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Iis Siti Jahro
Universitas Negeri Medan
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Journal : Jurnal Sains dan Teknologi

 1 
Analisis Perkembangan dan Inovasi Senyawa Kompleks sebagai Agen Terapeutik dan Diagnostik dalam Kedokteran Meli Sartika Silaban; Iis Siti Jahro
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 5 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i5.6498

Abstract

Research advances in coordination chemistry have opened up significant opportunities for the development of complex compounds as therapeutic and diagnostic agents in medicine. This literature review aims to examine several important innovations that are beneficial in chemical and medical knowledge literacy, especially the literacy of cancer therapy applications using platinum, gold, ruthenium, gadolinium, technetium, and bismuth derivatives that have developed into first-line treatments for internal organ cancers such as ovarian, testicular, gastric, and lung cancer. The method used is descriptive qualitative research utilizing international journals and textbooks to support the literature review. The results of the study show the study of the use of metal-based compounds such as platinum, ruthenium, gold, bismuth, technetium, and gadolinium with broad potential, both as chemotherapeutic agents, anti-inflammatory, radiotherapy, and medical imaging contrast agents. This review discusses various procedures for the synthesis of these complex compounds and challenges such as drug resistance, toxicity, and limited bioavailability that remain major obstacles in their application. Therefore, it is necessary to develop the synthesis of complex compounds using innovative ligands that can increase selectivity, reduce toxicity, and improve bioavailability. Based on the results of the literature review, it was concluded that the integration of nanotechnology and coordination chemistry is recommended to improve therapeutic and diagnostic effects in medicine.
Co-Authors Adelia Yesya Putri Hasibuan Agnes Yuniarty Simbolon Amalia, Meisya Angin, Jansen Riko Perangin Ani Sutiani Ani Sutiani Anisa Nursalsabillah Nasution Annisa Rahayu Annisa Rahayu Ardiansyah Ardiansyah Asep Wahyu Nugraha Asep Wahyu Nugraha Aulianti, Dita Ayi Darmana Ayi Darmana Ayi Darmana, Ayi Banu Nursanni Bohari M. Yamin Bohari M. Yamin Br Bangun, Kurnia Wati Catur Kurniawan CINDY CINDY Daeli, Dinastini Damanik, Syifa Namira Debora Putri Sitorus Debora Putri Sitorus Desri Berliana Daeli Djulia Onggo Djulia Onggo Djulia Onggo Dwi Rahmanisa Efrio Angelina Sitio Esther Jacoba Martha Vertelman Fadhila, Nabila Nur Fahimah Martak Fitria Febrianti, Fitria Gavril Orlando Tumio Manalu Gurning, Mita Agresia Hutagalung, Tien Parsaulian Hutagaol, Rahul Hutauruk, Rafli Intan Ayu Safitri Intan Fahira Yuzan Ismunandar Ismunandar . Ismunandar Ismu Izwani, Putri Khairi Jasmidi Jasmidi Jasmidi Juwitaningsih, Tita Khaira, Mutiah Khuzaimah Dasopang Maibang, Siti Rahmah MANIK, INDA WATI Manullang, Marisa Marham Sitorus Marpaung, Mutiara Evelin Yoseva Meli Sartika Silaban Moondra Zubir Nasution, Anisa Nursalsabillah Nasution, Fadiya Malona Nursanni, Banu Petra van Koningsbruggen Pratama, Muhammad Rizky Putri Faradilla Putri Yustika Sary Ratu Evina Dibyantini Ratu Evina Dibyantini Regina Gresella Br Panjaitan Retno Dwi Suyanti Rode Juwita Sinaga Sakinah, Sheila Saragih, Innovayani Sarah, Arina Sami Sary, Putri Yustika SATI, NAFFA Sembiring, Niki Arih Ersada Br Sembiring, Silvia Gressiela Br Siahaan, Suria Bersinar Sihombing, Cindy Monalisa Sijabat, Hotman Priwaldi SIMANJUNTAK, PUTRINA Simanullang, Selafionita Simaremare, Happy G. Maritoma Siregar, Anggita Rahma Siregar, Eka Guspi Anti Sitorus, Francisca T. A Situmorang, Elsa Hasri Novensa Sri Adelia Sari Suryani Suryani Suryani Suryani Susanto Imam Rahayu Susanto Imam Rahayu Sutiani, Ani Syafitri, Amelia Syahputra, Ricky Andi Tama, Gita Citra Tania Evelin Turnip, Yulika Hotrina Vebilla May Ningsih Veronika, Christy Chirona Windayani, Neneng