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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi JURNAL PHARMASCIENCE Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Jurnal Farmasi Sains dan Praktis Jurnal Farmasi Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Journal of Food and Pharmaceutical Sciences
Ronny Martien
Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Sekip Utara Yogyakarta 55281, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Analysis of Curcumin Contents in Curcuma xanthorrhiza using FTIR Spectroscopy and HPLC-UV in Combination with Multivariate Calibration Kusumadewi, Awal P.; Mujahid, Rohmat; Martien, Ronny; Purwanto, Purwanto; Styawan, Anita A.; Irnawati, Irnawati; Rohman, Abdul
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.82220

Abstract

Curcuma xanthorrhiza Roxb. or Java Turmeric with the local name of Temulawak is one of herbal medicines used in Indonesia. This plant is believed to prevent some degenerative diseases due to its active compounds, especially curcumin (CUR) contained in Java Turmeric. Therefore, analysis of active components including CUR is very urgent. This study highlighted the development of FTIR spectroscopy coupled with PLSR for the determination of CUR in Java Turmeric powders. The levels of CUR in Java Turmeric powders were determined using HPLC with UV detectors, and the obtained results were used as actual values to be predicted using FTIR spectroscopy-multivariate calibrations. The results revealed that the levels of CUR ranged from 0.6741 ± 0.0705% (g/100 samples) to 2.1062 ± 0.0095%. PLSR modeling for the relationship between the actual value of CUR as determined using HPLC and calculated values as predicted using FTIR spectroscopy provide the value of R2 of 0.9990 with RMSEC of 0.0028. The developed method offers reliable results providing a green analytical method due to the use of minimum solvent and reagent and does not involve extensive sample preparation.
In Situ Gel Termosensitif sebagai Sistem Penghantaran Obat Pintar: Formulasi dan Aplikasi Nakhil, Umaimatun; Martien, Ronny; Adhyatmika, Adhyatmika
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.85641

Abstract

Sistem penghantaran obat menggunakan gel mulai banyak berkembang salah satunya in situ gel. Bentuk sediaan ini menarik untuk dikembangkan karena hanya melibatkan transisi bentuk (sol-gel) sederhana tanpa adanya reaksi kimia. In situ gel termosensitif merupakan jenis sediaan in situ gel yang berbentuk larutan pada suhu ruang namun berubah menjadi gel pada suhu tubuh. Polimer basis yang digunakan pada formulasi in situ gel memiliki karakteristik khas yakni bersifat termosensitif. Artikel review ini bertujuan untuk membahas berbagai jenis polimer termosensitif dan mekanisme gelasinya serta aplikasi bidang medis dari in situ gel termosensitif. Polimer termosensitif memiliki sifat reserve gelation atau mengalami gelasi pada peningkatan suhu karena pengaruh kesetimbangan gugus hidrofil dan hidrofob dalam strukturnya. Sediaan in situ gel memberikan keleluasaan penggunaan dan modifkasi profil pelepasan obat dibandingkan sediaan konvensional. Beberapa karakteristik penting yang perlu diperhatikan pada desain sediaan ini diantaranya adalah suhu gelasi, mukoadesivitas, dan reologi. Sediaan in situ gel telah dikembangkan untuk sistem penghantaran berbagai obat seperti bukal dan sublingual, nasal, dan okular.
Systematic Review: Nanopartikel dari Bahan Obat Tradisional Indonesia Pradana, Theophani Bagas; Nugroho, Agung Endro; Martien, Ronny
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.91236

