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All Journal journal of internal medicine Jurnal Kedokteran Brawijaya Folia Medica Indonesiana Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Narra J JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Keperawatan Jurnal Penyakit Dalam Indonesia

Gatot Soegiarto

Allergy & Clinical Immunology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya

Author-ID : 3289438

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The effects of age on antibody response towards COVID-19 vaccination: A Systematic Review Hendra Ikhwan Gautama; Gatot Soegiarto; Laksmi Wulandari
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 8, No 1 (2023)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/jumantik.v8i1.13631

Background: Mortality rate of COVID-19 infection isexceptionally high in the older population. Various vaccines are being rapidly developed as an attempt to halt the pandemic. Although vaccination has been effective in reducing mortality and hospitalization rate in recent months, lower vaccine effectiveness has been reported among older adults.Aim: This review aims to evaluate and summarize current evidence on the effect of age on antibody response towards COVID-19 vaccines. Methods: Literature search was conducted on PubMed, Scopus, ScienceDirect and ProQuest for studies published up to 9th October 2022. The selected studies were assessed The Joanna Briggs critical appraisal tools. Qualitative analysis was then performed for the final studies.Result: A final of 9 studies were included in this review. A majority of the studies evaluated the responses of BNT162b2 or mRNA-1273 vaccine, while 1 study investigated the response towards ChAdOx1 vaccine. Outcomes were measured in term of IgG antibody levels or serum neutralization. Most studies demonstrated significantly lower antibody response and neutralization in older adults compared to younger vaccinees after administration of first and second vaccine dose. However, two studies reported no significant difference in vaccine responses across age groups after third dose administration.Conclusion: This systematic review highlights lowerimmunogenicity towards COVID-19 vaccines in older population. Further research into strategies to improve vaccine responses in the elderly is required to provide sufficient protection for this vulnerable group. Keywords: COVID-19 vaccine, antibody, neutralization, age, elderly

Evaluasi Efikasi Vaksin Covid-19 pada Sumber Daya Manusia Kesehatan Gatot Soegiarto; Laksmi Wulandari; Dewajani Purnomosari3; Delvac Oceandy
Jurnal Keperawatan Vol 14 No 3 (2022): Jurnal Keperawatan: September 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.248 KB)

Sejak WHO mengumumkan COVID-19 menjadi pandemic global, kasus infeksi COVID-19 di Indonesia telah menembus angka 1 juta kasus dengan angka kematian hampir 30 ribu kasus. Hingga saat ini masih belum ada terapi definitif untuk infeksi COVID-19, maka vaksinasi diharapkan menjadi tindakan preventif untuk menekan angka morbiditas dan mortalitas. Di Indonesia program vaksinasi menggunakan virus yang tidak aktif telah dilaksanakan pertama kali pada tanggal 13 Januari 2021 dengan sasaran pertama pada tenaga kesehatan. Penelitian ini bertujuan untuk mengevaluasi efikasi vaksin COVID-19 bagi sumber daya manusia kesehatan (SDMK) di RSUD Dr. Soetomo Surabaya. Penelitian ini menggunakan desain studi kohort prospektif dengan total sampel 101 sumber daya manusia kesehatan di RSUD Dr. Soetomo Surabaya yang diperoleh melalui metode consecutive sampling. Semua peserta melakukan wawancara sebelum mendapatkan vaksin dosis pertama untuk mengumpulkan data demografi serta riwayat penyakit penyerta. Selanjutnya semua peserta melakukan pengambilan darah sebanyak 10cc untuk pemeriksaan antibodi terhadap SARS-CoV-2, darah lengkap, laju endap darah, dan HbA1c (bagi yang menderita diabetes mellitus). Pengambilan darah dilakukan sebelum pemberian vaksin dosis pertama, kemudian 1, 3, dan 5 bulan setelah vaksinasi dosis kedua sebagai tindak lanjut. Interval pemberian vaksin antara dosis pertama dan kedua adalah 14-28 hari. Pada penelitian ini, kami menemukan bahwa kadar serum IgG meningkat secara signifikan pada 1 bulan pasca-vaksinasi virus SARS-CoV-2 tidak aktif dosis kedua, namun mulai menurun pada 3 dan 5 bulan pasca-vaksinasi. Data kami memberikan bukti tentang adanya pengaruh faktor demografis, yaitu usia dan riwayat penyakit penyerta, yaitu hipertensi pada respons antibodi terhadap vaksin virus SARS-CoV-2 yang tidak aktif.

