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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) JIKUM: Jurnal Ilmu Komputer
Rikarni Rikarni
Department Of Clinical Pathology And Laboratory Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Study of Analysis of Beta Human Chorionic Gonadotropin (hCG) Levels Before and After Hysterectomy in Gestational Trophoblastic Neoplasia (GTN) Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Wella Novile Izora; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1059

Abstract

Background: Gestational trophoblastic neoplasia (GTN) is a malignant tumor originating from placental trophoblast which causes mortality due to bleeding. Trophoblast produces beta hormone human chorionic gonadotropin (hCG). Quantitative examination of serum beta hCG is used to support the diagnosis and management of GTN. Hysterectomy is performed in bleeding conditions as the main therapy besides chemotherapy. This study aims to analyze differences in beta hCG levels before and after hysterectomy in GTN patients at Dr. M. Djamil General Hospital Padang. Methods: Retrospective observational analytical research design cross-sectional from 21 samples of GTN patients for the period July 2021 to June 2023 at Dr. M. Djamil General Hospital Padang. Quantitative beta hCG level examination is carried out before and after the hysterectomy. The Shapiro-Wilk test was carried out for data normality and continued with the Wilcoxon nonparametric tests to find out significant differences in beta hCG levels. Results: The most common characteristics of GTN patients were age ≥35 years, namely 15 (71.4%) patients, multiparity in 14 (66.7%) patients, and indication for hysterectomy due to bleeding in 14 (66.7%) patients. The median beta hCG level before hysterectomy was 46,000 (117.10-653,874) mIU/mL and the median after hysterectomy was 113.3 (0.12-3,693) mIU/mL. Beta hCG levels after hysterectomy were found to be normal (<5 mIU/mL) in five patients (23.8%). There was a significant difference in beta hCG levels before and after hysterectomy (p <0.001). Conclusion: Beta hCG levels after hysterectomy decreased compared to before hysterectomy. Hysterectomy therapy is useful for reducing beta hCG levels in GTN patients.
Differences in Average Albumin Levels in Coronavirus Disease 2019 (COVID-19) Survivor and Non-Survivor Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Doan Atrya; Rikarni; Elvira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1062

Abstract

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection triggers a systemic inflammatory response that can lead to a decrease in serum albumin levels. A more severe inflammatory response in non-survivor COVID-19 patients may correlate with a more significant decrease in albumin levels. This study aims to analyze differences in mean albumin levels in COVID-19 survivors and non-survivors. Methods: This cross-sectional analytical study involved 40 COVID-19 survivors and non-survivors treated at Dr. M. Djamil General Hospital Padang from July 2021 to September 2021. Serum albumin levels were checked using an automated clinical chemistry tool. Data analysis was carried out using the Mann-Whitney non-parametric test, with a significance level of p < 0.05. Results: The mean age of the study subjects was 49.4 (16.3) years, with the majority of cases occurring in men (67.5%). The median albumin levels in all COVID-19 patients, COVID-19 survivors, and COVID-19 non-survivors were 3.2 (2.20–5.00) g/dL, respectively; 4.1 (3.0–5.0) g/dL; and 2.9 (2.20–3.70) g/dL (p = 0.001). Conclusion: There is a significant difference in mean albumin levels between COVID-19 survivors and non-survivors. Lower albumin levels were found in non-survivor patients. Albumin can be a potential biomarker for predicting clinical outcomes of COVID-19 patients.
Study of Analysis of Beta Human Chorionic Gonadotropin (hCG) Levels Before and After Hysterectomy in Gestational Trophoblastic Neoplasia (GTN) Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Wella Novile Izora; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1059

Abstract

Background: Gestational trophoblastic neoplasia (GTN) is a malignant tumor originating from placental trophoblast which causes mortality due to bleeding. Trophoblast produces beta hormone human chorionic gonadotropin (hCG). Quantitative examination of serum beta hCG is used to support the diagnosis and management of GTN. Hysterectomy is performed in bleeding conditions as the main therapy besides chemotherapy. This study aims to analyze differences in beta hCG levels before and after hysterectomy in GTN patients at Dr. M. Djamil General Hospital Padang. Methods: Retrospective observational analytical research design cross-sectional from 21 samples of GTN patients for the period July 2021 to June 2023 at Dr. M. Djamil General Hospital Padang. Quantitative beta hCG level examination is carried out before and after the hysterectomy. The Shapiro-Wilk test was carried out for data normality and continued with the Wilcoxon nonparametric tests to find out significant differences in beta hCG levels. Results: The most common characteristics of GTN patients were age ≥35 years, namely 15 (71.4%) patients, multiparity in 14 (66.7%) patients, and indication for hysterectomy due to bleeding in 14 (66.7%) patients. The median beta hCG level before hysterectomy was 46,000 (117.10-653,874) mIU/mL and the median after hysterectomy was 113.3 (0.12-3,693) mIU/mL. Beta hCG levels after hysterectomy were found to be normal (<5 mIU/mL) in five patients (23.8%). There was a significant difference in beta hCG levels before and after hysterectomy (p <0.001). Conclusion: Beta hCG levels after hysterectomy decreased compared to before hysterectomy. Hysterectomy therapy is useful for reducing beta hCG levels in GTN patients.
Differences in Average Albumin Levels in Coronavirus Disease 2019 (COVID-19) Survivor and Non-Survivor Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Doan Atrya; Rikarni; Elvira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1062

