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All Journal BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Majalah Kedokteran Andalas Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Jurnal Implementa Husada Jurnal Pandu Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Pengabdian Ilmu Kesehatan
Nuralita, Nanda Sari
UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Cholesterol Levels in Angiotensin Converting Enzyme Gene Polymorphisms in Schizophrenia Patients Isra Thristy; Nanda Sari Nuralita; Debby Mirani Lubis
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.8330

Abstract

Abstract: Angiotensin-converting enzyme (ACE) is widely distributed on the surface of endothelial and epithelial cells. The renin-angiotensin system in the brain has implications for various functions, including cerebral blood circulation and brain protection, stress, depression, and the aetiology of schizophrenia. ACEs and angiotensin receptors can be found on dopaminergic neurons in the basal ganglia. Elevated levels of triglycerides and cholesterol can also be found in schizophrenic patients related to treatment and duration of the course of the disease. The purpose of this study was to determine the relationship between ACE gene polymorphism and cholesterol levels in schizophrenia patients. The design of this study was observational analytic with a cross-sectional approach. The sample in this study was schizophrenia patients who sought treatment at Madani Medan Hospital with a total of 42 people. The data obtained is then processed with the ANOVA one-way test. The results of the study were obtained from 42 samples, the most types of ACE gene polymorphisms were type II (76.2%), followed by the type of DD polymorphism (19%) and the least was the type of ID polymorphism (4.8%). The average value of cholesterol levels of the sample was 235.40 mg/dl with a standard deviation value of 47.618. Statistical test results of ACE gene polymorphism with cholesterol levels with p = 0.770 (p 0.05). It can be concluded that there is no relationship between the polymorphism of the ACE gene and the cholesterol levels of schizophrenic patients.
Hubungan Efek Metabolik dan Hormon Kortisol Terhadap Pasien Gangguan Ansietas yang Berobat di Poli Psikiatri RS Madani Medan Nanda Sari Nuralita
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p886-893.2023

Abstract

Pendahuluan: Gangguan ansietas merupakan suatu kondisi yang sering dijumpai pada masyarakat secara umum. Gangguan ansietas jangka panjang dapat menyebabkan peningkatan hormon adrenalin sehingga terjadi peningkatan asam lemak bebas dan kadar glukosa darah, dan juga menyebabkan pelepasan hormon kortisol, yaitu hormon glukokortikoid yang disintesis dari kolesterol di korteks adrenal, yang dapat memberikan dampak negative terhadap efek kardiovaskular, metabolisme dan pernapasan. Kortisol umumnya dikenal sebagai "hormon stres", yang hanya dilepaskan selama kondisi stres. Tujuan: tujuan penelitian ini unutuk melihat hubungan antara efek metabolik terhadap peningkatan hormon kortisol pada pasien yang mengalami gangguan ansietas. Metode: penelitian merupakan penelitian analitik numerik dengan cara cross sectional, cara pengambilan sampel dengan cara non probability sampling jenis consecutive sampling, dengan jumlah sampel sebanyak 25 orang. Hasil: Terdapat perbedaan bermakna antara gangguan ansietas terhadap peningkatan kadar gula darah (p=0.001, r =0,625) dan kadar kolesterol (p<0.001, r=0,717). Tidak Terdapat perbedaan yang bermakana antara gangguan ansietas terhadap peningkatan hormone kortiso dengan nilai P=0.366, r=0,189. Kesimpulan: Dijumpai perbedaan bermakna antara gangguan ansietas terhadap peningkatan kadar gula darah dan kolesterol, tidak dijumpai perbedaan yang bermakana antara gangguan ansietas terhadap peningkatan hormon kortisol.
PERBEDAAN TINGKAT KECEMASAN ANTARA SISWA YANG TERPAPAR PORNOGRAFI DENGAN SISWA YANG TIDAK TERPAPAR PORNOGRAFI DI SMA X KOTA MEDAN RIZANA, RARA; NURALITA, NANDA SARI; NURHASANAH, NURHASANAH
JURNAL ILMIAH SIMANTEK Vol 7 No 4 (2023): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Anxiety is a feeling of unclear, unpleasant feeling, excessive worry, fear, surprise and helplessness that can interfere daily life. One of the things that can cause anxiety is exposure to pornography. With the development of technology, pornography is not only consumed by adults but can be freely accessed by children and adolescents. Indonesia itself is ranked third with the most access to pornography in the world. In research on adolescents aged 18 years and over, it was found that the prevalence of anxiety, depression and stress caused by addiction to watching pornography reached up to 13.5%. In addition, exposure to pornography in children and adolescents, whether intentional or unintentional, will greatly affect the brain, mentality and behavior. This type of research is an observational analytic study with a cross-sectional study design of students at SMA X Medan City. The sample is 207 people collected using the Simple Random Sampling technique Probability Sampling method. This study uses primary data by providing a questionnaire using the Google form. The result of this research obtained by most respondents aged 17 years (60.5%), sex dominated by women (67.1%). The highest level of anxiety for those who exposed to pornography is mild anxiety (24.3%), likewise with students who were not exposed to pornography, the level of mild anxiety also obtained the highest number (32.4%). The results of the analysis of differences in anxiety levels between those who exposed to pornography and those who not exposed to pornography were P = 0.000 (P <0.05). In this study there were differences in the level of anxiety between students who were exposed to pornography and students who were not exposed to pornographic content at SMA X Kota Medan.
Differences in Sleep Quality of Schizophrenia Patients Based on Gender at Madani Hospital Medan, North Sumatra Zulhilmi, Zulhilmi; Nuralita, Nanda Sari; Rizaldi, Aril; Asfur, Robitah
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.16340

