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All Journal Damianus Journal of Medicine Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pengabdian Masyarakat: Humanity and Medicine Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Jurnal Penyakit Dalam Indonesia Journal of General-Procedural Dermatology & Venereology Indonesia
Nur Riviati, Nur
Division Of Geriatric, Department Of Internal Medicine, Faculty Of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Journal of General-Procedural Dermatology

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Efficiency of 7-dehydrocholesterol vitamin-D3 complex cream for xerosis and pruritus in elderly women Yahya, Yulia Farida; Rahmadini, Meirina; Jatmiko, Pandu Haryo; Emirzon, M. Afif Baskara; Nabila, Dewa Ayu Bulan; Kurniawati, Yuli; Toruan, Theresia Lumban; Riviati, Nur
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Xerosis and pruritus (XP) are the most common skin conditions in the elderly, manifesting clinically as roughness, scales, fissures, and mild-to-severe itching. Vitamin D improves skin hydration, transepidermal water loss (TEWL), and regulates the immune system. We aimed to determine the efficiency of topical 7-dehydrocholesterol (DHC)-vitamin D3 complex cream in elderly patients with XP. Methods: An experimental phase III study was performed on elderly women with XP from December 2021 to March 2022 at the Geriatric Dermatology Clinic of Dr. Mohammad Hoesin General Hospital, Palembang. Inclusion criteria were age older than 55 years, healthy or with comorbidity. The exclusion criteria include the use of moisturizer within two weeks before the study. DHC-vitamin D3 cream was applied on subject’s volar arms once a day. Overall dry skin score (ODSS), visual analog scale (VAS) for pruritus and adverse effects, skin hydration, TEWL, sebum level, serum vitamin D level, and dermatology life quality index (DLQI) were assessed at baseline and after 4 weeks. Statistical analysis was done with Wilcoxon and paired T-test. Results:Eighteen elderly women were included. Most subjects were 60 to 74 years old (83,3%). Half the subjects (50%) had comorbidity. There was a significant difference in skin hydration (p Conclusion: Topical 7-DHC vitamin D3 complex cream is proven to improve skin barriers, increase serum vitamin D levels, well-tolerated, and provided satisfaction and comfort in elderly women with XP.
Co-Authors Afifah Z Salsabila Ahmad Rasyid Aidi A Putri Ali Ghanie Ali Zainal Abidin Ardesy Melizah Kurniati Ari Dwi Prasetyo Ari Dwi Prasetyo Bima Indra Bintang A Prananjaya Cyntya Sari Sovianti Damai Trislinawati Desti Paramita Dibyantari, Ridzqie Dimas Ega Wijaya Putra Ditta Puspa Anggraini Djunaidi, Djunaidi Eddy Mart Salim Eddy Mart Salim Emirzon, M. Afif Baskara Erial Bahar Erial Bahar Erial Bahar Erial Bahar Erwin Sukandi Fadhyl Zuhry Lubis Fifi Yuniarti Gultom, Widya Mandala Sari Hermansyah Hermansyah Indra, Bima Indrajaya, Taufik Irsan Saleh Irsan Saleh Iswadi Tanzil Jatmiko, Pandu Haryo Khoirun Mukhsinin Putra Khoirun Mukhsinin Putra Khoirun Putra kurniati, nova Legiran Legiran Legiran Mediarty, Mediarty Mgs Irsan Saleh Mgs Irsan Saleh Muhammad Erfin Muhammad Hadi Wijaya Muhammad Haryadi Ade Kurnadi Muhammad Irsan Saleh Muhammad Reagan Muhammad Reagen Mukmin, Sugianto Murdani Abdullah Muthia, Putri Nabila, Dewa Ayu Bulan Nelda Aprilia Salim Nova Kuniati Nova Kurniati Nova Kurniaty Noveldy Calzoum Bachry Octyvani Vani Perdana, Rizky Purwita W Laksmi, Purwita W RACHMAT HIDAYAT Rahmadini, Meirina Rini Nindela Rizki Bastari Rizki Bastari Rizky Perdana Rukiah Chodilawati Siti Setiati Sudarto Sugianto Mukmin Surya Darma Surya Darma Surya Darma Surya Dharma Syafran Rasidi Syamsu Indra Syamsu Indra Syarif Husin Syarif Husin Syarif Husin Syifa Alkaf Tanzil, Iswadi Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Tiar Marina Toruan, Theresia Lumban Tri Nisdian Wardiah Umi Partan, Radiyati Welly Salutondok Widya Mandala Sari Gultom Yuli Kurniawati, Yuli Yulia Farida Yahya Yulianto kusnadi Yuniza Yuniza Yuniza, Yuniza