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All Journal e-Journal Pustaka Kesehatan Jurnal Kesehatan Masyarakat (IKESMA) Jurnal Kedokteran Indonesia Jurnal Berkala Epidemiologi Damianus Journal of Medicine Indonesian Journal of Tropical and Infectious Disease Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education The Indonesian Journal of Public Health UNEJ e-Proceeding Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal SOLMA Jurnal Epidemiologi Kesehatan Komunitas Unnes Journal of Public Health Journal of Health Sciences JURNAL FARMASIMED (JFM) Jurnal Kesehatan Medical Technology and Public Health Journal Jurnal Abdidas Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Pengabdian Masyarakat dalam Kesehatan PROFESSIONAL HEALTH JOURNAL Al-Khidmah Jurnal Pengabdian Masyarakat ABDIMAYUDA: Indonesian Journal of Community Empowerment for Health Jurnal Pengabdian Pada Masyarakat Dedikasi Saintek Jurnal Pengabdian Masyarakat DEDIKASI SAINTEK Jurnal Pengabdian Masyarakat Jurnal Ilmu Kesehatan Masyarakat
Irma Prasetyowati
Bagian Biostatistika Kependudukan Dan Epidemiologi Fakultas Kesehatan Masyarakat Universitas Jember
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Journal : JURNAL FARMASIMED (JFM)

 1 
Association Between Drug Related Problems and Outcomes of Tuberculosis Patients at Citra Husada Hospital Jember Lutvi Anggraeni; Fifteen Aprila Fajrin; Afifah Machlaurin; Irma Prasetyowati; Angga Mardro Rahardjo
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4h3axm73

Abstract

Background: Tuberculosis (TBC) remains a major global challenge. In Indonesia, the success rate for Drug-Sensitive Pulmonary TB (DS-TBC) treatment is still below target, often linked to Adverse Drug Reaction (ADR) and Drug Related Problem (DRP). The complexity of regimens and polypharmacy increases the risk of DRPs, which are strong predictors of treatment failure. Objective: This study aimed to identify DRPs and analyze their relationship with the clinical outcomes of DS-TBC. Method: A retrospective cohort study was conducted on 281 DS-TBC patients recorded at Citra Husada Hospital Jember from January 2020 to December 2023. Data were collected from medical records and the TBC Information System (SITB). DRPs were identified using the PCNE V9.1 classification, focusing on dose inappropriateness, drug interactions, and ADR. Outcomes were categorized as successful (cured/treatment completed) or unsuccessful. Result: Data analysis included descriptive statistics, bivariate analysis using Chi-Square, and multivariate analysis using Binary Logistic regression with a significance p < 0,05. The result of this study is that patients were predominantly male (55.16%), aged 46-65 years, with a treatment completion rate of 82.21%. DRPs were found in 84.34% of patients, dominated by drug interactions (79%) and ADRs (35.23%), although the accuracy of anti-TB drug dosage was 100%. In multivariate analysis, age ≥65 years was associated with a decreased likelihood of successful treatment (aOR 0.367), while respiratory tract medication administration was associated with an increased likelihood of successful treatment (aOR 2.477). The overall relationship between DRPs and outcome was not statistically significant. Conclusion: Sociodemographic factors (age) and clinical symptom management (respiratory therapy) play the most crucial roles in determining the treatment outcome. Effective pharmaceutical intervention is suggested to mitigate the impact of DRPs on treatment failure. More aggressive clinical management is necessary for elderly patients.
Co-Authors Abdul Basith Qodam Ali Adistha Eka Noveyani Adistha Eka Noveyani Ahmad Haryono Ahmad Mushthofa As'Adi Ahmad Nafi' Akhmad Haryono Akhmad Taufiq Ana Masfurotin Ni’mah Angga Mardro Rahardjo Anisa Yulia Wulandari Anisa Yulia Wulandari, Anisa Yulia Anita Dewi Prahastuti Sujoso Anwari, Imas Sa'idatul Arifin, Munif Arwi, Khoiriyatul Muhlishoh Aulia, Linda Ayunni, Kartika Astri Firda Candra Bumi Chatarina Umbul Wahyuni Citra Anggun Kinanthi Dena Anggraeni Harjanto Dini Kurniawati Dwi Eriyanti, Linda Dwi Martiana Wati Eka Afdi Septiyono Emi Dwi Astuti Evita Soliha Hani Fajrin, Fifteen Aprilla Farida Wahyu Ningtyias, Farida Wahyu Fariz Kustiawan Alfarisy Fifian Lula Fifteen Aprila Fajrin Fiya Wadudah Fiya Wadudah Furoidatul Husniah Haryanik, Meilinda Alya' Putri Haryanik, Meilinda Alya’ Putri Heni Nuraini Hilmiy, Daryta Balqis Nashifa Ida Srisurani Wiji Astuti Iken Nafikadini Illia Seldon Magfiroh Izza, Adha Dzulhidjatul Jannah, Hanifah Raudhatul Kamerawati, Choni Kinanthi, Citra Anggun Leersia Yusi Ratnawati Luh Putu Ratna Sundari Lutfi Arifianto Lutvi Anggraeni M. Hadi Makmur Machlaurin, Afifah Madani, Ainun Margareta, Amanda Cynthia Mazida, Zulfa Meggeria Dyah Matrika Tito Putri Mulyo, Fiskan Adi Santro Mury Ririanty Ni'mah, Ana Masfurotin Nindy Irsila Dwi Valentine Ni’mal Baroya Nurika, Globila Nurmusfiroh, Rizqi Faza Poerwahyuningrum, Neny Pudjo Wahjudi Pudjo Wahjudi Pudjo Wahjudi Pudjo Wahjudi Puspitasari, Muthia Fahriyah Putri Haryanik, Meilinda Alya' Putri, Syafira Aurellia Qaimima Ayuni Qaimima Ayuni Rachmawati, Septi Nur Ragil Ismi Hartanti Rahardjo, Angga Mardro Rahman, Hermanto Rahmawati, Iis Riski Anisa Rohman, Hermanto Salsabilah, Della Estelina Sasmita, Hasri Yulia Shabrina Izzata A.A. Shofiyah Vita Yuliana Silitonga, Indah Selli Zevania Simanjuntak, Tri Damayanti Siti Muslicha Suandaru, Yusrizal Fatria Suwardi, Regantia Happy Thoyiba, Nuzula Lailatul Umniyah, Zahratul umniyyah, zahratul Wahyu Martina Sari Wahyu Ningtyias, Farida Wati, Desy Dwi Ambar Wiastuti, Siti Marina Wijaya, Novita Dian Rahmawati Yennike Tri Herawati Yudhi Tri Gunawan Yunus Ariyanto Zahro, Adinda Khatimatuz Zulfa Mazida