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All Journal journal of internal medicine Jurnal Kedokteran Brawijaya Folia Medica Indonesiana Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Narra J JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Keperawatan Jurnal Penyakit Dalam Indonesia

Gatot Soegiarto

Allergy & Clinical Immunology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya

Author-ID : 3289438

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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THE ROLE OF PROBIOTICS AS ADJUVANT THERAPY IN INFLAMMATORY CARDIOVASCULAR DISEASES Yosephi, Valensa; Syakdiyah, Noer Halimatus; Atmaja, Peter Yustian; Soegiarto, Gatot
Jurnal Biosains Pascasarjana Vol. 26 No. 2 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i2.2024.152-164

Cardiovascular diseases are the leading cause of death worldwide. Probiotics are live microorganisms that can provide health benefits to the host when administered in adequate amounts. The anti-inflammatory effects of probiotics were initially studied in Crohn's disease (CD) and ulcerative colitis (UC). This research aim to provide scientific evidence and explanation on the effects of probiotic administration as adjuvant therapy for inflammatory diseases in cardiovascular health. The study employed a descriptive approach using the systematic literature review method on PubMed, Scopus, SAGE, and Web of Science. A total of 13 articles were included in this study. The probiotics used included Bifidobacterium in one clinical trial, Lactobacillus in eight clinical trials, Enterococcus in one clinical trial, a combination of Bifidobacterium and Lactobacillus in one clinical trial, and a combination of Lactobacillus and Propionibacterium in one clinical trial.

LYMPHOCYTE-T TYPE TH1 AND TH2 ACTIVITY DIFFERENCE OF LUNG TISSUE ON Heligmosomoides polygyrus NEMATODE AND Mycobacterium tuberculosis SEQUENTIAL CO-INFECTION Wulandari, Laksmi; Amin, Muhammad; Soedarto, Soedarto; Soegiarto, Gatot
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that are often associated with uneffectiveness of the BCG vaccine and the high worm infection. The objective of this study was to determine the differences in the activity of Limfosit T type Th1 (IFN-g) and Th2 (IL-4) in lung tissue on Heligmosomoides polygyrus nematode and Mycobacterium tuberculosis sequential co-infection. This research using 49 mice were divide into 7 groups treated with infection by Mycobacterium tuberculose inhaled and Heligmosomoides polygyrus orally within 8 and 16 weeks. The levels of IFN-g in peripheral blood serum (89.929 + 3.533 pg/mL) resembles the pattern of the percentage of lymphocytes T CD4+ Th1 in lung tissue (3.246 + 0.519%) and peripheral blood (4.950 + 0.237%), while the levels IL-4 in the peripheral blood serum (20.782 + 4.043%) resembles the pattern of the percentage of lymphocytes T CD4+ Th2 in intestinal tissue (1.048 + 0.359%) and peripheral blood (1.196 + 0.557%). In conclusion, there is difference in the activity of lymphocytes T type Th1 and Th2 but it does not affect the immune response to Mycobacterium tuberculosis infection.

CETIRIZINE SUPPRESSION TO SKIN PRICK TEST RESULTS IN ATOPIC ALLERGY PATIENTS Soegiarto, Gatot; Kurnia, David; Effendi, Chairul; Konthen, Putu Gedhe
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

This study was done to determine the suppression index of Cetirizine to the skin prick test results to obtain a correction constant or factor that can be used to assess the results of the skin prick test in patients who cannot stop the use of antihistamines (Cetirizine). This pre and post test study design clinical trial involved 22 atopic allergy patients who seek medical treatment at the Allergy and Immunology Outpatient Clinic Dr. Soetomo Hospital. Skin prick tests were done twice (SPT1 and SPT2) using house dust mite allergen extract to all study subjecs. The first (SPT1) were done after washout of all antihistamine for 1 week prior the test. All study subjects were then given Cetirizine 10 mg once daily for 5 days and on day 6 we performed the second test (SPT2). Cetirizine suppresion index and correction factor were calculated by comparing the wheal area of SPT1 and SPT2. All 22 study subjects (6 males and 16 females) were sensitized to house dust mite allergen. Mean serum total IgE levels were 176.42 + 352.5 IU/dL. Mean wheal area generated by the positive control (histamine 1 mg/mL) in SPT1 was 7.53 + 7.31 mm2, and in SPT2 was 1.08 + 1.46 mm2. Mean wheal area generated by house dust mite allergen in SPT1 was 43.57 + 36 mm2, and in SPT2 was 10.28 + 8.47 mm2. Cetirizine suppression index for positive controls (histamine 10 mg/mL) was 94.63 + 7.90% (p=0.000), while the Cetirizine suppression index for house dust mite allergen is 72.31 + 13.96% (p=0.000). There was no significant influence of serum total IgE levels to Cetirizine suppression index (p=0.381). The correction constant based on the calculation was 1.9. In conclusion, Cetirizine suppression index to the mean wheals area generated by house dust mite allergen was 72.31% and the correction constant was 1.9. In allergic patients who cannot stop their antihistamine drugs, Cetirizine 10 mg once daily can be used as a replacement and they still be able to undergo skin prick tests. The actual wheal diameter (or area) of the skin prick test results can be calculated by multiplying the measured wheal diameter (or area) under the Cetirizine administration with the correction constant.