Immunotherapy for Food Allergy: Myth or Reality? Soegiarto, Gatot
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Allergic reaction to food can have serious consequences. The only treatment option is strict allergen avoidance, but accidental ingestions happen frequently and can lead to severe and potentially life-threatening allergic reactions. Food allergy is one of the most common causes of anaphylactic reactions. Therefore self-injectable epinephrine should always be at hand in case of accidental exposure. Many food allergies may resolve over time, but most patients with persistent food allergies live with fear of anaphylactic reactions. Within the last several years, the usefulness of immunotherapy for food allergies has been investigated. Several food immunotherapies are being developed; which include oral, sublingual, epicutaneous, or subcutaneous administration. The approach follows the same principles as immunotherapy for other allergic disorders, consisted of an induction phase followed by a maintenance phase with regular intake of maximum tolerated amount of food. Although immunotherapy seems promising for food allergic patients, it remains an investigational treatment that need to be studied further before advancing into clinical practice. Hopefully, multicentre and randomizedcontrolled studies can provide answer to multiple questions including optimal dose, ideal duration of immunotherapy, degree of protection, efficacy for different ages, severity and type of food allergy responsive to treatment.

Correlation between Glycemic Control in Type 2 Diabetes Mellitus Patients with Natural Killer Cell Activity Ristanti, Dian; Soegiarto, Gatot; Novida, Hermina
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Introduction. Most of the previous studies showed decreased polymorphonuclear cells and monocytes/macrophages in type 2 diabetes mellitus (T2DM). Natural killer (NK) cell functions were rarely studied in T2DM. This study aimed to evaluate NK cell activity and determine its correlation with glycemic control in T2DM patients. Methods. Type 2 diabetes mellitus (T2DM) patients who regularly visit the diabetes outpatient clinic of Dr. Soetomo General Hospital during July – August 2018 and fulfill the inclusion-exclusion criteria were recruited to the study. The HbA1c level was measured according to the standard procedure. The NK cell activity was measured using flow cytometry and expressed as the percentage of activated NK cells from total NK cell numbers. Correlation between the two variables was determined. Results. There were 38 subjects eligible for this study, consisted of 15 males and 23 females, with mean of age 52 (standard deviation [SD] 6) years. The subjects routinely received OAD (36.8%), insulin (44.7%), or OAD-Insulin combination therapy (18.4%). Median HbA1c was 7.8% (range: 5.5 – 13%). Median NK cell activity was 7.08% (range: 2.95 – 21.55%). Using a Spearman test, there was no significant correlation between HbA1c levels and NK cell activity (r=0.292; p=0.075). Conclusions. The glycemic control in T2DM did not significantly influence NK cell activity. Further exploration and research should be done to determine whether there were changes in NK cells that contribute to innate immune dysfunction in T2DM patients.

IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol. 4 No. 4 (2013)
Publisher : Institute of Topical Disease Universitas Airlangga

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as "flu”. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

Different COVID-19 mRNA-based Vaccine Platforms as The Booster Dose and Their Impact on Omicron: A Literature-Based Overview Mahdi, Bagus Aulia; Soegiarto, Gatot; Wulandari, Laksmi; purnomosari, dewajani
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.39597

Globally, the vaccine has been determined as one of the principal policies to tackle the COVID-19 pandemic. However, some vaccinated individuals with two complete doses of inactivated experienced SARS-CoV2 infection, including the healthcare workers (HCWs). This threat led to the emergent need for a vaccine booster with different types of platforms aiming to enhance immunity from the Omicron variant. We conducted a literature study on the concept of heterologous compared to homologous vaccines in COVID-19 vaccination. We obtained 22 studies about COVID-19 booster vaccines. Referring to seven of them, we compared and distinguished between heterologous and homologous vaccines. We then reported the literature review according to PRISMA guideline. The study demonstrated qualitatively that heterologous vaccinations boosted antibody receptor binding domain, neutralizing antibody, and spike-specific Th1 type T cell responses and had an impact on omicron infection when compared to homologous vaccines. In conclusion, heterologous, mRNA based vaccine, predominantly induces cellular and humoral responses better than the homologous vaccine. This increased immune response is expected to provide profound immunity against the Omicron.

