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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT JI-KES (Jurnal Ilmu Kesehatan) Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Jurnal Abdi Masyarakat Kita JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Food and Pharmaceutical Sciences Indonesian Journal of Global Health Research
Kintoko, Kintoko
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Review on Ethnomedicinal and Potential Effect of Antibacterial Plants against Halitosis Kintoko Kintoko; Astri Desmayanti
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4748

Abstract

Halitosis is an oral malodor condition in the oral cavity that comes from the breakdown of protein by anaerobic gram-negative and gram-positive bacteria. Some bacteria that are often found in cases of halitosis are Solobacterium moorei, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Treponema denticola, dan Streptococcus mutans. Medicinal plants to treat various diseases have shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. As many as 7,000 species of medicinal plants in Indonesia have been studied to address health problems. Among the medicinal plants that have been studied are Green Betel (Piper betle L.), Cinnamon (Cinnamomum zeylanicum), Star Anise (Illicium verum), Mint (Mentha piperita) dan Oregano (Origanum vulgare) which have been shown to cure various diseases. This review article describes the potential of plants as an antibacterial against halitosis. The purpose of this review is to provide an overview of ethnomedicine and the potential effects of antibacterial medicinal plants that can be used in cases of halitosis.
Integrative Review of Indonesian Phytocosmetics: Resveratrol, Collagen, and Pachyrhizus erosus for Anti-Aging and Skin-Brightening in Multipurpose Serum Sofiani Lathifah; Kintoko Kintoko; Pradanty Anaperta Gulies Sentana
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nqkd8678

Abstract

Background: The demand for natural-based cosmetic products has increased substantially, driven by consumer awareness of safety, efficacy, and sustainability, with facial serums being preferred for anti-aging and skin-brightening applications. Objective: This review aimed to synthesise scientific evidence on the potential of resveratrol, marine collagen, and jicama (Pachyrhizus erosus) extract as key actives in multipurpose facial serum formulations with antioxidant, anti-ageing, and skin-brightening claims. Methods: A narrative review was conducted using original research articles published between 2015 and 2025 retrieved from PubMed and Crossref databases, focusing on quantitative outcomes including antioxidant and antityrosinase IC₅₀ values, changes in skin elasticity and hydration, transepidermal water loss (TEWL), and molecular biomarkers of skin ageing. Results: Of 1,393 identified records, 20 studies met the inclusion criteria (resveratrol n=6; collagen n=8; P. erosus n=6). Resveratrol shows strong antioxidant and anti-inflammatory activities that mitigate UV-induced photoaging; marine collagen, particularly hydrolysates, improves skin hydration and elasticity; and jicama extract provides antioxidant activity, including phenolic- and flavonoid-rich compounds, with tyrosinase inhibitory effects. Conclusion: Integrating these three actives may offer synergistic multi-target benefits; however, further formulation studies and clinical evaluations are required to confirm stability, compatibility, and combined efficacy within a single serum product.
Antibacterial Activity of Endophytic Fungi Isolated from Betel Leaf (Piper betle) Against Pseudomonas aeruginosa and Staphylococcus aureus Kintoko Kintoko; Khrisna Agung Cendekiawan; Sapto Yuliani; Siti Nur Hasana; Firdha Aprilia Wardhani
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43506

Abstract

Betel leaf (Piper betle) contains antibacterial compounds such as flavonoids, saponins, and alkaloids. Endophytic fungi within plant tissues can produce similar bioactive metabolites. This study aimed to isolate, identify, and evaluate the antibacterial activity of endophytic fungi from young betel leaves against Pseudomonas aeruginosa and Staphylococcus aureus. This was experimental research. Endophytic fungi were isolated from young betel leaves on Potato Dextrose Agar (PDA) and identified macroscopically and microscopically. Antibacterial activity was tested using the paper disk agar diffusion method. Three endophytic fungal isolates were obtained: Isolate 1 (Trichoderma sp.), Isolate 2 (Rhizoctonia sp.), and Isolate 3 (Fusarium sp.). Against P. aeruginosa, Isolate 2 produced an average inhibition zone of 7.33 mm, and Isolate 3 produced 8.00 mm. Against S. aureus, Isolate 1 produced 7.33 mm and Isolate 3 produced 7.33 mm. No inhibition was observed for the negative control (DMSO). Endophytic fungi from betel leaves, particularly isolates resembling Rhizoctonia sp., Fusarium sp., and Trichoderma sp., show weak to moderate antibacterial activity against P. aeruginosa and S. aureus under the tested conditions. Further studies using molecular identification and purified extracts are recommended.
Acute Toxicity Test of Black Rice and Soybean Extract Complex Liza Syafitri; Nina Salamah; Ichwan Ridwan Rais; Kintoko Kintoko; Sri Mulyaningsih; Moch Saiful Bachri
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43524

