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All Journal Jurnal Gizi dan Pangan MEDIA MEDIKA INDONESIANA Journal of Nutrition and Health JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Journal of Biomedicine and Translational Research WMJ (Warmadewa Medical Journal) Warta IHP (Warta Industri Hasil Pertanian) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) GIZI INDONESIA Jurnal Gizi Klinik Indonesia Jurnal Aplikasi Teknologi Pangan Pontianak Nutrition Journal (PNJ) Jurnal Biomedika Medica Hospitalia IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Bali Medical and Wellness Journal
Enny Probosari
Clinical Nutrition Department, Medical Faculty, Diponegoro University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : MEDIA MEDIKA INDONESIANA

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Pemberian Teh Rosela (Hibiscus sabdariffa Linn), Simvastatin dan Profil Lipid serta Serum ApoB pada Tikus Hiperkolesterolemi Enny Probosari; Hertanto WS; Niken Puruhita
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

ABSTRACTConsumption of roselle tea and simvastatin, lipid profile and apoB serum in hypercholesterolemic ratsBackground: Roselle is commonly used as herbal beverages in Indonesian that is known have a hypocholesterolemic effect. The study was conducted to determine the efficacy of roselle tea compared to simvastatin on lipid profile and apo B of hypercholesterolemic rats.Methods: This study was an animal experimental with randomized pre test post test control design. Sixteen hypercholesterolemic male wistar rats of 15 week-aged were devided into 3 groups: control groups (K) received normal feeding and water adlibitum, group P1 received normal feeding, water adlibitum and roselle tea 4.5 ml twice a day, group P2 received normal feeding, water adlibitum and simvastatin 0.4 mg daily. Blood samples were collected at baseline and 30 days after administration of roselle tea or simvastatin for the measurement of serum lipids and apoB using ELISA.Results: Administration of roselle tea 1.37gram twice a day decreased trigliserid concentrations from 81.7mg/dl±43.13 to 26.5mg/dl±13.92 (p=0.038), but increased total cholesterol concentrations from 62.1mg/dl±4.25 to 91.9mg/dl±11.74 (p=0.001). Administration of 0.4mg simvastatin didn’t decreased triglicerid concentrations (50.9mg/dl±55.95 to 67.9mg/dl±3.07, p=0.207), total cholesterol concentrations (67.9mg/dl±3.07 to 74.2mg/dl±10.65, p=0.146), LDL cholesterol concentrations (156.8mg/dl±291.9 to 34.0mg/dl±30.06, p=0.686) nor increased HDL cholesterol concentration (58.1mg/dl±12.73 to 60.5mg/dl±8.61, p=0.674).Conclusion: Intake of 1.37 gram rosella tea twice a day decreases trigliserid more effective than simvastatin. Administration of roselle tea and simvastatin are not effective to reduce LDL cholesterol concentrations and apoB concentrations, nor increased HDL cholesterol concentrations.Keywords: Lipid profile, apoB, roselle, simvastatinABSTRAKLatar belakang: Teh rosela merupakan salah satu bahan minuman yang diketahui mempunyai efek menurunkan kadar kolesterol. Penelitian ini bertujuan untuk mengetahui efektifitas pemberian teh rosela dibandingkan simvastatin terhadap profil lipid dan apolipoprotein B pada tikus hiperkolesterolemi.Metode: Penelitian ini adalah penelitian eksperimental laboratorium dengan desain pre-post-test dengan kelompok kontrol. Enam belas tikus putih jantan galur wistar hiperkolesterolemi, usia 15 minggu, dibagi menjadi kelompok kontrol (K) hanya diberi pakan standar dan minum adlibitum, kelompok perlakuan 1 (P1) diberi pakan standar minum adlibitum, seduhan rosela 2x4,5ml per haridan kelompok perlakuan 2 (P2) diberi pakan standar minum adlibitum dan simvastatin 0,4mg per hari, selama 30 hari. Pada awal dan akhir perlakuan diambil serum darah untuk mengetahui kadar trigliserid, kolesterol total, kolesterol LDL, kolesterol HDL, sedangkan kadar apo B diukur pada akhir penelitian menggunakan metode ELISA.Hasil: Pemberian teh rosela (kelompok P1) menurunkan kadar trigliserid dari 81,7mg/dl±43,13 menjadi 26,5mg/dl±13,92 (p=0,038) setelah perlakuan, namun kadar kolesterol totalnya meningkat dari 62,1mg/dl±4,25 menjadi 91,9mg/dl±11,74 (p=0,001) setelah perlakuan. Pemberian 0,4mg simvastatin tidak menurunkan kadar trigliserid (50,9mg/dl±55,95 menjadi 67,9mg/dl±3,07, p=0,207), tidak menurunkan kadar kolesterol total (67,9mg/dl±3,07 menjadi 74,2mg/dl±10,65, p=0,146), tidak menurunkan kadar kolesterol LDL (156,8mg/dl±291,9 menjadi 34,0mg/dl±30,06, p=0,686) dan tidak meningkatkan kadar kolesterol HDL (58,1mg/dl±12,73 menjadi 60,5mg/dl±8,61, p=0,674).Simpulan: Pemberian teh rosela dengan berat rata-rata 1,37 gram yang dikonsumsi dua kali per hari lebih efektif dalam menurunkan kadar trigliserid serum tikus hiperkolesterolemi dibandingkan pemberian 0,4mg simvastatin. Pemberian teh rosela dosis lazim dan pemberian simvastatin dosis 0,4mg sama tidak efektifnya dalam menurunkan kadar kolesterol LDL, kadar apolipoprotein B dan meningkatkan kadar kolesterol HDL.