Impact of Hypertension and Cardiovascular Diseases to Immune Response in COVID-19 Vaccination: A Systematic Review Fahmita, Karin Dhia; Soegiarto, Gatot; Wulandari, Laksmi; Purnomosari, Dewajani
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.40266

To determine impact of hypertension and cardiovascular diseases towards effectivity and safety of COVID-19 vaccination. Systematic review based on PRISMA statement was done. Searching was conducted in PubMed, ScienceDirect, Scopus, and ProQuest and resulting in 6 studies involving 4,053 participants which deemed on good quality according to Joanna Briggs Institute tools for critical appraisal. After thorough analysis, we found that two out of four studies assessing mRNA-based vaccine found out that hypertension lower antibody response significantly. Two out of two studies assessing inactivated virus vaccine shown that hypertensive patients tend to have lower antibody titers compared to control. One of studies mentioned above found that antibody titer was not different between populations with cardiovascular diseases and control.Hypertension lessened response to COVID-19 vaccination regardless of vaccine type used. However, lack of studies on cardiovascular disease suggested that more studies should be conducted, along with hypertension, in-order to make meta-analysis possible to provide better evidence.

Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.

More severe comorbidities, advanced age, and incomplete vaccination increase the risk of COVID-19 mortality Pradhevi, Lukita; Soegiarto, Gatot; Wulandari, Laksmi; Lusida, Michael AP.; Saefudin, Rendra P.; Vincent, Agustinus
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.949

Numerous studies have stated that comorbidities are risk factors for coronavirus disease 2019 (COVID-19) mortality, but few have considered the severity or stage of these comorbidities. The aim of this study was to determine the association between the severity of comorbidity, age, and number of COVID-19 vaccinations with COVID-19 mortality. This case-control study was conducted from July 2021 until December 2022 at the Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The patients were divided into non-survived patients (case group) and survived patients (control group). The inclusion criteria for cases were adult patients hospitalized with confirmed COVID-19, based on reverse transcriptase-polymerase chain reaction (RT-PCR) testing of nasopharyngeal swabs. Using total sampling, 1,046 confirmed COVID-19 patients, which consisted of 450 (43%) non-survived patients and 596 (57%) survived patients, were included. The most common comorbidity was diabetes mellitus (DM) (82.7%), chronic kidney disease (CKD) (43%), hypertension (25.7%), and obesity (23.6%). Our multivariate analysis indicated that older age (aOR: 1.03; 95%CI: 1.02–1.04, p<0.001), male sex (aOR: 1.29; 95%CI: 1.11–2.00, p=0.007), severe COVID-19 at first admission (aOR: 3.13; 95%CI: 2.08–4.73, p<0.001), having pneumonia (aOR: 1.99; 95%CI: 1.21–3.33, p=0.005), poorly controlled DM with HbA1c≥9% (aOR: 2.90; 95%CI: 1.72–4.89, p<0.001), severe obesity with body mass index (BMI)≥30 (OR: 2.90; 95%CI: 1.72–4.89, p<0.001), hypertension stage 2 (aOR: 1.99; 95%CI: 1.12–3.53, p=0.019) or stage 3 (aOR: 6.59; 95%CI: 2.39–18.17, p<0.001), CKD stage 3 (aOR: 2.50; 95%CI: 1.36–4.59, p=0.003), stage 4 (aOR: 5.47; 95%CI: 2.18–13.69, p<0.001) or stage 5 (aOR: 1.71; 95%CI: 1.04–2.81, p=0.036), and having chronic lung disease (aOR: 3.08; 95%CI: 1.22–7.77, p=0.017) significantly increased the risk of COVID-19 mortality. In contrast, COVID-19 vaccination reduced the risk of COVID-19-associated death. This study highlights that more severe comorbidities, advanced age, and incomplete vaccination were associated with COVID-19 mortality.

