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All Journal Paduraksa : Jurnal Teknik Sipil Universitas Warmadewa Alchemy : Journal of Chemistry Jurnal Harpodon Borneo Biotropika Jurnal Pendidikan dan Pembelajaran Kimia (JPPK) Jurnal Pengabdian Kepada Masyarakat Universitas Bangka Belitung Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Elkawnie EduChemia: Jurnal Kimia dan Pendidikan Pharmascience Chimica et Natura Acta Acta Pharmaciae Indonesia : Acta Pharm Indo Prosiding SNFA (Seminar Nasional Fisika dan Aplikasinya) Indonesian Journal of Pure and Applied Chemistry Chemistry Indonesian Journal of Chemical Research Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal GEOSAPTA Fullerene Journal of Chemistry ALKIMIA : Jurnal Ilmu Kimia dan Terapan Stannum : Jurnal Sains dan Terapan Kimia ASEAN Journal of Chemical Engineering Jurnal Abdi: Media Pengabdian Kepada Masyarakat EKOTONIA: Jurnal Penelitian Biologi, Botani, Zoologi dan Mikrobiologi Jurnal Sains dan Edukasi Sains Jurnal Pijar MIPA Asian Journal of Health and Applied Sciences Indonesian Journal of Community Empowerment Dharma Pengabdian Perguruan Tinggi (DEPATI) Jurnal Pengabdian Pada Masyarakat
Robby Gus Mahardika
Departement Of Chemistry, Faculty Of Engineering, Universitas Bangka Belitung Jl. Kampus Peradaban, Merawang, Bangka, 33172
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Journal : Asian Journal of Health and Applied Sciences

 1 
Synthesis of dihydropyrimidinone derivatives using kelubi fruit (Eleiodoxa conferta) as a catalyst and its antibacterial activity Sari, Ratih Puspita; Nurhadini, Nurhadini; Mahardika, Robby Gus
Asian Journal of Health and Applied Sciences Vol. 1 No. 1 (2022): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (555.555 KB) | DOI: 10.53402/ajhas.v1i1.5

Abstract

Kelubi fruit is one of the many fruits that grow in Bangka Belitung which has a sour taste. Kelubi fruit contains ascorbic acid, malic acid and oxalic acid. The potency and sour taste of Kelubi fruit can be used as a catalyst in the synthesis of dihydropyrimidinone compounds and activity as antibacterial. Dihydropyrimidinone compounds were synthesized using synthesis with the basic ingredients of benzaldehyde, urea and ethyl acetoacetate using natural catalysts that are more environmentally friendly. The purpose of this study was to determine the optimum volume, time and temperature catalyst used by kelubi fruit to synthesize pyrimidine-derived compounds as antibacterial. The optimization results on the synthesis of dihydropyrimidinone compounds using kelubi fruit water as a catalyst (Eleiodoxa conferta) with a lot of 0.3 mL catalyst, temperature of 50ºC and reaction time of 4 hours with yield of 46.75%. Antibacterial activity of dihydropyrimidinone compounds against Stapylococcus aureus bacteria at a concentration of 10 ppm, 30 ppm including the category and a concentration of 75 ppm including the medium category. Antibacterial activity against Eschericia coli bacteria at concentrations of 30 ppm and 75 ppm was categorized as weak.
Peel-off mask formulation from bintangur (Calophyllum inophyllum L.) leaf ethanol extract and its antibacterial activity Liska, Liska; Amanah, Hairil; Novianti, Shindi; Mahardika, Robby Gus
Asian Journal of Health and Applied Sciences Vol. 1 No. 2 (2022): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53402/ajhas.v1i2.29

Abstract

One of the most widely distributed plant species in Bangka Belitung is Bintangur (Calophyllum inophyllum L.) which is a genus of the Clusiaceae family. Bintagur leaf has the potential as a mask against acne-causing bacteria because it has high bioactivity such as antioxidants and antibacterials. Bitangur leaf extract masks were made by mixing the raw materials in the form of PVA 10 g; HPMC 1 g; glycerin 6 g; TEA 0.5 g; methylparaben 0.1 g; propylparaben 0.025 g; 30 ml distilled water and ethanol extract of Bintangur leaf formulation 0% 0 g; formulation 1% 0.5 g; 2% formulation 1 g and 3% formulation 1.5 g. Bintangur leaf ethanol extract mask in formulations F3 and F2 was the highest concentration producing an inhibition zone to inhibit the growth of Staphylococcus aureus and Propionibacterium acnes bacteria which were in the medium category and for formulations F1 and F3 the highest concentrations were to inhibit the growth of epidermal Staphylococcus bacteria which were categorized as The ethanol extract of Bintangur leaf whose antioxidant activity was measured obtained an IC50 value of 9.87 g/mL which was included in the very strong category. The mask of Bintangur leaf extract in the form of the peel-off gel has the potential to be used and marketed.
Co-Authors Adisyahputra Adisyahputra Adisyahputra Adisyahputra Adisyahputra Adisyahputra Adisyahputra Adisyahputra, Adisyahputra Afrilia, Mega Ajeng Triane Syawila Amanah, Hairil Amelia, Ririn Ana Mardliyah Anggraeni Anggraeni Ary Samsiar Ary Samsiar Benget Harmoko Manik Boy Dian Anugra Sandy Delvia Safitri Dewi Septia Ningsih Dianti Aviliani Eva Utami Fadiyah, Inas Fajar Indah Puspita Sari Fajar Indah Puspita Sari Fajar Indah Puspita Sari Fitri Afriani Fusfita Istiqomah Genta Febri Kusuma Gita Afriza Guskarnali, Guskarnali Henri Henri Henri Henri, Henri Herman Aldila Ila Rosilawati Janiar Pitulima Kasro Daniati khairul fajri, khairul Khoirotul Ummah Khoirotul Ummah Lestari, Iin Lidya, Lidya Liska Liska, Liska Mariam Ulfah Maya Yusnita Megiyo Megiyo Nazrun Nazrun Nina Kadaritna Nosa Mayasani Novianti, Shindi Nur Hidayatiandri Nurhadini Nurhadini Putri, Faizah Alivia Rani Rani RANI RANI, RANI Ristika Oktavia Asriza Roanisca, Occa Sari, Ratih Puspita Selvy Aprilia Sembiring, Rinawati Shakila, Shania Shania Sakhila Sito Enggiwanto Sito Enggiwanto Stefan Marco Rumengan Surtina, Surtina Susanti Susanti Syarmila, Syarmila Utami, Sri Risky Verry Andre Fabiani Widia, Widia Widodo Budi Kurniawan Yopan Pratama Yulia Yulia Zulita, Zulita