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All Journal Media Farmasi Community Development Journal Jurnal Ilmiah Medicamento Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Pengabdian Kefarmasian JURNAL KESEHATAN YAMASI MAKASSAR Media Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Hendra Stevani
Poltekkes Kemenkes Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Media Farmasi

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Efek Anti Diabetes Ekstrak Daun Maja (Aegle marmelos L.) pada Zebrafish (Danio rerio) Syahrir, Putri Damayanti; Stevani, Hendra; Dewi, Sisilia Teresia Rosmala
Media Farmasi Vol 20 No 1 (2024): Media Farmasi Edisi April 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i1.567

Abstract

Anti Diabetes Effect Of Maja (Aegle marmelos L.) Leaf Extract On Zebrafish (Danio rerio) Several studies show the effectiveness of Maja leaves in Diabetes mellitus, however further proof is still needed to confirm the effectiveness of Maja leaves, one of which is by using experimental animals that are more similar to humans such as Zebrafish (Danio rerio). This research aims to determine the anti-diabetic effectiveness of maja leaf extract (Aegle marmelos L.) on Zebrafish (Danio rerio) after being induced by Aloxan. Maja leaves (Aegle marmelos L.) were extracted using the maceration method. This research was carried out using Aloxan and 0.1% glucose as inducers, and Metformin as a positive control, with extract doses of 200 mg/2L, 300 mg/2L, and 400 mg/2L. The results of the observations showed that the average decrease for each treatment group was that the negative control group given Aloxan and 0.1% glucose had an average decrease of 130 ± 15.6 mg/dL, the group given 200 mg maja leaf extract had an average decrease was 62.33 ± 15 mg/dL, for the group given 300 mg maja leaf extract had an average decrease of 68 ± 15 mg/dL, the group given 400 mg maja leaf extract had an average decrease of 67±11.5mg/dL and the positive control group given Metformin had an average reduction of 57.66±12.7mg/dL. So it can be concluded that maja leaf extract 200 mg, 300 mg, and 400 mg has been proven to significantly reduce blood glucose levels in zebrafish (p<0.05). Terdapat beberapa penelitian yang menunjukkan efektivitas Daun Maja pada Diabetes melitus, namun pembuktian lebih lanjut masih diperlukan untuk memastikan efektivitas daun Maja, salah satunya dengan menggunakan hewan coba yang lebih memiliki kemiripan dengan manusia seperti Zebrafish (Danio rerio). Tujuan dari Penelitian ini adalah untuk mengetahui efektivitas anti diabetes esktrak Daun maja (Aegle marmelos L.) pada Zebrafish (danio rerio) setelah diinduksi Aloxan. Daun maja (Aegle marmelos L.) diekstraksi dengan menggunakan metode maserasi. Penelitian ini dilakukan dengan menggunakan Aloxan dan glukosa 0,1% sebagai penginduksi, Metformin sebagai kontrol positif, dengan dosis ekstrak 200 mg/2L, 300 mg/2L, dan 400 mg/2L. Hasil pengamatan menunjukkan bahwa rata-rata penurunan untuk setiap kelompok perlakuan yaitu pada kelompok kontrol negatif yang diberi Aloxan dan glukosa 0,1% memiliki rata-rata penurunan sebesar 130 ±15,6 mg/dL, kelompok yang diberi ekstrak daun maja 200 mg memiliki rata-rata penurunan sebesar 62,33±15 mg/dL, untuk kelompok yang diberi ekstrak daun maja 300 mg memiliki rata-rata penurunan sebesar 68 ± 15 mg/dL, kelompok yang diberi ekstrak daun maja 400 mg memiliki rata-rata penurunan sebesar 67±11,5mg/dL dan untuk kelompok kontrol positif yang diberi Metformin memiliki rata-rata penurunan sebesar 57,66±12,7mg/dL. Sehingga dapat disimpulkan bahwa ekstrak daun maja 200 mg, 300 mg, dan 400 mg terbukti dapat menurunkan kadar glukosa darah pada Zebrafish secara signifikan (p<0,05).
Peningkatan Kelarutan Ketoprofen Dalam Bentuk Mikropartikel Dengan Metode Emulsification-Ionic-Gelation Menggunakan Polyvinylprrolidone (PVP) Dan Tripolifosfat(TPP) Dirgahayu Yahya, Nurul Fitri; Sinala, Santi; Stevani, Hendra
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1006

Abstract

A nonsteroidal anti-inflammatory drug called ketoprofen is used to treat musculoskeletal and joint disorders, including osteoarthritis. Ketoprofen has a low solubility in water, which is a major obstacle to the absorption of the drug into the body.However, by using emulsification ion gelation technology, it is possible to create microparticles, which can improve the solubility of ketoprofen. . The aim of this study was to use emulsification and ion gelation to produce ketoprofen microparticles with higher solubility. SEM was used to characterize the structure of the ketoprofen particles. Subsequently, ketoprofen solubility and content tests were performed. When the properties were evaluated using SEM microparticles, the particle size gradually decreased from pH2, pH4, and pH6, and the water solubility of the drug increased due to the small particle size of the generated microparticles. After the emulsification-ionic gelation process, the solubility of ketoprofen increased two-fold and the pH of water increased two-fold compared to untreated ketoprofen. From this, it can be concluded that polyvinylpyrrolidone (PVP) and tripolyphosphoric acid (TPP) effectively improved the solubility of sparingly water-soluble ketoprofen in the emulsification ion gelation process of ketoprofen production.
Inkorporasi Ekstrak Daun Jarak Pagar (Jatropha Curcas L) dalam Patch Transdermal Sebagai Anti Hiperglikemi; Formulasi Dan Pankreatik Histopatologi Sukmawati, Muli; Arisanty; Daswi, Dwi Rachmawaty; Stevani, Hendra; Daton, Dicky Alexander
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1060