Abstract

The present study was conducted to assess the acute oral toxicity of a copigment complex formulated from extracts of black rice (Oryza sativa L., indica) and soybean (Glycine max (L.) Merr.). Despite extensive individual pharmacological investigations of these botanical sources, no safety data have previously been documented for their combined copigment complex intended as a functional beverage constituent. Following the Acute Toxic Class methodology (OECD 423), the complex was orally administered as a single dose at 300, 2000, or 5000 mg/kg body weight (BW) to female Swiss Webster mice (n=3 per dose group), alongside a vehicle control group administered 1% Na-CMC. A comprehensive 14-day monitoring program assessed mortality, a range of clinical indicators (including tremor, convulsions, salivation, diarrhea, lethargy, locomotion, coat condition, and ocular appearance), and body weight at Days 0, 7, and 14. No animal deaths occurred across any group. Transient, mild hypoactivity was noted in animals receiving 5000 mg/kg at 1–2 hours post-dose, which resolved completely by 4 hours post-administration. No additional adverse clinical manifestations or weight loss were detected. Based on these findings, the median lethal dose (LD50) is projected to surpass 5000 mg/kg BW, corresponding to GHS Category 5 (practically non-toxic). The results collectively establish a safety foundation for the use of this copigment complex as a functional ingredient in isotonic beverage products, while acknowledging the need for further subchronic and chronic toxicological investigations.
Effectiveness of Cupping Aromatherapy Nanoemulsion on Mean Arterial Pressure and Heart Rate in Hypertension Patients Aris Setyawan; Kintoko Kintoko; Wahyudi Widada
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.1193

Abstract

Hypertension is a cardiovascular disease that contributes to increased morbidity and mortality rates. Pharmacological therapy often causes side effects and decreases patient compliance, so a safe and effective complementary treatment approach is needed. Therapy is known to have physiological effects on the cardiovascular system, while aromatherapy has relaxing and vasodilatory effects. The development of aromatherapy in the form of nanoemulsion is expected to increase the stability and effectiveness of therapy, especially when combined with cupping therapy. This study aims to determine the effectiveness of nano aromatherapy cupping on mean arterial pressure (MAP) and heart rate in hypertensive patients. The study used a quasi-experimental design with a pretest-posttest control group design. The sampling method used random sampling, as many as 30 hypertensive patients were divided into two groups: the intervention group that received cupping therapy and aromatherapy nanoemulsion, and the control group that only received cupping therapy. The dependent variables included mean arterial pressure (MAP) and heart rate measured before and after the intervention. Data analysis used the T test. The results showed a significant decrease in MAP and heart rate in both groups after the intervention (p < 0.05). However, the results of the inter-group test showed that the difference in the decrease in MAP and heart rate between the intervention and control groups was not statistically significant (p > 0.05). The conclusion of this study shows that cupping therapy with aromatherapy nanoemulsion is effective in reducing MAP and heart rate in hypertensive patients.
Studi Kopigmentasi Antosianin Beras Hitam (Oryza sativa L. indica) Dengan Polifenol Kacang Kedelai (Glycine max L.) Aprilya Kumala Shary; Kintoko Kintoko; Wahyu Widyaningsih; Hari Susanti; Meki Pranata; Rizky Gustinanda
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.37235

