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Journal : The Indonesian Biomedical Journal

Musa balbisiana and Musa paradisiaca Starches Increase SCFA and Caspase-3 as well as Decrease β-glucuronidase and MDA of Mouse Model for Colon Cancer Diana Nur Afifah; Fauzia Purnamasari; Luthfiatul Khusna; Noviasti Rahma Utami; Aida Fitri Nazillah; Syafira Noor Pratiwi; Fillah Fithra Dieny; Aryu Candra; Ayu Rahadiyanti; Rachma Purwanti; Enny Probosari; Martha Ardiaria; Nyoman Suci Widiastiti; Ferry Sandra
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1320

Abstract

BACKGROUND: Administration of resistant starch (RS) influences the diversity and the composition of microbiota as well as inhibits the growth of cancer cell. Banana as a potential source of RS has been reported. Although Musa paradisiaca has been reported to induce apoptosis in colon cancer cells, Musa balbisiana, which has low glycemic index and suitable for particular patients, has not been investigated yet.METHODS: Starches of M. balbisiana and M. paradisiaca were prepared and mixed with other components to make 3 types of mouse pellets. Mouse model for colon cancer was prepared and fed with different types of mouse pellets. Blood was collected and processed for measuring β-glucuronidase and malondialdehyde (MDA) with Enzyme-linked Immunosorbent Assay (ELISA) method. Resected ceca were incised to collect the inner part for short-chain fatty acid (SCFA) measurement with gas chromatography analysis. Resected colas were fixed and processed for immunohistochemistry to detect Caspase-3.RESULTS: Colon-cancer-mice fed with the M. balbisiana and M. paradisiaca starches-contained pellets had significant higher concentrations of total SCFA (p=0.003), acetic acid (p=0.000), propionic acid (p=0.000) and butyric acid (p=0.000); lower concentration of β-glucuronidase (p<0.001); higher Caspase-3 score (p=0.040); and lower MDA concentration (p<0.001) than colon-cancer-mice fed with standard pellet (control).CONCLUSION: M. balbisiana and M. paradisiaca starches could be suggested as potential anti-colon cancer RS. Further research should be carried out to disclose the starches mechanisms in colon cancer cell.KEYWORDS: Musa balbisiana, Musa paradisiaca, colon cancer, resistant starch, Caspase-3, SCFA, β-glucuronidase, malondialdehyde
Co-Authors A Fahmy Arif Tsani Adinda Maharani Ahmad Syauqy Aida Fitri Nazillah Aisyah Aisyah Ajeng Pramudita Alfadila, Tsania Izza Andarbeni, Larasati Andriani Rizka Yasmina Anggraini, Wiriesta Anjani, Gemala Annisa Fauziah, Annisa Annta Kern Nugrohowati Aqmariya Syarafina Arwinda Nugraheni Aryu Candra Ayu Rahadiyanti Azalia, Fawnia Azhoranezar Ramadhani Betsi Kusumaningnastiti Binar Panunggal Brotoarianto, Happy Kurnia Chairunnisa, Otty Claudia Kartika Dewi Darmono SS Deny Yudi Fitranti Devana Doanaresta Devy Sukma Sari, Devy Sukma Dewi, Arini Citra Dewi, Suci Noviya Diana Nur Afifah, Diana Nur Dwi Pudjonarko Dwi Ratna Sari Eka Hermawati, Eka Eryn Trijayanti Etika Ratna Noer Etisa Adi Murbawani Fadzilah, Annisa Dwi Fatimah Muis, Siti Fauzia Purnamasari Febe Christianto Ferry Sandra Fillah Fithra Dieny Fillah Fithra Dieny Firdaus, Ozi Rahmat Fithri, Annisa Amala Handayani, Endah Nur Hartanti Sandi Wijayanti Hartanti Sandi Wijayanti Haznawati, Nur Dian Heri Nugroho Hertanto Wahyu Subagio Hertanto Wahyu Subagyo Hertanto WS Isvi Thuba Mustaghfiroh Joriandhita Ramadhan Kurniawati, Dewi Marfu’ah Kusumaningnastiti, Betsi Lady, Chantika Laurensia Mei Vrayanti Hutajulu Lili Nor Indah Sari Luthfiatul Khusna Marlina Rully Wahyuningrum MARTHA ARDIARIA Maulida Khurriya Rahman Mega Herdanti Febrikaharisma Merisa Inggit Widyaswari Muhammad Sulchan Niken Puruhita Ningsih, Ryta Ristantia Nisa, Ana Khoirun Nisa, Fitria Zahrotun Nisrina Hanisa Nissa, Choirun Novi Cynthia Prisma Dewi Novi Diah Pusparini Noviasti Rahma Utami Nungki Dwi Permatasari, Nungki Dwi Nur Rochmah, Nur Nurdini, Della Annisa Nurhasanah Nurhasanah Nurmasari Widyastuti Nurul Ratna Mutu Manikam Nuryanto Nuryanto Nyoman Suci Widiastiti Prayoga, Edwin Agung Putri, Nindya Marta Ghassani Putri, Tri Andianne Rachma Purwanti Rahmani, Shera Mutiara Ratha, Putu Prayoga Rhory Defie Rizki, Mawarni Uli Rizkita, Maura Sania Roberta Lei Easter, Roberta Lei Rohmatul Ummah Rujiantina, Ahaddini Septian Ruth Elizabeth Violita, Ruth Elizabeth Sandy Eka Pratama Sari, Mega Lucyta Siallagan, Rini Martina Siti Fatimah Muis Siti Fatimah Muis Siti Fatimah Muis Syafira Noor Pratiwi Tantri, Ignas Fawwaz Tri Hanni Desiana Putri Tri Indah Winarni Tugasworo Pramukarso, Dodik Widitha Gustining Asmariani Yuniari, Dwi Yushila Meyrina