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All Journal Dentika Dental Journal ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi MDJ (Makassar Dental Journal) Indian Journal of Forensic Medicine & Toxicology Cakradonya Dental Journal Odonto dental journal
Eriska Riyanti
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Odonto dental journal

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HUBUNGAN POLIMORFISME GEN RESEPTOR ESTROGEN ALFA DENGAN JUMLAH SEL T CD4+ PADA ANAK TERINFEKSI HIV Irna Sufiawati; Risti Saptarini; Eriska Riyanti
Odonto : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.934 KB) | DOI: 10.30659/odj.4.2.94-100

Abstract

Background: Estrogen plays a key role in human physiological processes. Polymorphisms of estrogen receptors have been implicated in the development of numerous diseases. The aim of this study was to evaluate the frequency of ERα gene Pvull and Xbal polymorphisms and assessing their association with CD4+ T-cell counts in HIV-infected children on highly active antiretroviral therapy.Methods: CD4+ T cell counts were determined using the FACS count system. ERα PvuII and XbaI polymorphisms were analyzed by PCR-RFLP.Results: This study enrolled 34 HIV-infected children on HAART. The frequencies of the PvuII and XbaI gene polymorphisms were PP 41,2%, Pp 26,5%, pp 32,4% and XX 35,3%, Xx 17,6%, xx 47,1% respectively. CD4+ T-cell counts were significantly associated with XbaI polymorphisms (p<0.05), but not PvuII polymorphisms (p>0.01).Discussion: Host genetic factor polymorphism is an important determinant of HIV  disease progression and treatment response. The ERα Pvull and Xbal polymorphisms can increase risk for the development of HIV-related complication,including oral diseases.Conclusion: The ERα gene XbaI polymorphism was significantly associated with CD4+ T-cell counts. It may explain the role of estrogen in the regulation of HIV replication. Studying human genetic variation in HIV-infected individuals is important to guide a new therapeutic approach.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BAWANG PUTIH (Allium sativum) Djuned Prasonto; Eriska Riyanti; Meirina Gartika
Odonto : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.822 KB) | DOI: 10.30659/odj.4.2.122-128

Abstract

Background: Organosulfur compound, allicin and phenolic are the main compound in garlic responsible for antioxidant activity. Correlation between free radicals and some dental diseases, such as free radicals and Reactive Oxygen Species (ROS) responsible for periodontal inflammation, caries, lesions and oral cancers. The research objective is to get scientifc data about the antioxidant activity from garlic extract (Allium sativum).Method: The research was conducted using three different varieties of garlic:local garlic varieties Ciwidey, single local garlic’s clove, and import garlic which is found at the market in Bandung. Garlic extract is made by maceration using ethanol 96% and antioxidant activity test using DPPH method (1,1-diphenyl-2- picrylhydrazyl). Statistical analysis using One Way ANOVA followed by post hoc analysisResult: three varieties of garlic have a strong antioxidant activity. Value of IC50 = 13.61 mg / ml for local garlic varieties Ciwidey, IC50 = 10.61 mg/ml for single local garlic’s clove and IC50 = 11.32 mg/ml for imports garlic.Conclusion: Three varieties of garlic have different antioxidant strength and the best antioxidant strength is single local garlic’s clove.
Co-Authors Achmad Syawqie Achmad Syawqie Adistia, Rinintha Ajeng Wulandari Allin Perama Iswari, Allin Perama Andiesta, Niekla Survia Andisetyanto, Prima Ani Melani Maskoen Arlette Suzy Puspa Pertiwi Azhar, Nor Fatihah Azhar, Nor Fatihah Biyantini, Nisa Milati Dede Hadidjah, Dede Diajeng Julian Casilda Efendi, Sjarief Hidajat Eka Chemiawan Fahmi Oscandar, Fahmi Gildasya Gildasya Harun Achmad Indra Primathena, Indra Inne Suherna Sasmita Irna Sufiawati Iwan Ahmad Musnamirwan Jakobus Runkat Lai Yi, Flora Ng Lusy Damayanti Maulani, Intan Maureen Martina Maureen Martina, Maureen Meirina Gartika Mia Giri Astri Mia Giri Astri Mia Giri Astri Nana Anggraini, Nana Naninda Berliana Pratidina Naninda Berliana Pratidina Nurhayani Safitri Prasonto, Djuned Pratidina, Naninda Berliana Puspitasari, Wita Ratna Ayu Alia Zulkarnain, Ratna Ayu Alia Ratna Indriyanti, Ratna Ria Noerianingsih Firman, Ria Noerianingsih Riana Noor Armedina Rini Sitanaya Risti Saptarini Risti Saptarini Primarti Riyadi, Auliya Yasyfi Roosje Oewen Roosje R. Owen Roosje Rosita Oewen Roosje Rosita Oewen, Roosje Rosita Rossa Ayu Sabilah, Rossa Ayu S. Supriatno Setiawan, Editha Meydiana Soewondo, Willyanti Stephanie Stephanie Supriatno Syarief Hidayat Tatiana Timokhina Ulfa Yasmin Vitaly V. Goncharov Wafa, Wade'ah Willyanti Soewondo Yana Paromova Yonathan, Heidy Stefanie