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All Journal Sainstek Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Nusantara Medical Science Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Contemporary Nursing Journal (ICON Journal) Jurnal Ilmu Alam dan Lingkungan Jurnal Biomedika Indian Journal of Forensic Medicine & Toxicology
Rosdiana Natzir
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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A Prototype N95 Sterilizer: An Alternative Solution during Personal Protective Equipment Crisis Azhar, Muh. Aprizal; Natzir, Rosdiana; Sjahril, Rizalinda; Palantei, Elyas; Katu, Sudirman; Hidayah, Najdah; Massi, Muhammad Nasrum
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.37427

Abstract

The high demand for N95 masks, especially during the COVID (Coronavirus disease)-19 pandemic, has caused shortages worldwide. This study aimed to examine the sterilization ability of the portable sterilizer prototype for N95 masks and its effect on the filtration ability and changes in air resistance on the N95 mask in order to thrift personal protective equipment (PPE) use during a shortage. The sample used was an N95 mask type 1860. The mask was contaminated with 0.6-0.8 MFU Staphylococcus aureus and Escherichia coli. The sterilization methods used were Ultraviolet Germicidal Irradiation (UVGI), Heat at 75°C, and a combination of both from 1 to 120 minutes. Next, the masks were cultured in a nutrient agar medium. For aerosol penetration and air resistance tests, masks were tested before and after the sterilization process, lasting from 5 to 60 minutes. This prototype sterilizer with Heat effectively killed E. coli and S. aureus starting from 3 minutes. The filtration ability of the N95 mask was maintained at >95% even after the sterilization process with 75°C heat, UVC, or a combination of both for up to 60 minutes. There was also no significant difference in air resistance between new masks and masks that had been sterilized using a portable sterilizer. This prototype sterilizer with Heat at 75°C can effectively sterilize against both gram-positive and negative bacteria in the N95 mask without reducing the aerosol filtration ability and changing the air resistance of the N95 mask.
Andrographis paniculata Leaf Extract Increases Interleukin-2 in Malnutrition Rat Model Dwiningsih, Fortuna; Natzir, Rosdiana; Ilhamuddin, Ilhamuddin; Yustisia, Ika; Sulfahri, Sulfahri
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.2950

Abstract

BACKGROUND: Malnutrition is a global health concern that results in changes in nutritional status, as indicated by alterations in phenotypic markers, hematological and biochemical parameters, and increased susceptibility to infection, as shown by decreased interleukin (IL)-2 levels. Andrographolide, the active component of Andrographis paniculata, stimulates the immune system and exhibits antibacterial and antiviral activity. Therefore, A. paniculata may serve as a potential adjuvant therapy for malnutrition. This study was conducted to analyze the effect of A. paniculata as an immunomodulator against malnutrition with characteristics of environmental enteric dysfunction (EED) and a low-protein diet by examining phenotypic markers, hematological, biochemical, and IL-2 levels.METHODS: Forty-five male Wistar rats were divided into seven groups. They were fed either a standard or a low-protein diet before receiving oral administration of various concentrations of A. paniculata leaf extract (APLE). APLE was administered 21 days after the initial low-protein diet. Hematological, biochemical, and phenotypic markers were assessed to determine the nutritional status of the rats. The protective effects of APLE were evaluated by measuring IL-2 levels using enzyme-linked immunosorbent assay (ELISA).RESULTS: Malnourished rats exhibited slow body growth, physical and behavioral changes, reduced leukocyte count, total protein, albumin, cholesterol, and villi length. Malnourished rats treated with APLE showed a more effective and significant increase in IL-2 levels, with higher concentrations of APLE resulting in higher IL-2 levels.CONCLUSION: APLE, in a concentration-dependent manner, can increase IL-2 levels, suggesting that APLE may have potential protective effects in a rat model of malnutrition.KEYWORDS: Andrographis paniculata, environmental enteric dysfunction, interleukin (IL)-2, low protein, malnutrition
Co-Authors A. Jayalangkara Tanra Ade Rifka Junita Ahyar Ahmad Ahyar Ahmad Alfina Baharuddin Ami Febriza Andi Asadul Islam Azhar, Muh. Aprizal Budu - Bukhari, Agussalim Burhanuddin Bahar Burhanuddin Bahar Chyntia Novita Kalalo Dwiningsih, Fortuna Elly Lilianty Sjattar Elmiana Bongga Linggi Fatmawati Annisa Syamsuddin Fatmawati Badaruddin Firdaus Hamid Gemini Alam Hidayah, Najdah Ibrahim Labeda Ilhamjaya Patellongi Ilhamuddin Aziz Ilhamuddin Ilhamuddin, Ilhamuddin Khairuddin Djawad Kusrini S. Kadar Luthfi, Muhammad M. Sabir Marcellus Simadibrata Meyke Tiku Pasang Mochammad Hatta Mochammad Hatta Mochammad Hatta Mochammad Hatta Muh. Nasrum Massi Muhammad Reza Primaguna Mushawwir Taiyeb Nuchrawi Nawir Nur Indah Purnamasari Nuralifah Nuralifah, Nuralifah Nurpudji Astuti Tazlim Palantei, Elyas Parawansah Parawansah Prihantono Prihantono Ressy Dwiyanti Ridwan Ridwan Rina Masadah Rinda Nariswati Riza Linda Sri Manovita Pateda Sri Wahyu Sri Wahyuni Sudirman Katu, Sudirman Sulfahri, Sulfahri Tjahjadi Robert Tedjasaputra Yustisia, Ika Yuyun Widaningsih