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All Journal Diponegoro Law Journal Journal of Agromedicine and Medical Sciences Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Buletin Poltanesa Jurnal Industri Pariwisata Solo Journal of Anesthesi, Pain and Critical Care Jurnal Rekonstruksi dan Estetik Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS) Folia Medica Indonesiana Jurnal Veteriner
Laksmi Indreswari
Anatomi, Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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A Meta-Analysis of 80% Fraction of Inspired Oxygen on Surgical Site Infection in Patients Undergoing Surgery Erisadana, Rifaldy Nabiel; Tohari, Achmad Ilham; Supranoto, Yehuda Tri Nugroho; Utami, Wiwien Sugih; Indreswari, Laksmi
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 3, No 1 (2023): April 2023
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v3i1.62251

Abstract

Background: WHO recommended the use of 80% FiO2 in patients undergoing general anesthesia with endotracheal intubation (ETI) to prevent surgical site infection (SSI). However, the ongoing debate regarding efficacy and safety raises because further trials have been published. We conducted a review based on recommendations in terms of SSI as the primary outcome and adverse events as the secondary outcome in both patients with or without ETI.Method: A literature search was carried out by PubMed, ScienceDirect, and Google Scholar for RCTs in all-type surgical patients who administrated 80% FiO2 compared with 30–35% FiO2. Pooled relative risks with a 95% confidence interval were conducted for meta-analysis. Result: Based on 23 RCTs included in the analysis, there were no significant differences in terms of SSI (RR,0.85; 95%CI, 0.72 to 1.01; p=0.07), sepsis (RR,1.47; 95%CI, 0.78 to 2.76; p=0.23), postoperative hospitalization days (PHD) (RR,0.16; 95%CI, -0.67 to 0.98; p=0.71), ICU admission (RR,0.94; 95%CI, 0.78 to 1.13; p=0.50), reoperation required (RR,0.78; 95%CI, 0.30 to 2.06; p=0.62), and 30-days mortality (RR,1.18; 95%CI, 0.76 to 1.84; p=0.45). In contrast, even though the subgroup analysis showed association that PHD longer in high FiO2 group for colorectal surgery (RR,0.80; 95%CI, 0.24 to 1.35; p=0.005), the high FiO2 significantly reduced SSI and anastomotic leakage in abdominal surgery (RR,0.78; 95%CI, 0.62 to 0.99; p=0.04 and RR,0.55; 95%CI, 0.36 to 0.85; p=0.008).Conclusion: This meta-analysis provides evidence that administration of 80% FiO2 even though association with longer of PHD in colorectal surgery, it is associated with a reduction in SSI and anastomotic leakage in patients who underwent abdominal surgery. It contrasts for sepsis, ICU admission, reoperation required, 30-day mortality, SSI, and PHD in all-type surgery. 
Co-Authors Adinningtyas Intansari Adji, Novan Krisno Ahmad Baihaqi Al Munawir Alif Mardijana Ancah Caesarina Novi Marchianti Ani Purwanti Anisa Rizca Putri Aris Prasetyo Aris Prasetyo Bagus Hermansyah Baladraf, Thabed Tholib BJ Azmy As'ady Cholis Abrori, Cholis Desie Dwi Wisudanti Dicky Setiawan Dini Agustina Dwita Aryadina Rachmawati El Milla, Kardiana Izza ENNY SUSWATI Erisadana, Rifaldy Nabiel F P H, Fransiska Nooril Habibi, Ali Hairrudin Hairrudin Handoko, Adelia Ida Bagus Suryaningrat Jauhar Firdaus Kristianningrum Dian Sofiana Lathifa Rusyda Gani Laylatul Fitriah Mukarromah Luh Putu Ratna Sundari M.S. Irham Rozaq Murniati, Yunita Nadie Fatimatuzzahro Nugraha, Muhammad Yuda Pipiet Wulandari Pralampita, Pulong Wijang Pranata, Dadin Gilang Prasetyo, Aris Purnomo, Farah Fadhila Nasywa Putri, Komang Yunita Wiryaning Rahmad Adi Prasetyo Rena Normasari Rendra Chriestedy Prasetya Rofifah, Salma Putri Rokhani Rokhani Rozaq, M.S. Irham Rusdianto, Andrew Setiawan Safitri, Raghda Gita Sampurna, Hadi septa surya wahyudi, septa surya Setia, Bagus Sofiana, Kristianingrum Dian Supangat Supangat Supangat Supangat Supranoto, Yehuda Tri Nugroho Suryono Suryono Tohari, Achmad Ilham Tristianti, Farmitalia Nisa Ulfa Elfiah Winda Amilia Wiwien Sugih Utami Yunita Armiyanti Yunita Dewi Anggraeni