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All Journal Jurnal Gizi dan Pangan SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Medical Journal of Indonesia Jurnal Sain Peternakan Indonesia Indonesian Journal of Human Nutrition Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan IJEMS (Indonesian Journal of Environmental Management and Sustainability) Window of Health : Jurnal Kesehatan Journal of Applied Food Technology Amerta Nutrition Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Livestock and Animal Research
Endang Mahati
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Experimental animal models for polycystic ovarian syndrome (methods, effects, and implications) Kurniawati, Erna Yovi; Pramono, Noor; Hidayat, Syarief Thaufik; Mahati, Endang
Livestock and Animal Research Vol 22, No 1 (2024): Livestock and Animal Research
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/lar.v22i1.79197

Abstract

Many studies have replicated the clinical and genetic features of polycystic ovarian syndrome (PCOS) using a range of experimental animal models to improve treatment outcomes. This article aims to present an overview of the various experimental animal models that have been used in PCOS research. In this study, we conducted a systematic review of relevant research articles on the induced animal model PCOS. We searched research articles in Indonesian and English published over the last five years through three databases: PubMed, ScienceDirect, Google Scholar. We use established inclusion and exclusion criteria to select suitable articles. Out of 19 research articles included in our systematic review, we found the animal model PCOS based Rotterdam criteria, PCOS-IR model, PCOS-Inflammation model, PCOS-Gut microbiota model and PCOS-syndrome metabolic model. Androgen agents such as testosterone propionate, free testosterone, DHEA, and letrozole, as well as sodium valproate, are effective in the induction of PCOS phenotypes based on the Rotterdam criteria (oligo/amenorrhea, hyperandrogenic, and polycystic ovaries).
Co-Authors Adriyan Pramono Ahmad Syauqy Al Atsariyah, Fatimah Albertus Ari Adrianto Anjani, Gemala Arviyani, Tiffany Nisa Astika Widy Utomo Bimby Irenesia Diana Nur Afifah, Diana Nur Elvina Astiningtyas Sudaryanto Etika Ratna Noer Fulyani, Faizah Hermina Sukmaningtyas Hesti Triwahyu Hutami Hidayat, Syarief Thaufik Ign Riwanto Ignatius Riwanto, Ignatius Junnaeni Junnaeni Kuntjoro, Lydia Purna Kurniawati, Erna Yovi Lestari Partiningrum, Dwi Lina Choridah MADE ASTAWAN Maulana, Reza Achmad Meira Astuti Mohammad Zen Rahfiludin Mufilhatul Muniroh Nafisah Nani Maharani Nani Maharani Noor Pramono Novit, Elmawati Nyoman Suci Widiastiti Parish Budiono, Bernardus Pravitha, Clarissa Aulia Puji Larasati Masyitoh Putri, Sylvia Rahmi Rahmawati, Irma Sarita Rahmawati, Siti Irma Renni Yuniarti Reyhan Zuhdi Gofita Widyawigata Selamat Budijitno Setyawati, Amalia Rani Shauma, Claradhita Ayu Suhartono Surya Utoyo, Frederick Tjandra, Kevin Christian Udadi Sadhana Udadi Sadhana, Udadi Udin Bahrudin, Udin Yan Wisnu Prajoko Yan Wisnu Prajoko Zaw Myo Hein