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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Health Science Journal of Indonesia Jurnal Farmasi Klinik Indonesia WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kesehatan Vokasional Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Hukum Prasada JURNAL ILKES (Jurnal Ilmu Kesehatan) Indonesian Journal of Global Health research Jurnal Health Sains Jurnal Locus Penelitian dan Pengabdian Public Health and Preventive Medicine Archive International Journal of Health and Pharmaceutical (IJHP) Journal of Law, Poliitic and Humanities Jurnal Penyakit Dalam Indonesia
R. A.T. Kuswardhani
Divisi Geriatri, Departemen Ilmu Penyakit Dalam, Universitas Udayana, Denpasar
Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

 1 
RISKS FOR PERIPHERAL ARTERIAL DISEASE IN THE ELDERLY WITH TYPE 2 DIABETES MELLITUS : Their Correlation with High Sensitivity C-reactive Protein and Ankle-Brachial Index Ayu Tuty Kuswardhani, Raden; Wita, Wayan; Bakta, Made; Santosa, Anwar
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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Abstract

The Indonesian elderly population has been projected to increase up to about four-fold inthree decades (1990-2020). As a consequence of this population trend, the increased prevalence ofdegenerative diseases would be inevitable; this would include the prevalence of peripheral arterialdisease.This study aims to identify the correlation of diverse risk factors, either traditional or nontraditional,with the ankle-brachial index scores, and the correlation of novel non-traditional riskfactor, e.i. high sensitive C-reactive protein with the prevalence of perioheral arterial disease in theelderly, age 60-80 years old, with type 2 diabetes mellitus.Among the 146 elderly patients with type 2 diabetes mellitus, and based on measurement ofthe ABI score, approximately 30.9% of them had PAD. Some traditional and non-traditional riskfactors having a significant correlation with the ankle-brachial index score, were age (r = -0.396, p <0.001 for right ABI; r = -0.509, p < 0.001 for left ABI), supine systolic blood pressure (r= -0.268, p =0.012 for right ABI; r = -0.267, p = 0.013 for left ABI), 2-hour post-prandial blood glucose (r= -0.252, p = 0.018 for right ABI), and hsCRP (r = -0.280, p = 0.011 for right ABI; r = -0.402, p <0.001 for left ABI); whereas other risk factors like obesity based on waist circumference and BMI,non-supine systolic blood pressure, fasting blood glucose, HbA1C, duration of diabetes, plasma lipidsdid not show statistically significant different odd ratios. After linear regression test for risk factorshaving significant correlations with ABI, age and hsCRP were found to influence the ABI scores.Based on a case-control study, risk factors which, to some extent, had statistically significant valuesas risk factors, include older age (? 70 years old; OR = 7.737 [CI = 2.515-23.805]; p < 0.001),relatively high supine diastolic blood pressure (? 90 mmHg; OR = 6.882 [CI = 0.789-60.060]; p =0.048), and high concentration of hsCRP (> 3 mg/L; OR = 4.420 [CI = 1.287-15.181]; p = 0.013).Among these statistically significant risk factors, after logistic regression test analysis, only the age ofthe patient appeared to have significant influence on the prevalence of PAD.In conclusion, this study demonstrates a negative correlation between hsCRP and ABI score;and high levels of hsCRP appeared to be a risk factor for PAD. The age of the patient, however,appeared to be the strongest risk factor for PAD.
Co-Authors A Santoso Adi Dharma, Ignasius Anak Agung Ayu Ratih Hapsari Anak Agung Gede Angga Puspa Negara Anak Agung Mas Putrawati Triningrat Anak Agung Wiradewi Lestari Andreany Kusumowardani Anwar Santosa Anwar Santoso Aryana, I Gust Putu Suka Astika, I Nyoman Baskoro Tri Laksono Budiana, I Nyoman Catarina Budi P Cilik Wiryani Cok I. I. Purwaningsih Cokorda Agung Wahyu Purnamasidhi Darta, I Wayan Dewianti Dewianti Dewianti, Dewianti Diah Pradnya Paramita Dian Pritasari Jeger Dyah Pradnyaparmita Duarsa Gede Sukrawan I Gusti Agung Gede Utara Hartawan I Gusti Agung Wilaja Putra I Gusti Putu Suka Aryana I Ketut Suastika I Made Ady Wirawan I Made Bakta I Made Dharma Atmaja I Made Jawi I Made Jawi I MADE MULIARTA . I Made Siswadi Semadi I Nyoman Adi Putra I Nyoman Astika I Nyoman Wande I Nyoman Wande I Nyoman Wande I Putu Gede Adiatmika I Putu Gede Adiatmika I Wayan Gede Artawan Eka Putra, I Wayan Gede Artawan Eka I Wayan Mustika I Wayan Mustika I Wayan Mustika I Wayan Wita I. N. Astika I.D. G.A.E. Putra Ida Bagus N Maharjana Ida Bagus Putu Putrawan Ida Bagus Udayana Hanggara IGP Adiatmika IN Astika Iswara, Ni Putu Ayu Astri Prana IW Yuna Ariawan J. A. Pangkahila K Andriyasa K Widana Kadek Tresna Adhi Ketut Tirtayasa Lanawati Lanawati, Lanawati Luh Putu Ratna Sundari M. Ali Imron Made Nopriantha Made Nopy Diah Sundari Made Oka Widyantara, Made Oka Muhammad Irfan N Astika N. Adiputra N. K.S. Diniari Ngakan Ketut Wira Suastika, Ngakan Ketut Wira Ni Ketut Rai Purnami Ni Putu Ayu Astri Prana Iswara Ni Wayan Tianing Nyoman Kertia Paramita, Diah Pradnya Purnami, Ni Ketut Rai Purwaningsih, Cok I. I. Putra, I Komang Wisuda Dwija Putu Ayu Indrayathi Putu Ayu Sani Utami Putu Mulya Kharismawan Putu Shely Prihastuti Rudy Rina Listyowati Rina Listyowati, Rina S. Indra Lesmana Saktivi Harkitasari, Saktivi Sawitri, Anak Agung Sagung Semaradana, Wayan Giri Putra Shelvy Florence Gousario Siti Nadhir Ollin Norlinta Sri Kayati Widyastuti Sriwijayanti, Luh Putu Eka Sundari, Made Nopy Diah Suparna, I Ketut Surya Rini, Sandra Susy Purnawati Trisna Yuliharti Tersinanda Wahyuddin, Wahyuddin Wayan Giri Putra Wimpie I Pangkahila Wira Gotera Wirawan, I Made Budi Wisnu Wardhana Yanson - Yosef Samon Sugi