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All Journal Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis

Ichwan Ridwan Rais

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Author-ID : 356592

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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ISOLASI DAN PENENTUAN KADAR FLAVONOID EKSTRAK ETANOLIK HERBA SAMBILOTO (Andrographis paniculata (BURM.F.) NESS) Ichwan Ridwan Rais
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

(Andrographis paniculata ( Burm.f. ) Ness ) is containing andrografolid, neoandrografolid,and flavonoids known as apigenin-7,4â€™-di-O-methyl ether, 5-hydroxy7,8,2â€™,3â€™tetrametoxyflavon,dihydroxy-dimetoxyflavon. Flavonoids as antioxidants, have potential as an anti-bacterial activity,anti-inflammatory, anti-allergic and anti-thrombosis. The chemical structure of the drug may explainthe nature of the drug and linkage units and structures of drug molecules with biological activity.Compounds with the same functional groups can provide the same biological response due to work onthe same receptors. This present study is determine the total flavonoid content of the ethanol extract ofA. paniculata use Chang method, identification using spectrophotometric method. The measurementresults showed that total flavonoid content of the ethanol extract of A. paniculata amounted to 46.322g/kg.

EKSTRAKSI ANDROGRAFOLID DARI Andrographis paniculata (Burm.f.) Nees MENGGUNAKAN EKSTRAKTOR SOXHLET Ichwan Ridwan Rais
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Chemical component extraction from plant herbal influenced by various aspect, such asextraction technique or chemical component character from the plant. Extraction method and solventpolarity exteremly influence chemical component transfer from the cell of plant to solvent solution.Soxhlet is extraction system instrument with frequently same solvent extraction based on liquid-steamcirculation process of the solvent. Solvent polarity to extract chemical component of the plant herbaldepend on chemical component character it self and ability to penetrate cell membrane.Andrographolide, an active chemical component of Andrographis paniculata has been suggested themost active constituent that responsible to activity of Andrographis paniculata in herbal medication.This chemical constituen has solubility character in solvent with middle polarity that indicates solventelection to extract it. This study shows that chemical component extraction of herbal plant influencedby solvent polarity. Thin Layer Chromatography qualitative analyses indicate that absolute polar andAndrographis paniculatanonpolar solvent could not extract andrographolide, different from middle polarity. Andrographolideextraction with similar solvent and correct method offer extract yield with 16,6% andrographolide.

AKTIVITAS ANTIOKSIDAN EKSTRAK Andrographis paniculata (Burm.f.) Ness DENGAN DUA PERBEDAAN PENGUAPAN Ichwan Ridwan Rais
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Andrographis paniculata (Burm.f.) Ness is one of the native tradisional medicine in Indonesia which contain active flavonoid. It has potential activity as antioxidant, antibacterial, and inflammation. Antioxidant sensitive to light and heat. Flavonoid antioxidant activity could be decline by heat and oxidation. We can find these caution while evaporate the liquid solvent with heating in conventional evaporation to get dry extract. One of the conventional evaporation instrument is Rotary Evaporator. Other evaporation system, lyophillization is alternative to evaporate solvent without heat. This system uses instrument called Freeze Dryer. Present study about antioxidant activity influenced by two different evaporation using IC50 determination in DPPH oxidation proved that evaporation difference could change antioxidant ability. The result shows freeze dryer evaporation result with 17.06% of extract yield and 585.730 Âµg/mL IC50 value better than rotary evaporator with 24.96% of extract yield and 792.196 Âµg/mL IC50 value in solvent evaporate ability and antioxidant activity.

PENENTUAN AKTIVITAS ISOLAT ANDROGRAFOLID TERHADAP α-AMILASE DAN α-GLUKOSIDASE MENGGUNAKAN METODE APOSTOLIDIS DAN MAYUR Ichwan Ridwan Rais; Agung Giri Samudra; Sitarina Widyarini; Agung Endro Nugroho
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Disorders of carbohydrate metabolism can lead to diabetes mellitus. Carbohydrates are metabolized in the gastrointestinal tract into simple glucose and absorbed into the bloodstream and affected blood glucose levels. The absorption process is catalyzed by α- 1 ,4 - glycoside breaking bond enzyme , namely α - amylase and α -1 ,6 - glycoside breaking bond enzyme, namely α – glucosidase. They are found in the intestinal cells. Research had been conducted in an effort to develop an alternative treatment of diabetes mellitus by testing the ability of isolates of andrographolide in inhibiting α-amylase activity and α-glucosidase in vitro. Andrographolide isolates showed fairly good activity in inhibiting α-amylase ( IC50 = 1,.49 mg/mL) and weak in inhibiting α-glucosidase (IC50 = 38,86 mg/mL). Inhibition of α-amylase activity is evidence of one mechanism of andrographolide in reducing carbohydrate metabolism that can affect blood glucose levels and indicates that andrographolide is a potential alternative medicine in addressing diabetes mellitus .

