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All Journal Microbiology Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Universa Medicina Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Human Care Journal Narra J Consilium Sanitatis: Journal of Health Science and Policy Media Penelitian dan Pengembangan Kesehatan
RAVEINAL RAVEINAL
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Universa Medicina

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Analysis of serum levels of B cell activating factor and soluble B cell activating factor receptor with disease activity in systemic lupus erythematosus Raveinal, Raveinal; Elvira, Dwitya; Delfin, Muhamad
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.181-189

Abstract

Background Systemic lupus erythematosus (SLE) is caused by B-cell hyperactivity, which stimulates the production of autoantibodies, leading to the formation of immune complexes and resulting in tissue damage. Increased B-cell activation is associated with disease activity in SLE. The cytokine B-cell Activating Factor (BAFF) and its soluble BAFF receptor (sBAFF-R) play a crucial role in B-cell activation and survival. Their serum levels may serve as potential biomarkers for SLE severity. This study aimed to compare serum levels of BAFF and sBAFF-R between SLE patients with mild, moderate, and severe disease activity. Methods A cross-sectional study was conducted involving 33 female SLE patients. Subjects were divided into mild, moderate, and severe disease activity groups. Disease activity was assessed using Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) scores. Serum BAFF and sBAFF-R levels were measured using ELISA. Data were analyzed using the Kruskal–Wallis and Mann-Whitney tests. A p-value < 0.05 was considered statistically significant. Results The median serum BAFF level in SLE patients was 0.51 ng/mL, and 4.66 ng/mL in sBAFF-R level.There was a statistically significant difference in serum BAFF and sBAFF-R levels between mild, moderate, and severe disease activity among SLE patients (p<0.0001). Conclusion Increased serum levels of BAFF and sBAFF-R may influence disease activity in SLE. Serum concentrations of BAFF and sBAFF-R were found to be associated with disease severity, including mild, moderate, and severe categories. These findings suggest that serum BAFF and sBAFF-R levels may serve as potential biomarkers for assessing SLE activity.
HIV-1 drug resistance-associated mutations in relation to viral load among HIV/AIDS patients at Dr. M. Djamil-Hospital Padang Nadia, Rizka; Elvira, Dwitya; Raveinal, Raveinal
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.38-43

Abstract

BackgroundAccording to the WHO, 38 million people suffer from HIV worldwide and according to the HIV Drug Resistance Report, the prevalence of antiretroviral therapy (ART) resistance is 3-29%. Drug resistance-associated mutations (DRAMs) are the presence of one or more HIV mutations that reduce the ability of certain drugs to inhibit viral replication and that will increase viral replication and HIV RNA, which can lead to therapeutic failure. The objective of this study was to determine the prevalence of HIV-1 DRAMs among patients with chronic HIV-1 infections and to compare HIV RNA viral load between M184V and K103N mutations. Methods A cross-sectional was conducted involving 80 patients with HIV who met the inclusion criteria. The study subjects were examined for genotype and HIV RNA viral load, both using the polymerase chain reaction (PCR). Data were analyzed with the Kruskal-Wallis test. Results The overall drug resistance mutation prevalence was 10.0%. The most common mutations were M184V and K103N. There was a significant difference between the median HIV RNA viral load counts in patients with either M184V or K103N, and with both M184V and K103N mutations, the values being 45.420, 13.207, and 97.517 copies/mL, respectively (p<0.001). Conclusion The HIV RNA viral load count was higher in the mutation group than in the group without mutation. Long-term and ongoing surveillance of HIV DRAMs among these patients is necessary, which will help us to adjust the treatment regimen.
Co-Authors Aisyah Elliyanti Akmal, Elfi Fauzana Alexander Kam Andani Eka Putra Arina Widya Murni Asir, Taufik Rizkian Delfin, Muhamad Deswinar Darwin Dwitya Elvira, Dwitya Eka Kurniawan Fadrian, Fadrian Fandi Triansyah Fauzar Fauzar Febrianti, Ika K. Febrianti, Ika Kurnia Harun Harnavi Helmi Arifin Ihsani, Aulia Ika Kurnia Febrianti Lia Dwi Lestari Malinda Meinapuri Marlina Marlina Nadia, Rizka Noverika Windasari Poedjijo, Yanuar Saputra Putra, Andani E. Ringga Novelni Ririn Anjelin Rose Dinda Martini Roza Kurniati Roza Mulyana Rudi Erwin Kurniawan Saptino Miro Selly Cintya Gusman Siti Nurhajjah Suci Maulida Yugo Berri Putra Rio Yuliana Arsil Yulistini, Yulistini Zikry Aulia Hidayat Zulkarnain Arsyad