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All Journal Jurnal Kesehatan Andalas Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Jurnal Kesehatan Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Jurnal Ilmu Kesehatan Indonesia (JIKSI) JIKUM: Jurnal Ilmu Komputer
Rikarni Rikarni
Department Of Clinical Pathology And Laboratory Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Limfopenia dan Rasio Neutrofil-Limfosit pada Infeksi Severe Acute Respiratory Syndrome Coronavirus 2 Yufani, Hevrina; Rikarni, Rikarni; Rofinda, Zelly Dia
Jurnal Kesehatan Andalas Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1734

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause cytokine storm characterized by the excessive release of pro-inflammatory cytokines, leading to lymphopenia and neutrophilia. Lymphopenia and high Neutrophil-Lymphocyte Ratio (NLR) on admission were associated with the severity of the disease. Objectives: To found out lymphopenia and high NLR in SARS-CoV-2 infection. Methods: This was a cross-sectional descriptive study on all patients infected with SARS-CoV-2 who met the inclusion and exclusion criteria at Dr. M. Djamil Hospital Padang from March until August 2020. Lymphocyte count and neutrophil count on admission were examined by flowcytometry method and NLR was calculated. Lymphopenia is a lymphocyte count of <1.5x103/mm3 and high NLR is ≥ 3.13.  Results: The study samples were 123 patients, with 58.5% women. The mean age was 47.80 (15.59) years. Lymphopenia was present in 39% of patients with mean lymphocyte count was 1.84 (0.83) x103/mm3. High NLR was present in 48% of patients with a mean NLR was 5.06 (4.87). Conclusion: Lymphopenia was present in 39% of patients infected with SARS-CoV-2 and high NLR was present in 48% of patients infected with SARS-CoV-2.Keywords:  lymphopenia, neutrophil-lymphocyte ratio, SARS-CoV-2
Perbedaan Derajat Adhesi Peritendinous Setelah Pemberian Platelet Rich Plasma (PRP) Terhadap Penyembuhan Ruptur Tendon Achilles Tikus Wistar Ananda, Gita Putri; Rahmadian, Rizki; Intan, Shinta Ayu; Rikarni, Rikarni; Rusjdi, Selfi Renita
Jurnal Kesehatan Andalas Vol. 14 No. 1 (2025): March 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Platelet-rich plasma (PRP) has been identified as a potential agent to enhance the tendon healing process and prevent complications such as adhesion and tendon displacement after surgery. Objective: To determined the difference in the degree of peritendinous adhesion after administration of platelet-rich plasma (PRP) on the healing of Achilles tendon rupture in Wistar rats. Methods: This study used a post-test only control group experimental design. Tendons in the control group were treated without PRP, while the treatment group received PRP before care. After one week, the degree of peritendinous adhesion was evaluated microscopically using the Tang scoring system. Results: The mean degree of adhesion in the control group was 3.38, and in the treatment group it was 3.83. The independent t-test yielded a non-significant value of 0.411 (p > 0.05). Conclusion: There was no significant difference in the degree of peritendinous adhesion in Achilles tendon rupture healing of Wistar rats between the group given PRP and the group not given PRP. Keywords: peritendinous adhesion, PRP, tendon rupture, Tang score
Korelasi Lactate Dehydrogenase dengan Rasio PaO2/FiO2 pada Pasien dengan COVID-19 di Intensive Care Unit Fitriani, Elsa; Rikarni, Rikarni; Yusri, Elfira
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p752-756.2023

