Article Per Year (5 Year)
p-Index From 2020 - 2025
1.829
P-Index
This Author published in this journals
All Journal Journal of Food and Pharmaceutical Science Jurnal Siasat Bisnis Majalah Obat Tradisional Majalah Farmaseutik Indonesian Journal of Chemistry Journal of Food and Pharmaceutical Sciences
Djoko Santosa
Faculty Of Pharmacy, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

Published : 18 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 18 Documents
Search

 1   2 
Uji Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total dan Fenolik Total Ekstrak Sidaguri (Sida rhombifolia L.) Asma Asma; Abdul Rohman; Djoko Santosa; Mohamad Rafi; Nanik Siti Aminah; Muhamad Insanu; Irnawati Irnawati
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4955

Abstract

Sidaguri atau Sida rhombifolia L. telah digunakan oleh masyarakat sebagai obat tradisional, yaitu: penghilang rasa nyeri, radang, asam urat, penyakit kuning, muntah darah, dan sakit gigi. Faktor yang mempengaruhi produksi kandungan metabolit sekunder adalah kondisi lingkungan seperti tempat tumbuh, iklim, interaksi intra dan inter-spesifik serta waktu panen. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan serta kadar flavonoid dan fenolik total ekstrak sidaguri berdasarkan tempat tumbuh. Sampel diekstraksi dengan ultrasonic-assisted extraction (UAE) dan diuji penangkapan radikal bebas menggunakan metode 2,2’-difenil-1-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3-diethyl4benzothiazoline-6-sulfonic acid) (ABTS), serta penetapan kadar flavonoid total dan kandungan fenolik total. Hasil uji aktivitas antioksidan sidaguri dari Cangkringan dan Ngemplak memiliki aktivitas antioksidan tertinggi baik pada metode penangkapan radikal DPPH dengan nilai IC50 masing-masing sebesar 0,400±0,004 dan 0,403±0,004 mg/mL, maupun metode ABTS dengan nilai TEAC masing-masing sebesar 40,733±0,240 dan 35,598±0,153 mg/g serbuk sidaguri, dengan kadar flavonoid total masing-masing sebesar 10,095±0,068 dan 12,066±0,025 mg/g serbuk sidaguri dan kadar fenolik total masing-masing sebesar 56,45±0,068 dan 31,502±0,025 mg/g serbuk sidaguri.
Using Macroscopic, Microscopic, and FTIR Spectroscopy combined with Chemometrics to Authenticate Arabica Coffee from Antbush Fernando, David; Santosa, Djoko; Rohman, Abdul
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.85039

Abstract

Limited coffee stocks, high consumption, export demands, and increasing prices may contribute to counterfeiting. In other countries, including India and Africa, coffee forgery using antbush has been extensively established. Due to its abundance in Indonesia, unscrupulous coffee growers allegedly employ antbush (Senna occidentalis) as an adulterant in coffee to increase commercial earnings. This study aims to authenticate coffee from antbush using macroscopic and microscopic differences and FTIR spectroscopy combined with chemometrics. The arabica coffee samples from various regions were oven-roasted to a second crack and milled. The materials were then examined under macroscopic, microscopic, and infrared spectroscopic conditions. The obtained responses were used to monitor the qualitative and quantitative information in the targeted samples. Antbush in coffee samples is successfully identified microscopically by remnants of palisade tissue as well as the structural differences of the endosperm. In addition, FTIR spectroscopy combined with multivariate calibration can accurately estimate the concentration of antbush as adulterants in the target sample. Principle component regression (PCR) provides the best modeling for the relationship between the actual value. FTIR predicted the value of antbush with the lowest RMSEC and RMSEP values of 0.852 and 0.896, respectively, with the coefficient of determination (R2) in calibration and validation models of 0.9996 and 0.9967, respectively. The combination of macroscopic, microscopic, and FTIR spectroscopy offered reliable tools to authenticate arabica coffee from antbush.
Essential Oil Profiling and Antibacterial Activity of Curcuma xanthorrhiza Roxb. Originated from Yogyakarta by GC-MS Rahman, Catur Aryanto; Rahmawati, Laily Mega; Santosa, Djoko; Indrasetiawan, Puguh; Purwanto, Purwanto
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.93649

