Anak Agung Wiradewi Lestari
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia

Published : 66 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : paediatrica indonesiana

Antibody-synthesizing lymphocytes (AS-LYMP) and reactive lymphocytes (RE-LYMP): novel predictors of severe dengue Saputra, I M Yullyantara; Gustawan, I Wayan; Utama, Made Gede Dwilingga; Lestari, AA Wiradewi; Adibrata, Antony Abel; Dewi, Eleonora Anindya Tiara
Paediatrica Indonesiana Vol. 66 No. 2 (2026): March 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Dengue fever is a major public health problem in Indonesia, where children are particularly at risk of severe disease. Early recognition of severe dengue is critical to reduce morbidity and mortality. Novel lymphocyte activation markers, such as antibody-synthesizing lymphocytes (AS-LYMP) and reactive lymphocytes (RE-LYMP), may improve risk stratification. Objective To evaluate antibody-synthesizing lymphocytes (AS-LYMP) and reactive lymphocytes (RE-LYMP) as potential diagnostic risk stratification markers for severe dengue fever. Methods This cohort retrospective study was conducted at Ngoerah General Hospital, Denpasar, Bali, and included children under 18 years with confirmed dengue infection. AS-LYMP and RE-LYMP counts were obtained using a Sysmex XN-3000 analyzer. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis, and optimal cut-off points were identified using the Youden index. Results Seventy-nine dengue patients were analyzed: 15 without warning signs, 39 with warning signs, and 25 with severe dengue. Both AS-LYMP and RE-LYMP counts were significantly elevated in severe dengue (P<0.001) compared to other two groups. The ROC analysis showed acceptable accuracy for AS-LYMP (AUC 0.749; cut-off 0.83 × 10³/μL; sensitivity 80.0%; specificity 63.0%) and RE-LYMP (AUC 0.729; cut-off 1.04 × 10³/μL; sensitivity 80.0%; specificity 59.3%). Hemoglobin level and leukocyte count demonstrated predictive value, but with lower accuracy. Conclusion AS-LYMP and RE-LYMP are promising biomarkers for early identification of severe dengue in children. Integration into routine hematology testing may support timely clinical decision-making.
Co-Authors Aakash Aakash Adibrata, Antony Abel Airin Que Anak Agung Ayu Lydia Prawita Anak Agung Ayu Yuli Gayatri Anak Agung Gde Bisma Sanjaya Anak Agung Ngurah Subawa Anak Agung Putri Satwika Aryana, I Gusti Ngurah Wien Aryati Aryati Bagus Anom Sudiada Bagus Ari Pradnyana Dwi Sutanegara Budi Santosa Budi Santosa Cong, Tzeto Han Desak Gde Diah Dharma Santhi Dewi, Eleonora Anindya Tiara Dewi, Ni Made Ratih Purnama Dharayani, Luh Anandita Diah Pradnya Paramita Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Eka Wiratnaya Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Endrawati KJ Felim, Jethro Gde Ary Putra Kamajaya Gede Wira Mahadita Giri, Kadek Gede Bakta Haneetha Yogarajah I A Putri Wirawati I Gde Raka Widiana I Gst Agung Dwi Mahasurya I Gusti Ngurah Wien Aryana I Gusti Putu Suka Aryana I Kadek Arya Candra I Ketut Suyasa I Nyoman Astika I Nyoman Hery Sumertayasa I Nyoman Indrawan Mataram I Nyoman Santa Wijaya I Nyoman Wande I Nyoman Wande I Putu Sidhi Rastu Karyana I Putu Yuda Prabawa I Wayan Agus Surya Pradnyana I Wayan Gustawan I Wayan Putu Sutirta Yasa I Wayan Suryanto Dusak I.A. Putri Wirawati Ida Ayu Ari Utami Ida Bagus Putu Putrawan Indrayani, Pande Kadek Putri Rahayu Intan Astariani Ketut Gede Mulyadi Ridia Ketut Siki Kawiyana Ketut Suega Komang Agus Widhy Utama Putra Komang Septian Sandiwidayat Krisna Yoga Pratama Made Ayu Widyaningsih Made Dyah Khrisnadewi Made Kris Budiman Made Wirabhawa Mahartini, Ni Nyoman Mardiyah Hayati Michael Ferdinand Milaviwanda, Luh Komang Ayu Nabu, Ekarini Katharina Yunarti Ni Gusti Ayu Putu Lestari Santika Dewi Ni Kadek Mulyantari Ni Ketut Rai Purnami Ni Komang Krisnawati Ni Luh Gede Yoni Komalasari Ni Luh Putu Pranena Sastri Ni Made Stithaprajna Pawestri Prabawa, I Putu Yuda Putu Astawa Putu Ayu Krisna Cahyaning Putri Putu Gde Hari Wangsa Putu Putri Titamia Saraswati Putu Ugi Sugandha R. A.T. Kuswardhani Sagung Novita Widyaningrat Saputra, I M Yullyantara Sianny Herawati Sianny Herawati Sri Darmawati Sudana, I Nyoman Gde Sudewa Djelantik Teguh Triyono Thaha .. Tjok Gde Oka Tjokorda Gede Oka Triningrat, Anak Agung Mas Putrawati Usi Sukorini Utama, Made Gede Dwilingga Vera Akmilia Wande IN Wayan Aryadana Wayan Giri Putra Wijaya Kusuma Wira Gotera Wirawati, Ida Ayu Putri Yenny Kandarini