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All Journal EKSAKTA: Journal of Sciences and Data Analysis Jurnal Ilmu Lingkungan Jurnal Vektor Penyakit Indonesian Journal of Tropical and Infectious Disease Jurnal Teknologi Laboratorium Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Indian Journal of Forensic Medicine & Toxicology Makara Journal of Science
Arif Nur Muhammad Ansori
Fakultas Kedokteran Hewan Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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A Computational Design of siRNA in SARS-CoV-2 Spike Glycoprotein Gene and Its Binding Capability toward mRNA Arli Aditya Parikesit; Arif Nur Muhammad Ansori; Viol Dhea Kharisma
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.68415

Abstract

COVID-19 pandemic has no immediate ending in sight, and any significant increasing cases were observed worldwide. Currently, there are only two main strategies for developing COVID-19 drugs that predominantly use a proteomics-based approach, which are drug repurposing and herbal medicine strategies. However, a third strategy has existed, called small interfering RNA or siRNA, which is based on the transcriptomics approach. In the case of SARS-CoV-2 infection, it is expected to perform by silencing the viral gene, which brings the surface glycoprotein (S) gene responsible for SARS-CoV-2 viral attachment to the ACE2 receptor on the human host cell. This third approach applies a molecular simulation method comprising data retrieval, multiple sequence alignment, phylogenetic tree depiction, 2D/3D structure prediction, and RNA-RNA molecular docking. The expected results are the prediction of 2D and 3D structures of both siRNA and mRNA silenced S genes along with a complex as the result of a docking method formed by those silenced genes. An Insilco chemical interaction study was performed in testing siRNA and mRNA complex’s stability with the confirmation result of a stable complex which is expected to be formed before mRNA reaches the ribosome for the translation process. Thus, siRNA from the S gene could be considered a candidate for the COVID-19 therapeutic agent.
Callus Induction of Gendarussa (Justicia gendarussa) by Various Concentration of 2,4-D, IBA, and BAP Dwi Kusuma Wahyuni; Putri Andriani; Arif Nur Muhammad Ansori; Edy Setiti Wida Utami
Biosaintifika: Journal of Biology & Biology Education Vol 9, No 3 (2017): December 2017
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v9i3.11347

Abstract

Justicia gendarussa Burm.f., a medicinal plant, is Acanthaceae that has many functions. Furthermore, the compounds in gendarussa must be produced in high quantity and quality by applying callus culture method. Accordingly, it is important to study the effects of plant growth regulators (2,4-D, IBA, and BAP) on callus induction of gendarussa leaves. This research design utilized a factorial design with two factors (2,4-D and IBA: 0.5, 1, 1.5 mg/L and BAP: 0.5, 1, 1.5, 2 mg/L). The experiment consisted of 24 treatments, each of which was repeated 3 times. Observation was carried out in 6 weeks. Data on the time of callus formation, percentage of explants formed callus, and callus morphology were analyzed descriptively,while data on fresh and dry weight were analyzed by Two-Way ANOVA (α = 0.5). Interestingly, the results showed that various concentration of plant growth regulators (2,4-D, IBA, and BAP) affected callus induction from leaf explants of gendarussa. We concluded that the most optimal treatment combination of concentration of plant growth regulators in inducing callus from leaf explants of gendarussa is 1.5 mg/L 2,4-D and 2 mg/L BAP with a relatively long period of callus formation at the earliest, i.e. on day 5, 2.247 g of fresh weight, 0.108 gof dry weight, white callus translucent, and friable. Moreover, the optimum treatment will be used to produce secondary metabolite and seed synthetic by cell suspension culture.
Pemantauan Kualitas Air dan Kontaminasi Vibrio spp. pada Udang Putih Pasifik (Litopenaeus vannamei) yang Dibudidayakan dengan Sistem Super – Intensif: Studi Kasus di Situbondo, Jawa Timur, Indonesia Putu Angga Wiradana; Mayadita Dwi Sani; Putu Eka Sudaryatma; I Made Gde Sudyadnyana Sandhika; I Gede Widhiantara; I Wayan Rosiana; Arif Nur Muhammad Ansori; Ummul Firmani
Jurnal Ilmu Lingkungan Vol 22, No 6 (2024): November 2024
Publisher : School of Postgraduate Studies, Diponegoro Univer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jil.22.6.1545-1553