Abstract

As a tropical country, Indonesia has a large diversity of flora and fauna, including numerous medicinal plants. Although herbs are widely used for medicinal purposes, their pharmacological effect often varies. This variability is frequently attributed to differences in the geographical locations where these plants are grown, leading to variations in the content of active metabolites. In this study, the profile of metabolite content in the essential oil of C. xanthorriza rhizomes was cultivated in three different regions in Yogyakarta, Indonesia, namely Mangunan, Ngawen, and Menoreh. Gas Chromatography-Mass Spectrometry (GC-MS) analysis was employed to assess the metabolite content of essential oil. At the same time, antibacterial activity against Escherichia coli and Staphylococcus aureus was evaluated using the microdilution method. Results indicated that the rhizome from Mangunan has the highest xanthorrhizol content with a percentage area of 21.07%. The Biplot on Principal Component Analysis (PCA) showed that the relationship of compound levels of the three essential oils has no similarity with one another. The Minimum Inhibitory Concentration at 50% (MIC-50) values of C. xanthorriza essential oils from Mangunan, Menoreh, and Ngawen regions were lower in inhibiting the growth of E. coli bacteria (1620.78 ppm; 1777.69 ppm; and 1688.39 ppm, respectively) compared to S. aureus bacteria (3080.80 ppm; 3340.14 ppm; and 2869.54 ppm, respectively).
Efek Kombinasi 2,4 D Dan Kinetin Pada Pembentukan Kalus Daun Catharanthus roseus (L.) G. Don Serta Deteksi Alkaloidnya Khoiriyah, Siti; Santosa, Djoko; Purwantini, Indah
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.82593

Abstract

Catharanthus roseus (L.) G. Don dikenal dengan tapak dara merupakan tanaman obat tradisional, yang telah dibudidayakan sebagai tanaman penghasil senyawa alkaloid vinkristin dan vinblastin sebagai antikanker. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi 2,4 D dan kinetin terhadap keberhasilan pembentukan dan pertumbuhan kalus serta mengetahui adanya kandungan senyawa alkaloid pada kalus. Eksplan diinokulasi dalam media Murashige-Skoog (MS) padat yang ditambahkan 2,4 D 1 mg/L dan kinetin 4 mg/L untuk menghasilkan kalus, kemudian kalus disubkultur dan dipanen setelah berumur 21 hari. Kalus dimaserasi dengan etanol p.a. Identifikasi senyawa dilakukan menggunakan KLT dengan fase diam silika gel 60 F254  dan fase gerak berupa kloroform:metanol (9:1). Bercak pada pelat KLT dideteksi dengan sinar UV 254 dan 366 nm serta pereaksi Dragendorff. Hasil penelitian menunjukkan kombinasi 2,4 D 1 mg/L dan kinetin 4 mg/L berpengaruh dalam memacu keberhasilan pembentukan dan pertumbuhan kalus dengan rata-rata berat basah dan berat kering kalus masing-masing sebesar 2,359 dan 0,249 gram. Hasil identifikasi senyawa menunjukkan bahwa pada kalus dan tanaman asal mengandung alkaloid yang kemungkinan sama, yaitu senyawa dengan nilai Rf 0,89 dan 0,86.
Study on the Utilization of Medicinal Plants by the Community of Uelawu Village, Konawe District, Southeast Sulawesi Tahoangako, Sarmadhan Saputra; Santosa, Djoko; Fakhrudin, Nanang
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.84448

Abstract

Ethnomedicine is the science related to ethnicity and medicine. Ethnomedicine studies are basically carried out to understand health culture from the point of view of local community knowledge, especially the medical system that has become a community tradition for generations. Local genius of the use of medicinal plants to prevent and treat various diseases has been passed down from generation to generation by ethnic groups in Southeast Sulawesi. Ethnomedicine research on medicinal plants in Uelawu Village, Konawe Regency, Southeast Sulawesi Province aims to find out the types of plants that are efficacious as traditional medicines, how to prepare them, the doses used and how to use them in traditional medicine. The research method used was snowball sampling, through interviews with the people of Uelawu Village using a questionnaire covering the type of disease, herb, or single plant used (local name of the plant, part of the plant used, and method of preparation). Each local plant name used is determined and its Latin name is determined and a herbarium is made. The results showed that in Uelawu Village, Konawe District, Southeast Sulawesi Province, there were 25 species from 15 plant families that were used by the traditional community of Uelawu Village as ingredients for plant ingredients. The most used part of the plant is the leaves. Preparation of medicinal plant ingredients by boiling and then drinking is the method most often used by traditional communities living in Uelawu Village in utilizing medicinal plants as a medium for traditional medicine.
Potensi Cengkeh (Syzygium aromaticum (L.) Merr. & Perry) di Indonesia Sebagai Sumber Daya Alam dan Bahan Baku Obat Antibakteri dan Antijamur Pradana, Andi; Santosa, Djoko; Sulaiman, Teuku Nanda Saifullah
Majalah Farmaseutik Vol 20, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i1.86004

Abstract

Popularitas tanaman sebagai penanganan infeksi mikroba kian meningkat. Cengkeh adalah tanaman dengan kandungan senyawa kimia utama eugenol yang dapat digunakan sebagai antibakteri. Review ini dibuat menggunakan data sekunder dari database literatur ilmiah PubMed, Scopus, Google Scholar, SINTA, dan Science-Direct yang bertujuan untuk melihat potensi dari ektrak etanol bunga, daun dan batang cengkeh sebagai agen antimikroba. Aktivitas antibakteri E. coli dari daun dan bunga secara berturut-turut 20% (14,6mm); 31,25% (14mm). Daya hambat terhadap bakteri S. aureus dari batang, daun, bunga secara berturut-turut 40% (21,5mm); 50% (14,66mm); 62,50% (5mm). Aktivitas antibakteri terhadap S. mutans dari bunga dan daun secara berturut-turut 40% (18,83mm); 40% (12mm). Aktivitas bunga cengkeh terhadap jamur C. albicans konsentrasi 12,5% (20mm) dan memiliki KHM 1 μL/mL (44mm).
POTENSI SUMBER DAYA ALAM INDONESIA SEBAGAI BAHAN BAKU ALTERNATIF PEMBUATAN CARBOXYMETHYLCELLULOSE – Natrium (CMC-Na) : review Nugraheni, Heka Mareta; Zai, Khadijah; Santosa, Djoko
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.93539

