansari, Nadia Ayu Nasution, Hiro Hidaya Danial Oktalia, Arisda Oni Khonsa Purnomo Hyaswicaksono Putra, Abdul Hafiidh Surya Ridwan, Alifaturrasyid Syafaatullah Rizky Humairah , Inas Sahat B. Matondang Sekarutami, Sri Mutya SEPTELIA INAWATI WANANDI Sini, Kieran Pasha Ivan Siregar, Trifonia Pingkan Sitorus, Christina Soloan, Garry Sri Mutya Sekarutami Surahman Hakim Surya Putra, Abdul Hafiidh Suryoadji, Kemal Akbar Tofan Widya Utami Tofan Widya Utami Tricia Dewi Anggraeni Utami, Tofan Widya Widya Utami, Tofan Wulandari, Anisa Saphira Wulyo Rajabto Zahra, Reihana