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All Journal EKSAKTA: Journal of Sciences and Data Analysis Jurnal Ilmu Lingkungan Jurnal Vektor Penyakit Indonesian Journal of Tropical and Infectious Disease Jurnal Teknologi Laboratorium Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Indian Journal of Forensic Medicine & Toxicology Makara Journal of Science
Arif Nur Muhammad Ansori
Fakultas Kedokteran Hewan Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Alpha-Mangostin and Gamma-Mangostin Isolated from Mangosteen (Garcinia mangostana L.) as Promising Candidates against SARS-CoV-2: A Bioinformatics Approach Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17611

Abstract

The world is endangered by the COVID‐19 pandemic caused by SARS‐CoV‐2, people are dying in thousands every day, and without an actual treatment, it seems that bringing this global health problem to a quit is impossible. Natural products have been in constant use since ancient times and are proven by time to be effective. Medicinal plants from Indonesia may lead to the discovery of the novel drugs. Mangosteen or Garcinia mangostana L. is a native tropical fruit from Southeast Asia and is known to contain bioactive compounds. Interestingly, the main xanthone derivatives are alpha-mangostin and gamma-mangostin, these compounds have a variety of pharmacological activities such as antiviral activity. In summary, this study showed potential pharmacological benefits of alpha-mangostin and gamma-mangostin isolated from mangosteen against SARS-CoV-2. Thus, mangosteen exhibits as a valuable plant and a candidate for future drug development to fight SARS-CoV-2. However, further trials, such as in vitro and in vivo evaluation, are needed to prove the validity of these findings.
The D614G Mutation in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Glycoprotein: A MiniReport Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14729

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a quickly spreading virus that posesa major burden on global human health. Thus, it is essential to develop COVID-19 vaccines. Vaccinedevelopment might not be easy, as a consequence of mutations. This study aimed to demonstrate the D614Gmutation in SARS-CoV-2 spike glycoprotein from Indonesia. 102 isolates from the GISAID EpiCoVdatabase and the Wuhan-Hu-1 isolate (reference sequence) from GenBank, NCBI were used in this study.BioEdit employed to examine the D614G mutation in the spike glycoprotein of SARS-CoV-2. In this report,there are 56 D614G mutations among 102 SARS-CoV-2 isolates. In summary, this report might suggestthat the D614G mutation implicates the COVID-19 pandemic in Indonesia. Nevertheless, this report was apreliminary study and this study recommends expanding molecular epidemiology and surveillance programsto monitor COVID-19
Alpinia galanga or Lengkuas (Zingiberaceae): A Possible Treatment for COVID-19 Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14730

Abstract

Alpinia galanga (Zingiberaceae) or lengkuas is one type of herbal plant that is widely grown in SoutheastAsia. Various countries cultivate this medicinal plant, including Indonesia. This medicinal plant has a varietyof benefits and also be used as a treatment for many diseases. Although the lengkuas rhizome is the mostwidely used and studied part of the plant, the flower on the lengkuas can also provide additional advantages,such as antioxidant and antimicrobial properties. Therefore, this study aimed to demonstrate lengkuas for thefuture prospects against SARS-CoV-2. In summary, this study suggests that lengkuas might be useful as atreatment for COVID-19, although further studies could be conducted to confirm the results of computationalstudies.
Discovery of Therapeutic Targets and Potential Drugs to Fight Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2): A Review Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14731

Abstract

SARS-CoV-2, the causative agent of COVID-19, has led to more than two million deaths worldwide. Thereare currently no specific therapies approved to treat COVID-19 and drug repositioning, rather than newdrug discovery, which may be the best short-term option for controlling the pandemic. In this review, theauthor discusses important viral targets such as the papain-like protease, RNA-dependent RNA polymerase,3-chymotrypsin-like protease, and spike protein. The information about chemical compounds and targetsprovided in this review will aid further in vitro and in vivo studies to discover drugs to treat COVID-19.
In Silico Study of SARS-CoV-2 Vaccine Candidate: Spike Glycoprotein Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14732