Abstract

Carboxymethylcellulose – Natrium (CMC-Na) merupakan salah satu senyawa turunan dari selulosa yang memiliki berbagai kegunaan baik pada bidang farmasi, tekstile, konstruksi dan makanan. CMC-Na dapat diperoleh dari bahan alam yang mengandung selulosa seperti batang tumbuhan, kayu, daun, kulit buah, tangkai maupun serabut. Berdasarkan banyaknya kegunaan dan berlimpahnya bahan alam sebagai bahan utama pembuatan CMC-Na menjadikan banyaknya penelitian terkait sintesis CMC-Na. Review artikel ini bertujuan untuk membahas potensi bahan alam sebagai bahan baku dalam pembuatan CMC-Na. Pencarian arikel dilakukan secara online melalui Google Scholar dengan katakunci tertentu untuk mendapatkan informasi terbaru yang dipubikasi pada tahun 2013 sampai tahun 2022. Proses sintesis CMC-Na melalui beberapa tahapan, yaitu delignifikasi, bleaching, alkalisasi dan karboksimetilasi. Disisi lain, terdapat beberapa faktor yang perlu dilakukannya penelitian lebih lanjut, seperti proses ekstraksi selulosa, konsentrasi NaOH dan Natrium Monokloroasetat yang dgunakan, serta waktu dan suhu. Faktor-faktor tersebut berperan penting dalam mempengaruhi kualitas CMC-Na yang dihasilkan, sehingga penelitian lebih lanjut diperlukan untuk memastikan bahwa bahan alam yang tersedia melimpah di Indonesia dapat menghasilkan produk CMC-Na dengan kualitas yang baik.
Sales volume analysis through trust in manufacturing companies: Study on dynamix cement consumers Santosa, Djoko; Hadi, Prasetyo; Astuti, Miguna; Manggabarani, Alfatih Sikki
Jurnal Siasat Bisnis VOL 29, NO 1 (2025)
Publisher : Management Development Centre (MDC) Department of Management, Faculty of Business and Economics Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jsb.vol29.iss1.art7

Abstract

Purpose – The purpose of this study is to find out and analyze whether trust, country of origin, brand image, and product quality influences sales volume both directly and indirectly through trust on consumers of Semen Dynamix in Indonesia.Design/methodology/approach – A quantitative approach was used with purposive sampling to select 210 respondents meeting the research criteria. Data were analyzed using the Structural Equation Modeling (SEM) method with the SmartPLS tool.Findings – The results show that country of origin, brand image, and product quality significantly influence sales volume, while the influence of country of origin is not statistically significant. Trust serves as a mediating factor in the indirect relationships between these variables and sales volume.Research limitations/implications – The limitation of this study is its sole focus on Semen Dynamix, which may restrict the generalizability of the findings. Future research could explore additional factors or apply similar methods across other product categories.Practical implications – The study suggests that enhancing trust by improving country of origin perceptions, brand image, and product quality can positively affect sales. Practical applications include marketing strategies that highlight these attributes to strengthen customer trust and, in turn, drive sales volume.Originality/value – This study offers a fresh perspective on trust, highlighting its active role in mediating the effects of brand-related factors on sales. Insights from this research can guide marketers and practitioners in developing brand and sales-oriented strategies.
Co-Authors Abdul Rohman Abdul Rohman Abdul Rohman Asefin Nurul Ikhtiarini Asma Asma Astuti, Miguna Fernando, David Indah Purwantini Indrasetiawan, Puguh Irma Puspita Dewi Irma Puspita Dewi, Irma Puspita Irnawati Irnawati Irnawati Irnawati Luthfia Nurul Aini Manggabarani, Alfatih Sikki Mohamad Rafi Mohamad Rafi Muhamad Insanu Nanang Fakhrudin, Nanang Nanik Siti Aminah Nugraheni, Heka Mareta Nurma Sabila Paulus Eko Murwanto Paulus Eko Murwanto, Paulus Eko Perdana Priya Haresmita Perdana Priya Haresmita, Perdana Priya Pradana, Andi Prasetyo Hadi Rahman, Catur Aryanto Rahmawati, Laily Mega Rony, Zahara Tussoleha Setyaningsih, Widiastuti Siti Khoiriyah SM Widyastuti Subagus Wahyuono Sugeng Riyanto Sulaiman, Teuku Nanda Saifullah Tahoangako, Sarmadhan Saputra zai, Khadijah