Abstract

AbstrakLatar Belakang: Severe Acute Respiratory Syndrome (SARS COV-2) menyebabkan COVID-19  dengan manifestasi klinis bervariasi, terutama menyebabkan kerusakan parenkim paru. Kerusakan parenkim paru menyebabkan peningkatan kadar enzim lactate dehydrogenase (LDH) dan manifestasi berat akan menimbulkan acute respiratory distress syndrome (ARDS). Derajat keparahan gagal nafas dinilai dengan rasio PaO2/FiO2. Tujuan: menganalisis korelasi LDH dan rasio PaO2/FiO2 pada COVID-19. Metode: Penelitian analitik potong lintang terhadap 52    orang pasien COVID-19 di intensive care unit (ICU). LDH diukur dengan alat clinical chemistry analyzer dan rasio PaO2/FiO2 dengan blood gas analyzer. Uji korelasi Pearson bermakna apabila p<0,05. Hasil Subjek penelitian sejumlah 52 orang, 27(51,9%) laki-laki dan 25(48,1%) perempuan dengan rerata usia 56(12,796) tahun. Manifestasi klinis ditemukan ARDS ringan (13,50%), sedang (42,30%), berat (44,20%). Rerata LDH adalah 459,33(203,95) U/L dan rerata rasio PaO2/FiO2 adalah 121,67(58,72) mmHg. Uji korelasi Pearson  menunjukkan r=-0,43 dan p=0,002. Pembahasan: Rerata kadar LDH serum meningkat pada penelitian ini. Kadar LDH dan rasio PaO2/FiO2 pasien COVID-19 di ICU menunjukan korelasi sedang dan bermakna. Simpulan: Hasil penelitian terdapat korelasi LDH dengan rasio PaO2/FiO2 pasien COVID-19. Pemeriksaan LDH  digunakan sebagai parameter untuk menilai kerusakan jaringan parenkim paru pasien COVID-19. Kata kunci: COVID-19; SARS-CoV-2;ARDS, LDH;  Rasio PaO2/FiO 
Implementasi Fungsi Hash dalam Kriptografi Modern untuk Enkripsi Data Satu Arah Winanda, Mirza; Defrianti, Serli; Nabila, Wulan; Rikarni, Rikarni; Alfarizhi, Habieb
JIKUM: Jurnal Ilmu Komputer Vol. 1 No. 1 (2025): JIKUM: Jurnal Ilmu Komputer, Mei 2025
Publisher : LEMBAGA KAJIAN PEMBANGUNAN PERTANIAN DAN LINGKUNGAN (LKPPL)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62671/jikum.v1i1.34

Abstract

Cryptography is the science and art used to maintain data privacy. In its development, modern cryptographicalgorithms work by processing data in the form of a series of bits. One important approach in cryptography is the useof a one-way hash function (one-way hash function), which is able to change data into a fixed representation thatcannot be returned to its original form.This paper discusses the implementation of hash functions in modern cryptography for the one-way encryptionprocess. The hashing application is developed using the Python programming language with the hashlib library and aTkinter-based GUI interface. This application allows users to enter text, select a hash algorithm such as MD5, SHA1, SHA-256, SHA-512, and HSE, and get the hash results directly. Tests were carried out on several algorithms totrigger differences in the length and complexity of the results.The main characteristic of a one-way hash function is that two different messages will always produce different hashvalues. The test results show that each algorithm produces a unique hash value for a given input, with varying lengthsdepending on the algorithm used. SHA-512 produces the longest hash and is considered the most secure among otheralgorithms.
Platelet Large Cell Ratio as a Prothrombotic Biomarker to Predict the Severity of COVID-19 Rikarni, Rikarni; Najirman, Najirman; Yulia, Dwi; Burhan, Ida Rahmah; Amalina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2622

