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All Journal Medicina E-Jurnal Medika Udayana JURNAL BIOMEDIK WMJ (Warmadewa Medical Journal) Molecular and Cellular Biomedical Sciences (MCBS) Berkala Ilmiah Kedokteran Duta Wacana ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Lumbung Farmasi : Jurnal Ilmu Kefarmasian IJAAM (Indonesian Journal of Anti-Aging Medicine) Jurnal Sains dan Teknologi Peternakan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Pharmaceutical Science and Application (JPSA)
I Gusti Made Aman
Department Of Medical Pharmacology, Faculty Of Medicine, Universitas Udayana, Denpasar, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pemberian deer placenta secara oral meningkatkan kadar hormon testosteron pada tikus Wistar (Rattus norvegicus) jantan muda I Made Oka Negara; Wimpie Pangkahila; I Gusti Made Aman; Alex Pangkahila; I Wayan Weta; Ni Nyoman Ayu Dewi
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.658 KB) | DOI: 10.15562/ism.v11i2.651

Abstract

Background: Men who experience hypogonadal symptoms are increasingly experienced by a younger age. This is due to a decrease in the hormone testosterone. Efforts to increase the hormone testosterone in hypogonadal men are often made to restore sexual function, libido, muscle mass, physical strength, bone density, and feelings of pleasure. This study aims to determine the effect of giving deer placenta orally in increasing levels of the hormone testosterone in young male Wistar rats (Rattus norvegicus).Methods: The experimental study was conducted using a pretest and posttest control group design involving 18 young male Wistar rats aged 2.5-3 months with a bodyweight of 150-180 grams. Wistar rats were divided into two groups, each totaling 9 rats, one group as a control group (giving placebo for 28 days) and the treatment group (giving deer placenta orally as much as 10.5 grams per day for 28 days). The data obtained were analyzed by SPSS version 20 for Windows.Results: The results showed that there was a significant increase in testosterone levels both before (3.018±0.282 ng/ml) and after (4.516±0.796 ng/ml) giving deer placenta orally as much as 10.5 grams for 28 days (p <0.010). However, the results of this study showed that there was no increase in testosterone levels in the control group either before or after the placebo treatment (p> 0.05).Conclusion: The results of this study indicate that the administration of deer placenta orally for 28 days showed an increase in testosterone levels among young male Wistar rats. Latar Belakang: Laki-laki yang mengalami gejala-gejala hipogonad semakin dialami oleh usia yang semakin muda. Hal ini dikarenakan terjadi penurunan hormone testosterone. Upaya meningkatkan hormon testosteron pada laki-laki hipogonad kerap dilakukan untuk dapat mengembalikan fungsi seksual, libido, masa otot, kekuatan fisik, densitas tulang, dan perasaan senang. Penelitian ini bertujuan untuk mengetahui efek pemberian deer placenta secara oral dalam meningkatkan kadar hormon testosteron pada tikus Wistar (Rattus norvegicus) jantan muda.Metode: Penelitian eksperimental dilakukan dengan menggunakan pretest and posttest control group design yang melibatkan 18 ekor tikus putih Wistar jantan muda berusia 2,5-3 bulan dengan berat badan 150-180 gram. Tikus Wistar terbagi menjadi dua kelompok masing-masing berjumlah 9 ekor tikus dimana satu kelompok sebagai kelompok kontrol (pemberian plasebo selama 28 hari) dan kelompok perlakuan (pemberian deer placenta secara oral sebanyak 10,5 gram per hari selama 28 hari).  Data yang diperoleh dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Hasil penelitian menunjukkan terdapat peningkatan kadar testostesteron secara bermakna baik sebelum (3,018±0,282 ng/ml) maupun setelah (4,516±0,796 ng/ml) pemberian deer placenta secara oral sebanyak 10,5 gram selama 28 hari (p<0,010). Akan tetapi hasil penelitian ini menunjukkan tidak terdapat peningkatan kadar testosteron pada kelompok kontrol baik sebelum atau setelah perlakuan yang diberikan plasebo (p>0,05).Kesimpulan: Hasil penelitian ini menunjukkan bahwa pemberian deer placenta secara oral selama 28 hari menunjukkan terdapat peningkatan kadar testosteron pada tikus Wistar jantan muda.
PENGARUH PEMBERIAN AROMATERAPI MINYAK MELATI (Jasminum sambac L.) TERHADAP PENURUNAN DERAJAT INSOMNIA PADA LANSIA DI BANJAR GEDE KELURAHAN SEMPIDI Ni Putu Yuliana Assari; Ida Ayu Manik Partha Sutema; I Gusti Made Aman
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.505