Abstract

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection triggers a systemic inflammatory response that can lead to a decrease in serum albumin levels. A more severe inflammatory response in non-survivor COVID-19 patients may correlate with a more significant decrease in albumin levels. This study aims to analyze differences in mean albumin levels in COVID-19 survivors and non-survivors. Methods: This cross-sectional analytical study involved 40 COVID-19 survivors and non-survivors treated at Dr. M. Djamil General Hospital Padang from July 2021 to September 2021. Serum albumin levels were checked using an automated clinical chemistry tool. Data analysis was carried out using the Mann-Whitney non-parametric test, with a significance level of p < 0.05. Results: The mean age of the study subjects was 49.4 (16.3) years, with the majority of cases occurring in men (67.5%). The median albumin levels in all COVID-19 patients, COVID-19 survivors, and COVID-19 non-survivors were 3.2 (2.20–5.00) g/dL, respectively; 4.1 (3.0–5.0) g/dL; and 2.9 (2.20–3.70) g/dL (p = 0.001). Conclusion: There is a significant difference in mean albumin levels between COVID-19 survivors and non-survivors. Lower albumin levels were found in non-survivor patients. Albumin can be a potential biomarker for predicting clinical outcomes of COVID-19 patients.
Correlation Between C-Reactive Protein Level and Outcome In Coronavirus Disease 2019 Patients At COVID Intensive Care Unit RSUP. Dr. M. Djamil Padang Putri Ariani; Dedy Kurnia; Malinda Meinapuri; Rudy Afriant; Rina Gustia; Rikarni; Rinal Effendi
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 3 (2023): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan Special Issues: Jambi M
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i3.25078

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a respiratory system disease transmitted to humans and has infected humans in almost every country. Plasma cytokine levels, such as C-reactive protein (CRP), are elevated inflammatory markers in most COVID-19 patients and are routinely examined, especially in the intensive care Unit (ICU). Elevated CRP levels are associated with higher rates of severity and death. Objective: This study aimed to determine the correlation between CRP levels and outcomes in COVID-19 patients at COVID ICU RSUP. Dr. M. Djamil Padang Period July – December 2021. Method: This research was conducted using by analytic observational method with a retrospective cohort design. Secondary data was collected from the medical records of COVID-19 patients treated in the ICU COVID RSUP. Dr. M. Djamil Padang from July – December 2021, using total sampling as a technique, 107 samples met the inclusion criteria. Data analysis was carried out using univariate and bivariate methods. Result: The result shows more male patients (51.4%) than women (48.6%). From the age range, most age was found in the range > 59 years (54.2%). The most common type of comorbid disease was diabetes (32.7%). The highest CRP level at the initial ICU admission was >160 mg/L (70.1%), and the highest ferritin level was >434 ng/mL (86.0%). The most common patient outcome was death (65.4%). There is a relationship between CRP levels (p = 0.029) and the outcome of COVID-19 patients in the COVID ICU. Conclusion: This study concludes that there is a correlation between C-Reactive Protein (CRP) levels and Outcomes in COVID-19 patients at COVID ICU RSUP. Dr. M. Djamil Padang Period July – December 2021. Keywords : COVID-19, CRP, Patient Outcome, ICU
Uji Kesesuaian Hasil Pemeriksaan Sedimen Urine Metode Shih-Yung pada Volume Urine 10 mL dan 5 mL Niawaty, Putri; Rikarni, Rikarni; Yulia, Dwi
Andalas Journal of Health Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1721