Abstract

 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the lungs causes alveolar cell inflammation and disruption, leading to increased levels of proinflammatory cytokines that stimulate platelet activation and consumption. In response, megakaryocytes will increase the production of large, immature platelets. Large platelets bind more to fibrinogen than small platelets, increasing the potential for thrombus formation. This study aims to analyze the platelet large cell ratio as a prothrombotic biomarker to predict the severity of thrombosis in patients. A prospective cohort study was conducted in May-November 2021 at M. Djamil Hospital involving 206 samples of confirmed coronavirus disease 2019 (COVID-19) patients. The examinations included platelet count, P-LCR, and D-dimer. Large platelet counts were calculated using the Platelet Large Cell Ratio (P-LCR) parameter with an automated hematology analyzer. Clinical manifestations of disease severity were monitored based on WHO criteria, grouped into non-severe and severe disease. The 3 results showed a mean age of 47.41 (SD = 17.82). Platelet count was 263,690 (116,995)/mm , P-LCR was 30.86 (6.63)%, and D-dimer value was 2,215.97 (2,590.86) ng/mL. The P-LCR in the severe group was 35.08 (8.21)%, and the non-severe group was 26.64 (6.81)%, with p <0.001. D-dimer in the severe group was 3,680.36 (3,006.23) ng/mL, and in the non-severe group, 869.12 (977.03) ng/mL, with p <0.001. The relative risk of a high P-LCR causing severe COVID-19 is 2.35 compared to a low P-LCR, with p <0.001. The relative risk of a high D-dimer value causing severe COVID-19 is 6.80 compared to a low D-dimer, with p <0.001. The conclusion is  that a greater increase in large platelet production occurs in severe COVID-19 disease. P-LCR is a crucial biomarker for evaluating platelet activity. A high P-LCR value is a risk factor for predicting the severity of COVID-19. Suggestions for the use of PLCR. Increased risk of thrombotic events in COVID-19 patients can be identified by P-LCR examination upon admission to the hospital, allowing for preventive treatment.
Hubungan Faktor Risiko Aloimunisasi dengan Kejadian Inkompatibilitas Crossmatch Pada Pasien Keganasan Darah Dewasa yang Ditransfusi Packed Red Cell Berulang di RSUP Dr M Djamil Padang Herinda, Dwi Putri; Rofinda, Zelly Dia; Elvira, Dwitya; Rikarni, Rikarni; Aprilia, Dinda
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1132

Abstract

Latar Belakang: Pasien keganasan darah yang mendapatkan transfusi packed red cell (PRC) berulang akan menyebabkan pembentukan aloantibodi yang dapat terdeteksi pada pemeriksaan crossmatch dan mempersulit proses transfusi selanjutnya. Objektif: Penelitian ini bertujuan untuk mengetahui hubungan antara usia, jenis kelamin, jenis keganasan, dan jumlah unit transfusi dengan kejadian inkompatibilitas crossmatch. Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain cross- sectional. Terdapat 50 sampel yang didapatkan dari rekam medis dan laboratorium. Penelitian ini menggunakan analisis univariat dan analisis bivariat. Hasil: Hasil penelitian ini menunjukan prevalensi inkompatibilitas crossmatch sebesar 16% dengan keseluruhan inkompatibilitas minor. Kejadian terbanyak didapatkan pada usia <60 tahun, perempuan, LMA dan transfusi > 10. Hasil uji statistik menunjukan tidak adanya hubungan yang signifikan antara faktor usia (p= 0,322), jenis kelamin (p= 0,050), jenis keganasan darah (p= 0,662), dan jumlah unit transfusi (p= 0,702) dengan kejadian hasil pemeriksaan crossmatch. Kesimpulan: Faktor risiko seperti usia, jenis kelamin, jenis keganasan, dan jumlah unit transfusi tidak mempunyai hubungan signifikan dengan kejadian inkompatibilitas crossmatch pada pasien keganasan darah yang mendapatkan transfusi PRC berulang
Korelasi Skor SOFA dengan Kadar Kortisol Darah pada Pasien Sepsis di RSUP Dr. M. Djamil Padang Fahmi, Rahmadina Zesfira; Fadrian, Fadrian; Rikarni, Rikarni; Husni, Husni; Bilmahdi, Rohayat; Irramah, Miftah
Jurnal Kesehatan Andalas Vol. 14 No. 3 (2025): November 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v14i3.2671

