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All Journal Medicina E-Jurnal Medika Udayana JURNAL BIOMEDIK WMJ (Warmadewa Medical Journal) Molecular and Cellular Biomedical Sciences (MCBS) Berkala Ilmiah Kedokteran Duta Wacana ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Lumbung Farmasi : Jurnal Ilmu Kefarmasian IJAAM (Indonesian Journal of Anti-Aging Medicine) Jurnal Sains dan Teknologi Peternakan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Pharmaceutical Science and Application (JPSA)
I Gusti Made Aman
Department Of Medical Pharmacology, Faculty Of Medicine, Universitas Udayana, Denpasar, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PENGARUH PEMBERIAN AROMATERAPI MINYAK MELATI (Jasminum sambac L.) TERHADAP PENURUNAN DERAJAT INSOMNIA PADA LANSIA DI BANJAR GEDE KELURAHAN SEMPIDI Ni Putu Yuliana Assari; Ida Ayu Manik Partha Sutema; I Gusti Made Aman
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.505

Abstract

The humans’ organs function will be decreased when humans are getting older. It caused they to had insomnia. Insomnia is a condition of humans’ sleeping problem. Jasmine oil aromatherapy is an essential oil which is used to decrease insomnia. The research aimed at knowing or prove that jasmine oil aromatherapy can reduce the degree of insomnia in the elderly. The research method was a quasy experimental one group pretest-posttest design. The research subject was 34 elderlies who were selected by the purposive sampling. The degree of insomnia before and after the intervention was measured using the Insomnia Severity Index (ISI) questionnaire. The test result of Friedman showed that there was differences in the degree of insomnia after giving jasmine oil aromatherapy to the elderly (p=0,001). Before giving jasmine oil aromatherapy, the average value was 19,147. Meanwhile, after using jasmine oil aromatherapy on the 8th day, the average value was 13,000 and on the 15th day there was a significant decrease in the degree of insomnia with an average value of 7,147. the administration of jasmine oil aromatherapy can significantly reduced the degree of insomnia in the elderly in Banjar Gede, Sempidi Village started on day 8 (2nd posttest) and day 15 (3rd posttest).
ANTIFUNGAL ACTIVITIES OF ETHANOL EXTRACT OF ROSEMARY LEAF (Rosemarinus officinalis L.) AGAINST Candida albicans Dewa Ayu Made Adnya Swari; I Wayan Martadi Santika; I Gusti Made Aman
Journal Pharmaceutical Science and Application Vol. 2 No. 1 (2020): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i01.p05

Abstract

Background: This study was a preliminary study aimed to investigating the in vitro activity of rosmarinic acid contained on Rosemary leaves (Rosemarinus officinalis L.) on the Candida albicans. Rosmarinic acid can be an inhibitor of the RTPase enzyme in the fungus Candida albicans. Objective: This study is expected to provide information in the development of science about the antifungal activity of ethanol extract of Rosemary leave (Rosmarinus officinalis L.) againsts C.albicans. The recent research was an laboratory experimental. Experiments on an ethanol extract of Rosemary leaves (Rosemarinus officinalis L.) and posttest design of the control group. Methods: The extraction method used in this study was a multilevel extraction method. The antifungal activity testing method uses discs and MIC methods. Replication was done six times at two concentration namely, 80% (b/v) and 100% for each measurement. Results: The data analysis was carried out using SPSS with 95% of confidence level with the Kruskal Wallis analysis then completed with the Mann Whitney U test. The results of the MIC experiment showed all the various concentrations of ethanol extract performed Candida albicans growth on the surface of the media. Extract with 80% (b/v) concentration showed greater antifungal activity. Furthermore the MIC was shown by 80% (b/v) concentration of the ethanol extract of Rosemary leaves against Candida albicans. The test results of the antifungal activity of the Rosemary leaf ethanol extract showed the presence of inhibitory diameter in the ethanol extract of the Rosemary leaf concentration of 80% (b/v) with a mean ± SD of 10.6 ± 0.57735 and RSD of 5.774%. Conclusion: The ethanol extract of Rosemary leaves (Rosmarinus officinalis L.) has an inhibitory effect on the fungus Candida albicans at a concentration of 80% (b/v). Keywords: Antifungal activity; Candida albicans; Rosemary; RTPase; Ethanol extract
Efek Pemberian Virgin Coconut Oil (Cocos nucifera) terhadap Dislipidemia pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diberi Diet Tinggi Kolesterol Augus Venty; I Gusti Made Aman; Wimpie Pangkahila
WMJ (Warmadewa Medical Journal) Vol 1 No 2 (2016): November 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.2.28.58-65