Co-Authors A Fahmy Arif Tsani Adinda Maharani Ahmad Syauqy Aida Fitri Nazillah Aisyah Aisyah Ajeng Pramudita Alfadila, Tsania Izza Andarbeni, Larasati Andriani Rizka Yasmina Anggraini, Wiriesta Anjani, Gemala Annisa Fauziah, Annisa Annta Kern Nugrohowati Aqmariya Syarafina Arwinda Nugraheni Aryu Candra Ayu Rahadiyanti Azalia, Fawnia Azhoranezar Ramadhani Betsi Kusumaningnastiti Binar Panunggal Brotoarianto, Happy Kurnia Chairunnisa, Otty Claudia Kartika Dewi Darmono SS Deny Yudi Fitranti Devana Doanaresta Devy Sukma Sari, Devy Sukma Dewi, Arini Citra Dewi, Suci Noviya Diana Nur Afifah, Diana Nur Dwi Pudjonarko Dwi Ratna Sari Eka Hermawati, Eka Eryn Trijayanti Etika Ratna Noer Etisa Adi Murbawani Fadzilah, Annisa Dwi Fatimah Muis, Siti Fauzia Purnamasari Febe Christianto Ferry Sandra Fillah Fithra Dieny Fillah Fithra Dieny Firdaus, Ozi Rahmat Fithri, Annisa Amala Handayani, Endah Nur Hartanti Sandi Wijayanti Hartanti Sandi Wijayanti Haznawati, Nur Dian Heri Nugroho Hertanto Wahyu Subagio Hertanto Wahyu Subagyo Hertanto WS Isvi Thuba Mustaghfiroh Joriandhita Ramadhan Kurniawati, Dewi Marfu’ah Kusumaningnastiti, Betsi Lady, Chantika Laurensia Mei Vrayanti Hutajulu Lili Nor Indah Sari Luthfiatul Khusna Marlina Rully Wahyuningrum MARTHA ARDIARIA Maulida Khurriya Rahman Mega Herdanti Febrikaharisma Merisa Inggit Widyaswari Muhammad Sulchan Niken Puruhita Ningsih, Ryta Ristantia Nisa, Ana Khoirun Nisa, Fitria Zahrotun Nisrina Hanisa Nissa, Choirun Novi Cynthia Prisma Dewi Novi Diah Pusparini Noviasti Rahma Utami Nungki Dwi Permatasari, Nungki Dwi Nur Rochmah, Nur Nurdini, Della Annisa Nurhasanah Nurhasanah Nurmasari Widyastuti Nurul Ratna Mutu Manikam Nuryanto Nuryanto Nyoman Suci Widiastiti Prayoga, Edwin Agung Putri, Nindya Marta Ghassani Putri, Tri Andianne Rachma Purwanti Rahmani, Shera Mutiara Ratha, Putu Prayoga Rhory Defie Rizki, Mawarni Uli Rizkita, Maura Sania Roberta Lei Easter, Roberta Lei Rohmatul Ummah Rujiantina, Ahaddini Septian Ruth Elizabeth Violita, Ruth Elizabeth Sandy Eka Pratama Sari, Mega Lucyta Siallagan, Rini Martina Siti Fatimah Muis Siti Fatimah Muis Siti Fatimah Muis Syafira Noor Pratiwi Tantri, Ignas Fawwaz Tri Hanni Desiana Putri Tri Indah Winarni Tugasworo Pramukarso, Dodik Widitha Gustining Asmariani Yuniari, Dwi Yushila Meyrina