Abstract

Microscopic examination of urine sediment using shih-yung system requires 10ml urine volume. Pediatric patients and kidney disease patients with oliguria difficult to get 10mL urine samples, so it needs to be studied to determine the accuracy of results with smaller sample volumes. Objectives: To analyze agreement of urine sediment examination using Shih-yung system in 10 mL and 5 mL urine volume. Methods: This study was a cross-sectional analysis of 37 urine specimens that met inclusion and exclusion criteria at the central laboratory of Dr. M. Djamil Hospital from July to September 2020. Examination of erythrocyte sediment, leukocyte sediment, and non-hyaline cast using Shih-yung system was done in 10 mL and 5 mL urine volume. Data were analyzed using kappa reliability/agreement test and significant if p<0.05. Results: Agreement test of erythrocyte sediment examination using Shih-yung system in 10ml and 5mL urine volume were moderate significantly (κ=0.600; p<0.05), agreement of leukocyte sediment examination were moderate significantly (κ=0.571; p<0.05), and agreement of nonhialin cast examination were substantial significantly (κ=0.767; p<0.05). Conclusion: Agreement test of erythrocyte and leukocyte sediment examination in 10ml and 5mL urine volume is moderate, so 5ml urine volume was not recommended. Manual examination with microscope and difference in urine sample volume causing difference sediment concentration and amount of sediment per microscope field of view.Keywords: Shih-yung,  urine sediment,  urine volume
Limfopenia dan Rasio Neutrofil-Limfosit pada Infeksi Severe Acute Respiratory Syndrome Coronavirus 2 Yufani, Hevrina; Rikarni, Rikarni; Rofinda, Zelly Dia
Andalas Journal of Health Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1734

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause cytokine storm characterized by the excessive release of pro-inflammatory cytokines, leading to lymphopenia and neutrophilia. Lymphopenia and high Neutrophil-Lymphocyte Ratio (NLR) on admission were associated with the severity of the disease. Objectives: To found out lymphopenia and high NLR in SARS-CoV-2 infection. Methods: This was a cross-sectional descriptive study on all patients infected with SARS-CoV-2 who met the inclusion and exclusion criteria at Dr. M. Djamil Hospital Padang from March until August 2020. Lymphocyte count and neutrophil count on admission were examined by flowcytometry method and NLR was calculated. Lymphopenia is a lymphocyte count of <1.5x103/mm3 and high NLR is ≥ 3.13.  Results: The study samples were 123 patients, with 58.5% women. The mean age was 47.80 (15.59) years. Lymphopenia was present in 39% of patients with mean lymphocyte count was 1.84 (0.83) x103/mm3. High NLR was present in 48% of patients with a mean NLR was 5.06 (4.87). Conclusion: Lymphopenia was present in 39% of patients infected with SARS-CoV-2 and high NLR was present in 48% of patients infected with SARS-CoV-2.Keywords:  lymphopenia, neutrophil-lymphocyte ratio, SARS-CoV-2
Perbedaan Derajat Adhesi Peritendinous Setelah Pemberian Platelet Rich Plasma (PRP) Terhadap Penyembuhan Ruptur Tendon Achilles Tikus Wistar Ananda, Gita Putri; Rahmadian, Rizki; Intan, Shinta Ayu; Rikarni, Rikarni; Rusjdi, Selfi Renita
Jurnal Kesehatan Andalas Vol. 14 No. 1 (2025): March 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Platelet-rich plasma (PRP) has been identified as a potential agent to enhance the tendon healing process and prevent complications such as adhesion and tendon displacement after surgery. Objective: To determined the difference in the degree of peritendinous adhesion after administration of platelet-rich plasma (PRP) on the healing of Achilles tendon rupture in Wistar rats. Methods: This study used a post-test only control group experimental design. Tendons in the control group were treated without PRP, while the treatment group received PRP before care. After one week, the degree of peritendinous adhesion was evaluated microscopically using the Tang scoring system. Results: The mean degree of adhesion in the control group was 3.38, and in the treatment group it was 3.83. The independent t-test yielded a non-significant value of 0.411 (p > 0.05). Conclusion: There was no significant difference in the degree of peritendinous adhesion in Achilles tendon rupture healing of Wistar rats between the group given PRP and the group not given PRP. Keywords: peritendinous adhesion, PRP, tendon rupture, Tang score
Korelasi Lactate Dehydrogenase dengan Rasio PaO2/FiO2 pada Pasien dengan COVID-19 di Intensive Care Unit Fitriani, Elsa; Rikarni, Rikarni; Yusri, Elfira
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p752-756.2023

