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All Journal Jurnal Teknik Industri VALENSI Alchemy : Journal of Chemistry Jurnal Ilmu Kimia Universitas Brawijaya Jurnal Teknologi Pertanian Natural B AGRIVITA, Journal of Agricultural Science ALKIMIA : Jurnal Ilmu Kimia dan Terapan Sains dan Matematika Pharmademica: Jurnal Kefarmasian dan Gizi Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Journal of Tropical Pharmacy and Chemistry
Rurini Retnowati
Jurusan Kimia, FMIPA, Universitas Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Fajriah, Sofa; Retnowati, Rurini; Supratman, Unang
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46788

Abstract

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.
The Phenolic Compounds Isolated from Myristica fragrans and Their Cytotoxic Effects on B16-F10 Melanoma Cancer Cell Lines Hasbilla, Raihan Fathurrahman; Riyadi, Sandra Amalia; Safriansyah, Wahyu; Hidayat, Ace Tatang; Susianti, Susianti; Salam, Supriyanto; Lesmana, Ronny; Retnowati, Rurini; Supratman, Unang
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.16265

Abstract

Phenolic compounds are a major type of secondary metabolite found in plants. These compounds are synthesized through shikimic and phenylpropanoid pathways, resulting in the formation of numerous unique structures and bioactivities. In addition, a significant amount has been reported in nutmeg, an endemic plant of Indonesia, which has been widely used in traditional medicine. A previous study also revealed that ethyl acetate extract of the plant has notable cytotoxic effects against melanoma B16-F10. Therefore, the purpose of this study is to isolate and evaluate phenolic compounds in nutmeg for their potential to inhibit B16-F10 melanoma cancer cell growth. The seeds extract of nutmeg was separated by various chromatographic techniques to yield a total of five compounds, which were identified through spectroscopic analysis (HR-TOF-ESI-MS, IR, and NMR) as well as comparison with literature. The compounds 1-5 were identified as (+)-veraguensin (1), 3',4',5'-trimethoxycinnamyl alcohol (2), (+)-galbegin (3), (-)-polysphorin (4), and 7-methoxycoumarin (5). Cytotoxic effects were then assayed against B16-F10 melanoma cell lines using the Resazurin method. Furthermore, compound 1 displayed the highest cytotoxic activity, with an IC50 value of 112.71 µM.
Influence of Solvent Polarity on Color Intensity of Marigold Flower Extracts Retnowati, Rurini; Sulistyarti, Hermin; Suratmo; Ulfa, Siti Mariyah; Kamulyan, Budi; Destiara, Irena Amelia; Muzdhalifa, Sefira Putri; Ananda, Regina Ridha
ALKIMIA Vol 10 No 1 (2026): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/gfzt5f62

Abstract

In this paper, we report research on the extraction of natural dyes from yellow and orange marigold (Tagetes erecta L.) petals using different solvents. This research aims to determine the optimal dye removal process, investigate stability, and establish color intensity profiles. In order to extract natural dyes that produced various shades of the dried powder of yellow and orange marigold flower petals, two solvents with different polarities, n-hexane and ethyl acetate were used. The maceration procedure using different solvent types was carried out separately. The stability study revealed that all the dyes at room temperature showed better stability with minor changes observed by UV-Visible (UV-Vis) spectrum profiles, indicating that the extracts were stable until the 30th day. To ascertain the color intensity profiles, analytical tests such as UV-Vis spectroscopy and colorimetry utilizing a color reader device were carried out. The color intensity profile of the yellow and orange marigold flower extracts resulting from the UV-Vis spectrum analysis showed that the absorption of the ethyl acetate extract is higher. The pigment concentration, which is also expressed by absorbance, is connected to variations in color intensity. Additionally, the color intensity profile characterization using a color reader revealed that the n-hexane and ethyl acetate extracts had different Commission Internationale d'Eclairage (CIE) L*, a*, and b* values. The yield and color intensity of the extracts were affected by the solvent polarity. In conclusion, the study of the extract's color intensity profile using UV-Vis spectroscopy and a color reader shows that the intensity parameters are aligned.
Co-Authors A. Ghanaim Fasya Ace Tatang Hidayat Alief, M. Fadel Ananda, Regina Ridha Anisa Lailatusy Syarifah Azzahra, Vina Octavia Bambang Poerwadi Budi Kamulyan Chasana, Nuraini Uswatun Christina Melani Brawijayanti Muda Makin Destiara, Irena Amelia Devina Azzuhro Dr.Ir. Yunianta, DEA Fahmi Hidayat Farabi, Kindi Hasbilla, Raihan Fathurrahman Heny Lohono Putri Herman Tolle Hermin Sulistyarti Lestari, Martina S M. Farid Rahman M. Rahman Maira, Faizah Martina S Lestari Masruri Masruri Muzdhalifa, Sefira Putri Naini, Al Arofatus Ni Made Wartini Nihayati, Ellis Nurita, Friska Devi Mella Pulung Yudhariska Pradana Puspitaloka, Paradhita Ayu Putra, Boyfannie Ivan Rinda Sulistyo Ronny Lesmana Safriansyah, Wahyu Salam, Supriyanto Sandra Amalia Riyadi SATRIYAS ILYAS Sentot Joko Raharjo Siti Alfisyah Nur Aziza Siti Mariyah Ulfa Soebiantoro Soebiantoro Soebiantoro soebiantoro Soebiantoro, Sofa Fajriah Suleman Duengo Sumarno . Suratmo Suratmo Suratmo Suratmo Suratmo Suratmo, Suratmo Susianti, Susianti Syarifah, Anisa Lailatusy Tatik Wardiyati Toepak, Erwin Prasetya Toto Himawan Tri Mayanti Tri Susanto Unang Supratman Warsito Warsito