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All Journal ComEngApp : Computer Engineering and Applications Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Medicinus : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis
Rizal Sanif
Department Obstetrics And Gynecology Faculty Of Medicine, Sriwijaya University, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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WHO Global Strategy in Eradication of Cervical Cancer Patiyus Agustiansyah; Rizal Sanif; Siti Nurmaini; Irfannuddin; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.328

Abstract

WHO has created a global strategy to accelerate the elimination of cervical canceras a public health problem and a world burden. Cervical cancer is a disease thatcan be prevented and cured, as long as it is detected early and treated effectively.Cervical cancer is also a disease that reflects global injustice. The burden isgreatest in low- and middle-income countries, where access to public healthservices is limited and screening and treatment for the disease has not been widelyapplied. In 2018, nearly 90% of all deaths worldwide occurred in low and middleincome countries. Furthermore, the proportion of women with cervical cancer whodie from the disease is more than 60% in these countries, more than double thenumber in many high-income countries, which is only 30%.
Screening for Cervical Cancer Patiyus Agustiansyah; Rizal Sanif; Siti Nurmaini; Irfannuddin; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.329

Abstract

Screening is a public health intervention administered to a target population without symptoms. Screening is not performed to diagnose a disease, but to identify individuals with a higher likelihood of developing the disease itself or a precursor to the disease. Not all diseases are suitable for screening programs. The following criteria help determine whether a disease is suitable for a screening program: (1) The disease is bound to have serious consequences. (2) The disease must have a detectable preclinical and asymptomatic stage. (3) Treatment at the preclinical stage should influence the long-term course and prognosis of the disease being screened. (4) Care must be available and accessible to those who have a positive screening test. History, screening tests and treatment options for cervical pre-cancer meet these criteria.
Relationship Between Vitamin D Supplementation and Improvement in Body for Carcinogenesis: A Literature Review Irawan Sastradinata; Rizal Sanif; Cindy Kesty; Siti Hardianti Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 2 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i2.447

Abstract

Vitamins are probably the best-selling dietary supplements in the United States, in which an estimated 35% of the population take multivitamin and mineral supplements. Data relating microconstituents to carcinogenesis are extremely limited, as explained in the first report. A striking feature of many of the compounds in the three groups mentioned above is their capacity to prevent or retard the occurrence of neoplasia. However, there is a paucity of data concerning the conditions under which inhibition occurs, the mechanisms of inhibition, and the precise impact of these microconstituents on humans. A literature review was conducted in the electronic databases PubMed and Google Scholar using the index terms "carcinogenesis" and "cancer" and "vitamin D" All types of studies were included for this study, such as randomized controlled trials, systematic reviews, literature reviews, and pilot studies published between 2010 and 2021. Articles which not written in English were excluded from the study. This search resulted in 10 papers. Many of the mechanisms proposed for vitamin D and cancer prevention have been studied only in the context of one tissue or one type of cancer and so further studies must be conducted to determine if these mechanisms can be generalized. For example, while higher serum (25(OH)D3) is associated with reduced cancer risk, and CYP27B1 is expressed in non-renal cells, there is no evidence that the low-level expression of CYP27B1 in tissues leads to meaningful local production of 1a,25(OH)2D3 or calcitriol, and that this mediates the protection from cancer provided by high vitamin D status. In conclusion, we suggest that vitamin D compounds to be employed in the treatment of, alone or in combination with other anticancer agents. solar UV-B radiation, acting through the production of vitamin D, is a risk reduction factor for over a dozen forms of cancer.
FACTORS RELATED UTERINE MIOMAS (UTERINE FIBROIDS) AT RSUP DR. MOHAMMAD HOESIN PALEMBANG Amanda Moeza Fadillah; Rizal Sanif; Indri Seta Septadina
Majalah Kedokteran Sriwijaya Vol 54, No 1 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i1.18064