The antioxidant activity of several antidiabetic herbal products Ichwan Ridwan Rais; Andhika Septiawan; Meta Ayuni; Dhega Agung Wichaksono; Nanik Sulistyani
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The oxidative stress mechanism in the body involves the balance between increased ROS and decreased antioxidant agents. ROS can damage DNA, proteins, and lipids, leading to pathology and impaired insulin secretion by dysregulation of several genes expression. High concentrations of ROS are often followed by a low activity of antioxidants from endogenous sources. As a result, exogenous antioxidants are required to neutralize ROS. As reported, medicinal plants, which have had various traditional applications, contain large amounts of secondary metabolites, proven to be exogenous antioxidant agents. Jamu, a traditional medicine, also known as an alternative medication, can be widely and easily found in traditional markets. Antidiabetic herbal products are among the most popular of jamu. Antidiabetic mechanism has a strong relationship with antioxidant roles in many biological systems. The aim of this research was to figure out the potential antioxidant activity of antidiabetic herbal products. Eight antidiabetic jamu samples were analyzed for their antioxidant activity by measuring the DPPH radical scavenging activity, phosphomolybdenum antioxidant activity, and FRAP, as well as for their total phenolic and flavonoid contents. Good linearity was a general finding for the quantitative analysis, with an average correlation coefficient of 0.999 for the standards. The highest total flavonoid content found was 8.66 ± 0.11 mgQE/g, and the highest total phenolic content was 22.66 ± 0.15 mgGAE/g. With regard to antioxidant activity, all of the samples demonstrated weak DPPH radical scavenging activity, while phosphomolybdenum antioxidant activity and FRAP were the highest at 48.58 ± 0.45 mgQE/g extract and 226.98 ± 0.19 mgQE/g extract, respectively. These results indicated that the claimed antidiabetic herbal products could be prepared as exogenous antioxidant sources, irrespective of being with or without antioxidant activity, for diabetes treatment.

Antioxidant, Tyrosinase Inhibition Activity, and In Vitro SPF Evaluation of Pepino Fruit Extract (Solanum muricatum Aiton) in Different Solvent Types and Concentrations Sugihartini, Nining; Firsty, Girly Risma; Laila, Wahyu Kumil; Mulyaningsih, Sri; Rais, Ichwan Ridwan
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Solvent is a key factor that affects the effectiveness of active compound extraction from plant materials (simplisia). This study aimed to determine the optimal type and concentration of solvent used in the extraction of pepino fruit based on the parameter of antioxidant and tyrosinase inhibition activity, as well as Sun Protection Factor (SPF) value. The extraction was carried out using the maceration method with ethanol or ethyl acetate as the solvent, each at concentrations of 50%, 70%, and 96%, respectively. The antioxidant activity of the extracts was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The inhibition of tyrosinase and the determination of the SPF value were carried out using in vitro test. The results showed that the ethyl acetate extract was better than that of the ethanol extract in terms of antioxidant activity, tyrosinase inhibition, and SPF value. In the ethyl acetate solvent, a concentration of 96% provided the strongest antioxidant, tyrosinase inhibition activity, and the second highest in SPF test. It can be concluded that the optimal solvent for extracting pepino fruit as promising compound for sunscreen formulation is 96% ethyl acetate.

AUTHENTICATION OF PATCHOULI OIL FROM VARIOUS GROWING REGIONS USING GC-MS METHOD WITH CHEMOMETRIC COMBINATION ON THE PRODUCTS IN THE MARKET Nurani, Laela Hayu; Guntarti, Any; Milanie, Rida Dwi; Gandjar, Ibnu Gholib; Rais, Ichwan Ridwan; Prasasti, Dian; Edityaningrum, Citra Ariani
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10523

Adulteration in patchouli oil trade is an ancient practice, where additional substances like turpentine oil are added to increase volume and odor. Therefore, this research aimed to determine the composition of patchouli oil, considering variations in growing regions and potential adulteration in the products available in the market. The analysis was carried out using the Gas Chromatography-Mass Spectrormetry (GC-MS) method with a Principal Component Analysis (PCA) chemometric combination for authentication. The sample obtained from Bantul, Kulon Progo, and Purworejo was isolated through steam and water distillation. Subsequently, it was tested in accordance with SNI standard 06-2385-2006 and analyzed using GC-MS. The results were compared to the products on the market and processed using multivariate chemometric, namely PCA with Minitab 19 software. GC-MS analysis showed the presence of various compounds contained in the oil, including alcohol, alpha-guaiene, beta-humulene, seychellene, trans-caryophyllene, neoalloocimene, and beta-patchoulene. The combination of GC-MS and PCA chemometrics was able to distinguish patchouli oil from others and the products available on the market. PCA chemometric analysis showed that the patchouli oil from various growing regions had the same chemical components as essential oil. Furthermore, PCA chemometric analysis of market products also showed similar results but varied significantly from turpentine oil. This showed that the patchouli oil product available on the market did not contain turpentine oil.

