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All Journal MEDIA PETERNAKAN - Journal of Animal Science and Technology AL KAUNIYAH Prosiding Seminar Biologi Jurnal Kesehatan BERITA BIOLOGI BIOEDUSCIENCE Bioma : Jurnal Biologi Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Kesehatan Tambusai Jurnal Farmasi Etam Asian Journal of Healthcare Analytics Mestaka: Jurnal Pengabdian Kepada Masyarakat GEMBIRA (Pengabdian Kepada Masyarakat) Borneo Journal of Pharmacy Science and Technology: Jurnal Pengabdian Masyarakat
Fathin Hamida
Institut Sains Dan Teknologi Nasional (ISTN)
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Journal : BERITA BIOLOGI

 1 
EFEKTIVITAS DOSIS KARBON TETRAKLORIDA (CCl4) TERHADAP TIKUS (Rattus norvegicus L.) SEBAGAI HEWAN MODEL FIBROSIS HATI Fahri Fahrudin; Sri Ningsih; Hajar Indra Wardhana; Dinda Rama Haribowo; Fathin Hamida
BERITA BIOLOGI Vol 19, No 3B (2020)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v19i3B.3961

Abstract

Liver damage can produce fibrosis condition both acute and chronic. Development of liver fibrosis in animal models is valuable information in order to gain new entities for treatment. The aim of this study is to get an optimal condition of CCl4 induction for achieving animal models of liver fibrosis. CCl4 diluted in coconut oil was administrated orally for 6 consecutive weeks. Total 25 male rats were divided into 5 treatment groups, namely, P1 was a normal group (without CCl4). P2 (CCl4 40%), 1 ml/kg bw 3 times a week. P3 (CCl4 40%), 0.5 ml/kg bw 3 times a week, P4 (CCl4 10%) 1 ml/kg bw 3 times a week, and P5 (CCl4 10%) 1 ml/kg bw twice a week. The analyzed parameters were the activity of liver enzymes, macro and microscopic liver damage, and the percentage of rat deaths. The results of this study indicated an increase in liver enzymes in all treatments which was higher than P1 (P<0.05). Analysis of liver histopathology exhibeted the same result. However, if viewed the percentage of rat deaths, P5 demonstrated the lowest compared to all treatment groups. It could be concluded  that the administration of CCl4 (10%) was able to create an animal model of liver fibrosis optimally.  
Co-Authors Agustin, Anglia Ananda Ainun Wulandai Ainun Wulandari Aliya, Lisana Sidqi Aliya, Lisana Sidqi Alma'arik, Difa Alma’arik, Difa Amalina, Risma Kamila Ambarsari, Ratna Ami Rahmawati Sukamto Angraini, Isty Anja Meryandini Arsa, Imalia Aslamiyah Putri Aulia Rahimi Blyzensky, Tamara Carla Febriayu Ramadhani Chori Azizah Danang Aji Pangestu Dasumiati Dasumiati Della Pratiwi Devi Purwita Sari Dian Puspita Dian Puspita Dinda Rama Haribowo Dini Juliana Djuhariah, Yayah Siti Djuhariyah, Yayah Siti Elsa V. Nanda Erna Yanti Eva Oktavia Fahri Fahrudin Fahri Fahrudin Fahri Fahrudin, Fahri Febriani , Amelia Febriani, Amelia Fitria Haryani H Herdini Hajar Indra Wardhana Haryani , Fitria Herdini Hervianti Nurfitria Nugrahani I Komang Gede Wiryawan Ika Maruya Kusuma Jessica Khairunnisa Kusuma , Ika Maruya Lili Musnelina Lisana Sidqi Aliya Lisana Sidqi Aliya Meilisa Rahmasari Mulandita Munawarohthus Sholikha Munawarohthus Sholikhah Musnelina , Lili Nanda, Elsa Vera Nur Hanifah Nurfitri Nurfitri Nurul Akhatik Nurul Laili Oktaviani, Rista Pangestu, Danang Aji Pramana, Firza Andika Pratiwi Ally Florentina Pratiwi, Della Rahmi Karmila Rani Damayanti Ratna Nilam Cahya Refdanita Refdanita Refdanita Rosario Trijuliamos Manalu Saiful Bahri Salshabil, Khairunnisa Sholikhah , Munawarohthus Siti Fadila Azahra Sri Ningsih Subaryanti Sukamto, Ami Rahmawati Suyatno Suyatno Syafriana, Vilya Teodhora, Teodhora Tiah Rachmatiah V. Nanda, Elsa Vera Nanda, Elsa Veryanti, Putu Rika Widyapratiwi , Ritha Wulandari , Ainun Yuliawati, Chyntia Zahra, Aishah Az