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All Journal Jurnal Anestesiologi Indonesia MEDIA MEDIKA INDONESIANA International Journal of Science and Engineering (IJSE) JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Jurnal Kedokteran Diponegoro Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Interest : Jurnal Ilmu Kesehatan Jurnal Keperawatan dan Kesehatan Masyarakat CENDEKIA UTAMA Jurnal Epidemiologi Kesehatan Komunitas Medica Hospitalia Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Diponegoro International Medical Journal (DIMJ) Narra J JHeS (Journal of Health Studies) Neurona Jurnal Bidan Cerdas
Dwi Pudjonarko
Fakultas Kedokteran Universitas Diponegoro
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : JURNAL GIZI INDONESIA

 1 
The effect of additional protein, phosphatidylcholine, phosphatidylserine, and inulin on S100β levels of acute ischemic stroke patients at Dr. Kariadi Central Hospital, Semarang Stephani Nesya Renamastika; Endang Mahati; Martha Kartasurya; Dodik Pramukarso; Dwi Pudjonarko; Retnaningsih Retnaningsih
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 9, No 2 (2021): Juni
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.9.2.172-183

Abstract

Background: The brain releases biochemical substrates, such as S100β protein, into circulation in response to ischemic conditions as a sign of damage in nerve cells and disruption of the blood-brain barrier’s integrity. Thrombolytic therapy has led to the development of many neuroprotective therapies such as protein, phosphatidylcholine, phosphatidylserine, and inulin, which can be added to food products. Protein, phospholipids, and inulin, have a neuroprotective impact on nerve cells in the brain and blood-brain barrier.Objective: To prove the effect of protein, phosphatidylcholine, phosphatidylserine, and inulin on S100β levels and clinical outcomes in patients with acute ischemic stroke.Materials and Methods: This study was done in a single-blind RCT. Eighteen ischemic stroke patients were randomly divided into nine subjects for the intervention group and nine subjects for the control group. The Control group received 250 ml conventional formula milk (11.8 g protein) 3 times/day. The intervention group received 250 mL commercial milk 3 rimes/day which contained 15 g protein with 128 mg phosphatidylcholine, 32 mg phosphatidylserine, and 3 g inulin. All of the groups were given hospital-standard therapy for ischemic stroke. S100β levels were measured at pre and post-intervention.Results: Pre and post S100β levels in intervention and the control group did not show any statistically difference (p = 0.777 and p = 0.096), but there was a trend of decreasing  levels of S100β in the intervention group (-24.6 + 252.0 pg/mL) versus control group (135.8 + 216.2 pg/mL).Conclusions: The addition of protein, phosphatidylcholine, phosphatidylserine, and inulin did not have a significant effect on S100β levels.
Relationship between skeletal muscle mass index and length of stay in stroke patient Murbawani, Etisa Adi; Wahyu Subagio, Hertanto; Tugasworo Pramukarso, Dodik; Fatimah Muis, Siti; Pudjonarko, Dwi; Probosari, Enny; Candra, Aryu; Ardiaria, Martha
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2026: Just Accepted Manuscript and Article In Press 2026
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.0.0.%p

Abstract

Background: Sarcopenia is a syndrome characterized by progressive condition and generalized loss of skeletal muscle mass and strength. It is associated with poor prognosis and increased length of stay in stroke patients. Skeletal Muscle Mass Index (SMI) is an important parameter for assessing skeletal muscle mass and the clinical outcomes of stroke patients.Objective: to examine the relationship between SMI and length of stay in stroke patient.Materials and Methods: Cross-sectional observational analytical research was conducted at Dr. Kariadi Semarang Hospital from June 2024 to March 2025 in hospitalized stroke patients aged >18 years. Body composition, including skeletal muscle mass, is measured using BIA. Data were analyzed by Independent t-test, Pearson Correlation and Double Linear Regression.Results: The average length of stay among the 78 individuals (43 males and 35 females) was 11 days. The SMI levels were normal, indicating no sarcopenia.Conclusion: Skeletal Muscle Mass Index (SMI) was significantly related (p<0.05) with length of stay in stroke patients; the higher the SMI score, the shorter the duration of hospital stay. 
Co-Authors Amin Husni Ani Margawati Annastasia Ediati Aria Nurahman Hendra Kusuma Arif Iskandar Arinta Puspita Wati, Arinta Puspita Aris Catur Bintoro Arlina, Yani Armatussolikha, Herna Rizkia Aryu Candra Bagaskoro, Yoseph Cahyo Budisulistyo, Trianggoro Darmawati Ayu Indraswari Dewi Siyamti Diah Pasmanasari, Elta Dian Ratna Sawitri Dodik Pramukarso Dodik Tugasworo Dodik Tugasworo Dodik Tugasworo Pramukarso Edi Dharmana Endang Mahati Enny Probosari Etisa Adi Murbawani Fatimah Muis, Siti Fauzi, Muhammad Iqbal Fitria Handayani Fitria Handayani Handayani Fitria Handayani Handayani Handayani, Fitria Hardhono Susanto Hari Peni Julianti Hartono, Jimmy Eko Budi Hassa, Nazwan Hastaning Sakti Herinawati, Herinawati Herman Kristanto Hermawan Istiadi Hermina Sukmaningtyas Hertanto Wahyu Subagio Ignatius Riwanto, Ignatius Julian Dewantiningrum Koestoer, Clara Krishanti Kusman Ibrahim Latifah Latifah Lestari, Lis Mukti Lis Mukti Lestari M Naharuddin Jenie Mardiyono, Mardiyono Maria Mexitalia MARTHA ARDIARIA Martha Irene Kartasurya Mateus Sakundarno Adi, Mateus Sakundarno Meidiana Dwidiyanti Meutia, Yurida Binta Muis, Siti F. Murbawani, Etisa A. Nugraha, Laksmana AK. OS Hartanto Pangesti, Adelia Pradesta, Rizki Rudwi Pramukarso, Dodik T. Pranoto, Stephano Rahmawati, Maria Belladonna Ramadhany, Ghifarie A. Respati, Danendra RP. Retnaningsih Retnaningsih Rifky Ismail Satrio Adi Wicaksono Setyowati Setyowati Soejoenoes, Ariawan Sri Achadi Nugraheni Stephani Nesya Renamastika Subagio, Hertanto W. Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Sunjata, Winda Putri Suparyatmo, J.B Suryawati, Herlina Tjandra, Kevin C. Tugasworo Pramukarso, Dodik Udadi Sadhana, Udadi Untung Sujianto Vania Pangestika Purwaningrum