Abstract

Abstract: Schizophrenia is a severe mental disorder, this disorder is characterized by delusions, hallucinations, thought disorder, restlessness, strange or hostile behaviour, feeling (affect) dull or flat, interest away from social interactions, little emotional contact (quiet, difficult to talk to), passive, apathetic or indifferent, difficult to think abstractly and lose of motivation. Sleep disturbances have been assessed in various studies in patients with schizophrenia, using subjective (ie daily interviews, sleep diaries) and objective (ie, polysomnography and actigraphy) parameters. Compared with healthy controls, patients with schizophrenia exhibit longer sleep onset latency, decreased sleep efficiency, more nighttime awakenings, increased daytime dysfunction due to sleep deprivation, poorer overall sleep quality, and a higher proportion of sleep disturbances. Previous studies have suggested that poor sleep quality is associated with female gender in schizophrenic patients. This study aims to determine the difference in sleep quality of schizophrenia patients based on gender at Madani Hospital Medan, North Sumatra. This study is an analytical descriptive with a cross-sectional study approach, sampling method using a purposive sampling technique. The data of this study were obtained from primary data using questionnaire instruments and patient medical records. Data analysis using Chi-Square test. The results showed that the sleep quality of male research respondents with disturbed sleep quality was found in 18 people (51.4%), and undisturbed sleep quality was found in 17 people (48.6%). Of female research respondents, 22 people (62.9%) had disturbed sleep quality and 13 people (37.1%). The p-value was found to be 0.334 (p0.05), which means that there was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra. There was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra.
The Relationship of Cognitive Function to Nutritional Status and Blood Pressure in the Tegal Sari Mandala Village, Medan City Nuralita, Nanda Sari; Damayanti, Amelia Eka
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.3316

Abstract

Cognitive function is an intellectual function that plays a role in carrying out daily activities. The main risk factor for impaired cognitive function is hypertension. In addition, nutritional status also influences cognitive function disorders. Currently, in Indonesia, people with increased blood pressure and unbalanced nutritional status are often found, and without realizing it can have a bad influence on cognitive function. This is a categorical analytic study with a cross-sectional method, the sampling method is non-probability sampling with consecutive sampling types, with a sample of 40 people. There is a significant difference between the difference in blood pressure on cognitive function and there is also a significant difference between nutritional status on cognitive function with a P-value = 0.001. There is a significant difference between cognitive function on blood pressure and weight gain
Hubungan Tingkat Kecacatan dengan Derajat Depresi pada Penderita Kusta di SiCanang, Belawan, Sumatera Utara Batubara, Dian Erisyawanty; Nuralita, Nanda Sari
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.3329

