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All Journal Bioscientist : Jurnal Ilmiah Biologi JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Jurnal PADE: Pengabdian & Edukasi Jurnal Pengabdian Masyarakat (Jupemas) Cigarskruie Jurnal Pharma Bhakta
Hari Untarto Swandono
Institut Ilmu Kesehatan Bhakti Wiyata
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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test Analisis Farmakofisika Ekstrak Buah Maja (Aegle marmelos (L.) Corrêa): test Arifah, Farida Noor; Prodyanatasari, Arshy; Swandono, Hari Untarto; Widiastuti, Eka
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 6 No 1 (2025): Juni 2025
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v6i1.260

Abstract

Tanaman maja (Aegle marmelos (L.) Corrêa) merupakan sumber penting metabolit sekunder, terutama senyawa flavonoid yang termasuk dalam golongan fenolik alam terbesar dan terbukti memiliki sifat antioksidan. Fokus penelitian ini adalah melakukan analisis kadar flavonoid menyeluruh dalam ekstrak buah maja dengan menerapkan metode spektrofotometri UV-Vis. Sampel buah maja yang diambil dari Kecamatan Mojo terlebih dahulu diolah menjadi simplisia menggunakan dehidrator pada suhu 50°C, selanjutnya dilakukan proses maserasi dengan pelarut etanol berkonsentrasi 70% dalam perbandingan 1:10 antara sampel dan pelarut. Analisis kualitatif menggunakan metode Wilstater (HCl pekat) dan Bate Smith-Mercalf (Mg serbuk + HCl pekat) memberikan hasil positif, dengan indikator visual berupa perubahan warna menjadi jingga dan merah tua. Pengukuran kuantitatif flavonoid menggunakan spektrofotometri visibel (430 nm) dengan standar kuersetin menghasilkan kurva kalibrasi y = 0,0078x - 0,0221 (r = 0,9978). Kadar flavonoid total ekstrak buah maja yang diperoleh adalah 86,979 mg kuersetin ekuivalen per gram ekstrak (8,698%).
Studi Fitokimia Kualitatif Daun Kelor (Moringa oleifera) Berbasis Reaksi Kimia-Fisika Swandono, Hari Untarto; Prodyanatasari, Arshy; Hidayah, Nurul; Laksono, Adi
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 6 No 1 (2025): Juni 2025
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v6i1.269

Abstract

Antibacterial Activity Test of Srikaya Leaf Ethanol Extract (Annona Squamosa L) Against Staphylococcus Epidermidis with Typical Layer Chromatography Profile Dian Kurnia Sari; Hari Untarto Swandono
Cigarskruie: Journal of Educational and Islamic Research Vol. 1 No. 1 (2023): September
Publisher : Saniya Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/t6a14528

Abstract

Srikaya leaves have long been used in traditional medicine for the treatment of cough, fever, rheumatism, diarrhea, and dysentery, as well as an antibacterial and dysentery. The aim of this study is to determine the phytochemical and antibacterial compounds of Srikaya leaf ethanol extract, as well as its antibacterial against Staphylococcus epidermidis bacteria. They also determined the concentration of Srikaya leaf ethanol extract that was most effective in stopping the growth of Staphylococcus epidermidis bacteria. After the Srikaya leaf extract is extracted through the maceration process, phytochemical screening is carried out before the dilution of the extract, which produces 25%, 50% and 75% ethanol concentrations. Disc diffusion method is used to enhance the antibacterial properties of Srikaya leaves on the media Mueller Hinton Agar (MHA). There are alkaloid compounds, flavonoids, tannins, and saponins, according to the findings of this study. With an optimal barrier zone at a concentration of 75% of 11.26 mm, Srikaya leaf extract shows antibacterial capabilities of Staphylococcus epidermidis. It suggests that Srikaya leaf extract contains alkaloids, flavonoids, tannins, and saponins. Further research is needed to find out the antibacterial properties of Srikaya leaves against bacteria such as Bacillus anthraces, Pseudomonas aeruginosa
Karakterisasi dan Potensi Ekstrak Daun Paitan (Tithonia diversifolia) sebagai Penolak Nyamuk Aedes aegypti Wahyuni, Dwi; Swandono, Hari Untarto; Mawardika, Herlinda; Prana, Mega Yuliya
Bioscientist : Jurnal Ilmiah Biologi Vol. 11 No. 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.8844