Abstract

Incorporation Of Jarak Pagar Leaves Extract (Jatropha Curcas L) In Transdermal Patch As Antihyperglycemic ; Formulation And Pancreatic Histopathology Transdermal patches are known to have a more immediate therapeutic effect and could avoid the risk of side effects that may arise compared to oral. This study aimed to produce Jarak Pagar leaves ethanolic extract transdermal patch (JPL-EETP) to enhance the penetration of Jarak Pagar leaves extract (JPL-EE) to maximize the systemic therapeutic effect of antidiabetics. In addition, easy and enjoyable medication could improve patient compliance. Transdermal patch was prepared by making the formula of JPL-EETP with different concentrations of extract with solvent-evaporated methods. JPL-EETP optimization was carried out by determining the pH, aeration, folding resistance, and organoleptic. Furthermore, the optimal JPL-EETP formulas were followed by the in vivo assay, ex vivo assay, and pancreatic histopathology assay. The JPL-EETP physicall determination were carried out the appropriate of transdermal patch measurements.  F3 with an JPL-EE concentration of 1.75 g can provide an antidiabetic effect on in vivo asay that is as good as oral antihyperglycemic drugs (p>0.05). Ex vivo study confirmed that the gallate acid permeation across the porcine skin of F2 showed higher percentage of permeation of 94,2% respectively after 24 h. The histophatology assay presence no significant difference between the surface area of ​​the islets of Langerhans and the histopathological after administration of metformin or Jarak Pagar leaves extract transdermal patch. The results suggest that Jarak Pagar leaves ethanolic extract transdermal patch is a potential candidate of antidiabetics drug from natural source and can provide a higher patient compliance along with effectiveness in the management and treatment of diabetes which can be easily applied to the skin. Sediaan patch transdermal diketahui memiliki efek terapi yang lebih cepat dan dapat amenghindari resiko efek samping yang mungkin timbul dibanding sediaan oral. Penelitian ini bertujuan untuk membuat ekstrak etanol daun Jarak Pagar (PT-EJPL) yang diformulasikan dalam bentuk patch transdermal untuk meningkatkan efektifitasnya sebagai antihiperglikemi. Patch transdermal dibuat dalam beberapa konsentrasi EJPL dengan metode solvent-evaporated. Karakteristik PT-EJPL ditentukan dengan pengukuran pH, daya lipat, dan uji organoleptik. Penentuan efek antihiperglikemi dilakukan secara in vivo menggunakan tikus wistar putih. Persentase pelepasan fenolik dilakukan secara ex vivo menggunakan kulit babi selama 24 jam. Analisis pakreas histopatologi dilakukan dengan melihat luar area pulau langerhans sebelum dan sesudah perlakuan. Hasil pengujian menunjukkan karateristik patch yang sesuai persyaratan. Formula 3 dengan konsentrasi EEJPL 1.75 g menunjukkan efek antihiperglikemi pakling baik (p<0.05) sejalan dengan hasil uji pelepasan asam gallat pada F3 mencapai 94,2% pada jam ke 24. Analisis histopatologi luas permukaan sel langerhans menunjukkan tidak perbedaan signifikan antara kelompok kontrol dan perlakuan (p>0.05). Penelitian ini berhasil memformulasikan EJPL kedalam sistem penghantaran transdermal dan dapat dipertimbangkan sebagai kandidat antidiabetik herbal.
Co-Authors - Ermawati - Husnul Afifa Thamrin***) - Nur Filda Utami Abdullah, Tajuddin Adelia Nurrochifah Andi Fadillah Andi Muh Farid arafah, Salmah Arisanty Arisanty Arisanty Arisanty, Arisanty Ariyani Buang Asmawati Asmawati Asyikin, Asyhari Ayu Nabila Putri Base, Nurul Hidayah Daswi, Dwi Rachmawaty Daton, Dicky Alexander Dewi Ratnasari Dewi, Sisilia Teresia Rosmala Dirgahayu Yahya, Nurul Fitri Djuniasti Karim Dwi Rachmawati Eka Santi Fahmi Ali Fajar, Desi Reski Fitria Fitria Hasanuddin Nuru Hasni Hasni Hesty Setiawati Hidayati Hidayati Hijrawati Ayu Wardani Ikke Nurjannah Intang, Nur Ivonne Siswanty Jumain Jumain Kamaruddin Kamaruddin Mahfudzah, Nur Arifah Mispari Mispari Mudyawati Kamaruddin Muli Sukmawaty Nana Warsi Nurfitriana Hasyim Nurhayana Nurhayana Nurisyah Nurisyah Rafidah Rafidah Rahayu, Amelia Putri Raimundus Chaliks Ratna Sari Dewi Ratnah, St. Ratnasari Dewi Ratnasari Dewi Ratnasari Dewi Ridha, Ridha Amelia Rusdiaman Rusdiaman Rusli Rusli Salasa, Alfrida Monica Seli Sulfiana Serang, Aditya Anugerah F Sinala, Santi St. Rahmah Syam Sukmawati, Muli Syachriani Syachriani Syahrir, Putri Damayanti Syarifuddin Side Tajuddin Abdullah Tasman, Rahmat Setiady Wahyudin Wahyudin