Abstract

Antosianin merupakan pigmen alami yang berperan penting sebagai antioksidan namun stabilitasnya relatif rendah terhadap faktor lingkungan seperti cahaya, pH dan suhu. Upaya untuk meningkatkan stabilitas antosianin dapat dilakukan melalui mekanisme kopigmentasi dengan senyawa polifenol. Penelitian ini bertujuan untuk mengevaluasi pengaruh kopigmentasi antara antosianin beras hitam (Oryza sativa L. indica) dengan polifenol yang diperoleh dari rebusan kacang kedelai (Glycine max L.) terhadap kestabilan warna dan aktivitas antioksidan. Ekstraksi antosianin dilakukan menggunakan pelarut asam sitrat, sedangkan polifenol kacang kedelai diperoleh melalui ekstraksi maserasi dari rebusan kacang kedelai yang diperkaya senyawa fenolik. Kopigmentasi dilakukan dengan variasi rasio perbandingan 1:1, 1:2 dan 1:3, kemudian dianalisis melalui spektrofotometri UV-Vis untuk menentukan pergeseran λmaks, intensitas warna, serta kestabilan pigmen. Hasil penelitian menunjukkan bahwa penambahan polifenol kacang kedelai mampu meningkatkan intensitas warna pada antosianin beras hitam. Selain itu, aktivitas antioksidan menunjukkan peningkatan dibandingkan antosianin tunggal, menandakan adanya sinergi antara kedua senyawa bioaktif. Dengan demikian, kopigmentasi antosianin beras hitam dengan polifenol kacang kedelai berpotensi meningkatkan kestabilan pigmen alami, dengan rasio 1:1 menunjukkan keseimbangan terbaik antara stabilitas warna dan aktivitas antioksidan.
TRANSFORMASI FORMULASI MINYAK ATSIRI STIKESMAMBA’UL ULUM SURAKARTA BERSAMA CV.NATURONAL CREATAMA INDONESIA Hardi Astuti Witasari; Kintoko Kintoko; Yusron Umar; Nova Rahma Widyaningrum Widyaningrum; Kiki Puspitasary; Meliana Novitasari
Jurnal Abdi Masyarakat Kita Vol. 6 No. 2 (2026): Jurnal Abdi Masyarakat Kita
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/asta.v6i2.1051

Abstract

The use of essential oils extracted from plants as an alternative treatment is known as essential oils. This method has been proven to provide various health benefits. This collaboration created an integrated essential oils training program that aims to synergize academic knowledge with its application in the business world. This program was held to enrich participants' understanding and skills regarding the basic concepts of herbal business classes, essential oils making practices, and production process observations. Using a one-group pretest-posttest design approach, this activity summarizes the delivery of theoretical material, making essential oils products, and reviewing the production process in the factory. Based on the evaluation results, there was a significant increase in knowledge with an achievement rate of 90.34% in various aspects measured. Overall, this training successfully honed the technical competencies of participants while opening up opportunities for small-scale business startups in the field of essential oils products.
Co-Authors Adhi Gunawan Alfian Syarifuddin Anandita Nurwijayanti Any Guntarti Aprilya Kumala Shary Aris Setyawan Astri Desmayanti Astri Desmayanti Astri Desmayanti Aulia Rahman Ayu Shabrina Baso Didik Hikmawan Citra Ariani Citra Ariani Edityaningrum, Citra Cut Raihanah Dyah Aryani Perwitasari Eka Fitri Susiani Eka Siswanto Syamsul Elfasyari, Trie Yuni Endang Darmawan Ersi Arviana Ihsan Fajar Slamet Riana Feby Zulien Hanifah Karimatulhajj Hardi Astuti Witasari Hardi Astuti Witasari Hardi Astuti Witasari Hari Susanti Hayatus Sa`adah Ichwan Ridwan Rais Khoiriyah Isni Khrisna Agung Cendekiawan Kiki Puspitasary Leswara, Dianita Febrina Lintang Cahya Saputri Liza Syafitri Lusi Mardika Ariyanti Meki Pranata Meliana Novitasari Meta Damaharyuningtyas Moch Saiful Bachri Nadiya Utari Nanik Sulistyani Neni Tri Anggraini Nina Salamah Nining Sugihartini Nova Rahma Widyaningrum Widyaningrum Nura Ustrina Nurkhasanah Nurkhasanah Nurul Mahyani Pradanty Anaperta Gulies Sentana Puspawan Hariadi Putra, Teguh Adiyas Rifqi Ferry Balfas Rizky Gustinanda Rukaya, Benazir Evita Salsabila Ramadhan Sapto Yuliani Septian Emma Dwi Jatmika Sitarina Widyarini Siti Nur Hasana Sofiani Lathifah Sri Mulyaningsih Supomo Supomo Suwijiyo Pramono Swastika Praharyawan Tsania Taskia Nabila Wahyu Widyaningsih Wardhani, Firdha Aprillia Warsi Warsi Widada, Wahyudi Widiyastuti, Lina Yuda Fajar Pratama Yusron Umar