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Journal : Asian Journal of Health and Applied Sciences

Synthesis of dihydropyrimidinone derivatives using kelubi fruit (Eleiodoxa conferta) as a catalyst and its antibacterial activity Sari, Ratih Puspita; Nurhadini, Nurhadini; Mahardika, Robby Gus
Asian Journal of Health and Applied Sciences Vol. 1 No. 1 (2022): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (555.555 KB) | DOI: 10.53402/ajhas.v1i1.5

Abstract

Kelubi fruit is one of the many fruits that grow in Bangka Belitung which has a sour taste. Kelubi fruit contains ascorbic acid, malic acid and oxalic acid. The potency and sour taste of Kelubi fruit can be used as a catalyst in the synthesis of dihydropyrimidinone compounds and activity as antibacterial. Dihydropyrimidinone compounds were synthesized using synthesis with the basic ingredients of benzaldehyde, urea and ethyl acetoacetate using natural catalysts that are more environmentally friendly. The purpose of this study was to determine the optimum volume, time and temperature catalyst used by kelubi fruit to synthesize pyrimidine-derived compounds as antibacterial. The optimization results on the synthesis of dihydropyrimidinone compounds using kelubi fruit water as a catalyst (Eleiodoxa conferta) with a lot of 0.3 mL catalyst, temperature of 50ÂșC and reaction time of 4 hours with yield of 46.75%. Antibacterial activity of dihydropyrimidinone compounds against Stapylococcus aureus bacteria at a concentration of 10 ppm, 30 ppm including the category and a concentration of 75 ppm including the medium category. Antibacterial activity against Eschericia coli bacteria at concentrations of 30 ppm and 75 ppm was categorized as weak.
Peel-off mask formulation from bintangur (Calophyllum inophyllum L.) leaf ethanol extract and its antibacterial activity Liska, Liska; Amanah, Hairil; Novianti, Shindi; Mahardika, Robby Gus
Asian Journal of Health and Applied Sciences Vol. 1 No. 2 (2022): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53402/ajhas.v1i2.29

Abstract

One of the most widely distributed plant species in Bangka Belitung is Bintangur (Calophyllum inophyllum L.) which is a genus of the Clusiaceae family. Bintagur leaf has the potential as a mask against acne-causing bacteria because it has high bioactivity such as antioxidants and antibacterials. Bitangur leaf extract masks were made by mixing the raw materials in the form of PVA 10 g; HPMC 1 g; glycerin 6 g; TEA 0.5 g; methylparaben 0.1 g; propylparaben 0.025 g; 30 ml distilled water and ethanol extract of Bintangur leaf formulation 0% 0 g; formulation 1% 0.5 g; 2% formulation 1 g and 3% formulation 1.5 g. Bintangur leaf ethanol extract mask in formulations F3 and F2 was the highest concentration producing an inhibition zone to inhibit the growth of Staphylococcus aureus and Propionibacterium acnes bacteria which were in the medium category and for formulations F1 and F3 the highest concentrations were to inhibit the growth of epidermal Staphylococcus bacteria which were categorized as The ethanol extract of Bintangur leaf whose antioxidant activity was measured obtained an IC50 value of 9.87 g/mL which was included in the very strong category. The mask of Bintangur leaf extract in the form of the peel-off gel has the potential to be used and marketed.