GENETIC AND ENVIRONMENTAL FACTORS AS STRONG DETERMINANTS OF ATOPIC ALLERGIC DISEASE CLINICAL MANIFESTATIONS IN SURABAYA'S SCHOOL CHILDREN Soegiarto, Gatot; Damayanti, Luki Agustina; Effendi, Chairul
Folia Medica Indonesiana Vol. 53 No. 3 (2017): September 2017
Publisher : Universitas Airlangga

This case-control study was conducted to assess the relative role of genetic and environmental factors in determining the clinical manifestations of atopy allergy disease in school children, which is part of a large study of the prevalence of allergic diseases in school children in Surabaya. Using a simple multi-stage random sampling, 348 children from 5 elementary schools, 4 junior high schools, and 4 senior high schools in Surabaya were involved in the study. The subjects of the study along with her parents were guided to fill out the modified ISAAC questionnaire and underwent physical examination and skin prick test using 27 common allergen types found in the environment. For the analysis, 110 school children were randomly selected from the parent sample and included in the case group of 55 people (positive skin prick test against > 1 type of allergen), and the control group of 55 people (negative skin prick test). All genetic and environmental factors data were collected and analyzed. Most of the subjects had clinical manifestations of allergic rhinitis (66.36%), asthma (21.82%), food allergies (10.9%), and atopic dermatitis (6.36%). Complete models for multiple logistic regression analysis can only be performed for overall atopic disease and allergic rhinitis disease. The first birth order and exposure to home dust mites were the most significant clinical manifestations of atopy disease (OR 4.548, 95% CI: 1.813-11.410, p=0.01). Atopy status of the father was the only significant determinant factor for the manifestation of allergic rhinitis in the study subjects (OR 3.929; 95% CI: 1.143-13.052, p=0.03). Both genetic and environmental factors interacted and determined clinical manifestations of atopy allergy disease in school pupils. The father's genetic factors were more dominant than maternal genetic factors in determining the clinical manifestations of allergic rhinitis in offspring.

Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation Isyroqiyyah, Nur Moya; Soegiarto, Gatot; Setiawati, Yuani
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient's demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.

Lactiplantibacillus plantarum IS-10506 Enhances Tight Junction Integrity in Bronchial Epithelium: An Experimental Study Fetarayani, Deasy; Soegiarto, Gatot; Surono, Ingrid Suryanti; Endaryanto, Anang; Athiyyah, Alpha Fardah; Hernaningsih, Yetti; Fauziah, Dyah; Sudiana, I Ketut; Utomo, Budi; Prakoeswa, Cita Rosita Sigit
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2995

BACKGROUND: Airway epithelium constitutes the initial structural defense against inhaled allergens, with its integrity primarily maintained through the formation of tight junctions (TJ) consisting of claudins, occludins, and zonula occludens (ZO). Currently, the effects of probiotics on airway TJ remain unclear. Therefore, this study was conducted to explore the impact of Lactiplantibacillus plantarum IS-10506, a native probiotic from Indonesia, on bronchial epithelial TJ in a mouse model of allergic airway inflammation.METHODS: Twenty-four BALB/c mice were randomly assigned to three groups: negative control, positive control subjected to Dermatophagoides pteryonissinus (Der p) sensitization and challenge, and treatment group exposed to Der p and administered L. plantarum IS-10506 since one week before sensitization up to three weeks after. The expression levels of claudin-18, occludin, and ZO-1 were investigated through immunohistochemistry analysis and quantified based on the immunoreactive score (IRS). RESULTS: The results of this study demonstrated that L. plantarum IS-10506 significantly enhanced the expressions of claudin-18, occludin, and ZO-1 (p<0.05).CONCLUSION: These findings underscore the probiotic's role in fortifying the integrity of airway TJ.KEYWORDS: allergic inflammation, probiotic Lactiplantibacillus plantarum, immunology, respiratory system, tight junction, occludin, claudin, zonula occludens

Co-Authors Aldise Mareta, Aldise Alpha Fardah Athiyyah Alphania Rahniayu Anang Endaryanto Anggoro, Adhitri Ari Baskoro Ariani, Grace Atmaja, Peter Yustian Azwin Mengindra Putera Bayu Dharma S Budi Utomo Camilia Metadea Aji Savitri Chairul Effendi Chandra, Christopher Marcellino Cita Rosita Sigit Prakoeswa Damayanti, Luki Agustina Deasy Fetarayani Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dian Ristanti Djoko Poetranto, Djoko Djuanda, Stephanie N. DYAH FAUZIAH, DYAH Edi Suyanto Edith Frederika, Edith Fahmita, Karin Dhia Far-Far, Imanuel Gunawan, Vania A. Handoko Hariyono Hendra Ikhwan Gautama Hermina Novida, Hermina INGRID SURYANTI SURONO Isyroqiyyah, Nur Moya Isyroqiyyah, Nur Moya Konthen, Putu Gedhe Kristyono, Irwan Kurnia, David Kusumastuti, Etty H. Laksmi Wulandari Lefi, Achmad Lilihata, Jilientasia G. Lucia Landia Setyowati, Lucia Landia Lusida, Michael AP. Maharani, Andi RK. Mahdi, Bagus Aulia Marhana, Isnin A. Masaoki Yamaoka, Masaoki Muhammad Amin Mukti Fahimi Nila Kurniasari Noer Halimatus Syakdiyah Nugraha, Ricardo A. Nugroho, Gilang MS. Nugroho, Puguh Setyo Pradhevi, Lukita Rahaju, Anny S. Reinaldi Rachmadhianto Resti Yudhawati Retno Asih Setyoningrum Rinjani, Lalu GP. Ristanti, Dian Rosyid, Alfian N. S.Pd. M Kes I Ketut Sudiana . Saefudin, Rendra P. Semedi, Bambang P. Setiawati, Yuani soedarto soedarto, soedarto Supriadi Supriadi Suwandi Tri Hartini Yuliawati Ummi Maimunah Vincent, Agustinus Wahyu, Dwi Wiratama, Priangga A. Yandi, I KR. Yetti Hernaningsih Yosephi, Valensa Yuani Setiawati

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