Abstract

This study aimed to perform the analysis of toxicity prediction, allergenicity prediction, and in silico cloningof peptides originated from SARS-CoV-2 spike glycoprotein in the previous study. Allergenicity predictionemployed AllerPred to predict the non-allergen peptides and toxicity prediction performed using ToxinPred.Then, this study designed the in silico cloning of SARS-CoV-2 spike glycoprotein with pET-28a(+) usingSnapGene software. Therefore, this study successfully constructed the SARS-CoV-2 vaccine candidate viain silico method. Therefore, these data could be used to design a peptide-based vaccine against SARSCoV-2. However, the advanced study is recommended confirmation, such as in vitro and in vivo study
Characterization of Newcastle Disease Virus in Southeast Asia and East Asia: Fusion Protein Gene Arif Nur Muhammad Ansori; Viol Dhea Kharisma
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art3

Abstract

The aim of this study was to generate the bioinformatics analysis of the circulating NDVs in Southeast Asia, East Asia, and the vaccine virus strains through a database of isolates stored in GenBank® (National Center for Biotechnology Information, USA). The used isolates were AJ629062.1 (La Sota), AF309418.1 (B1), EF201805.1 (Mukteswar), KT445901.1 (Komarov), JX524203.1 (V4), AY935499.2 (I-2), KC987036.1 (F), KF767104.1 (Indonesia), KF767105.1 (Indonesia), KF767106.1 (Indonesia), HQ697255.1 (Indonesia), HQ697256.1 (Indonesia), HQ697261.1 (Indonesia), JX012096.2 (Malaysia), GU332646.1 (Vietnam), AF358786.1 (Taiwan), AF358788.1 (China), KT380032.1 (Republic of Korea), and KC503416.1 (Japan). As the results, this study have revealed the data of homology, pathotype, genetic distance, B cell epitope prediction, and molecular phylogenetic analysis of circulating NDVs in Southeast Asia and East Asia and vaccine virus strains. Thus, the results of this study can be used as a reference for vaccine design studies in the applications of poultry vaccine industryReceived: 28 August 2019; Accepted: 31 December 2019; Published: 11 January 2020.
Efektivitas Biolarvasida Ekstrak Fraksi Polar Daun Citrus hystrix dan Citrus aurantifolia terhadap Culex quinquefasciatus Arif Nur Muhammad Ansori; Hebert Adrianto; Hamidah Hamidah
Jurnal Vektor Penyakit Vol 12 No 1 (2018): Edisi Juni
Publisher : Balai Penelitian dan Pengembangan Kesehatan Donggala, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.374 KB) | DOI: 10.22435/vektorp.v12i1.261

Abstract

Abstract The development of resistance to chemical insecticides against mosquitoes has beenconsidered as a setback in vector control. This study was aimed to identify LethalConcentration 90% (LC90) of polar fraction extract from Citrus hystrix and Citrusaurantifolia leaves as biolarvicide against mosquito larvae after 24 hours of exposure.This study was an experimental research based on a Completely Randomized Design(CRD). The polar fraction extract of C. hystrix and C. aurantifolia were tested in concentrations of 0 ppm, 500 ppm, 1375 ppm, 2250 ppm, 3125 ppm, and 4000 ppm againstthe 3rd instar larvae of Culex quinquefasciatus. Each treatment was done in five independent replications. The numbers of deceased mosquito larvae were determinedafter 24 hours of treatment and analyzed by probit. The results showed that the polarfraction extract of C. hystrix and C. aurantifolia have bio-larvicidal activity against the 3rdinstar larvae of Cx. quinquefasciatus at LC90 of 1,653 ppm and 2,797 ppm, respectively. In conclusion, the polar fraction extract of C. hystrix leaf is more toxic than C. aurantifolialeaf's against Cx. quinquefasciatus larvae. Abstrak Perkembangan resistensi terhadap insektisida kimia di antara spesies nyamuk telahdianggap sebagai kemunduran dalam pengendalian vektor. Penelitian ini bertujuanuntuk mengetahui Lethal Concentration 90% (LC90 ) ekstrak fraksi polar daun C. hystrix dan C. aurantifolia sebagai biolarvasida terhadap larva nyamuk setelah paparan 24 jam. Penelitian ini adalah penelitian eksperimental dengan Rancangan Acak Lengkap (RAL).Ekstrak fraksi polar daun C. hystrix dan C. aurantifolia diuji dengan konsentrasi 0 ppm,500 ppm, 1.375 ppm, 2.250 ppm, 3.125 ppm, dan 4.000 ppm terhadap larva nyamuk Cx.quinquefasciatus instar III. Setiap konsentrasi dilakukan replikasi sebanyak lima kali.Jumlah larva nyamuk yang mati dihitung setelah 24 jam. Setelah itu, data dari larvanyamuk yang mati dianalisis menggunakan probit. Hasil penelitian ini mengungkapkanbahwa ekstrak fraksi polar daun C. hystrix dan C. aurantifolia memiliki aktivitas sebagai biolarvasida terhadap larva nyamuk Cx. quinquefasciatus instar III dengan LC 90= 1.653 ppm dan 2.797 ppm, secara berurutan. Kesimpulan dari penelitian ini adalah ekstrakfraksi polar dari daun C. hystrix lebih toksik dibandingkan dengan C. aurantifoliaterhadap larva nyamuk instar III.
Potensi Larvasida dari Ekstrak Daun Jeruk Bali Citrus maxima terhadap dan Aedes aegypti dan Culex quinquefasciatus Hebert Ardianto; Arif Nur Muhammad Anshori; Hamidah Hamidah
Jurnal Vektor Penyakit Vol 12 No 1 (2018): Edisi Juni
Publisher : Balai Penelitian dan Pengembangan Kesehatan Donggala, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.235 KB) | DOI: 10.22435/vektorp.v12i1.280

