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All Journal Jurnal Teknik Industri VALENSI Alchemy : Journal of Chemistry Jurnal Ilmu Kimia Universitas Brawijaya Jurnal Teknologi Pertanian Natural B AGRIVITA, Journal of Agricultural Science Sains dan Matematika Pharmademica: Jurnal Kefarmasian dan Gizi Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Journal of Tropical Pharmacy and Chemistry
Rurini Retnowati
Jurusan Kimia, FMIPA, Universitas Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Fajriah, Sofa; Retnowati, Rurini; Supratman, Unang
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46788

Abstract

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.
The Phenolic Compounds Isolated from Myristica fragrans and Their Cytotoxic Effects on B16-F10 Melanoma Cancer Cell Lines Hasbilla, Raihan Fathurrahman; Riyadi, Sandra Amalia; Safriansyah, Wahyu; Hidayat, Ace Tatang; Susianti, Susianti; Salam, Supriyanto; Lesmana, Ronny; Retnowati, Rurini; Supratman, Unang
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.16265

Abstract

Phenolic compounds are a major type of secondary metabolite found in plants. These compounds are synthesized through shikimic and phenylpropanoid pathways, resulting in the formation of numerous unique structures and bioactivities. In addition, a significant amount has been reported in nutmeg, an endemic plant of Indonesia, which has been widely used in traditional medicine. A previous study also revealed that ethyl acetate extract of the plant has notable cytotoxic effects against melanoma B16-F10. Therefore, the purpose of this study is to isolate and evaluate phenolic compounds in nutmeg for their potential to inhibit B16-F10 melanoma cancer cell growth. The seeds extract of nutmeg was separated by various chromatographic techniques to yield a total of five compounds, which were identified through spectroscopic analysis (HR-TOF-ESI-MS, IR, and NMR) as well as comparison with literature. The compounds 1-5 were identified as (+)-veraguensin (1), 3',4',5'-trimethoxycinnamyl alcohol (2), (+)-galbegin (3), (-)-polysphorin (4), and 7-methoxycoumarin (5). Cytotoxic effects were then assayed against B16-F10 melanoma cell lines using the Resazurin method. Furthermore, compound 1 displayed the highest cytotoxic activity, with an IC50 value of 112.71 µM.
Co-Authors A. Ghanaim Fasya Ace Tatang Hidayat Alief, M. Fadel Anisa Lailatusy Syarifah Azzahra, Vina Octavia Bambang Poerwadi Chasana, Nuraini Uswatun Christina Melani Brawijayanti Muda Makin Devina Azzuhro Dr.Ir. Yunianta, DEA Fahmi Hidayat Farabi, Kindi Hasbilla, Raihan Fathurrahman Heny Lohono Putri Herman Tolle Hermin Sulistyarti Lestari, Martina S M. Farid Rahman M. Rahman Maira, Faizah Martina S Lestari Masruri Masruri Naini, Al Arofatus Ni Made Wartini Nihayati, Ellis Nurita, Friska Devi Mella Pulung Yudhariska Pradana Puspitaloka, Paradhita Ayu Putra, Boyfannie Ivan Rinda Sulistyo Ronny Lesmana Safriansyah, Wahyu Salam, Supriyanto Sandra Amalia Riyadi SATRIYAS ILYAS Sentot Joko Raharjo Siti Alfisyah Nur Aziza Soebiantoro soebiantoro Soebiantoro Soebiantoro Soebiantoro, Sofa Fajriah Suleman Duengo Sumarno . Suratmo Suratmo Suratmo Suratmo Suratmo, Suratmo Susianti, Susianti Syarifah, Anisa Lailatusy Tatik Wardiyati Toepak, Erwin Prasetya Toto Himawan Tri Mayanti Tri Susanto Unang Supratman Warsito Warsito