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All Journal Jurnal Ilmu Pertanian Indonesia Journal of Food and Pharmaceutical Science Jurnal Farmasi Udayana Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT JI-KES (Jurnal Ilmu Kesehatan) Jurnal Ilmu Kefarmasian Indonesia Borneo Journal Of Pharmascientech International Journal of Islamic and Complementary Medicine Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Food and Pharmaceutical Sciences
Kintoko, Kintoko
Universitas Ahmad Dahlan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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REVIEW : KAJIAN ETNOMEDISIN, FITOKIMIA, DAN FARMAKOLOGI DARI TANAMAN OBAT UNTUK WASIR: REVIEW : STUDY OF ETHNOMEDICINE, PHOTOCHEMICAL, AND PHARMACOLOGY OF MEDICINAL PLANTS FOR HEMORRHOIDS Kintoko; Astri Desmayanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.492

Abstract

Wasir merupakan salah satu gangguan anorektal yang paling umum dari semua gangguan klinis gastrointestinal. Jumlah penderita wasir di Indonesia mencapai 12,5 juta orang dan diprediksi akan meningkat menjadi 21,3 juta pada tahun 2030. Tingginya prevalensi wasir ini dipengaruhi oleh beberapa faktor seperti kehamilan, konstipasi, usia, dan jenis pekerjaan. Nyeri dan rasa tidak nyaman pada dubur, gatal, perdarahan, dan pembengkakan yang dirasakan di area perianal merupakan gejala utama wasir. Gejala-gejala tersebut dapat diatasi oleh senyawa yang memiliki aktivitas antiinflamasi. Graptophyllum pictum, Plectranthus scutellarioides, Curcuma longa, Hedyotis corymbosa dan Nigella sativa memiliki kemampuansebagai antiinflamasi yang potensial dalam mengatasi wasir. Tujuan dari penulisan ini adalah untuk mengetahui efektivitas tanaman obat diatas berdasarkan kajian etnomedisin, fitokimia dan farmakologinya. Metode yang digunakan yaitu Systematic Literature Review. Pencarian literatur yang komprehensif dilakukan menggunakan beberapa database seperti PubMed, Scopus, Google Scholar dan sumber lainnya. Berdasarkan studi referensi, ketiga tanaman tersebut memiliki khasiat yang sama sebagai antiinflamasi yang diharapkan dapat efektif untuk mengatasi inflamasi pada kasus wasir. Dengan adanya kombinasi dari ketiga tanaman tersebut akan meningkatkan efektivitasnya dalam mengatasi wasir. Kata kunci : wasir, etnomedisin, fitokimia, farmakologi, antiinflamasi
Aktivitas Anti-Wrinkle Gel Ekstrak Binahong (Anredera cordifolia) secara In Vivo Kintoko Kintoko; Hardi Astuti Witasari; Yuda Fajar Pratama
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p01

Abstract

Sinar ultraviolet memicu terbentuknya radikal bebas penyebab kerutan. Daun binahong (Anredera cordifolia) memiliki aktivitas antioksidan yang dapat menstabilkan radikal bebas. Penggunaan ekstrak daun binahong dalam bentuk gel lebih praktis dan nyaman dikulit. Penelitian ini bertujuan untuk mengetahui aktivitas anti-wrinkle pemberian gel ekstrak binahong pada mencit yang diinduksi sinar UV-B. Penelitian ini menggunakan 25 ekor mencit jantan, dibagi 5 kelompok. Kelompok normal (perlakuan apapun), kelompok UV-B (hanya paparan sinar UV-B), kelompok tretinoin (paparan sinar UV-B dan gel tretinoin), kelompok perlakuan 1 (paparan sinar UV-B dan gel ekstrak binahong satu kali sehari), kelompok perlakuan 2 (paparan sinar UV-B dan gel ekstrak binahong dua kali sehari. Paparan dilakukan dengan lampu UV-B Kernel KN-4003 selama 2 minggu. Pengamatan kerutan secara visual scoring dengan metode Bissett. Data yang diperoleh dianalisis menggunakan uji statistik SPSS. Skor kerutan pada kelompok normal adalah 0, kelompok UV-B 2,66±0,48, kelompok tretinoin 0,44±0,38, kelompok perlakuan 1 1,06±0,61, dan kelompok perlakuan 2 0,80±0,84. Kelompok UV-B memberikan perbedaan yang signifikan terhadap tretinoin, perlakuan 1, dan 2 (P<0,05). Kelompok tretinoin tidak berbeda signifikan terhadap skor kerutan pada perlakuan 1 dan 2 (P>0,05). Pemberian gel ekstrak binahong memiliki aktivitas sebagai anti-wrinkle dalam mencegah terjadinya kerutan pada mencit yang diinduksi sinar UV-B. Penambahan frekuensi memberikan perbedaan yang tidak signifikan. Kata kunci: anti-wrinkle, ekstrak daun binahong, gel
Review on Ethnomedicinal and Potential Effect of Antibacterial Plants against Halitosis Kintoko Kintoko; Astri Desmayanti
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4748

