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Dwi Gusfarenie
UIN Sulthan Thaha Saifuddin Jambi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Environmental Science Immunology & microbiology Neuroscience Social Sciences Other

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Uji Efektifitas Ekstrak Daun Sirih Merah sebagai Anti Hiperglikemia pada Tikus Putih Diinduksi Aloksan Susanti, Try; Gusfarenie, Dwi; Nuraida, Nining
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.10427

Abstract

Diabetes melitus or diabetes is a health disorder in the form of a collection of symptoms that arise in a person caused by increased blood sugar leves due to insulin deficiency or insulin resistance and metabolic disorders in general. Red bete leaves contain chemical compounds of alkaloids, flavonoids, tannins and saponins which can lower blood sugar leves. The aim of this study was to determine the effectiveness of red bete leaf extract suspension (Piper crocatum) as antihyperglycemia in male white rats (Rattus novergicus) induced by alloxan. This research method is experimental. The extraction process for red bete leaves uses 70% ethanol solvent using the maceration method, then concentrated using a rotary evaporator and thickened using a water bath, then a suspension preparation is made, the doses given to male white rats are 2%, 4% and 6%. Glibenclamide suspension as a positive control and suspending agent as a negative control. The effectiveness of the red bete leaf extract suspension was seen from the reduction in blood sugar leves in mice after being induced by alloxan. The research data were analyzed using One Way ANOVA and paired sample t-test. The resuts of the study showed that red bete leaf extract suspension was effective as an antihyperglycemia, where the most effective dose was 6%. The suspension preparation of red bete leaf extract meets the requirements for evaluation of the preparation and stability of the preparation.
Co-Authors Ali Murtadlo Andesmora, Evan Vria Anisia, Ica Wandari Aprianto, Riko Chatib, Muhsin Darma Putra Gusriani, Nanda Hasibuan, Maimunah Permata M Husaini Ma’aruf, Reza Nining Nuraida Nofriadi, Nanang Novallyan, Devie Oktaviani, Widia Bela Rahmat Hidayat Rahmi, Miftahur Redita Nur Aini Reny Safita Reny Safita Reny Safita Riany, Hesti Rika Kitri Ardianti Rita Simatupang Saputra, Dalli Yulio Sari, Defita Permata Siti Nuraisyah Sumitro Sumitro Suraida Suraida Syahmi, Wahilman Tomi, Dodo Tri Setia Try Susanti Try Susanti