Abstract

Background: Uterine fibroids or uterine myomas are benign tumors cell myometrial smooth muscle surrounded by a pseudocapsule. Uterine fibroids occur in reproductive age women and will slowly disappear at menopause. Uterine fibroids are the second most common reproductive problem experienced by women in Indonesia after cervical cancer. The world incidence rate of uterine myomas is 20-35%, while Indonesia ranges from 2.4% to 11.7%. The study was conducted to know related factors with incident of uterine myomas at RSUP Dr. Mohammad Hoesin Palembang. Methods: This research is an analytic observational study with a cross-sectional approach. The sample of this study were gynecological patients at RSUP Dr. Mohammad Hoesin Palembang and data collected for the period January 2020 - July 2021 that met the inclusion criteria and exclusion criteria. Results and Conclusions: From 60 patients, the proportion of patients with uterine myomas was 61.7%. The analysis using the Chi-square test showed that age ( p = 0.005) had a significant relationship with the incidence of uterine myomas. The results of the analysis using the Chi-square test showed that age at menarche ( p= 1.00), parity ( p= 0.761), body mass index ( p =0.559), infertility ( p =0.112), history of hypertension ( p =1.00 ), history of diabetes mellitus ( p = 1.00), history of using hormonal contraception ( p = 0.634) did not have a significant relationship with the incidence of uterine myoma. Conclusion of this study is the mostr related factors of uterine myomas is age factor. 
Strengthening the Healthy Living Society Movement (GERMAS) during the Covid Pandemic 19 Rizal Sanif
Conferences of Medical Sciences Dies Natalis Vol. 2 No. 1 (2020): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (669.959 KB)

Abstract

Health problems in Indonesia are very serious challenges. The main problem is that there is a triple burden or three important health problems related to the eradication of infectious diseases, an increase in cases of non-communicable diseases and the re-emergence of types of diseases that should have been successfully resolved. Infectious diseases such as diarrhea, tuberculosis and dengue fever were the most common health cases; now there has been a marked change in the number of cases of non-communicable diseases such as diabetes, cancer and coronary heart disease. The Government of the Republic of Indonesia at the Ministry of Health in 2017 launched GERMAS or Healthy Living Community Movement. GERMAS is a movement that aims to promote a culture of healthy living and leave unhealthy habits and behavior of society. The GERMAS action was also followed by promoting hygiene and healthy living habits and support for community-based infrastructure programs. This program has several focuses, such as building access to meet drinking water needs, community health installations and the construction of habitable settlements. The three of them are the basic infrastructure that is the foundation of the healthy life movement.
GESTATIONAL TROPHOBLASTIC DISEASE Rizal Sanif
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.238 KB)

Abstract

Gestational trophoblastic disease (GTD) is a group of tumors defined by abnormal trophoblastic proliferation. GTD is divided into hydatidiform moles (contain villi) and other trophoblastic neoplasms (lack villi).1 The malignant forms of the disease are also collectively known as gestational trophoblastic tumors or neoplasia (GTN).GTN includes the invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Southeast Asia and Japan have the highest reported incidence estimated to be two in 1000 pregnancies. In high-income countries, the incidence of a complete mole is approximately 1–3 per 1000 pregnancies, and the incidence of a partial mole is about 3 per 1000 pregnancies. Approximately 15–20% of patients will be treated for gestational trophoblastic neoplasia after the evacuation of complete hydatidiform mole. GTD develop from abnormal proliferation of trophoblastic tissue and form botryoid arranged vesicles. Risk factors include extremes of age, ethnicity, and a prior history of an HM, suggesting a genetic basis for its etiology. GTD causes a broad spectrum of different symptoms. The most frequent clinical symptom is abnormal vaginal bleeding. Other signs include uterine enlargement more significant than expected for gestational age, absent fetal heart tones, cystic ovary enlargement, hyperemesis gravidarum, and abnormally high level of β-hCG for gestational age. Ultrasound is the gold standard in non-invasive techniques, but histological examination is necessary to reach the final diagnosis. Different treatment modalities are available for gestational trophoblastic neoplasm depending on the type and stage; these include D&C (dilation and curettage), chemotherapy, hysterectomy, or a combination of these.2 The prognostic score for GTN reported by FIGO is a score of 0–6 is the low-risk group and 7 is the high-risk group. All patients who have hydatidiform mole should be up for β-hCG surveillance and monitoring. Most relapses occur within the first year after completion of chemotherapy. A generally approved schedule of β-hCG surveillance indicates monitoring weekly for six weeks after chemotherapy followed by biweekly measurements until six months after chemotherapy. Afterward, a biannual measurement of β-hCG for five years is sufficient.1 Seeing this, the determination of the diagnosis of GTD becomes very important. With the proper diagnosis, the management of the patient will also improve.
Risk Factors of Cervical Cancer in Outpatient and Inpatient at Obstetric and Gynecology RSUP Dr. Mohammad Hoesin Palembang Trifitriana, Monica; Sanif, Rizal; Husin, Syarif; Mulawarman, Rido
Medicinus Vol 8, No 3 (2019): June 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i5.2470