Abstract

The humans’ organs function will be decreased when humans are getting older. It caused they to had insomnia. Insomnia is a condition of humans’ sleeping problem. Jasmine oil aromatherapy is an essential oil which is used to decrease insomnia. The research aimed at knowing or prove that jasmine oil aromatherapy can reduce the degree of insomnia in the elderly. The research method was a quasy experimental one group pretest-posttest design. The research subject was 34 elderlies who were selected by the purposive sampling. The degree of insomnia before and after the intervention was measured using the Insomnia Severity Index (ISI) questionnaire. The test result of Friedman showed that there was differences in the degree of insomnia after giving jasmine oil aromatherapy to the elderly (p=0,001). Before giving jasmine oil aromatherapy, the average value was 19,147. Meanwhile, after using jasmine oil aromatherapy on the 8th day, the average value was 13,000 and on the 15th day there was a significant decrease in the degree of insomnia with an average value of 7,147. the administration of jasmine oil aromatherapy can significantly reduced the degree of insomnia in the elderly in Banjar Gede, Sempidi Village started on day 8 (2nd posttest) and day 15 (3rd posttest).
ANTIFUNGAL ACTIVITIES OF ETHANOL EXTRACT OF ROSEMARY LEAF (Rosemarinus officinalis L.) AGAINST Candida albicans Dewa Ayu Made Adnya Swari; I Wayan Martadi Santika; I Gusti Made Aman
Journal Pharmaceutical Science and Application Vol. 2 No. 1 (2020): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i01.p05

Abstract

Background: This study was a preliminary study aimed to investigating the in vitro activity of rosmarinic acid contained on Rosemary leaves (Rosemarinus officinalis L.) on the Candida albicans. Rosmarinic acid can be an inhibitor of the RTPase enzyme in the fungus Candida albicans. Objective: This study is expected to provide information in the development of science about the antifungal activity of ethanol extract of Rosemary leave (Rosmarinus officinalis L.) againsts C.albicans. The recent research was an laboratory experimental. Experiments on an ethanol extract of Rosemary leaves (Rosemarinus officinalis L.) and posttest design of the control group. Methods: The extraction method used in this study was a multilevel extraction method. The antifungal activity testing method uses discs and MIC methods. Replication was done six times at two concentration namely, 80% (b/v) and 100% for each measurement. Results: The data analysis was carried out using SPSS with 95% of confidence level with the Kruskal Wallis analysis then completed with the Mann Whitney U test. The results of the MIC experiment showed all the various concentrations of ethanol extract performed Candida albicans growth on the surface of the media. Extract with 80% (b/v) concentration showed greater antifungal activity. Furthermore the MIC was shown by 80% (b/v) concentration of the ethanol extract of Rosemary leaves against Candida albicans. The test results of the antifungal activity of the Rosemary leaf ethanol extract showed the presence of inhibitory diameter in the ethanol extract of the Rosemary leaf concentration of 80% (b/v) with a mean ± SD of 10.6 ± 0.57735 and RSD of 5.774%. Conclusion: The ethanol extract of Rosemary leaves (Rosmarinus officinalis L.) has an inhibitory effect on the fungus Candida albicans at a concentration of 80% (b/v). Keywords: Antifungal activity; Candida albicans; Rosemary; RTPase; Ethanol extract
Co-Authors ., Nuriyah A.A.G.P. Wiraguna AAGP Wiraguna Agung Nova Mahendra Akpriyanti, DG Ika Ana Yulia Anak Agung Gde Putra Wiraguna Anak Agung Gede Budhiarta Arina Papita Simanungkalit Augus Venty Bagiada NA Bagus Komang Satriyasa Bissi Herliane Citra Anissa Ayu Cynthia Sofyanti Sugiharto Delly Dahlia Dewa Ayu Made Adnya Swari Dewa Ayu Made Adnya Swari Dhiancinantyan Windydaca Brata Putri Dian Andriani Dian Andrieany Husodo Diana Niti Santoso Dinda Paramaningtyas Sudibya Eveline Margo Fanny Rustandi Felix Kusmana Ferbian Milas Siswanto Gde Ngurah Idraguna Pinatih Gede Gunawan Mahardika Golda Bernadet Lemewu Hayatul Firi Hayyu Kusumaningtyas Heidy Dwi Nadia Hendrik Danico Heny Widiyowati S I Gusti Ayu Artini I Ketut Suada I Nyoman Adiputra I Putu Eka Kusuma Yasa I Wayan Martadi Santika I Wayan Martadi Santika I Wayan Putu Sutirta Yasa I Wayan Weta Ida Ayu Dewi Wiryanthini Ida Sri Iswari Irtanto, Okky J. A. Pangkahila Ken Andrina Anindita Ketut Widyani Astuti Laura Indriana Liya Rosdiana Made Dio Lokantara Made Oka Negara Manus, Widya Christine Maria Eka Patri Yuliati Maulidha Suzi Annisa Melita Hidajat Nadia Anastasia Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Yuliana Assari Ni Wayan Sucindra Dewi Noviyanti Situmorang Olivia Olivia Priskila Ariana Putu Ayu Melati Widyasari Setia Wardani Silvia Irani Sriwiyanti Sriwiyanti Suarni . Sukoco, Hendro Sulaiman, Yogie Susianingsih Murni Hartati Sutema, Ida Ayu Manik Partha Syafii, Corry P. Valentine Retny Shiajanto Wimpie I Pangkahila Yuliana Tjua