Abstract

Tanaman obat di Indonesia memberikan berbagai manfaat, namun menghadapi kendala dalam aktivitas farmakologi, kelarutan dalam tubuh, dan disolusi obat yang rendah. Salah satu pendekatan untuk mengatasi masalah ini adalah melalui penggunaan sediaan nanopartikel. Penelitian ini bertujuan untuk meninjau penelitian sebelumnya tentang pembuatan sediaan nanopartikel dari tanaman obat di Indonesia dan manfaatnya dalam meningkatkan aktivitas farmakologi. Metode penelitian yang digunakan adalah systematic review dengan melakukan pencarian literatur melalui berbagai portal jurnal seperti Google Scholar, Science Direct, dan Scopus, dengan mempertimbangkan kriteria inklusi dan eksklusi. Jenis sediaan nanopartikel yang umum digunakan melibatkan Self-Nanoemulsifying Drug Delivery Systems (SNEDDS), nanoemulsi, dan nanosuspensi. Sediaan nanopartikel dari tanaman obat di Indonesia umumnya memiliki ukuran partikel yang memenuhi standar, berkisar antara 1-1000 nm, dan termasuk dalam golongan monodispersi dengan nilai polidispersitas <0,3. Hasil penelitian menunjukkan bahwa sediaan nanopartikel ini secara signifikan meningkatkan disolusi obat dibandingkan dengan sediaan non-nanopartikel. Peningkatan disolusi obat tersebut berdampak positif pada aktivitas farmakologi dari tanaman obat di Indonesia. Dari tinjauan literatur, dapat disimpulkan bahwa tanaman obat di Indonesia dapat dikembangkan menjadi sediaan nanopartikel, dan penerapan sediaan nanopartikel ini dapat meningkatkan aktivitas farmakologi tanaman obat tersebut.
Validation of Analytical Method for Vitamin A in Bioadhesive Ocular Cationic Nanoemulsion Loaded into Thermosensitive Gel Using RP-HPLC Fatimah, Siti Fatmawati; Lukitaningsih, Endang; Martien, Ronny; Nugroho, Akhmad Kharis
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.93395

Abstract

Various test methods have been previously documented for determining vitamin A levels in different dosage forms. This study specifically examines an isocratic reverse phase-high performance liquid chromatography (RP-HPLC) method designed for the direct extraction of vitamin A. The objective is to validate an analytical method for quantifying vitamin A in bioadhesive cationic nanoemulsions incorporated into thermosensitive gels. The method employs isocratic RP-HPLC with a YMC-Triart C18 column (L1), dimensions of 4.6 mm × 250 nm, particle size of S-5 µm, and a UV detector at λ = 265 nm. The mobile phase consists of HPLC-grade methanol, acetonitrile, and n-hexane in a ratio of 46.5:46.5:7. Validation parameters were assessed including selectivity, linearity, accuracy, precision, limit of quantification (LOQ), and limit of detection (LOD). Correlation coefficients were determined with an R2 value of 0.9995 in the concentration range of 264–396 μg/mL (w/v). Recovery percentages ranged from 99.295% to 99.878%. Repeatability and intermediate precision relative standard deviations (RSD) were found to be 0.318% and 0.254%, respectively. The LOD was established at 2.018 μg/mL, and the LOQ was determined to be 6.114 μg/mL. The results affirm cost-effective and well-suited for the accurate measurement of vitamin A levels in bioadhesive thermosensitive gel formulations.
Formulation and Characterization Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Chloroform Extract of Gaharu Leaves (Gyrinops verstegii (Gilg.) Domke Dewi, Siska Noviana; Martien, Ronny; Novitasari, Laras; Nuringtyas, Tri Rini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.179-188.2024

Abstract

Gaharu (Gyrinops versteegii (Gilg.) Domke) is a native Indonesian plant with many potential medicinal compounds. The compounds contained in the chloroform extract of gaharu leaves are mostly nonpolar terpenoids and fatty acids, so their solubility in water is low. Self-nanoemulsifying drugs delivery system (SNEDDS) technology can increase the solubility and bioavailability of drugs or active compounds in cells. This study aims to formulate and characterize SNEDDS from chloroform extract of gaharu leaves. The research began with the extraction of gaharu leaves by soxhletation. Formula optimization was carried out with various oils, surfactants, and cosurfactants. SNEDDS preparations were then characterized by testing particle size, polydispersity index, percent transmittance, and determining globule morphology. The optimal SNEDDS formula contained miglyol® 812N oil and Tween 80 (32%:68%) with particle size 63.25 ± 5.93 nm, polydispersity index 0.272 ± 0.016, and percent transmittance 98.33 ± 0.23%, spherical globule morphology. This study concluded that the optimal formula for SNEDDS chloroform extract of gaharu leaves (Gyrinops versteegii (Gilg.) Domke) had good physical characteristics. Keywords: Gyrinops verstegii (Gilg.) Domke; gaharu; SNEDDS gaharu; miglyol
Perbandingan Stabilitas Nanopartikel Erithropoietin dalam Asam Klorida dan Phospate Buffer Saline Nuryanti, Nuryanti; Nugroho, Akmad Kharis; Martien, Ronny; Julia, Madarina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (669.181 KB) | DOI: 10.35617/jfionline.v14i2.25