Abstract

 Introduction: Cervical cancer is a malignant tumor originating from primary squamous epithelial cells and it is one of the several types of cancers that affects more to women. Methods: This research uses descriptive analytic with case- control. The sample was 52 patients who divided into 26 patients with cervical cancer and 26 patients with non - cervical cancer were outpatient and inpatient at Department of Obstetrics and Gynecology Hospital Dr. Mohammad Hoesin Palembang during the period September 2016 -November 2016. This study uses primary data in the form of interviews. Data was analyzed by univariate and presented in a frequency distribution table. Furthermore, using bivariate analysis to determine the relationship and OR. Result: From 8 risk factors studied, there is sygnificancy correlation between pathological vaginal discharge (p= 0,0005 OR= ∞), parity (p= 0,0005 OR= 22,7), age (p= 0,0005 OR= 19,2), oral contraception usage for a long time (p= 0,0005, OR= 12,4), age of the first intercourse (p= 0,006, OR= 6,1 ), and the husband’s occupation (p= 0,05 OR= 3,6) with the incidence of cervical cancer. While, there are two risk factors that don’t have a sygnificancy correlation between smoking (p= 1,0) and changing sexual partners (p= 1,0) with the incidence of cervical cancer. Conclusion: The results of this research identified  risk factors that significantly related to cervical cancer incidence was the age, the age of first sexual intercourse, parity, long-term oral contraceptive use, a history of vaginal discharge, and the husband's occupation.
TeleOTIVA: Advanced AI-Powered Automated Screening System for Early Detection of Precancerous Lesions Rachmamtullah, Muhammad Naufal; Nurmaini, Siti; Agustiansyah, Patiyus; Sanif, Rizal; Sastradinata, Irawan; Arum, Akhiar Wista; Firdaus, Firdaus; Darmawahyuni, Annisa; Tutuko, Bambang; Sapitri, Ade Iriani; Islami, Anggun
Computer Engineering and Applications Journal Vol 14 No 1 (2025)
Publisher : Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18495/comengapp.v14i1.1197