Abstract

Abstract The used of chemical insecticides for mosquito control has caused resistance in themosquito populations. The aims of this study are to find out Lethal Concentration of non-polarextract from pomelo (Citrus maxima) leaf against mosquito larvae after 24 hoursexposure. Aedes aegypti and Culex quinquefasciatus larvae were tested in the study A.Larvicidal assay was using 20 larvae for each concentration in 100 ml solution with 5replications. The non-polar extract was tested at concentrations of 0 ppm, 500 ppm, 1375ppm, 2250 ppm, 3125 ppm, and 4000 ppm. The number of larvae mortality wasdetermined after 24 hours exposure. The dead larvae were counted and the data wasanalyzed using probit analyze. The results showed that non-polar extract from Citrusmaxima Leaf has potential larvicidal, LC90 = 880 ppm for mortality of Aedes aegypti larvae, LC90 = 408 ppm for mortality of Culex quinquefasciatus larvae, the non-polar extract is more toxic against Culex quinquefasciatus than Aedes aegypti larvae. The non-polar extract from pomelo (Citrus maxima) leaf has the potential of being developed aslarvicides for mosquito control. Abstrak Penggunaan insektisida kimia untuk mengontrol nyamuk dapat menyebabkanresistensi pada populasi nyamuk. Tujuan dari penelitian ini adalah untuk menemukannilai Konsentrasi Letal (LC90 ) ekstrak non polar daun jeruk bali (Citrus maxima) terhadap nyamuk setelah 24 jam. Larva yang digunakan dalam penelitian ini adalahlarva Aedes aegypti dan Culex quinquefasciatus. Kematian larva dihitung setelah 24 dan 48 jam.Uji larvasida menggunakan 20 ekor larva untuk setiap konsentrasi di dalam 100ml larutan ekstrak dengan lima replikasi. Ekstrak non polar diuji dengan konsentrasi 0ppm, 500 ppm, 1.375 ppm, 2.250 ppm, 3.125 ppm, dan 4.000 ppm. Angka kematianlarva dihitung setelah 24 jam paparan. Data dihitung dan dianalisa dengan analisisprobit. Hasil penelitian menunjukkan bahwa ekstrak non polar daun Citrus maximaberpotensi sebagai larvasida, Nilai LC90 = 880 ppm untuk kematian larva nyamuk Aedesaegypti, Nilai LC90 = 408 ppm untuk kematian larva nyamuk Culex quinquefasciatus, Ekstrak non polar lebih toksik terhadap larva Culex quinquefasciatus daripada larva Aedes aegypti. Ekstrak non polar dari daun Citrus maxima memiliki potensi untukdikembangkan sebagai larvasida untuk pengendalian nyamuk.
Correlation Between Influenza Virus Replication and ATP6V0C of Trivalent Influenza (TIV) Vaccination in Ferret Ira Humairah1,2, Reviany V. Nidom3 , Setyarina Indrasari3,4, Ema Qurnianingsih2 , Arif Nur Muhammad
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10707

