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All Journal BALI MEDICAL JOURNAL (BMJ) journal of internal medicine Majalah Ilmiah Peternakan E-Jurnal Medika Udayana Jurnal Veteriner ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bali Medika Jurnal Journal of Global Pharma Technology Biosaintifika: Journal of Biology & Biology Education
Anak Agung Ngurah Subawa
Bagian Patologi Klinik RSUP Sanglah Fakultas Kedokteran Universitas Udayana/Rumah Sakit Umum Pusat Sanglah Denpasar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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KARAKTERISTIK FERITIN SERUM PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS DI RSUP PROF. DR. I.G.N.G. NGOERAH Wikananda, Made Argyanta; Herawati, Sianny; Mulyantari, Ni Kadek; Subawa, Anak Agung Ngurah
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P04

Abstract

Penyakit ginjal kronik (PGK) sebagai permasalahan kesehatan global dengan resiko terjadinya kematian. Abnormalitas pada struktur ginjal menyebabkan adanya penurunan fungsi ginjal dengan kerusakan pada histologi dan penurunan laju filtrasi glomerulus. Faktor yang mempengaruhi terjadinya PGK antara lain usia tua, diabetes, hipertensi, obesitas, penyakit kardiovaskular dan pola hidup tidak sehat. Perkembangan medis telah mengembangkan pergantian fungsi ginjal dengan menggunakan alat berfungsi sebagai ginjal buatan yang dinamakan hemodialisis. Pemeriksaan feritin serum dan saturasi transferin menjadi parameter laboratorium paling umum. Rancangan penelitian deskriptif observasional dengan menggunakan metode potong lintang. Sampel total dipilih sebagai metode pengambilan sampel. Subjek PGK pada penelitian ini berjumlah 143 orang dengan feritin serum tinggi yaitu 113 orang (79%) distribusi pasien terbanyak ditemukan pada jenis kelamin perempuan yaitu 58 orang (40.6%), Pada kelompok usia dengan feritin serum tinggi terbanyak pada kelompok lansia awal (46-55 tahun) berjumlah 31 orang (21,7%). Berdasarkan lama menjalani hemodialisis terbanyak menjalani hemodialisis >5 tahun yaitu 57 orang (39,9%), Riwayat penyakit terdahulu didapatkan banyak mengalami hipertensi yaitu 29 orang (20,3%). Seluruh pasien mengalami derajat PGK yang sama yaitu stadium 5. Pasien PGK yang menjalani hemodialisis dominan mengalami feritin serum tinggi. Ditemukan pada jenis kelamin perempuan, kelompok usia lansia dewasa dengan lama menjalani hemodialisis >5 tahun dan memiliki riwayat penyakit terdahulu yakni hipertensi. Kata kunci : feritin serum, PGK, Hemodialisis
Karakteristik Hasil Pemeriksaan Hematologi dan Kecepatan Pemulihan Pasien DBD di RSUD Bali Mandara Tahun 2019-2020 Nugraha, Ketut Yoga Wira; Subawa, Anak Agung Ngurah; Herawati, Sianny; Mulyantari, Ni Kadek
E-Jurnal Medika Udayana Vol 11 No 10 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i10.P05