Abstract

Sepsis is a life-threatening organ dysfunction due to dysregulation of the body's immune response to infection. The Sequential Organ Failure Assessment score (SOFA score) is a diagnostic tool used to quantitatively and objectively assess the level of organ dysfunction. Sepsis as a stressor of systemic inflammation, causes an increase in cortisol secretion by the adrenals to target tissues, which suppresses inflammation. Objective: To determine the correlation between SOFA score and blood cortisol levels in sepsis patients at RSUP Dr. M. Djamil Padang. Method: Observational analytic study with a cross-sectional method. The sample consisted of 55 patients who had been diagnosed with sepsis. The data used was secondary data from medical records. The data were tested using the Spearman correlation test. Result: A correlation was found between the SOFA score and blood cortisol levels, yielding a correlation coefficient of r = 0.338 and a p-value of 0.012. Conclusion: There is a significant moderate correlation between SOFA scores and blood cortisol levels. Keywords:  blood cortisol, sepsis, SOFA score
Analisis Status Gizi Siswa SD Bustanul Ulum Batu Busuk Padang Melalui Pengabdian Masyarakat Berbasis Pengukuran Indeks Massa Tubuh Dwi yulia; Rikarni Rikarni; Ellyza Nasrul; Husni Husni; Elfira Yusri; Zelly Dia Rofinda; Efrida Efrida; Syofiati Syofiati; Yhosie Anto Chicamy; Deswita Sari; Desywar Desywar; Dian Pertiwi; Almurdi Almurdi; Rismawati Yaswir; Atika Indah Sari; Nanda Oktavia
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 8 No. 3 (2025)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v8i3.762

Abstract

Nutritional status is an important indicator that determines the quality of health and development of school-age children. Adequate nutrition supports children's physical growth and cognitive abilities, and contributes to academic achievement. This community service activity aims to analyze the nutritional status of Bustanul Ulum Elementary School students by measuring height, weight, and Body Mass Index (BMI). The method used is quantitative descriptive with a sample of 150 students from grades 1 to 6. Measurements were carried out using standard and calibrated measuring instruments, while BMI was calculated using the formula body weight (kg) divided by the square of height (m²). The results showed that 75% of students had normal nutritional status, 10% were underweight and stunted, and 15% were overweight and obese. Factors that influence nutritional status include an unbalanced diet, lack of physical activity, and family socio-economic background. Children from families who have access to healthy food and good nutrition education tend to have better nutritional status. Based on these results, a comprehensive intervention program is needed in the form of nutrition education for students and parents, provision of healthy food at school, and promotion of regular physical activity. Collaboration between schools, health workers, and parents is essential to create an environment that supports optimal and sustainable child growth and development.
Association of Carcinoembryonic Antigen, Hemoglobin, and Neutrophil to Lymphocyte Ratio with Colorectal Cancer Histopathological Grade in West Sumatra, Indonesia Muhammad Zidane Innanda; Dwi Yulia; Avit Suchitra; Wirsma Arif Harahap; Rikarni Rikarni; Eka Nofita
Jurnal Kesehatan Vol 17 No 1 (2026): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v17i1.5584

Abstract

Colorectal cancer is a global health issue with a significant incidence and mortality rate. Identifying clinical characteristics using tumor biomarkers and hematological parameters is a crucial aspect in evaluating tumor cell differentiation grade. This study aims to determine the characteristics of Carcinoembryonic Antigen (CEA) levels, hemoglobin, and Neutrophil to Lymphocyte Ratio (NLR) values as indicators of histopathological differentiation grade in colorectal cancer patients. This was an observational, analytic study with a retrospective design, using medical record data from patients at Dr. M. Djamil General Hospital in Padang, from January 2023 to December 2024. A total of 154 patients meeting the inclusion and exclusion criteria were selected using a total sampling technique. Data were analyzed using statistical tests to assess the significance of the relationship between variables. The patient distribution showed a higher prevalence of females (55.8%), and more than half (62.3%) were aged 50 years or older. The histopathological profile was predominantly low grade (81.2%). Statistical test results showed a significant association between CEA levels and histopathological differentiation grade (p=0.017). However, no statistically significant association was found between hemoglobin levels (p=0.822) or NLR values (p=0.303) and histopathological differentiation grade. There is a potential association between CEA levels and histopathological differentiation grade, whereas hemoglobin levels and NLR values did not show a significant association. CEA levels can serve as a potential indicator in predicting tumor differentiation grade in colorectal cancer patients.
Development and diagnostic performance of a novel scoring system for predicting COVID-19 severity in a national referral hospital Rikarni Rikarni; Najirman Najirman; Dwi Yulia; Ricvan D. Nindrea; Muhammad AP. Yudha; Amalina Amalina
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.2987