Abstract

Penyakit yang disebabkan oleh kelompok Vibrio spp. selama program budidaya Litopenaeus vannamei berpotensi menyebar ke perairan melalui perpindahan larva, kontaminasi silang, hingga tingginya padat tebar. Penelitian ini bertujuan untuk menyelidiki kualitas air dan kelimpahan Vibrio spp. pada L. vannamei yang dibudidayakan menggunakan sistem super-intensif. Evaluasi fluktuasi kualitas air dan bakteri Vibrio spp. dilakukan dengan pengukuran parameter kualitas air (suhu, oksigen terlarut, salinitas, nilai pH, dan amoniak) pada media pemeliharaan L. vannamei. Pemeriksaan Vibrio spp. dilakukan pada air pemeliaraan dan tubuh udang L. vannamei dengan mengkultur pada media selektif CHROMAgar serta identifikasi pada kenampakan hepatopankreas. Pemantauan dilakukan mulai dari Days of Culture (DOC) 30 – 150. Hasil penelitian menunjukkan bahwa nilai DO pada pemeliharaan hari ke-150 cenderung mengalami peningkatan, yang diikuti dengan peningkatan nilai suhu dan kadar amoniak secara signifikan dibandingkan dengan usia pemeliharaan 30 hari (p≤0.05). Tidak terdapat perbedaan yang signifikan pada nilai pH dan salinitas pada DOC 30 dan 150. Cemaran Vibrio spp. pada media pemeliharaan cenderung tinggi pada DOC 30, sedangkan cemaran V. parahaemolyticus dan V. cholera cenderung tinggi pada DOC 90 dan 60 pada tubuh L. vannamei. Cemaran Vibrio spp., pada L. vannamei dapat dikaitkan dengan tingginya padat penebaran, berdampak pada penurunan DO dan peningkatan suhu dan amoniak pada system budidaya super-intensif.
Co-Authors Alyaa Farrah Dibha Arli Aditya Parikesit Arli Aditya Parikesit Astria Novitasari Nidom Balqis Afifah Cinantya Dwi Jayanti Dhani Prakoso Dwi Kusuma Wahyuni Edy Setiti Wida Utami Erindra Budi Cahyanto Fedik Abdul Rantam Hafi Nurinasari Hafidzhah, Muhammad Aldino Hamidah Hamidah Haris Nur Ashfi Arifa Hebert Adrianto I Gede Widhiantara I Made Gde Sudyadnyana Sandhika I Wayan Rosiana Imam Mustofa Kharisma, Viol Dhea Kuncoro Puguh Santoso Maksim Rebezov Maria Kiseleva Maulina, Rufidah Mayadita Dwi Sani Muhammad Hermawan Widyananda Muhammad Khaliim Jati Kusala Nadezhda Kenijz Nanda Yuli Rahmawati Nidom, Chairul Anwar Nor Laela Ramadhaniyah Nur Ahwanah, Nur Pemta Deka, Pemta Posa, Gabrielle Ann Villar Putri Andriani Putri Andriani Putu Angga Wiradana Putu Eka Sudaryatma Rahadian Zainul Rahmahani, Jola Rasyadan Taufiq Probojati Revi Gama Hatta Novika Reviany Vibrianita Nidom Rizky, Wahyu Choirur Setyarina Indrasari Siti Churrotin, Siti Siti Nurhidayati Soegeng Soegijanto Soeharsono Soeharsono Soetrisno Soetrisno Sofy Permana Sri Wahyuningsih Svetlana Artyukhova Tacharina, Martia Rani Teguh Sucipto, Teguh Tomohiro Kotaki, Tomohiro Turista, Dora Dayu Rahma Ummul Firmani Vikash Jakhmola Viol Dhea Kharisma Viol Dhea Kharisma Viol Dhea Kharisma Viol Dhea Kharisma Wijaya, Renadya Maulani Yulanda Antonius Yulia Matrosova