Abstract

ABSTRACT Dengue Hemorrhagic Fever (DHF) as one of the most common infectious diseases in the world is still a major concern even though the incidence and mortality rates have decreased. The study objective is to determine hematological examination results and the speed of recovery of DHF patients reviewed according to age, gender, BMI, degree of DHF, and duration of fever before being treated. This was cross-sectional study using secondary data from medical records of 193 DHF patients treated from year 2019 to 2020. In 193 patients, before being admitted to the hospital, the patient had an average fever for 4.12±1.16 days with an average 4.69±1.2 days of hospitalization. Hematological test on hospital admission showed the average platelet value was 83.06±28.74 x103 cells/µL with 187 (96.9%) patients had platelet values below the normal value. Average leukocyte count was 4.13±2.01 x 103 cells/µL with 126 (65.3%) patients having a leukocyte value below the normal value. Average hematocrit value was 40.31±4.96% with 113 (58.6%) patients had normal hematocrit values. The duration of hospitalization for DHF patients had a significant difference when viewed according to age (p=0.000), BMI (p=0.000), and duration of fever before being treated (p=0.000). The mean platelet values were significantly different when compared according to the duration of fever before being treated (p=0.018). The mean leukocyte values were significantly different when compared according to age (p=0.007) and gender (p=0.008). The mean hematocrit value was significantly different when compared according to age (p=0.000) and gender (p=0.008). Keywords: Dengue hemorrhagic fever, hematological examination, duration of hospitalization
PERAN KOLOSTRUM FORMULA SAPI KOMERSIAL (PIGSTRUM®) SEBAGAI IMMUN FACTOR DAN GROWTH FACTOR DALAM MENGATASI KEJADIAN DIARE DAN PERTUMBUHAN ANAK BABI PRA-SAPIH I B K, Ardana; D K H, Putra; A A N, Subawa
Majalah Ilmiah Peternakan Vol 19 No 2 (2016): Vol 19, No 2 (2016)
Publisher : Fakultas Peternakan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.543 KB) | DOI: 10.24843/MIP.2016.v19.i02.p03

Abstract

Penelitian ini bertujuan untuk menguji respon kolostrum formula sapi komersial (Pigstrum) dalam mengatasikejadian diare pada anak babi pra-sapih. Sebanyak 45 ekor anak babi dikelompokkan secara acak menjadi tigakelompok. Sebagai kontrol (P0) sebanyak 15 ekor anak babi diberi aquades (placebo) pada umur 2 hari. 15 ekoranak babi yang diberi Pigstrum secara oral (cengkok) sebanyak 1 ml/ekor umur 2 hari sebagai perlakuan 1 (P1) dan15 ekor anak babi yang diberi Pigstrum sebanyak 2 ml/ekor umur 2 hari sebagai perlakuan 2 (P2). Pengamatangejala diare pada anak babi sampai umur 30 hari. Hasil penelitian menunjukkan bahwa pemberian pigstrum dosis2 ml/ekor mulai umur 2 hari dapat menurunkan kejadian diare menjadi 26,7 % dan pertambahan berat badansebesar 6,7 Kg pada umur 30 hari. Namun, menggunakan analisis sidik ragam terhadap rataan pertambahan beratbadan anak babi umur 30 hari dan uji Chi-Square terhadap persentase rataan kejadian diare anak babi pra-sapihmenunjukkan perbedaan yang tidak signifikan di antara semua kelompok perlakuan (P>0,05). Dapat disimpulkanbahwa pemberian kolostrum formula pada anak babi prasapih menurunkan kejadian diare dan respon peningkatanberat badan.
The Role of Sembung (Blumea balsamifera) Leaf Extract in Preventing Atherosclerosis in Hyperlipidemia Rat Models I Made Jawi; I Wayan Putu Sutirta Yasa; I Gede Widhiantara; Anak Agung Ngurah Subawa; Putu Angga Wiradana; Naw, Sin War
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 2 (2024): August 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i2.6673

Abstract

This study aims to prove that administering BBLE as a natural antioxidant can prevent atherosclerosis by maintaining lipid profiles, antioxidant enzymes, and netrin-1 levels in hyperlipidemia in rat models. The research subjects were 20 adult male Wistar rats (Rattus norvegicus), which were divided into 2 groups using a randomized pretest and posttest control group design. Before treatment and after treatment for 3 months, lipid profiles, MDA, SOD, and netrin-1  were examined. The control group was only given high-cholesterol diets (HCD), while the treatment, apart from HCD, was also given BBLE 4mg/day. The data obtained was tested using paired t-test and group t-test. The results of the study showed that there was a significant decrease in netrin-1 in the control group (p<0.05) after being given HCD for three months. In the treatment group, it also decreased but it was not significant (p>0.05). Netrin-1 levels in the treatment group were higher than the control (p<0.05). The lipid profile experienced a significant increase in HDL in the treatment group accompanied by a significant decrease in MDA and an increase in SOD (p<0.05) when compared with the control group. This study concludes that administering BBLE at a dose of 4 mg/day to rats given HCD caused an increase in netrin-1 levels accompanied by improvements in lipid profiles and prevention of oxidative stress. The findings of this study reveal the novelty of BBLE in treating and maintaining blood vessel function in mice given HCD by increasing netrin-1 levels.
Correlation of Pancreatic Stone Protein (PSP) with Procalcitonin in Early-Onset Neonatal Sepsis (EONS) Patients Desak Laksmi; I Nyoman Wande; Anak Agung Ngurah Subawa; Sianny Herawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini; I Made Kardana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2425