Abstract

The paitan plant (Tithonia diversifolia) contains alkaloids, saponins, flavonoids, tannins and phenolics which have the potential to prevent Dengue Hemorrhagic Fever (DHF). This plant also has various insecticidal activities. In society, there are many mentions of the paitan plant, so people need to know the characteristics of this paitan plant. The aim of this research is to determine the morphological characterization and specific fragments of the paitan plant, as well as to determine the activity and effective concentration of the ethanol extract of paitan leaves as a repellent for the Aedes aegypti mosquito. Two types of methods were used, namely descriptive qualitative for observing morphology, specific fragments, pollen, and phytochemical screening, and experimental methods for mosquito repellent testing, and calculating the protective power of the ethanol extract of paitan leaves. The results obtained are flowers consisting of two shapes, namely ribbon flowers in the outer circle, infertile, and tube shapes in the inner circle. Stomata are anomocytic type, while trichomes are non-glandular multicellular type. Pollen characteristics, namely small size, colpate, number 3, aperture shaped trizonocolpate with echinate ornamentation. The screening results for the ethanol extract of paitan leaves were positive for containing metabolite compounds, such as flavonoids, alkaloids, tannins, saponins, terpenoids and phenolics. The results of the mosquito repellent test showed that the higher the concentration of the extract, the fewer mosquitoes that landed. Calculation of protective power shows that the most effective concentration in repelling mosquitoes is 15%, namely 93.64%. The conclusion is that paitan (Tithonia diversifolia) leaf extract has potential activity as a repellent against Aedes aegypti mosquitoes with the most effective concentration being 15%.
Potensi Infusa Daun Paitan (Tithonia diversifolia) sebagai Larvasida Terhadap Mortalitas dan Morfologi Larva Aedes aegypti Wahyuni, Dwi; Swandono, Hari Untarto; Purwani, Asih Imulda Hadi; Pramasari, Nadia; Putri, Sherlyna Rizkiya
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12902

Abstract

Dengue Hemorrhagic Fever is an infectious disease caused by the Dengue virus through the Aedes aegypti mosquito vector, which is controlled both at the larval and adult stages. The use of chemicals that are difficult to degrade in nature can pollute the environment. The Paitan plant (Tithonia diversifolia) contains secondary metabolite compounds that have the potential to be natural larvicides. This study aims to determine the natural larvicidal activity of Paitan leaf infusion. This study is an experimental study. The results of this study indicate that (1) Paitan leaf infusion contains alkaloid, flavonoid, terpenoid, saponin, phenolic, and tannin compounds. At concentrations of 1.8%, 3.2% and 5.6%, the mortality percentage results were 41.30%, 50.60% and 60% respectively; (2) The administration of Paitan leaf infusion has an effect on morphological damage Aedes aegypti larvae in the thorax, digestive tract and siphon. The content of different metabolite compounds causes different levels of morphological damage at each concentration
AKTIVITAS LARVASIDA ALAMI EKSTRAK ETANOL DAUN PAITAN (TITHONIA DIVERSIIFOLIA) TERHADAP LARVA NYAMUK AEDES AEGYPTI Wahyuni, Dwi; Swandono, Hari Untarto; Kristianingsih, Ida
JURNAL PHARMA BHAKTA Vol 3 No 2 (2023): November 2023
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Demam Berdarah Dengue (DBD) adalah penyakit menular yang disebabkan oleh virus Dengue dari nyamuk Aedes aegypti. Tanaman paitan merupakan famili dari Asteraceae, diketahui memiliki kandungan bahan aktif yaitu alkaloid, flavonoid, saponin, tanin, terpenoid dan fenolik yang dapat digunakan sebagai larvasida. Penelitian ini bertujuan untuk mengetahui ekstrak etanol daun paitan (Tithonia diversiifolia) memiliki aktivitas larvasida alami terhadap larva nyamuk Aedes aegypti instar III. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 70%. Hasil ekstrak dibuat menjadi 3 konsentrasi yaitu konsentrasi 1,8%, 3,2% dan 5,6% dengan kontrol negatif berupa aquadest dan kontrol positif berupa abate. Uji larvasida dilakukan dalam waktu 24 jam dengan menghitung jumlah kematisn larva pada masing masing-masing kelompok perlakuan. Berdasarkan Nilai probit LC50 didapatkan hasil yaitu 0.913, sedangkan hasil statistik, konsentrasi ekstrak etanol Daun Paitan yang paling efektif yaitu 5,6% (tidak ada perbedaan signifikan dengan control positif). Hal ini dikarenakan semakin tinggi konsentrasi ekstrak maka senyawa metabolit yang terkandung juga semakin banyak.
Co-Authors Apriliawan, Pinky Arifah, Farida Noor Arshy Prodyanatasari Arya Ulilalbab Asih Imulda Hari Purwani Dian Kurnia Sari Dian Kurnia Sari Dwi Wahyuni DWI WAHYUNI Fadhiila, Indah Tentamia Hanaa Faizatul Fitria Herlinda Mawardika Ida Kristianingsih Krisnita Dwi Jayanti Laksono, Adi Mardiana Prasetyani Putri Mega Yuliya Prana Mely Purnadianti Nadia Pramasari NURUL HIDAYAH PALUPI SUSILOWATI Prana, Mega Yuliya Putri, Sherlyna Rizkiya Rokhima, Ainur Rosa Juwita Hesturini Widiastuti, Eka Zurinah, Silva