Abstract

Abstrak: Sistem nanopartikel eritropoietin terbentuk dari adanya interaksi muatan positif kitosan dan negatif pektin  pada kondisi asam, sehingga stabilitas sistem nanopartikel pada asam klorida dan fosfat buffer adalah parameter penting dalam pilihan medium uji permeasi . Tujuan dari penelitian ini adalah untuk membandingkan stabilitas sistem nanopartikel eritropoietin dalam HCl pH 1,2 dan phosphat buffer salin (PBS) pH 7.4. Penelitian yang dilakukan merupakan penelitian laboratorium eksperimental meliputi analisis eritropoietin yang dilepaskan dari sistem nanopartikel yang dilarutkan dalam HCl pH 1,2 dan PBS pH 7,4 menggunakan metode spektrofotometri.  Kadar eritropoietin yang dihitung adalah kadar eritropoietin yang bebas dari sistem nanopartikel pada menit ke 15, 30, 45, 60, 90, 120, 180 dan 240. Kadar eritropoietin yang dilepaskan dari sistem nanopartikel eritropoietin pada menit ke 15 dalam medium HCl pH 1,2 lebih rendah yaitu 33, 63 %, dibandingkan dalam medium PBS pH 7,4 dengan kadar eritropoietin bebas 50,85%.  Namun setelah waktu 240 menit, kadar eritropoietin bebas dari sistem nanopartikel lebih tinggi dalam medium PBS pH 7,4 (60,49%) dibandingkan medium HCl pH 1,2 (57, 85%).  Hasil penelitian menunjukkan bahwa sistem nanopartikel eritropoietin lebih stabil di medium HCl pH 1,2 dibandingkan di PBS pH 7,4.
Enhancement of Losartan Transdermal Transport Through Incorporation into Chitosan Nanoparticles Efiana, Nuri Ari; Nugroho, Akhmad Kharis; Martien, Ronny
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49978

Abstract

Losartan, an antihypertensive agent, has low oral bioavailability. Therefore, developing a design for transdermal delivery of losartan is interesting. This study aims to enhance losartan in vitro transport by incorporating it into chitosan nanoparticles. Transdermal transport studies were conducted using two experimental groups: the pretreatment group using oleic acid and propylene glycol, and the group without pretreatment. The results showed that losartan incorporated into chitosan nanoparticles resulted in a significantly higher amount of drug being transported than the losartan solution (control) in both experimental groups. In the experiment without pretreatment, the amount of losartan from the control could not be detected in the receptor compartment until 28 hours. In contrast, losartan was detected at 16 hours of transport from chitosan nanoparticles. In pretreatment, chitosan nanoparticles exhibited 6.6fold higher losartan transport than the control. In addition, losartan chitosan nanoparticles showed significant increases in steady-state flux and transport efficiency by 3.3 and 6.6 times higher than the control, respectively. It can be concluded that the incorporation of losartan into chitosan nanoparticles can increase its transdermal transport.
Physicochemical Characterization and Fatty Acid Profiles of Catfish Oil (Clarias gariepinus) Ningrum, Karina Primatyas; Rohman, Abdul; Martien, Ronny
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7418

Abstract

Indonesian aquaculture cultivation production of catfish has been growing faster than other fish. It is a potential source of fish oil and contains polyunsaturated fatty acids that have health benefits. The objective of this study was to perform physicochemical characterization and fatty acid profile of catfish oil. This study used fish oil extracted from the head and the flesh of catfish using dry rendering with a mechanic press. The result showed that catfish flesh oil (CFO) and catfish head oil (CHO) were significantly different parameters (p<0.05) in terms of physicochemical characteristics including acid value, peroxide value, iodine value, and saponification value. The best characteristics are catfish flesh oil than catfish head oil for acid value, peroxide value, iodine value, and saponification value following the number is 2.17 mg KOH/g, 5.15 meqO2/kg, 76.13 I2/100 g, 175.86 mg KOH/g. The predominant fatty acids were oleic, palmitic, and linoleic acids. These catfish oils are found suitable for consumption for beneficial health effects.
The Employment of ATR-FTIR Spectroscopy and Chemometrics for Authentication of Bawal (Colossoma macromopum) Fish Oil from Palm Oil Anggriani, Firhani; Rohman, Abdul; Martien, Ronny
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7956