Abstract

Sepsis is defined as a systemic condition that arises from bacterial, viral or fungal infection, associated with hemodynamic changes and clinical findings that cause high morbidity and mortality. Neonatal sepsis that occurs 72 hours after birth is called early-onset neonatal sepsis (EONS). Procalcitonin is secreted by various tissues and is a marker of the acute phase of systemic reactions. Pancreatic stone protein (PSP) is a novel marker for identifying sepsis. High PSP levels are associated with more severe sepsis conditions. This analytical observational study aimed to determine the correlation between PSP levels and procalcitonin levels in patients with EONS. The study was conducted at the Clinical Pathology Laboratory of Ngoerah Hospital, Denpasar and the Integrated Biomedical Laboratory of the Faculty of Medicine, Udayana University from May 2024 to July 2024. The subjects in this study were 48 EONS patients undergoing treatment at Ngoerah Hospital who met the inclusion criteria. The results of the Spearman correlation test revealed a moderate correlation between PSP levels and procalcitonin levels in EONS patients (r = 0.581; p <0.001). Furthermore, multivariate analysis revealed that PSP levels significantly influenced procalcitonin levels after controlling for confounding variables (B = 0.137; 95% CI 0.101-0.174; p <0.001). These findings highlight the potential of PSP as a reliable marker in diagnosing sepsis and suggest that further exploration in this area could enhance our understanding of neonatal sepsis management.
Co-Authors Ali Djamhuri Anak Agung Wiradewi Lestari Anggraeni Suarsana Ardana I B K, Ardana Christian Nurtanto Putra Claudia Anastasia Desak Gde Diah Dharma Santhi Desak Laksmi Dewa Ayu Putu Rasmika Dewi Dewa Ngurah Suprapta Felicia Suryanto Gopi Krishnan I Dewa Ketut Harya Putra I Gede Soma I Gede Widhiantara I Gusti Kamasan Arijana I Made Bagus Cahya Wibawa I Made Dwikayana I Made Jawi I Made Kardana I NYOMAN MANTIK ASTAWA I Nyoman Wande I Wayan Agus Surya Pradnyana I Wayan Putu Sutirta Yasa I.B.GDE ANANTA MAHESVARA Ida Ayu Putri Wirawati Ida Bagus Komang Ardana Ida Bagus Ngurah Indira Pratiwi Kadek Pipin Rahina Soethama Ketut Suega Komang Agus Widhy Utama Putra Komang Vika Nariswari Ratna Kinasih Made Wulan Utami Dewi Made Yuliantari Dwi Astiti Mahardika, Ketut Indah Karina Naw, Sin War Ni Kadek Mulyantari Ni Kadek Nita Utami Ni Made Evitasari Dwitarini Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Yuliantini Nugraha, Ketut Yoga Wira Putra D K H, Putra Putu Angga Wiradana Putu Ayu Krisna Cahyaning Putri Putu Bihan Surya Kinanta Putu Devita Sucitawati Putu Purna Astika Utama Raka-Sudewi A. A. S. Herawati, S. Sari, Lia Cahya Sianny Herawati Sianny Herawati Stephanie Inge Wijanarko Sudewa Djelantik Tjokorda Gede Oka Wikananda, Made Argyanta