Abstract

Leprosy and the disability it causes, have a negative stigma in community; however only a few reports have investigated the link between leprosy and psychiatric morbidity such as depression. This study aimed to asses correlation between leprosy disability grade and depression severity among people with leprosy in Sicanang, Belawan, North Sumatera. This study was unpaired categorical comparative analytic study and 54 participants were enrolled to this study. We found a high percentage of leprosys disability, 88,9% participants were having second grade leprosys disability that means the disability was obviously seen. We found that 29,63% participant suffered from a moderate depression, 14,82% with severe depression and 10,27% suffered from extreme depression. The correlation between disability grade and depression severity was analyzed with chi square test and p value was 0,182 which means that no significant relationship between disability grade and depression severity. Depression severity among people with leprosy in Sicanang was determined by patients self perception, spouse, onset of diagnosis and patients perception about their religion.
Relationship between Polymorphism of Angiotensin Converting Enzyme Gene with Symptoms of Depression in Schizophrenic Patients Nuralita, Nanda Sari; Thristy, Isra; Lubis, Debby Mirani
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.9483

Abstract

In schizophrenic patients, symptoms of depression are often found which can lead to adverse effects on the treatment process, such as increasing the length of treatment, increasing the possibility of relapse, non-adherence in taking medication, and can also lead to suicide in schizophrenic patients. In schizophrenic patients, the activity of the central angiotensin converting enzyme (ACE) gene is altered and angiotensin II interacts with central dopamine, thereby contributing to the pathophysiology of schizophrenia. In addition, it is likely that the ACE gene variant is also involved in the development of depressive symptoms in schizophrenic patients. This research is a categorical analytic study with a cross sectional method, the sampling method is non-probability sampling with consecutive sampling type, with a total sample of 42 people. There was no significant difference between depression symptoms and ACE gene polymorphisms with P value = 0.746. There was no significant difference between depression symptoms and ACE gene polymorphisms.
Hubungan Durasi Sakit dan Fungsi Keluarga terhadap Fungsi Pasien dengan Gangguan Kecemasan Nurhasanah, Nurhasanah; Nuralita, Nanda Sari
ANATOMICA MEDICAL JOURNAL | AMJ Vol 8, No 1 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v8i1.22876

Abstract

Gangguan kecemasan adalah kondisi yang memengaruhi kualitas hidup, termasuk fungsi sosial dan pekerjaan. Selain faktor individu, dukungan keluarga juga memainkan peran penting dalam mempengaruhi tingkat keparahan gangguan kecemasan. Penelitian ini bertujuan untuk menganalisis hubungan antara durasi sakit, fungsi keluarga, dan dampaknya terhadap fungsi pasien gangguan kecemasan di Rumah Sakit Madani, Sumatera Utara. Metode: Desain penelitian ini adalah cross-sectional dengan sampel pasien gangguan kecemasan yang dirawat di Rumah Sakit Madani, Sumatera Utara. Data dikumpulkan menggunakan kuesioner yang mengukur durasi sakit, dukungan keluarga, dan fungsi sosial pasien. Analisis data dilakukan menggunakan uji statistik bivariat, Spearman. Hasil: Penelitian menunjukkan hubungan signifikan antara durasi sakit dengan fungsi pasien (p-value 0,001; r = 0,650), yang berarti semakin lama durasi sakit, semakin buruk fungsi pasien. Selain itu, ada hubungan signifikan antara fungsi keluarga dan fungsi pasien (p-value 0,001; r = -0,651) yang mengindikasikan bahwa semakin baik fungsi keluarga, semakin rendah skor fungsi pasien. Kesimpulan: Durasi sakit yang panjang memperburuk fungsi psikososial pasien gangguan cemas, sementara dukungan keluarga yang baik dapat meningkatkan kualitas hidup pasien. Dukungan keluarga yang kuat dan pengelolaan durasi sakit yang tepat penting dalam pemulihan pasien gangguan cemas.Kata Kunci: durasi sakit, fungsi keluarga, fungsi pasien
The RelationshipBetween Online Game Exposure and Sleep Quality in Students at SMAN 13 Medan City Azzahra, Syifa Nadya; Nuralita, Nanda Sari
Buletin Farmatera Vol 10, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i2.24505