Abstract

Fish is a product with high nutritional content, and the development of fish oil has made it easier for consumers to consume. High-quality fish oil can be a target for adulteration, such as with vegetable oils like palm oil. FTIR spectroscopy was developed for the authentication of bawal fish oil (BFO) from palm oil (PO). Bawal fish oil and palm oil were prepared in binary mixtures with concentrations from 0-100%, resulting in 21 mixtures. The oil was directly measured by attenuated total reflectance (ATR) spectral measurement in the mid-infrared region (4000-600 cm-1). The results were combined with linear discriminant analysis (LDA) and multivariate calibration, such as PLSR or PCR. The results showed that LDA could make clear discrimination between bawal fish oil, palm oil, and their mixtures without any misclassification observed. Multivariate calibration with PLSR using the first derivative spectrum provided the best model for the relationship between actual and predicted FTIR values. At this conditions, the R2 values for the calibration and validation models obtained were 0.9966 and 0.9969, with RMSEC and RMSEP values of 0.0249 and 0.0248, respectively. Therefore, FTIR spectroscopy combined with LDA and PLSR is an effective method for authenticating bawal fish oil from palm oil.
Characterization and Effect of Chitosan Concentration Variations on the Nanosuspension Formula of Ethanol Extracts from Plantago major L. Leaves Using the Ionic Gelation Method Irawan, Muhamad Bayu; Hertiani, Triana; Martien, Ronny
Majalah Farmaseutik Vol 21, No 4 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i4.107330

Abstract

The ethanol extract of Plantago major L. leaves contains secondary metabolites, including phenolics and iridoid glycosides, which exhibit anti-inflammatory and wound-healing properties. Nanoparticle technology, in the form of nanosuspensions, is a method that can enhance the ability of active compounds to pass through cell membranes at the nanoscale. This study aimed to characterize and investigate the effects of varying chitosan concentrations on the nanosuspension formulation of Plantago major L. ethanol leaf extract using the ionic gelation method. The ethanol extract was formulated into nanosuspensions with five different concentrations of chitosan polymer: 0.25% (F1), 0.5% (F2), 0.75% (F3), 1% (F4), and 1.25% (F5). Testing parameters included particle size, polydispersity index (PDI), and zeta potential, measured using the Malvern Zetasizer Nano ZS instrument. The characterization results for all formulations showed an average particle size ranging from 445.7 to 811.5 nm, a PDI ranging from 0.385 to 0.518, and a zeta potential between 23.9 and 31.0 mV. These results indicate that all formulations fall within the nanoparticle size range (10–1,000 nm), exhibit relatively homogeneous polydispersity indices, and display stable zeta potentials. Variations in chitosan concentration in each nanosuspension formula of ethanol extract of Plantago major L. influenced the characterization, with increasing chitosan concentration resulting in larger particle sizes and higher zeta potentials, thereby enhancing the potential for these nanosuspensions to be formulated into drug delivery systems.
Co-Authors Abdul Rohman Adhyatmika, Adhyatmika Agung Endro Nugroho Akhmad Kharis Nugroho Anggriani, Firhani Artemisia, Rahma Artemisia, Rahma Dewi, Siska Noviana Endang Lukitaningsih Erna Prawita Setyowati Fajar Waskito He Yeon Asva Nafaisa Hilda Ismail, Hilda Iis Wahyuningsih Irawan, Muhamad Bayu Irnawati Irnawati Kusumadewi, Awal P. Lina Winarti Lutfi Chabib, Lutfi Madarina Julia Nakhil, Umaimatun Ningrum, Karina Primatyas Novitasari, Laras Nugroho, Akmad Kharis Nuri Ari Efiana Nuryanti Nuryanti Perkasa, DP Pradana, Theophani Bagas Rohmat Mujahid, Rohmat Rony, Zahara Tussoleha Sinurat, Ellya Sismindari . Siti Fatmawati Fatimah, Siti Fatmawati Sofia Mubarika Haryana Styawan, Anita A. Sugiyanto - Sumadi, Firasti A.N Tri Rini Nuringtyas Triana Hertiani wardana, Tirta Yuswanto, Ag