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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biopropal Industri Jurnal Ilmu Kefarmasian Indonesia Daengku: Journal of Humanities and Social Sciences Innovation Basic and Applied Nursing Research Journal Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Jurnal Pelayanan Pastoral (JPP) Sciences of Pharmacy Jurnal Kefarmasian Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI)
. Syamsudin
Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Ilmu Kefarmasian Indonesia

 1   2 
Efek Antioksidan dari Ekstrak Biji Petai Cina (Leucaena leucocephala L.) pada Tikus Putih Fatty Nurhasanah; Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The study deals with the examination of the antioxidative effect of a Leucana leucocephala L. seed extract on diabetic rats induces with streptozotosin. The rats were divided in to 6 groups, each consisting of 5 rats i.e. group 1: normal, group 2: control (chlorpropamide), group 4: low dose of Laucaena seed extract 0,5/kg BW and group 6: high dose of Laucaena seed extract 1 g/kg BW. The malon dialdehyde (MDA) and superoxid dismutase (SOD) contents were analyzed by ANOVA and continued with the ttest. The result obtained shows that an increase of SOD could be observed by a Laucaena seed extract of resp 0.25;0.5 and 1 g/kg BW.
Beberapa Kelainan Genetik yang Bersifat Protektif terhadap Infeksi Malaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Resistance to malarial infection is dependent on the development of an immune response by the host and to a varying extend, a certain innate characteristics possessing protective value against infection. Innate resistance is not always absolute and genetically determined factors, but instead can act to reduce the severity of infection and improve survive. Mechanism of action resistance to malarial infection will be discussed in this article.
Kemotaksonomi dan Farmakologi Tumbuhan Keluarga Guttiferae Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The Guttiferae family has many species with interesting phytochemical properties. Is has been widely used in the traditional medicine and contains xanthones as constituent, exhibiting biological and pharmacological activities for example, e. g. as antimalaria, antimicrobe, antioxidant, anticancer and HIV-1 protease inhibitor.
Penapisan Senyawa Antimalaria yang Berasal dari Tumbuhan SYAMSUDIN SYAMSUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Efforts to discover and develop new antimalarial drugs have increased dramatically in recent years mainly because of the parasites’ resistance to existing antimalarial drugs. Selection of drug candidates for clinical trials in man and the design of clinical protocols are based upon consideration of data from a battery of preclinical test systems. All compounds are assessed initially in one or more primary models. A compound which is considered active by well established criteria in primary screening test is considered for further evaluation in successively more rigorous clinical test. At the end of each stage of testing, a decision is taken to advance the compound to the next stage or to discontinue it. Primary screening tests should have optimal sensitivity, a high degree of reproducibility, high throughput, should require a minimum quantity of test compound and bear low cost. As there is growing need for newer and more efficacious antimalarial drugs escpecially in tropical countries, more sensitive and economical screening models are needed. This review is an update of various conventional and latest in vitro and in vivo screening methods being used for evaluation of antimalarial compounds.
Efek Kurkumin terhadap Aktivitas Enzim Glutation Peroksidase Mitokondria Hati Tikus Syamsudin Syamsudin; Suyatna FD; Ganiswarna S; Sadikin M
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study was conducted to prove the hypothesis that Curcumin could prevent the oxidative damage of rat liver mitochondria induced by t-butylhydroperoxide (t-BHP). The induction of 400 uMt-BHP reduced Gluthatione Peroxidase (GPx) activity from (0.29+0.03) to (0.04+0.01) umol/min/mg protein. Instillation of Curcumin of 1000 uM could elevate GPx activity to (0.16+0.002) umol/min/mg protein.
Karakterisasi Nanopartikel dan Uji Antiagregasi Platelet Secara In-Vitro terhadap Ekstrak Rumput Laut Coklat (Sargassum polycystum) Hasil Hidrolisis Enzim Sellulase Kartiningsih Kartiningsih; Syamsudin Abdillah; Partomuan Simanjuntak; Cyntia Cyntia; Haryo Haryo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (478.048 KB) | DOI: 10.35814/jifi.v17i2.720

