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All Journal HAYATI Journal of Biosciences Padjadjaran Journal of Dentistry Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Jamu Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Muhammadiyah Journal of Geriatric Cermin Dunia Kedokteran Indonesian Journal of Jamu
Nafrialdi Nafrialdi
Department Of Pharmacology And Therapeutics, University Of Indonesia Medical School/ Dr. Cipto Mangunkusumo Hospital, Jakarta.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Squamous cell carcinoma of the tongue in Sprague-Dawley rats using 4-nitroquinoline 1-oxide model Erfan, Erni; N., Nafrialdi; Ekawuyung, Puspita
Padjadjaran Journal of Dentistry Vol 28, No 1 (2016): March 2016
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1371.838 KB) | DOI: 10.24198/pjd.vol28no1.13510

Abstract

Background. 4-nitroquinoline 1-oxide (4NQO) is a water soluble carcinogen which is often used to induce cancer in oral cavity. Objective. The purpose of this study was to know the incidence of histopathological lesions in the tongue of rats after administration of 4-nitroquinoline 1-oxide (4NQO) for a model of oral carcinogenesis in the animal experimental laboratory. Materials and Methods. This study was conducted in the Department of  Pathological Anatomy, Faculty of Medicine, University of Indonesia (FMUI). 4NQO (30 ppm) was administered by drinking water ad libitum to the Sprague Dawley (SD) rats during different time inductions (4-9 and 36-46 weeks). The present of tumor in oral cavity of the 4NQO-treated rats were observed macroscopically and microscopically. Tumor volume were measured based on the formula established by G. Carlsson. The degree of histological changes was determined according to observation towards their Hematoxylin and Eosin (HE) staining results. Results. Dysplasia and invasive squamous cell carcinoma (SCC) were respectively found in the tongue of the group given 4NQO for 4-9 and 36-46 weeks. The tongue from rats (4NQO for 36-46 weeks) exhibited whitish protuberant nodular lesions with the longest diameter was 17 mm. The histopathological lesion incidences for dysplasia and invasive SCC respectively were 25% (5/20) and 75% (15/20). The rats had tumor in their tongues with variation of degree alteration which proportional to the induction time. The extension of 4NQO induction time increasing the degree of change in the tumor. Conclusion. 4NQO represents a good model of carcinoma of tongue and gives consistence results with histological changes degree being related to duration of exposure.
Cardioprotective Effect of Quercetin in 5/6-Nephrectomized Rats: Focus on Myocardial fibrosis and Oxidative Stress Yuliani, Tri; Louisa, Melva; Arozal, Wawaimuli; Soetikno, Vivian; Nafrialdi, Nafrialdi; Dewijanti, Indah D
Jurnal Jamu Indonesia Vol. 2 No. 3 (2017): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v2i3.37

Abstract

Uremic cardiomyopathy is the leading cause of death in patients with chronic kidney disease. Fluid overload and oxidative stress play important roles in its pathogenesis. This study aims to determine the effect of quercetin on uremic cardiomyopathy in 5/6-nephrectomized rats. To our knowledge, its cardioprotective effect on uremic cardiomyopathy induced in rats by 5/6 nephrectomy has not been investigated yet. Uremia was induced surgically in male Sprague-Dawley rats via 5/6 nephrectomy. Quercetin was administered per orally at a dose of 100 mg/kg/day for 8 weeks prior to sacrifice. Meanwhile, captopril was administered at a dose of 10 mg/kg/day. Lipid peroxidation was assessed using TBARS reaction, while GPX activity was determined to explore the endogen antioxidant mechanism. Myocardial fibrosis was analyzed using Massons’ Trichrome staining and the level of NT-proBNP in plasma was measured as a marker of cardiac dysfunction. Nephrectomy 5/6 had no effects on plasma NT– proBNP levels, cardiac and plasma MDA levels, but induced mild myocardial fibrosis and significant increase in cardiac GPX activity in comparison with normal rat (p<0.05). However, administration of quercetin or captopril did not ameleriote those mild myocardial fibrosis and increased GPX activity. Uremic cardiomyopathy induced by 5/6 nephrectomy demonstrated mild myocardial fibrosis but preservation of cardiac function demonstrated by NT-proBNP levels. Increased of GPX activity in the nephrectomized-rats compared to the control rats (p<0.05) suggests induction of antioxidant defense mechanisms that might not be exhausted yet. This condition highlighted a compensatory phase which was unchanged following chronic administration of either quercetin or captopril.
Co-Authors -, Paramita Agatha Grace Ali Sulaiman Arini Setiawati Dewi Sharon Simorangkir Dewi, Yulia Ratna Ening Krisnuhoni Erni Erfan, Erni Eziefule, Oluebube Magnificient F. D. Suyatna Felix F. Widjaja Femmi Dwinda Agustini Frans D. Suyatna Gayatri, Anggi Handini, Novita M. Helyanna Helyanna, Helyanna Imam Effendi Indah D Dewijanti Indah D Dewijanti, Indah D Instiaty, Instiaty Irsan Hasan Isnani A.S. Suryono Joedo Prihartono Kenichi Watanabe Laurentius A Lesmana, Laurentius A Lukman H. Makmun M. Zaim Madoka Takeuchi Maemun, Siti Masahiro Takeuchi Meilei Ma Melva Louisa Mulyadi Djer Nabillah, Deya Adiby Nina Mariana, Nina Paramita, Paramita Pradana Soewondo Punniyakoti T. Veeraveedu Purwantyastuti Purwantyastuti Purwita Wijaya Laksmi Puspita Eka Wuyung Puspita Ekawuyung, Puspita Pustika Amalia Wahidiyat Rachman, Andika Raymond R. Tjandrawinata Rianto Setiabudy Rino Alvani Gani Sake Juli Martina Saut Horas Hatoguan Nababan SEPTELIA INAWATI WANANDI Seruni Tyas Khairunissa Setiabudy, Rahajuningsih D Setyawati, Rumaisah Siti Setiati Soni Siswanto Syarifah Dewi Theresia G Kurniawan, Theresia G Tirza Z Tamin Tri Yuliani Tri Yuliani, Tri Vetnizah Juniantito Vivian Soetikno Vivian Soetikno Vivian Soetikno Wasilah Rochmah Wawaimuli Arozal Wawaimuli Arozal Wawaimuli Arozal Wijaya, Ika P. Wijaya, Surya Oto