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Journal : Jurnal Inotera

Evaluating the Impact of Data Balancing Techniques on the k-Nearest Neighbors Algorithm for Microarray Data Classification Febi Nur Salisah; Inggih Permana; Sanusi; Shir Li Wang
Jurnal Inotera Vol. 10 No. 2 (2025): July - December 2025
Publisher : LPPM Politeknik Aceh Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31572/inotera.Vol10.Iss2.2025.ID497

Abstract

Microarray data classification poses significant challenges in bioinformatics due to the nature of the data, which has a very high number of features but a limited number of samples, and an unbalanced class distribution. This condition can cause a decrease in the performance of classification models, including k-Nearest Neighbor (kNN). This study aims to evaluate the performance of the kNN algorithm in classifying unbalanced and balanced data. The balancing techniques used are Random Undersampling (RUS), Random Oversampling (ROS), and Synthetic Minority Over-sampling Technique (SMOTE). The datasets used in this study are three leukemia datasets with different class structures, namely two, three, and four classes. The experimental results show that the ROS and SMOTE techniques consistently improve the performance of kNN, with the best accuracy reaching more than 97%. In the two-class dataset, ROS gave the best performance (99.4%), while in the three-class dataset, SMOTE showed the most optimal results (98.5%). In the four-class dataset, the performance improvement due to balancing was very significant; SMOTE and ROS were able to improve the accuracy from 89.7% (without balancing) to 99.0% and 98.8%, respectively. Although RUS recorded perfect accuracy of 100%, the results were anomalous and inconsistent. RUS showed less stable performance and was often lower than the condition without balancing, especially on datasets with four classes. Overall, the SMOTE technique proved to be the most stable and effective for various class structures. This study shows the importance of balancing strategies in the classification of complex and imbalanced microarray data.
Co-Authors A Anggraini Afdal Muhammad Efendi Ahsyar, Tengku Khairil Alfaridzi, Gemma Tahmid Aliya, Rahma Anggi Widya Atma Nugraha Anggia Anfina Anisa Nirmala, Fitri Anwar, Tengku Khairil Arabiatul Adawiyah Arif Marsal Arif Marsal Arif Marsal Arrazak, Fadlan Bayu Putra Danil Risaldi Darmawan, Reza Devi, Rahma Dewi Astuti Efendi, Harisman Eki Saputra Eki Saputra Eki Saputra Elin Haerani Endah Purnamasari Esis Srikanti Fachrurozi Fadhilah Syafria Fadil Rahmat Andini Febrian, Dany Fernanda, Ustara Dwi Fiki Fitri Wulandari Fitriah, Ma’idatul Fitriah, Ma’idatul Fitriani Muttakin Fitriani Muttakin Giansyah, Qhoiril Aldi Gustinov, Mhd Dion Hasbi Sidiq Arfajsyah Hendri, Desvita Husaini, Fahri Idria Maita Idria Maita Idria Maita Idriani R, Nova Imam Muttaqin Indah Lestari Indri Dian Pertiwi Inggih Permana Intan, Sofia Fulvi Jayadi, Puguh Jazma, Muhammad Jazman , Muhammad Jazman, Muhammad Kusuma, Gathot Hanyokro Leony Lidya M Afdal M Afdal M. Afdal M. Afdal M. Afdal M.Afdal Maulana, Rizki Azli Mawaddah, Zuriatul Mega wati, Mega Megawati Megawati - Megawati Megawati Mona Fronita Mubarak MR, Najmuddin Muhammad Afdal Muhammad Iqbal Indrawan Muhammad Jazman Muhammad Luthfi Muhammad Luthfi Hamzah Muhammad Munawir Arpan Munzir, Medyantiwi Rahmawita Mustakim Mustakim Muttakin, Fitriani Nabila Putri Nailul Amani Nardialis Nardialis Nasution, Nur Shabrina Naufal Fikri, R. Adlian Nesdi Evrilyan Rozanda Nesdi Evrilyan Rozanda Norhavina Norhavina Nuraisyah Nuraisyah Nurkholis Nurkholis Nurrahma, Intan Puput Iswandi Putri, Amanda Iksanul Rahmawita M, Medyantiwi Rahmawita, Medyantiwi Rangga Arief Putra Ria Agustina Rice Novita Rice Novita Rizka Fitri Yansi Rizki Pratama Putra Agri Rozanda, Nesdi Evrilyan Sanusi Saputri, Setia Ningsih Sari, Gusmelia Puspita Sarjon Defit Setiawati, Elsa Shir Li Wang Shulhan Abdul Gofar Siti Zainah Sulthan Habib Suryani Suryani Susilawati Susilawati Syahri, Alfi Syaifullah Syaifullah Syaifullah Syaifullah Syaifullah Syaifullah Syarif, Yulia Tengku Khairil Ahsyar Tengku Khairil Ahsyar Tengku Khairil Ahsyar Tengku Khairil Ahsyar Tshamaroh, Muthia Uci Indah Sari Winda Wahyuti Wira Mulia, M. Roid Zarnelly Zarry, Cindy Kirana