Abstract

AbstrakLatar Belakang: Severe Acute Respiratory Syndrome (SARS COV-2) menyebabkan COVID-19  dengan manifestasi klinis bervariasi, terutama menyebabkan kerusakan parenkim paru. Kerusakan parenkim paru menyebabkan peningkatan kadar enzim lactate dehydrogenase (LDH) dan manifestasi berat akan menimbulkan acute respiratory distress syndrome (ARDS). Derajat keparahan gagal nafas dinilai dengan rasio PaO2/FiO2. Tujuan: menganalisis korelasi LDH dan rasio PaO2/FiO2 pada COVID-19. Metode: Penelitian analitik potong lintang terhadap 52    orang pasien COVID-19 di intensive care unit (ICU). LDH diukur dengan alat clinical chemistry analyzer dan rasio PaO2/FiO2 dengan blood gas analyzer. Uji korelasi Pearson bermakna apabila p<0,05. Hasil Subjek penelitian sejumlah 52 orang, 27(51,9%) laki-laki dan 25(48,1%) perempuan dengan rerata usia 56(12,796) tahun. Manifestasi klinis ditemukan ARDS ringan (13,50%), sedang (42,30%), berat (44,20%). Rerata LDH adalah 459,33(203,95) U/L dan rerata rasio PaO2/FiO2 adalah 121,67(58,72) mmHg. Uji korelasi Pearson  menunjukkan r=-0,43 dan p=0,002. Pembahasan: Rerata kadar LDH serum meningkat pada penelitian ini. Kadar LDH dan rasio PaO2/FiO2 pasien COVID-19 di ICU menunjukan korelasi sedang dan bermakna. Simpulan: Hasil penelitian terdapat korelasi LDH dengan rasio PaO2/FiO2 pasien COVID-19. Pemeriksaan LDH  digunakan sebagai parameter untuk menilai kerusakan jaringan parenkim paru pasien COVID-19. Kata kunci: COVID-19; SARS-CoV-2;ARDS, LDH;  Rasio PaO2/FiO 
Implementasi Fungsi Hash dalam Kriptografi Modern untuk Enkripsi Data Satu Arah Winanda, Mirza; Defrianti, Serli; Nabila, Wulan; Rikarni, Rikarni; Alfarizhi, Habieb
JIKUM: Jurnal Ilmu Komputer Vol. 1 No. 1 (2025): JIKUM: Jurnal Ilmu Komputer, Mei 2025
Publisher : LEMBAGA KAJIAN PEMBANGUNAN PERTANIAN DAN LINGKUNGAN (LKPPL)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62671/jikum.v1i1.34

Abstract

Cryptography is the science and art used to maintain data privacy. In its development, modern cryptographicalgorithms work by processing data in the form of a series of bits. One important approach in cryptography is the useof a one-way hash function (one-way hash function), which is able to change data into a fixed representation thatcannot be returned to its original form.This paper discusses the implementation of hash functions in modern cryptography for the one-way encryptionprocess. The hashing application is developed using the Python programming language with the hashlib library and aTkinter-based GUI interface. This application allows users to enter text, select a hash algorithm such as MD5, SHA1, SHA-256, SHA-512, and HSE, and get the hash results directly. Tests were carried out on several algorithms totrigger differences in the length and complexity of the results.The main characteristic of a one-way hash function is that two different messages will always produce different hashvalues. The test results show that each algorithm produces a unique hash value for a given input, with varying lengthsdepending on the algorithm used. SHA-512 produces the longest hash and is considered the most secure among otheralgorithms.
Co-Authors Adi K Aman, Adi K Agri Febria Sari Agri Febria Sari Alfarizhi, Habieb Almurdi Almurdi Amalina Ananda, Gita Putri Asterina Asterina Beti E. E Dewi, Beti E. E Chairunnisa Kusumawardhani Dedy Kurnia Defrianti, Serli Deswita Sari Desywar Desywar Dia Rofinda, Zelly Dia Dian Pertiwi Doan Atrya Dwi Yulia Dwi Yulia Efrida Efrida Elfira Yusri Ellyza Nasrul Elmatris Sy Elsa Fitriani Elvira Yusri Endrinaldi Fakhriyyatur Rahmi M Fitriani, Elsa Harika Putra Harry Isbagyo, Harry Hevrina Yufani Ida Rahmah Burhan Intan, Shinta Ayu Jesi Anggraini lillah . Malinda Meinapuri Nabila, Wulan Najirman Najirman Najirman, Najirman Niawaty, Putri Nora Harminarti Nuzirwan Acang Putri Ariani Putri Niawaty Rahajuningsih Dharma Rahmadian, Rizki Ratih Hasma Rianto Setiabudy Rika Florensia Rina Gustia Rinal Effendi Rudy Afriant Saptino Miro Selfi Renita Rusjdi Suryo Nugroho Suhardi Tambunan L Tambunan, Tambunan L Tuti Asryani Tutty Prihandani Wella Novile Izora Winanda, Mirza yoesri . Yufani, Hevrina Yulia, Dwi Yusri, Elfira Yustini Alioes Zelly Dia Rofinda