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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biopropal Industri Jurnal Ilmu Kefarmasian Indonesia Daengku: Journal of Humanities and Social Sciences Innovation Basic and Applied Nursing Research Journal Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Jurnal Pelayanan Pastoral (JPP) Sciences of Pharmacy Jurnal Kefarmasian Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI)
. Syamsudin
Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Mekanisme Kerja Obat Antimalaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.85 KB)

Abstract

Malaria remains the most devastating infectious parasitic disease, inflicting both death and economic losses on at least half the world's population. Numerous attempts have been made to control the disease using vector control measures and/or chemoprophylaxis. Antimalarial drugs have a selective action on the different phases of the parasite life cycle. Mechanism of antimalarial drugs action will be discussed in this article.
Toxicity of Sida rhombifolia L. 96% ethanol extract based on LD50 and macropathological examination of mice's organs Aulena, Desi Nadya; Kumala, Shirly; Abdillah, Syamsudin; Rahmat, Deni; Zaidan, Sarah; Fitriyani, Dwi; Raihan, Dany
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1463

Abstract

The Indonesian people empirically use Sidaguri (Sida rhombifolia L.) in medicine, such as anti-hyperuricemia. Herbal-based treatment is currently much preferred. Drug metabolism, in general, mainly occurs in the liver, so the possibility of damage to this organ is high. This study aims to determine the acute toxicity category of 96% ethanol extract of sidaguri based on the LD50 value, changes in body weight, changes in organ weight, and macro pathology in the organs of male DDY mice in vivo. The method used in this research was experimental with a fixed dose design following the Indonesian Food and Drug Authority regulations regarding guidelines for in vivo non-clinical toxicity tests. The test group was divided into six dose groups (standard, 50, 300, 2000, 5000, and 15000 mg/kg Body of weight). Observations were made for 24 hours. Observations were continued for 14 days on death parameters, toxicity symptoms, body weight, and relative organ weights using five main organs (heart, lungs, liver, spleen, and kidneys, and pathological examination). The acute toxicity test results showed no death in all dose treatment groups. Macropathological analysis did not show abnormalities in organs in all groups of mice. LD50 value is more than 15000 mg/kg. Sidaguri 96% ethanol extract is safe and Practically non-toxic.
Penelitian Terbaru terhadap 3 (Tiga) Jenis Ekstrak Teripang di Pulau Tegal Mas, Lampung Hutapea, Manuel; Swandiny, Greesty Finotory; Syafawi, M. Irfan; Putra, Fahreza Pratama; Kokadir, Sucipto; Basilianus, Edward; Putri, Vinessa Gracia; Abdillah, Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1447

Abstract

Sea cucumbers are deep-sea-dwelling invertebrate animals that are rich in nutrients and have been empirically used to prevent various degenerative diseases, especially due to their ability to dampen free radicals. The purpose of this study was to identify, and determine antioxidant activity, total phenolic content, and toxic properties in extracts of several sea cucumber species originating from Tegal Mas Island, Lampung. The identification results of the three sea cucumber species were Stichopus vastus Sluiter (SV), Stichopus monotuberculatus Quay & Gaimard (SM), and Stichopus quadrifasciatus Massin. (SQ). The extraction was performed by kinetic maceration against all parts of the sea cucumber using a 70% ethanol solvent. Antioxidant activity test using the DPPH (2,2-diphenylpicrilhydrazyl) free radical suppression method and determination of the total phenolic content using the Folin-Ciocalteu method. The results showed that SV had the highest total phenolics and antioxidants with the lowest toxicity. However, optimisation of extraction between wet and dry sea cucumbers is still required. Extraction optimisation with various solvents can also be done to gain secondary metabolites more effectively.
Co-Authors . Darmono A. Keban, Sesilia Anisa Rachmita Arianti Antonius Antonius Asarini Aulena, Desi Nadya Basilianus, Edward Budi Prasetyo Chandra Wiguna Brata Cyntia Cyntia Dacosta, Fransiska Deni Rahmat Dian Ratih Laksmitawati Dwi Fitriyani, Dwi Fatty Nurhasanah Fetri Charya Munarsih Ganiswarna S Gemini Alam Gracia Sakristi, Maria Antonia Greesty Finotory Swandiny Haryo Haryo Hendig Winarno Hermawati, Ema Hikariastri, Pangartika Humairoh Hanan I. W.T. Wibawan Indarwati Indarwati Irma L. M. Kartiningsih Kartiningsih Kokadir, Sucipto Kusmardi Kusmardi Lilik Sulastri Lusi Nursilawati Syamsi MANUEL HUTAPEA, MANUEL Natadidjaja, Ronald Irwanto Nur Rahmi Hidayati, Nur Rahmi Partomuan Simanjuntak Partomuan Simanjuntak Putra, Fahreza Pratama Putri, Vinessa Gracia RAHMAT, DENI Raihan, Dany Riza Darma Putra ROS SUMARNY Sadikin M Sesilia A. Keban Shirly Kumala Subasno, Yohanes Sugiastuti, Fenty Suyatna FD Swandiny, Greesty Finotory Syafawi, M. Irfan Yayan Rizikiyan Yulvian Sani Zaidan, Sarah