Abstract

In 2023, the Indonesian Ministry of Health launched the Rencana Aksi Nasional (RAN) to enhance the detection and management of cervical cancer in Indonesia. One of the main pillars in this movement is the implementation of early screening for precancerous lesions aimed at identifying and treating these lesions before they develop into cervical cancer. This effort includes improving public access to healthcare services, providing education and awareness about the importance of early detection, and utilizing the latest technology in screening procedures. It is hoped that, through these targeted and effective interventions, the incidence of cervical cancer can be significantly reduced. This research aims to facilitate the early detection screening process for cervical precancerous lesions, particularly in difficult areas for medical experts to reach. This study also seeks to assist obstetricians and gynecologists in detecting precancerous lesions automatically, quickly, and accurately. By developing an advanced technology-based screening system, it is hoped that early detection of precancerous lesions can be carried out more efficiently, thereby increasing the chances of timely treatment and reducing the incidence of cervical cancer across various regions in Indonesia. This system is designed to provide reliable and user-friendly diagnostic support as it is developed on a mobile platform that can be accessed anytime and anywhere. This research developed a system for early screening called Tele-OTIVA. The Tele-OTIVA application system is an advanced platform that uses artificial intelligence (AI) based approaches to provide optimal services in early detection of precancerous lesions. This application is designed for mobile, allowing users to access and use its advanced features anytime and anywhere. With the integration of AI technology, Tele-OTIVA can detect and analyze cervical precancerous lesions accurately and quickly to provide accurate and efficient screening results. The Tele-OTIVA application system is capable of providing satisfactory detection results. The performance of the proposed model achieves accuracy, sensitivity, and specificity levels above 90%. With this high performance, Tele-OTIVA ensures that the detection of precancerous lesions is carried out with high reliability and precision, instilling greater confidence in healthcare professionals and users during the screening and diagnosis process. The implementation of our application model offers numerous advantages over traditional methods. It significantly enhances efficiency by automating processes, reduces human error through rigorous error-checking mechanisms, and accelerates the processing of large datasets. These improvements streamline operations and ensure more reliable and rapid data analysis.
Characteristics of Epithelial Ovarian Cancer at RSUP Dr. Mohammad Hoesin Palembang Period from January 2020 to September 2023 Zaen, Wildana Ilmia Uli El Nuha; Agustiansyah, Patiyus; Oktharina, Eka Handayani; Sanif, Rizal; Purnamasari, Septi
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 1 Maret 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i1.762

Abstract

Objective: To determine the characteristics of epithelial ovarian cancer patient at Dr. Mohammad Hoesin Palembang General Hospital from January 2020 to September 2023.Methods: This study is a descriptive observational study utilizing secondary data from the Medical Records Department. The inclusion criteria included all patients diagnosed with epithelial ovarian cancer based on anatomical pathology results from the Medical Records Department at Dr. Mohammad Hoesin Palembang Hospital, covering the period from January 2020 to September 2023.Results: A total of 153 patient medical records met the inclusion and exclusion criteria. The results of the study findings revealed that the majority of epithelial ovarian cancer patients were aged 45–59 years (pre-elderly) (51%), had an normal Body Mass Index of 18.5–22.9 kg/m² (57.5%), were most commonly diagnosed at FIGO Stage IIIC (42.5%), had no family history of the disease (98.7%), and were nulliparous (32.7%)Conclusion: Epithelial ovarian cancer patients were predominantly found in the pre-elderly age group, with a normal Body Mass Index, the majority diagnosed at stage IIIC, without a family history, and nulliparous.Karakteristik Kanker Ovarium Epitel di RSUP Dr. Mohammad Hoesin Palembang Periode Januari 2020 – September 2023AbstrakTujuan: Mengetahui karakteristik pasien kanker ovarium epitel di RSUP Dr. Mohammad Hoesin Palembang periode Januari 2020 – September 2023Metode: Penelitian ini merupakan deskriptif observasional menggunakan data sekunder dari Instalasi Rekam Medis. Kriteria inklusi, yaitu seluruh pasien yang didiagnosis kanker ovarium epitel berdasarkan hasil patologi anatomi di Instalasi Rekam Medis RSUP Dr. Mohammad Hoesin Palembang periode Januari 2020 – September 2023.Hasil: Mayoritas pasien kanker ovarium epitel berusia 45 – 59 tahun (pra-lanjut) (51%), Indeks Massa Tubuh normal 18,5–22,9 kg/m2 (57,5%), mayoritas pada stadium IIIC (42,5%), tidak memiliki riwayat keluarga (98,7%), dan nuliparitas (32,7%).Kesimpulan:Penderita kanker ovarium epitel sebagian besar ditemukan pada kelompok usia pra-lansia, dengan ndeks Massa Tubuh normal, sebagian besar berada pada stadium IIIC, tidak memiliki riwayat keluarga, dan nuliparitas.Kata kunci: Kanker Ovarium Epitel, Karakteristik.
Eliminating HPV DNA Positive Result with Large Loop Excision of the Transformation Zone (LLETZ)/Loop Electrosurgical Excision Procedure (LEEP) in Precancerous Cervical Lesions Sanif, Rizal; Agustiansyah, Patiyus; Nurwany, Raissa; Sastradinata, Irawan; Theodorus; Agustian, Wisman
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.1897

