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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biopropal Industri Jurnal Ilmu Kefarmasian Indonesia Daengku: Journal of Humanities and Social Sciences Innovation Basic and Applied Nursing Research Journal Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Jurnal Pelayanan Pastoral (JPP) Sciences of Pharmacy Jurnal Kefarmasian Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI)
. Syamsudin
Universitas Pancasila
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Journal : Jurnal Kefarmasian Indonesia

 1 
Aktivitas Antiinflamasi Crude Extract Fukoidan dari Sargassum crassifolium pada Sel RAW 264.7 yang Diinduksi LPS Hikariastri, Pangartika; Winarno, Hendig; Kusmardi, Kusmardi; Laksmitawati, Dian Ratih; Abdillah, Syamsudin
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1547

Abstract

Inflammation is known as the basic mechanism underlying various chronic diseases. Macrophage activation by inflammatory stimulus induces the release of inflammatory mediators, thus the mediators becoming a promising target of anti-inflammatory drug development. Previous studies indicated that fucoidan has anti-inflammatory activity by inhibiting the release of proinflammatory mediators. The aim of this study is determining anti-inflammatory activity of fucoidan crude extract form Sargassum crassifolium Garut waters by observing its effect on proinflammatory cytokines TNF-α, IL-1β, dan IL-6. Fucoidan is a polysaccharide substance which has various characteristics, depending on the source and the extraction method which is influencing its bioactivity. Sargassum crassifolium collected from Garut-West Java is extracted using diluted HCl 0,1 M and precipitated with ethanol to obtain fucoidan crude extract. The crude extract is tested on LPS-induced RAW 264.7 cells to evaluate its effect on TNF-α, IL-1β, and IL-6 level using ELISA method. The result showed that fucoidan crude extract decreased the level of TNF-α by the dose of 25 and 50 μg/ml, and decreased the level of IL-1β and IL-6 by the dose of 25 μg/ml. The dose of 50 μg/ml failed to inhibit IL-1β and IL-6 production. This study showed that fucoidan crude extract derived from S. crassifolium has anti-inflammatory activity to RAW 264.7 cells by the dose of 25 μg/ml.
Co-Authors . Darmono A. Keban, Sesilia Anisa Rachmita Arianti Antonius Antonius Asarini Aulena, Desi Nadya Basilianus, Edward Budi Prasetyo Chandra Wiguna Brata Cyntia Cyntia Dacosta, Fransiska Deni Rahmat Dian Ratih Laksmitawati Dwi Fitriyani, Dwi Fatty Nurhasanah Fetri Charya Munarsih Ganiswarna S Gemini Alam Gracia Sakristi, Maria Antonia Greesty Finotory Swandiny Haryo Haryo Hendig Winarno Hermawati, Ema Hikariastri, Pangartika Humairoh Hanan I. W.T. Wibawan Indarwati Indarwati Irma L. M. Kartiningsih Kartiningsih Kokadir, Sucipto Kusmardi Kusmardi Lilik Sulastri Lusi Nursilawati Syamsi MANUEL HUTAPEA, MANUEL Natadidjaja, Ronald Irwanto Nur Rahmi Hidayati, Nur Rahmi Partomuan Simanjuntak Partomuan Simanjuntak Putra, Fahreza Pratama Putri, Vinessa Gracia RAHMAT, DENI Raihan, Dany Riza Darma Putra ROS SUMARNY Sadikin M Sesilia A. Keban Shirly Kumala Subasno, Yohanes Sugiastuti, Fenty Suyatna FD Swandiny, Greesty Finotory Syafawi, M. Irfan Yayan Rizikiyan Yulvian Sani Zaidan, Sarah