Abstract

Brown seaweed contains fucoidan, a large molecular weight sulfate polysaccharide (about 100,000 Da) which has platelet antiagregation activity. This activity is achieved if the fucoidan has a small molecular weight (3900-7600 Da) so this activity can increase by hydrolized with sellulase Enzym. The purpose of this study was to obtain extract nanoparticles that meet physical quality requirements and have a higher platelet antiagregation activity than brown seaweed extract both before and after hydrolysis. Extraction was using kinetic maseration method using 80% ethanol after that using 2% calcium chloride solution. The results were dried and hydrolyzed with cellulase enzyme and nanoparticles were made by ionic gelation method. Nanoparticle characterization results in particle size of 552.8, polydispersity index of 0.569, potential zeta of +53.5 mV, and spherical shape. In-vitro testing results for platelet antiagregation activity showed the percentage of platelet aggregation inhibition of brown seaweed extract with a concentration 500µg / mL is 22.19% and extracts after hydrolysis was 57.94% and nanoparticles extract after hydrolysis was 72.93%. Extract nanoparticles meet physical quality requirements and extracted nanoparticles after hydrolysis have the highest platelet antiagregation activity compared to brown seaweed extract both before and after hydrolysis.
Ekstrak Propolis sebagai Imunomodulator Irma L. M.; Syamsudin Syamsudin; I. W.T. Wibawan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A study was done to evaluate the effect of propolis on phagocytic activity and capacity of cells phagocyts with induction SGB (Streptococcus Grup B). In vivo methods were used on the study. In vivo study treatments were divided in four groups. Each group was inducted by 109 cell/ml of SGB. The group consists of treatment by given propolis at dosage 25 mg/kgBW, 50 mg/kgBW, 100 mg/kgBW, and group control, not given propolis. The result showed activity dosage value of propolis were significantly different (p<0.01) at dosage 50 mg/kgBW and capacity dosage value of propolis were significantly different (p<0.01) at dosage 100 mg/kgBW.
Efek Ekstrak Biji Leucaena leucocephala L. terhadap Profil Lipid Darah Tikus Diabetes Humairoh Hanan; Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 1 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The use of Leucaena leucochepala as an antidiabetic has already been known in society, but the support experiment was very rare. The purpose of this experiment is to know whether the extract of L. leucochepala semen have an effect to the blood lipid profile of a NIDDM rat which is streptozotocin (stz) induced. It is made in 6 groups, each group consist of 5 rats. Group 1: Normal control, group 2: Negative control (stz), group 3: Positive control (clorpropamid), group 4: Extract of Leucaena semen low dose (0.25 g/kg BW), group 5: Extract of Leucaena semen medium dose (0.5 g/kg BW) and group 6: Extract Leucaena semen high dose (1 g/kg BW). Rats are made hiperglycemia with iv induction of stz 50 mg/kg BW. Chlorpropamid and Leucaena semen extract are given orally. The experiment results of blood sugar level, total cholesterol, triglyceride, HDL and LDL are analyzed by ANOVA and continued with BNT test (p < 0.05). The result from the experiment is the high reduction of blood sugar level from the Leucaena semen extract high dose in amount of 65.30%. Results from the total cholesterol level of group 1:61.60 mg/dl, group 2: 91.60 mg/dl, group 3: 62.20 mg/dl, group 4: 76.00 mg/dl, group 5: 65.40 mg/dl and group 6: 55.80 mg/dl. Results from the triglyceride level of group 1: 83.40 mg/dl, group 2: 201.40 mg/dl, group 3: 133.40 mg/dl, group 4: 114.80 mg/dl, group 5: 93.20 mg/dl and group 6: 80.40 mg/dl. Results from the HDL level of group 1: 47.60 mg/dl, group 2: 26.40 mg/dl, group 3: 35.20 mg/dl, group 4: 43.40 mg/dl, group 5:58.40 mg/dl and group 6: 90.40 mg/dl. Results from the LDL level of group 1: -2.68 mg/dl, group 2:26.72 mg/dl, group 3: 0.32 mg/dl, group 4: 9.64 mg/dl, group 5:-11.64 mg/dl and group 6: -50.16 mg/dl.
Efek Antiplasmodium dari Ekstrak Etilasetat Kulit Batang Asam Kandis (Garcinia parvifolia) secara In Vitro Syamsudin Syamsudin; Budi Prasetyo; Antonius Antonius
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This research was carried out to assess the antiplasmodic activity of six fractions from the aethylacetate extract of the stem barks of Garcinia parfivolia. The result showed that fractions C, D, and G were IC50 < 10 µg/ml, fraction E: IC50 24,19 µg/ml, and fraction F and H: > 100 µg/ml against a chloroquine resistant strain of P. falciparum FCR-3.
Stres Oksidatif di dalam Model Kerja Obat Antimalaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Several antimalarial drugs may act by producing free radicals, anion superoxide through a redox cycling process with oxygen. The mode of action of chloroquine, primaquine, artemisinin, anthraquinone and xanthones as antimalarial drug is partly increasing the oxidative stress in the parasitized red blood cell.
Co-Authors . Darmono A. Keban, Sesilia Anisa Rachmita Arianti Antonius Antonius Asarini Aulena, Desi Nadya Basilianus, Edward Budi Prasetyo Chandra Wiguna Brata Cyntia Cyntia Dacosta, Fransiska Deni Rahmat Dian Ratih Laksmitawati Dwi Fitriyani, Dwi Fatty Nurhasanah Fetri Charya Munarsih Ganiswarna S Gemini Alam Gracia Sakristi, Maria Antonia Greesty Finotory Swandiny Haryo Haryo Hendig Winarno Hermawati, Ema Hikariastri, Pangartika Humairoh Hanan I. W.T. Wibawan Indarwati Indarwati Irma L. M. Kartiningsih Kartiningsih Kokadir, Sucipto Kusmardi Kusmardi Lilik Sulastri Lusi Nursilawati Syamsi MANUEL HUTAPEA, MANUEL Natadidjaja, Ronald Irwanto Nur Rahmi Hidayati, Nur Rahmi Partomuan Simanjuntak Partomuan Simanjuntak Putra, Fahreza Pratama Putri, Vinessa Gracia RAHMAT, DENI Raihan, Dany Riza Darma Putra ROS SUMARNY Sadikin M Sesilia A. Keban Shirly Kumala Subasno, Yohanes Sugiastuti, Fenty Suyatna FD Swandiny, Greesty Finotory Syafawi, M. Irfan Yayan Rizikiyan Yulvian Sani Zaidan, Sarah