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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Indonesian Journal of Biotechnology JURNAL PHARMASCIENCE Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Jurnal Farmasi Sains dan Praktis Jurnal Farmasi Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Journal of Food and Pharmaceutical Sciences
Ronny Martien
Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Sekip Utara Yogyakarta 55281, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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ANTIOXIDANT ACTIVITY OF INDONESIAN BROWN MARINE ALGAE (Sargassum turbinarioides) Artemisia, Rahma; Sinurat, Ellya; Setyowati, Erna Prawita; Martien, Ronny; Nugroho, Akhmad Kharis
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.9673

Abstract

Brown marine algae are provided for an excellent source of bioactive compounds especially fucoidan. Fucoidan is primarily composed of L-fucose residues linked by α-1,3 and α-1,4 glycosidic bonds, with sulfate groups as its main chemical components. One of the biological activities of fucoidan is antioxidant. Antioxidant activities of Indonesian brown marine algae were investigated. The phytochemical screening of the crude extract was conducted to identify various phytochemical constituents, including carbohydrates, flavonoids, phenolic compound, terpenoids, and proteins and amino acid. The antioxidant activity of the brown marine algae Sargassum turbinarioides was evaluated using free radical scavenging through the DPPH assay and a reducing power assay. The antioxidant capacity of the extracted fucoidan was measured against ascorbic acid, revealing that fucoidan from brown marine algae exhibited lower DPPH radical scavenging activity compared to vitamin C. Meanwhile, the reducing power of the extract increased with higher concentrations, demonstrating a dose-dependent effect. These findings suggest that brown marine algae extract has potential for commercialization as a functional food or dietary supplement owing to its significant antioxidative properties.
Development of green synthesis silver nanoparticle with Ocimum sanctum leaf extract: characterization and stability study Niswah, Sukma Uswatun; Kusumorini, Nindya; Martien, Ronny
Majalah Farmaseutik Vol 22, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i1.113027

Abstract

This study aimed to synthesize, characterize, and evaluate the stability of silver nanoparticles (AgNPs) produced using Ocimum sanctum L. leaf extract through a green synthesis method. The aqueous extract of fresh basil leaves served as a natural reducing and stabilizing agent in the reduction of 1 mM silver nitrate solution at 80 °C, indicated by a color change from light yellow to brown. Phytochemical screening confirmed the presence of phenolic compounds, saponins, and flavonoids responsible for the reduction and stabilization processes. Characterization by UV–Visible spectrophotometry showed a surface plasmon resonance peak at 450 ± 4.93 nm, while particle size analysis indicated a Z-average of 85.77 ± 0.46 nm and a polydispersity index of 0.222 ± 0.003, reflecting uniform and monodisperse nanoparticles. The zeta potential of –14.23 ± 0.30 mV suggested moderate colloidal stability. After 30 days of refrigerated storage, the nanoparticles exhibited a red shift of the absorption peak, an increased particle size of 111.12 ± 1.24 nm, and a slightly higher zeta potential, indicating partial aggregation. These findings demonstrate that O. sanctum extract can effectively mediate the eco-friendly synthesis of stable silver nanoparticles, although their long-term stability is influenced by physicochemical interactions of surface biomolecules.
Decoding the role of tannic acid in wound healing: a dual‐action mechanism linking IL‐1β modulation and FGF‐driven tissue repair Swastini, Dewa Ayu; Nugroho, Agung Endro; Martien, Ronny; Fachiroh, Jajah; Khafi, Muhammad; Putra, Komang Dian Aditya
Indonesian Journal of Biotechnology Vol 31, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.113925

Abstract

Tannic acid (TA) has been shown in a previous study to expedite cutaneous wound healing in rats; however, the precise mechanism by which it operates remains poorly understood. This research evaluates the effects of TA on wound healing using both in vitro and in silico methods. In vitro, its influence on the inflammatory cytokine interleukin‐1β (IL‐1β) and the growth factor fibroblast growth factor (FGF) throughout the healing process were assessed. In silico molecular docking was employed to predict direct ligand–protein interactions and to provide a mechanistic insight into whether these proteins represent primary molecular targets or downstream effects. Parameters evaluated included cell viability and proliferation, scratch assays, and the activity of pro‐inflammatory cytokines in the lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophage cell line, together with growth factors in the NIH 3T3 fibroblast cell line; all were evaluated using enzyme‐linked immunosorbent assay (ELISA). The results indicate that TA significantly facilitates wound closure by promoting NIH 3T3 fibroblast cell proliferation, enhancing FGF expression, and suppressing IL‐1ß synthesis in both in vitro and in silico approaches. These findings suggest that TA may hold considerable promise for wound‐healing management.
Co-Authors Abdul Rohman Adhyatmika, Adhyatmika Agung Endro Nugroho Akhmad Kharis Nugroho Anggriani, Firhani Artemisia, Rahma Artemisia, Rahma Dewa Ayu Swastini Dewi, Siska Noviana Endang Lukitaningsih Erna Prawita Setyowati Fajar Waskito He Yeon Asva Nafaisa Hilda Ismail, Hilda Iis Wahyuningsih Irawan, Muhamad Bayu Irnawati Irnawati Jajah Fachiroh, Jajah Khafi, Muhammad Kusumadewi, Awal P. Kusumorini, Nindya Lina Winarti Lutfi Chabib, Lutfi Madarina Julia Nakhil, Umaimatun Ningrum, Karina Primatyas Niswah, Sukma Uswatun Novitasari, Laras Nugroho, Akmad Kharis Nuri Ari Efiana Nuryanti Nuryanti Perkasa, DP Pradana, Theophani Bagas Putra, Komang Dian Aditya Rohmat Mujahid, Rohmat Rony, Zahara Tussoleha Sinurat, Ellya Sismindari . Siti Fatmawati Fatimah, Siti Fatmawati Sofia Mubarika Haryana Styawan, Anita A. Sugiyanto - Sumadi, Firasti A.N Tri Rini Nuringtyas Triana Hertiani wardana, Tirta Yuswanto, Ag