Abstract

Coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical manifestations, ranging from mild illness to severe and critical disease. Early identification of patients at risk of deterioration remains important for timely clinical decision-making. The aim of this study was to develop a novel scoring system for predicting COVID-19 severity in a national referral hospital. This prospective cohort study included patients with confirmed COVID-19 admitted to Dr. M. Djamil Hospital, Padang, Indonesia, from May to December 2021. Demographic, clinical, and laboratory data were collected, and disease severity was classified according to the World Health Organization criteria. Univariate analysis was performed to identify candidate variables, followed by multivariable logistic regression analysis to determine independent predictors of severity. A scoring system was then constructed based on the retained predictors, and its diagnostic performance was evaluated using receiver operating characteristic analysis and the Youden index. Five variables were independently associated with COVID-19 severity: white blood cell count (WBC) ≥10,000/mm3, absolute lymphocyte count (ALC) <1,500/mm3, platelet large cell ratio (PLCR) ≥30%, interleukin-6 (IL-6) ≥7 pg/mL, and D-dimer ≥500 ng/mL. These variables were incorporated into a scoring system with a maximum total score of 6. Using a cut-off score of 3.5, the model showed a sensitivity of 96.15% and a specificity of 79.03% for differentiating severe from non-severe COVID-19. This study highlights that a novel scoring system based on WBC, ALC, PLCR, IL-6, and D-dimer performed well in predicting COVID-19 severity and may support early risk stratification in hospitalized patients.
Co-Authors Adi K Aman, Adi K Agri Febria Sari Agri Febria Sari Alfarizhi, Habieb Almurdi Almurdi Amalina Amalina Amalina Ananda, Gita Putri Aprilia, Dinda Asterina Asterina Atika Indah Sari Avit Suchitra Beti E. E Dewi, Beti E. E Bilmahdi, Rohayat Chairunnisa Kusumawardhani Defrianti, Serli Deswita Sari Deswita Sari Desywar Desywar Desywar Desywar Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Dwi yulia Dwi Yulia Dwi Yulia Dwi Yulia Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Eka Nofita Elfira Yusri Elfira Yusri Ellyza Nasrul Elmatris Sy Elsa Fitriani Endrinaldi Fadrian, Fadrian Fahmi, Rahmadina Zesfira Fakhriyyatur Rahmi M Fitriani, Elsa Harika Putra Harry Isbagyo, Harry Herinda, Dwi Putri Hevrina Yufani Husni Husni Husni Husni Ida Rahmah Burhan Intan, Shinta Ayu Jesi Anggraini lillah . Miftah Irramah Muhammad AP. Yudha Muhammad Zidane Innanda Nabila, Wulan Najirman Najirman Najirman Najirman Najirman, Najirman Nanda Oktavia Niawaty, Putri Nora Harminarti Nuzirwan Acang Putri Niawaty Rahajuningsih Dharma Rahmadian, Rizki Ratih Hasma Rianto Setiabudy Ricvan D. Nindrea Rika Florensia Rismawati Yaswir Saptino Miro Selfi Renita Rusjdi Syofiati Syofiati Tambunan L Tambunan, Tambunan L Tuti Asryani Tutty Prihandani Winanda, Mirza Wirsma Arif Harahap Yhosie Anto Chicamy yoesri . Yufani, Hevrina Yulia, Dwi Yusri, Elfira Yustini Alioes Zelly Dia Rofinda