Abstract

Abstract Objective: To determine the use of LLETZ/LEEP to eliminate HPV DNA positive result in patients with cervical precancerous lesions at General Hospital dr. Mohammad. Hoesin, Palembang. Methods: A case series with cervical precancerous lesions was undertaken at the Oncology Polyclinic of dr.Mohammad Hoesin Hospital Palembang from January to October 2022. There were 24 samples with positive HPV DNA before LLETZ/LEEP. Samples then checked for HPV DNA after LLETZ/LEEP. The effectiveness of LLETZ/LEEP therapy was analyzed using the Mc Nemar test. Comparison of HPV DNA outcomes (positive or negative) based on procedure, HPV DNA type and histopathological type was analyzed using Fisher Exact and Pearson Chi Square tests. All data were analyzed using SPPS version 22.0. Results: In this study, it was found that the average age of patients with cervical precancerous lesions was 40.25 ± 7.67 years (28 - 57 years). Based on the diagnosis, 8 samples were found with High-grade Squamous Intraepithelial Lesion (HGSIL) and 16 samples with Low-grade Squamous Intraepithelial Lesion (LGSIL). All samples in this study were housewives and the majority were multiparas (75.0%). History of abortion in the patients in this study was only found in 5 samples (20.8%). The results showed that there were significant differences in the HPV DNA before and after LLETZ/LEEP therapy (p = 0.000). In addition, the results showed that there was no difference in the outcome of HPV DNA based on the procedure (p = 1.000) and the type of HPV DNA (p = 0.643). After LLETZ/LEEP therapy was carried out, it was found that only 1 subject has positive HPV DNA result and the HPV DNA virus found was type 52 and (high risk) and 42 (low risk). Conclusion: It can be concluded that LLETZ/LEEP therapy is effective in eliminating HPV DNA positive results in cervical precancerous lesions Keywords: cervical cancer, HPV DNA, LLETZ/LEEP, precancerous lesions, RCT
Co-Authors Agustian, Wisman Agustria Z Saleh Agustria Z. Saleh Amanda Moeza Fadillah Amirah Novaliani Amirah Novaliani Arum, Akhiar Wista Bambang Sutrisna Bambang Tutuko Benyamin Rakhmatsyah Cindy Kesty Darmawahyuni, Annisa Diana Polania Firdaus Firdaus Indri Seta Septadina Irawan Sastradinata Irfannuddin Irfannuddin Islami, Anggun Khrismawan Khrismawan Laila Nuranna Legiran Legiran Monica Trifitriana Mulawarman, Rido Nurwany, Raissa Oktharina, Eka Handayani Patiyus Agustiansyah PATIYUS AGUSTIANSYAH, PATIYUS Purnamasari, Septi Rachmamtullah, Muhammad Naufal Raissa N. Rizal Rakhmatsyah, Benyamin Rustham Basyar Saleh, Agustria Z Sapitri, Ade Iriani Sastradinata, Irawan Siti Hardianti Harahap Siti Nurmaini Suriani Rosida Syarif Husin Syarif Husin Theodorus Theodorus Theodorus Theodorus trifitriana, Monica Trifitriana, Monica Yuwono Yuwono Yuwono Yuwono Zaen, Wildana Ilmia Uli El Nuha