Abstract

Influenza virus infections are a major public health threat. Influenza viruses are associated with high mortality and morbidity worldwide through seasonal epidemics. Vaccination programs are available, but unpredictable antigenic changes in circulating strains require annual modification of seasonal influenza vaccines. Influenza vaccines are given, one of which is a trivalent influenza vaccine (TIV) aimed at the formation of antibodies that are specific to influenza viruses by B cells. In this study TIV vaccination has an effect in the form of decreasing viral replication in ferret that have been tested with H1N1 and H3N2 viruses. The results of this study are data about viral replication obtained from hemagglutination tests (HA test) and ATP6V0C expression with SDS-Page.
COVID-19 In Silico Drug with Zingiber officinale Natural Product Compound Library Targeting the Mpro Protein Wijaya, Renadya Maulani; Hafidzhah, Muhammad Aldino; Kharisma, Viol Dhea; Ansori, Arif Nur Muhammad; Parikesit, Arli Aditya
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide pandemic. Ginger (Zingiber officinale) is a rhizome, which is commonly used for culinary and medicinal purposes. In Indonesia, ginger is taken as traditional medicine by processing it into a drink known as jamu. The present study aimed to assess and evaluate the bioactive compounds in ginger that can be used in drug design for treating COVID-19. The crystal structure of the SARS-CoV-2 main protease (Mpro) was generated from a protein sequence database, i.e., Protein Data Bank, and the bioactive compounds in ginger were derived from the existing compounds library. Mpro is involved in polyprotein synthesis, including viral maturation and nonstructural protein gluing, making it a potential antiviral target. Furthermore, the bioactive compounds in ginger were analyzed using Lipinski’s rule of five to determine their drug-like molecular properties. Moreover, molecular docking analysis was conducted using the Python Prescription 0.8 (Virtual Screening Tool) software, and the interaction between SARS-CoV-2 Mpro and the bioactive compounds in ginger was extensively examined using the PyMOL software. Out all of the 16 bioactive compounds that were docked successfully, 4-gingerol, which has the lowest binding energy against SARS-CoV-2 Mpro, as per the virtual screening results, was proven to have the most potential as a viral inhibitor of SARS-CoV-2
Co-Authors Alyaa Farrah Dibha Arli Aditya Parikesit Arli Aditya Parikesit Astria Novitasari Nidom Balqis Afifah Cinantya Dwi Jayanti Dhani Prakoso Dwi Kusuma Wahyuni Edy Setiti Wida Utami Erindra Budi Cahyanto Fedik Abdul Rantam Hafi Nurinasari Hafidzhah, Muhammad Aldino Hamidah Hamidah Haris Nur Ashfi Arifa Hebert Adrianto I Gede Widhiantara I Made Gde Sudyadnyana Sandhika I Wayan Rosiana Imam Mustofa Kharisma, Viol Dhea Kuncoro Puguh Santoso Maksim Rebezov Maria Kiseleva Maulina, Rufidah Mayadita Dwi Sani Muhammad Hermawan Widyananda Muhammad Khaliim Jati Kusala Nadezhda Kenijz Nanda Yuli Rahmawati Nidom, Chairul Anwar Nor Laela Ramadhaniyah Nur Ahwanah, Nur Pemta Deka, Pemta Posa, Gabrielle Ann Villar Putri Andriani Putri Andriani Putu Angga Wiradana Putu Eka Sudaryatma Rahadian Zainul Rahmahani, Jola Rasyadan Taufiq Probojati Revi Gama Hatta Novika Reviany Vibrianita Nidom Rizky, Wahyu Choirur Setyarina Indrasari Siti Churrotin, Siti Siti Nurhidayati Soegeng Soegijanto Soeharsono Soeharsono Soetrisno Soetrisno Sofy Permana Sri Wahyuningsih Svetlana Artyukhova Tacharina, Martia Rani Teguh Sucipto, Teguh Tomohiro Kotaki, Tomohiro Turista, Dora Dayu Rahma Ummul Firmani Vikash Jakhmola Viol Dhea Kharisma Viol Dhea Kharisma Viol Dhea Kharisma Viol Dhea Kharisma Wijaya, Renadya Maulani Yulanda Antonius Yulia Matrosova