Abstract

Halitosis is an oral malodor condition in the oral cavity that comes from the breakdown of protein by anaerobic gram-negative and gram-positive bacteria. Some bacteria that are often found in cases of halitosis are Solobacterium moorei, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Treponema denticola, dan Streptococcus mutans. Medicinal plants to treat various diseases have shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. As many as 7,000 species of medicinal plants in Indonesia have been studied to address health problems. Among the medicinal plants that have been studied are Green Betel (Piper betle L.), Cinnamon (Cinnamomum zeylanicum), Star Anise (Illicium verum), Mint (Mentha piperita) dan Oregano (Origanum vulgare) which have been shown to cure various diseases. This review article describes the potential of plants as an antibacterial against halitosis. The purpose of this review is to provide an overview of ethnomedicine and the potential effects of antibacterial medicinal plants that can be used in cases of halitosis.
Proximate Characteristics and Antioxidant Activity of Polyherbal Extract in Yogurt Andhini Noor Chandra, Meta; Epi Taufik; Kintoko, Kintoko
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 4 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.4.638

Abstract

Fermented dairy products, such as yogurt, are well known for their health advantages. Enhancing their functional value using polyherbal mixtures constitutes a big step forward in functional food development. This study looks at the proximate composition (fat, protein, moisture, and ash content) and antioxidant activity of polyherbal yogurt enriched with green tea, cinnamon, and fenugreek seed extracts. Formulations were created with varied amounts of polyherbal extract at 0% (P0), 1% (P1), 2% (P2), and 3% (P3), with Lactobacillus bulgaricus and Streptococcus thermophilus as starter cultures (Lactina Ltd). A completely randomized design with three replications was used, and the data were analyzed using ANOVA at a 95% confidence level. The results showed substantial variations in fat (2.84−3.62%) and moisture (88.17−8.83%) content between treatments. Protein (3.92−5.03%) and ash level (0.76−0.77%) met the Indonesian National Standard (SNI) for yogurt. Polyherbal yogurt demonstrated considerably higher antioxidant activity and capacity than the control. The control yogurt (P0) had a poor antioxidant capacity of 60.81±10.89%, while polyherbal yogurt (P1, P2, and P3) had a high antioxidant capacity ranging from 252.40±11.20% to 267.44±1.44%. These findings indicate that including polyherbal extracts into yogurt not only ensures compliance with national nutritional standards (SNI), but also considerably increases antioxidant potential. Thus, polyherbal yogurt is an appealing prospect for development as a beneficial dairy product. Keywords: antioxidant, polyherbal, proximate, yogurt
Physical and Chemical Characteristics of Combined Polyherbal Yogurt Nazziyah, Salmaa Sayyidah; Taufik, Epi; Kintoko, Kintoko
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 4 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.4.675

Abstract

Yogurt has become a popular dairy product and is considered a promising candidate for functional food intake. Innovations in yogurt production continue to develop, increasing public interest in yogurt consumption by using herbal plants. The combination of active ingredients from multiple herbal plants may provide higher effectiveness compared to single herbal plants. Lactic acid fermentation in herbal plants significantly increases phenolic and flavonoid levels. This study aims to analyze the effect of polyherbal (green tea, fenugreek seed, and cinnamon) on yogurt with physical and chemical parameters. This study was conducted with the stages of making polyherbal extract, preparing polyherbal yogurt, and analyzing physical (viscosity) and chemical (pH, total titrated acid (TTA), total phenolic content, and total flavonoid content using a completely randomized design with four different polyherbal levels (0%, 1%, 2%, and 3%) in triplicates. Physical and chemical characteristics data were summarized using analysis of variance. The lactic acid fermentation process in yogurt form on polyherbal had a significant effect on chemical characteristics, such as pH, TTA, total phenolic and flavonoid contents. The best treatment level in this research is 3% polyherbal extract addition because it contains the highest total phenolic and flavonoid. Keywords: fermentation, Lactobacillus bulgaricus, polyherbal, Streptococcus thermophillus, yogurt
Co-Authors Adhi Gunawan Alfian Syarifuddin Anandita Nurwijayanti Andhini Noor Chandra, Meta Any Guntarti Astri Desmayanti Astri Desmayanti Astri Desmayanti Aulia Rahman Ayu Shabrina Baso Didik Hikmawan Citra Ariani Citra Ariani Edityaningrum, Citra Cut Raihanah Dyah Aryani Perwitasari Eka Fitri Susiani Eka Siswanto Syamsul Elfasyari, Trie Yuni Endang Darmawan Epi Taufik Ersi Arviana Ihsan Fajar Slamet Riana Feby Zulien Hanifah Karimatulhajj Hardi Astuti Witasari Hardi Astuti Witasari Hayatus Sa’adah Khoiriyah Isni Leswara, Dianita Febrina Lintang Cahya Saputri Lusi Mardika Ariyanti Meta Damaharyuningtyas Nadiya Utari Nanik Sulistyani Nazziyah, Salmaa Sayyidah Neni Tri Anggraini Nining Sugihartini Nur Idha Sri Budiarti Nura Ustrina Nurkhasanah Nurkhasanah Nurul Mahyani Puspawan Hariadi Putra, Teguh Adiyas Rifqi Ferry Balfas Rukaya, Benazir Evita Salsabila Ramadhan Sapto Yuliani Septian Emma Dwi Jatmika Sitarina Widyarini Supomo Supomo Suwijiyo Pramono Swastika Praharyawan Tsania Taskia Nabila Warsi Warsi Widiyastuti, Lina Yuda Fajar Pratama