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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Klinik Indonesia Majalah Kesehatan FKUB Narra J Malang Respiratory Journal Asian Journal of Health Research Jurnal Ilmu Kedokteran Keluarga Journal of Clinical Microbiology and Infectious Diseases
Dewi Santosaningsih
Department Of Parasitology, Faculty Of Medicine, Universitas Brawijaya, Malang 65145, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Comparison between cytomegalovirus and HIV viral load among HIV patient who underwent antiretroviral therapy Tulle, Andrew; Santosaningsih, Dewi; Hastuti, Nurima Diyah Puji
Journal of Clinical Microbiology and Infectious Diseases Vol. 5 No. 2 (2025): Available online : 1 December 2025
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v5i2.75

Abstract

Introduction: Cytomegalovirus (CMV) is one of the most prevalent viral infections in humans. The prevalence is approximately 20 percent among children and nearly 100 percent among adults. Among immunocompetent individuals, CMV infection remains predominantly asymptomatic. However, in immunocompromised patients such as people with HIV (PWH), it can cause end-organ diseases that may be life-threatening. With the increasing administration of antiretroviral therapy (ART), HIV infection can be controlled, and complications from CMV infection have been decreasing. One critical method for monitoring CMV infection is identifying CMV viremia. This study aims to investigate whether CMV viremia persists in PWH undergoing ART and to explore its relationship with HIV viral load. The research seeks to provide insights to guide clinical management of CMV reactivation in this patient population Methods: This cross-sectional study analysed archived plasma samples to detect and compare CMV viral load and HIV viral load among PWH undergoing ART. The samples were archived biological materials collected for HIV viral load detection. All samples were previously tested by PCR to detect CMV. Data were analysed using the Mann-Whitney test and Spearman correlation test. Result: Among 67 total samples, seven were identified as CMV positive, displaying various viral load concentrations. Analysis using the Mann-Whitney test demonstrated a statistically significant difference between variables, while the Spearman correlation test showed no correlation between them. This indicated that CMV viremia may not be directly influenced by HIV infection. Conclusion: Despite the significant difference between variables, the CMV viral load among PWH undergoing ART was not correlated with HIV viral load status. These findings suggest that CMV monitoring should be considered independently of HIV viral load status. However, the limited sample size suggests caution in generalizing these findings.
Co-Authors 'Arifin, Miftah Saiful Abousouh, Emad Khaleefah Achmad Rudijanto Agustina Tri Endharti Agustinus Santoso Anita Purnamayanti Arie Zainul Fatoni Arief Satria Hardika Aslam, Achmad Dian Handayani Endang S. Rahayu Erikawati, Dewi Fikhy Rizky Hapsari Gatya, Mifta Halim, Putri Aulawiya Rosyida Hastuti, Nurima Diyah Puji Hidayah, Rizka Nurul Irene Ratridewi, Irene Jonny K. Fajar Kristi, Brenda Lilik Zuhriyah Lucida, Maria Inge Mariyatun Mariyatun, Mariyatun Martha Nurani P Martin, Amandus Michael Mayniar Ayu Rahmadianti, Mayniar Ayu Melani, Ira Resmi Muti'ah, Roihatul Muwarni, Sri Nafisa, Belia Bima Nanik Setijowati Nazila Tanasya Nirwan Nugraha L. Noorhamdani AS Pramesi, Putrika C. Putra, Ngakan Rahayu, Siwipeni I. Ramadhona, Aisya Rasyidin Rumlus Riandinata, Mohammad Reza Rika Yulia Roekistiningsih Roekistiningsih Sanarto Santoso Sjoekoer M. Dzen Sugiri, Jane Suheni Ninik Hariyati Sutjipto, Yossy I. Syifa Mustika Teguh Wiyono Thomas E. C. J. Huwae Tulle, Andrew Wafi, Muhammad Farid Wijaya Kartanegara Wildan Aulia Firdaus Wiyasa, I Wayan Arsana Yaman, Muli Yusuf, Evira Natasya