UJI IN VITRO NILAI SUN PROTECTING FACTOR (SPF) EKSTRAK ETANOL DAN EKSTRAK HEKSANA DAUN KENIKIR (Cosmos caudatus Kunth.) Rahmi, Lisa Amelia; Emelda, Emelda; Solikah, Wahyu Yuliana; Rais, Ichwan Ridwan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2106

Bioactive substances found in kenikir leaves may be used as sunscreens. The purpose of the study is to evaluate the kenikir leaf ethanol extract (EEDK) and hexane extract (EHDK) as potential sunscreens. The maceration method is used for extraction, and 70% ethanol and n-hexane are used as each solvent. employing the UV-Vis spectrophotometric method at a wavelength of 290–400 nm and concentration series of 200, 400, 600, and 800 ppm to measure the SPF value of EEDK and EHDK. With SPF values of 1.3896 ± 0.0343, 1.7936 ± 0.0144, 2.2282 ± 0.0580, and 3.2575 ± 0.2257 obtained at concentrations of 200 ppm, 400 ppm, 600 ppm, and 800 ppm, respectively, the results demonstrate the potential of EEDK as a sunscreen. 1.1454 ± 0.0204; 1.3193 ± 0.0048; 1.4993 ± 0.0169 are the EHDK SPF values.

Nanostructured lipid carrier (NLC) in topical preparations: a narrative review of components, manufacturing methods, characteristics and activities Rizikiyan, Yayan; Sugihartini, Nining; Rais, Ichwan Ridwan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1643

Nanostructured Lipid Carries NLCs have gained attention in formulation science and nanotechnology due to their biocompatible material and ability to enhance skin penetration. The goal is to create products that can effectively deliver active compounds to desired skin layers with minimal side effects. This review focuses on the use of functionalized NLCs in dermocosmetics, specifically looking at their composition, manufacturing method, characteristics, and role in delivering active compounds. The review obtained articles from databases such as Scopus, Pubmed, and Google Scholar, covering the years 2014-2024. Data search was conducted in May 2024. The search used keywords such as "NLC OR formulation OR dermal OR activity”. By considering factors such as NLC composition, manufacturing method, and impact on compound delivery, researchers aim to optimize NLCs for use in topical preparations. This research contributes to the development of dermocosmetics that can address various skin problems more effectively. The search results from 32 articles gave an overview of the widely used NLC components: solid lipids: glycerol monostearate, compitrol 888 ATO, and tristearin; liquid lipids: myglyol, transcutol, and oleic acid; surfactants: poysorbat 80 and polysorbate 20. The widely used methods were ultrasonication and high pressure homogenization. Frequently performed characterizations include particle size, polydispersity index (PDI), zeta potential, and Entrapment Efficiency (EE). The pharmacological activity of active components loaded into NLCs increased than without NLCs. The active ingredient formulated in NLC can produce better activity compared to the active substance formulated directly in the conventional preparation. The application of nanostructured lipid carrier (NLC) nanoparticles on the skin is very beneficial. These nano systems have shown promising results and more commercial formulations, so it is expected to be done in further research.

Peran edukasi dalam pemilihan makanan sehat pada anak sekolah Ma'ruf, Muhammad; Rais, Ichwan Ridwan; Bachri, Moch. Saiful
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 5 No. 1 (2024)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v5i1.21427

Anak usia sekolah adalah konsumen makanan yang aktif dan mandiri dalam memilih jajanan di sekolah atau tempat lain. Pemilihan makanan sehat dan bergizi sangatlah penting untuk tumbuh kembang yang baik. Kegiatan ini bertujuan untuk memberikan edukasi kepada anak sekolah dasar di SD Muhammadiyah Purbayan dalam peningkatan pengetahuan siswa terhadap pemilihan makanan sehat. Kegiatan program pemberdayaan umat (PRODAMAT) menggunakan metode Participatory Action Research (PAR). Hasil dari kegiatan ini diperoleh bahwa siswa kelas 5 memperoleh nilai rata-rata pre-test sebesar 87,15 dan post-test sebesar 91,90. Sedangkan hasil pre-test kelas 6 memperoleh nilai rata-rata sebesar 91,50 dan post-test sebesar 97,50. Dengan itu, dapat disimpulkan bahwa peran edukasi dapat meningkatkan pengetahuan dan pemahaman siswa kelas 5 dan kelas 6 di SD Muhammadiyah Purbayan. Diharapkan hasil dari kegiatan PRODAMAT ini dapat meningkatkan kesadaran siswa terhadap pentingnya pemilihan makanan sehat dan aman untuk di konsumsi bagi anak sekolah.

Co-Authors Agung Endro Nugroho Agung Giri Samudra Akrom, Akrom Andhika Septiawan Anwar, Muslih Any Guntarti Arif Budi Setianto Capritasari, Rafiastiana Citra Ariani Edityaningrum, Citra Dhega Agung Wichaksono Dian Prasasti emelda, emelda Firsty, Girly Risma Ibnu Gholib Gandjar Laela Hayu Nurani Laila, Wahyu Kumil Ma'ruf, Muhammad Meta Ayuni Milanie, Rida Dwi Moch. Saiful Bachri Nanik Sulistyani Nining Sugihartini Rahmi, Lisa Amelia Ria Indah Pratami Sitarina Widyarini Solikah, Wahyu Yuliana Sri Mulyaningsih Sun, Suny Yayan Rizikiyan

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