Abstract

Abstract: Playing online games done during activities at night can come at the expense of sleep. The quality of a person's sleep is influenced by several aspects such as the duration of sleep, the time it takes to fall asleep, the frequency of waking up, and the level of sleep deprivation. Sleep disorders are a decrease in sleep quality that occurs due to daily activities, especially in adolescents. The quality of sleep can continue to decline with this bad routine continuously. This study aims to find out the effect of exposure to online games on sleep quality. The research is a cross sectional  research conducted by filling out questionnaires by 81 students and students at SMAN 13 Medan City. The data obtained will be analyzed with Chi-square. Based on data analysis, P=0.004 was obtained where there was a relationship between exposure to online games and sleep quality at SMAN 13 Medan City. There is a significant relationship between exposure to online games and sleep quality at SMAN 13 Medan City. 
Fungsi Keluarga Dan Self-Esteem Berhubungan Dengan Simtom Kecemasan Pada Siswa SMA Tingkat Akhir Maharani, Vivia; Nurhasanah, Nurhasanah; Nuralita, Nanda Sari; Suryani, Des
JURNAL PANDU HUSADA Vol 6, No 4 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v6i4.23529

Abstract

Abstrak : Kecemasan merupakan suatu perasaan gelisah dan tidak bahagia yang kerap kali muncul pada diri seseorang ketika menghadapi suatu situasi yang tidak menyenangkan. Simtom kecemasan sering terjadi pada remaja seiring pertumbuhan seperti, merasa gelisah, cemas, jantung berdebar, tremor, berkeringat, mual, karena terlalu khawatir terhadap berbagai hal, termasuk prestasi sekolah, hubungan sosial, atau ketidakpastian tentang masa depan. Faktor internal self-esteem dan faktor eksternal fungsi keluarga adalah dua faktor yang dapat menyebabkan kecemasan. Penelitian ini menganalisis hubungan fungsi keluarga dan self-esteem dengan simtom kecemasan pada siswa SMA tingkat akhir dengan penelitian analitik desain cross-sectional melalui kuesioner Zung-Self Anxiety Rating Scale (ZSAS), Family APGAR, dan Coopersmith Self Esteem Inventory (CSEI) pada sampel 164 siswa. Data penelitian ini menggunakan uji univariat dan bivariat uji Spearman. Uji normalitas didapatkan nilai signifikan 0,001 (p0,05). Hasil uji korelasi Spearman diperoleh p=0.001(p0.05) dan koefisien korelasi -0.629 serta hubungan antara self-esteem dengan simtom kecemasan diperoleh p=0.001(p0.05) dan koefisien korelasi -0.548. Terdapat hubungan fungsi keluarga dengan simtom kecemasan, yaitu jika fungsi keluarga meningkat maka kecemasan akan menurun. Selain itu, terdapat juga hubungan self-esteem dengan simtom kecemasan, yaitu jika self-esteem meningkat maka kecemasan akan menurun pada siswa SMA tingkat akhir.
Co-Authors Adelia azis Azis Nasution Amelia Eka Damayanty Asri Ludin Tambunan Azzahra, Syifa Nadya BAITUL AMANAH BATUBARA, DIAN ERISYAWANTY CHANIAGO, LITA SEPTINA DAMAYANTI, AMELIA EKA DAPOT PARULIAN GULTOM Debby Mirani Lubis Debby Mirani Lubis Des Suryani Des Suryani ELMAN BOY ELMEIDA EFFENDY ELVIANI . ILHAM SYAHPUTRA Isra Thristy Isra Thristy LITA SEPTINA CHANIAGO Lubis, Debby Mirani Maharani, Vivia Melviana Lubis Muhammad Alwi Pohan Muhammad Iqbal Nathasya Putri Kinanti Nurhasanah Nurhasanah Nurhasanah Nurhasanah Octari Auliati Pohan, Muhammad Alwi Rizaldi, Aril RIZANA, RARA RIZKI WAHYU NAFIAH Robitah Asfur SAID MUNAZAR RAHMAT Siregar, Pinta Pudiyanti Siregar, Syahroni Siti Andira Sri Rizky Ayunita Tambunan, Asri Ludin Toniara, Safriwan TRIA ARDITA ZAHRAH SAFIRA Zulhilmi, Zulhilmi