Nasal Symptoms of Chronic Rhinosinusitis were Related to Its Nasoendoscopic Findings: A Retrospective Cohort Study at Dr. Soetomo General Academic Hospital, Surabaya Chandra, Christopher Marcellino; Kristyono, Irwan; Soegiarto, Gatot; Nugroho, Puguh Setyo
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.83-87

Highlights: Nasal congestion was the most common symptom presented in CRS patients. Nasal symptoms of CRS were positively associated with nasoendoscopic findings (Polyp, Edema, Secretions). Abstract Introduction: Chronic rhinosinusitis (CRS) is often encountered in Indonesia. Nasal endoscopy, or nasendoscopy, is considered the gold standard for assessing the severity of CRS. However, as nasendoscopy is unavailable in Indonesia, only symptom assessments can be conducted at primary healthcare facilities. This study aimed to elucidate the relationship between nasoendoscopic findings based on the Lund-Kennedy score (LKS) and symptoms in CRS patients based on the visual analogue scale (VAS) score. Methods: This retrospective analytic study evaluated CRS cases identified in the Ear, Nose, and Throat (ENT) Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, from July 2021 to July 2022. Statistical analysis was conducted using Spearman’s rank correlation test to identify the correlation (r) between LKS and the VAS score. Statistical significance was achieved if p<0.05. All statistical tests were conducted using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 26.0 for Windows. Results: A total of 57 CRS patients were included in this study, mostly females (64.9%) and those aged 50–59 years old (26.9%). Nasal congestion was the dominant nasal symptom (80.7%), with mostly moderate symptom severity (VAS 4-7) reported. Across both nasal cavities, the most frequent nasoendoscopic finding among CRS patients was nasal edema (82.4% and 93%). A positive and weak correlation existed between the total VAS score of all symptoms and the total LKS of both nasal cavities (r=0.387, p=0.003). Conclusion: The nasal symptoms of CRS patients were significantly associated with its nasoendoscopic findings (Polyp, Edema, Secretions).

Co-Authors Aldise Mareta, Aldise Alpha Fardah Athiyyah Alphania Rahniayu Anang Endaryanto Anggoro, Adhitri Ari Baskoro Ariani, Grace Atmaja, Peter Yustian Azwin Mengindra Putera Bayu Dharma S Budi Utomo Camilia Metadea Aji Savitri Chairul Effendi Chandra, Christopher Marcellino Cita Rosita Sigit Prakoeswa Damayanti, Luki Agustina Deasy Fetarayani Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dian Ristanti Djoko Poetranto, Djoko Djuanda, Stephanie N. DYAH FAUZIAH, DYAH Edi Suyanto Edith Frederika, Edith Fahmita, Karin Dhia Far-Far, Imanuel Gunawan, Vania A. Handoko Hariyono Hendra Ikhwan Gautama Hermina Novida, Hermina INGRID SURYANTI SURONO Isyroqiyyah, Nur Moya Isyroqiyyah, Nur Moya Konthen, Putu Gedhe Kristyono, Irwan Kurnia, David Kusumastuti, Etty H. Laksmi Wulandari Lefi, Achmad Lilihata, Jilientasia G. Lucia Landia Setyowati, Lucia Landia Lusida, Michael AP. Maharani, Andi RK. Mahdi, Bagus Aulia Marhana, Isnin A. Masaoki Yamaoka, Masaoki Muhammad Amin Mukti Fahimi Nila Kurniasari Noer Halimatus Syakdiyah Nugraha, Ricardo A. Nugroho, Gilang MS. Nugroho, Puguh Setyo Pradhevi, Lukita Rahaju, Anny S. Reinaldi Rachmadhianto Resti Yudhawati Retno Asih Setyoningrum Rinjani, Lalu GP. Ristanti, Dian Rosyid, Alfian N. S.Pd. M Kes I Ketut Sudiana . Saefudin, Rendra P. Semedi, Bambang P. Setiawati, Yuani soedarto soedarto, soedarto Supriadi Supriadi Suwandi Tri Hartini Yuliawati Ummi Maimunah Vincent, Agustinus Wahyu, Dwi Wiratama, Priangga A. Yandi, I KR. Yetti Hernaningsih Yosephi, Valensa Yuani Setiawati

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