Abstract

Dislipidemia adalah kelainan metabolisme lipid yang ditandai peningkatan kolesterol total, kolesterol LDL, trigliserida diatas nilai normal serta penurunan kolesterol HDL di dalam darah. Virgin coconut oil (VCO) mengandung 92% lemak jenuh sehingga dikaitkan dengan peningkatan resiko penyakit kardiovaskular. Tidak semua asam lemak jenuh buruk bagi kesehatan. VCO terdiri dari medium chain triglycerides (MCT) dan komponen polifenol bekerja secara sinergis dalam mencegah dislipidemia. Penelitian ini bertujuan untuk mengetahui kegunaan VCO sebagai alternatif untuk mencegah dislipidemia pada tikus putih jantan galur wistar yang diberi diet tinggi kolesterol. Penelitian ini adalah penelitian eksperimental murni dengan randomized post-test only control group design menggunakan 36 ekor tikus putih jantan. Semua sampel diberikan diet tinggi kolesterol, lalu dibagi menjadi 2 kelompok secara random yaitu kelompok kontrol yang diberikan plasebo berupa akuades sebanyak 0,8 ml/ hari dan kelompok perlakuan yang diberikan VCO sebanyak 0,8 ml/ 200 gram berat badan/ hari selama 28 hari. Hasil penelitian ini menunjukkan bahwa rerata kolesterol total kelompok perlakuan lebih rendah dari kelompok kontrol (113,49±4,31 mg/dl vs 222,61±6,41 mg/dl) (p<0,05). Rerata trigliserida kelompok perlakuan lebih rendah dari kelompok kontrol (91,46±5,56 mg/dl vs 153,51±5,40 mg/dl) (p<0,05). Rerata kolesterol LDL kelompok perlakuan lebih rendah dari kelompok kontrol (37,94±3,32 mg/dl vs 71,25±2,76  mg/dl) (p<0,05). Rerata kolesterol HDL kolesterol total kelompok perlakuan lebih tinggi dari kelompok kontrol (41,62±1,58 mg/dl vs 25,02±2,59 mg/dl) (p<0,05). Penelitian ini menyimpulkan bahwa virgin coconut oil mencegah dislipidemia pada tikus jantan galur wistar yang diberi diet tinggi kolesterol.Kata Kunci: virgin coconut oil, profil lipid, dislipidemia. [The Effect of Virgin Coconut Oil (Cocos nucifera) to Dyslipidemia in Male Wistar Rats (Rattus norvegicus) Fed with High Cholesterol Diet].Dyslipidemia is a lipid metabolism disorder followed by high total cholesterol level, high LDL cholesterol level, high tryglyceride level and low HDL cholesterol level. Virgin coconut oil (VCO) contains 92% saturated fat that is associated with an increased risk of cardiovascular disease. Not all saturated fatty acids are bad for health. VCO consist of medium chain triglycerides (MCTs) and polyphenol components that work synergistically in preventing dyslipidemia. This research was aimed to determine the usefulness of VCO as an alternative to prevent dyslipidemia in male wistar rats fed with high cholesterol diet. This study was a true experimental research with randomized post-test only control group design using 36 male rats. All samples were given a high cholesterol diet and were divided into 2 groups randomly: a control group were given a placebo (distilled water) 0,8 ml/ day and a treatment group were given VCO 0,8 ml/ 200gram weight/ day for 28 days. The results showed that the treatment group had a significantly lower total cholesterol levels compared to the control group (113,49±4,31 mg/dl vs 222,61±6,41 mg/dl) (p<0,05). The treatment group had a significantly lower triglycerides levels compared to the control group (91,46±5,56 mg/dl vs 153,51±5,40 mg/dl) (p<0,05). The treatment group had a significantly lower LDL cholesterol levels compared to the control group (37,94±3,32 mg/dl vs 71,25±2,76  mg/dl) (p<0,05). The treatment group had a significantly higher HDL cholesterol levels compared to the control group (41,62±1,58 mg/dl vs 25,02±2,59 mg/dl) (p<0,05). This research concluded that virgin coconut oil was proved in preventing dyslipidemia in male wistar rats fed with high cholesterol diet.Keywords: virgin coconut oil, lipid profile, dyslipidemia.
Co-Authors ., Nuriyah A.A.G.P. Wiraguna AAGP Wiraguna Agung Nova Mahendra Akpriyanti, DG Ika Ana Yulia Anak Agung Gde Putra Wiraguna Anak Agung Gede Budhiarta Arina Papita Simanungkalit Augus Venty Bagiada NA Bagus Komang Satriyasa Bissi Herliane Citra Anissa Ayu Cynthia Sofyanti Sugiharto Delly Dahlia Dewa Ayu Made Adnya Swari Dewa Ayu Made Adnya Swari Dhiancinantyan Windydaca Brata Putri Dian Andriani Dian Andrieany Husodo Diana Niti Santoso Dinda Paramaningtyas Sudibya Eveline Margo Fanny Rustandi Felix Kusmana Ferbian Milas Siswanto Gde Ngurah Idraguna Pinatih Gede Gunawan Mahardika Golda Bernadet Lemewu Hayatul Firi Hayyu Kusumaningtyas Heidy Dwi Nadia Hendrik Danico Heny Widiyowati S I Gusti Ayu Artini I Ketut Suada I Nyoman Adiputra I Putu Eka Kusuma Yasa I Wayan Martadi Santika I Wayan Martadi Santika I Wayan Putu Sutirta Yasa I Wayan Weta Ida Ayu Dewi Wiryanthini Ida Sri Iswari Irtanto, Okky J. A. Pangkahila Ken Andrina Anindita Ketut Widyani Astuti Laura Indriana Liya Rosdiana Made Dio Lokantara Made Oka Negara Manus, Widya Christine Maria Eka Patri Yuliati Maulidha Suzi Annisa Melita Hidajat Nadia Anastasia Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Yuliana Assari Ni Wayan Sucindra Dewi Noviyanti Situmorang Olivia Olivia Priskila Ariana Putu Ayu Melati Widyasari Setia Wardani Silvia Irani Sriwiyanti Sriwiyanti Suarni . Sukoco, Hendro Sulaiman, Yogie Susianingsih Murni Hartati Sutema, Ida Ayu Manik Partha Syafii, Corry P. Valentine Retny Shiajanto Wimpie I Pangkahila Yuliana Tjua